Page last updated: 2024-08-23

halofantrine and mefloquine

halofantrine has been researched along with mefloquine in 107 studies

Research

Studies (107)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (10.28)	18.7374
1990's	62 (57.94)	18.2507
2000's	24 (22.43)	29.6817
2010's	10 (9.35)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Abla, N; Besson, D; Bombrun, A; Brun, R; Burt, H; Georgi, K; Kaiser, M; Molette, J; Muzerelle, M; Nwaka, S; Routier, J; Scheer, A	1
Avery, VM; Buchholz, M; Delves, MJ; Duffy, S; Fischli, C; Held, J; Knaab, TC; Kuna, K; Kurz, T; Lehmann, U; Leven, M; Lungerich, B; Meister, S; Meitzner, D; Mordmüller, B; Stahlke, P; Winzeler, EA; Wittlin, S	1
Badoual, J	1
Fadat, G; Gardon, J; Gazin, P; Hengy, C; Jambou, R; Louis, FJ; Louis, JP; Trebucq, A	1
Jatapadma, S; Ketrangsee, S; Rooney, W; Thimasarn, K; Vijaykadga, S; Yamokgul, P	1
Bustos, MD; Ciceron, L; Danis, M; Gay, F; Gentilini, M; Pichet, C; Rojas-Rivero, L	1
Basco, LK; Farinotti, R; Gillotin, C; Gimenez, F; Le Bras, J	1
Chuanak, N; Sookto, P; Thimasarn, K; Webster, HK; Wernsdorfer, WH; Wimonwattrawatee, T; Wongsrichanalai, C	1
Bauchet, J; Hatin, I; Le Bras, J; Legros, F; Trape, JF	1
Basco, LK; Bouchaud, O; Coulaud, JP; Farinotti, R; Gillotin, C; Gimenez, F; Le Bras, J; Rabenjarson, E; Ringwald, P	1
Baudon, D; Cordoliani, G; Da Conceicao, S; Delolme, H; Doury, JC; Hovette, P; Lecamus, JL; Martet, G; Raphenon, G; Touze, JE	1
Trigg, PI	1
Edstein, MD; Kowinwiphat, W; Panpunnung, S; Shanks, GD; Suriyamongkol, V; Watanasook, C; Watt, G; Webster, HK	1
Bustos, DG; Danis, M; Diquet, B; Gay, F; Gentilini, M; Litaudon, M; Pichet, C; Rojas Rivero, L	1
Bourdeau, EF; Childs, GE; Milhous, WK; Pang, L; Wimonwattratee, T	1
Le Bras, M; Mazaudier, E; Raccurt, CP; Ripert, C; Schmitt, A	1
Jeandel, P; Touze, JE	1
Bustos, MD; Danis, M; Diquet, B; Félix, R; Gay, F; Gentilini, M; Lyogoubi, A	1
Coulaud, JP; Ngo Van, P	1
Bowdre, JH; Desjardins, RE; Milhous, WK; Oduola, AM; Weatherly, NF	1
Chanthavanich, P; Karbwang, J; Looareesuwan, S; Phillips, RE; Supanaranond, W; Turner, RC; Warrell, DA; White, NJ	1
Childs, GE; Pooyindee, N; Wimonwattrawatee, T	1
Boudreau, EF; Canfield, CJ; Dixon, KE; Pang, LW; Pavanand, K; Somutsakorn, P; Tosingha, L; Webster, HK	1
Boudreau, EF; Pang, LW; Pavanand, K; Webster, HK; Yongvanitchit, K	1
Canfield, CJ; Cosgriff, TM; Pamplin, CL; Willet, GP	1
Coulanges, P; Deloron, P; Le Bras, J; Ramanamirija, JA	1
Boudreau, EF; Pavanand, K; Pinswasdi, C; Thaithong, S; Webster, HK; Yongvanitchit, K	1
Boudreau, EF; Pavanand, K; Thosingha, L; Webster, HK	1
Coulanges, P; Coulaud, JP; Deloron, P; Le Bras, J	1
Eichenlaub, D; Jelinek, T; Löscher, T; Schelbert, P	1
Nosten, F; Price, RN	1
Duong, TH; Igwangou, P; Kombila, M; Ngou-Milama, E; Ozouaki, P	1
Dolan, G; Edstein, MD; Keeratithakul, D; Nosten, F; Phaipun, L; Teja-Isavatharm, P; Ter Kuile, FO; Webster, HK; White, NJ	1
Basco, LK; Le Bras, J; Makler, MM; Marquet, F	1
Edwards, G; Ward, SA; Winstanley, PA	1
Baric, RS; Bright, P; Handy, J; Peel, SA; Yount, B	1
Basco, LK; Le Bras, J	2
Chongsuphajaisiddhi, T; Dolan, G; Edstein, MD; Luxemburger, C; Nosten, F; Phaipun, L; ter Kuile, FO; Webster, HK; White, NJ	1
Chongsuphajaisiddhi, T; Kyle, DE; Luxemburger, C; Nosten, F; ter Kuile, FO; White, NJ; Woodrow, C	1
Fleckenstein, L; Jongsakul, K; Karnasuta, C; Loesuttiviboon, L; Ohrt, CK; Schuster, B; Shanks, GD; Watt, G	1
Basco, LK; Le Bras, J; Ramiliarisoa, O	1
Cowman, AF; Galatis, D; Thompson, JK	1
Bunnag, D; Chittamas, S; Harinasuta, T; Horton, J; Karbwang, J; Looareesuwan, S; Serville, P; Viravan, C	1
Go, ML; Lee, HS; Ngiam, TL	1
Kyle, DE; Martin, RK; Milhous, WK; Thaithong, S; Volkman, SK; Wilson, CM; Wirth, DF	1
Baric, RS; Handy, J; Merritt, SC; Peel, SA	1
Gerena, L; Karle, JM; Milhous, WK; Olmeda, R	1
Touze, JE	1
Basco, LK; de Pecoulas, PE; Le Bras, J; Wilson, CM	1
Watkins, WM	1
Brault, M; Delling, U; Gros, P; Ruetz, S; Schurr, E	1
Brewer, TG; Leo, KU; Marino, MT; Wesche, DL	1
Bray, PG; Green, JE; Hawley, SR; Mungthin, M; Ritchie, GY; Ward, SA	1
Fleck, SL; Peters, W; Robinson, BL	1
Chiwakata, CB; Dietrich, M; Egbring, R; Gaus, W; Hassemer, M; Hemmer, CJ; Hogel, J; Hort, G; Kern, P; Nawroth, PP; Seitz, R	1
Pillans, PI; Tish, KN	1
Boele van Hensbroek, M; Kager, PA; Wetsteyn, JC; Zijlmans, CW	1
Doury, JC; Fusai, T; Pradines, B; Rogier, C; Tall, A; Trape, JF	1
Kremsner, PG; Philipps, J; Radloff, PD; Wernsdorfer, W	1
Coulibaly, SO; Dutheil, Y; Guiguemdé, TR; Ouédraogo, JB; Tall, F; Tinto, H; Traoré, B; Zampa, H	1
Clerinx, J; Colebunders, R; Coppens, G; Depraetere, K; Peetermans, WE; Schroyens, W; Van den Ende, J; Van den Enden, E; Van Gompel, A; Van Haegenborgh, T; Verstraeten, T	1
Bray, PG; Mungthin, M; Ridley, RG; Ward, SA	1
Bhattacharjee, AK; Karle, JM	1
Deharo, E; Haemers, A; Ludwig, A; Mbela, TK	1
Bourgeade, A; Delmont, J	1
Burgel, PR; Camara, P; Hovette, P; Klotz, F; Mbaye, PS; Sane, M	1
Le Bras, J	1
Chongsuphajaisiddhi, T; Luxemburger, C; Nosten, F; Phaipun, L; Price, R; Simpson, JA; ter Kuile, F; van Vugt, M; White, NJ	1
Baune, B; Farinotti, R; Furlan, V; Taburet, AM	1
Bray, PG; Mungthin, M; Ward, SA	1
Danis, M; Delhaes, L; Gay, F; Lazaro, JE; Thellier, M	1
Duraisingh, MT; Jones, P; Pinder, M; Sambou, I; von Seidlein, L; Warhurst, DC	1
Batey, AJ; Coker, SJ; Díaz, ME; Eisner, DA; Lightbown, ID	1
Caruana, SR; Cowman, AF; Kirk, K; Reed, MB; Saliba, KJ	1
Makonnen, E; Mengesha, T	1
Hombhanje, FW	1
Emerole, GO; Farombi, EO; Olowu, BI	1
Coker, SJ; Edwards, G; Lambert, JP; Lightbown, ID	1
Adoro, S; Farombi, EO; Uhunmwangho, S	1
Bedos, JP; Bruneel, F; Danis, M; Gachot, B; Regnier, B; Vachon, F; Wolff, M	1
Alberti, C; Bédos, JP; Bruneel, F; Chevret, S; Durand, R; Hocqueloux, L; Le Bras, J; Régnier, B; Vachon, F; Wolff, M	1
Atteke, C; Aubouy, A; Bakary, M; Deloron, P; Lébibi, J; Ndong, JM	1
Jambou, R; Randrianarijaona, A; Randrianarivelojosia, M; Randrianasolo, L; Ratsimbasoa, A	1
Nakajima, Y	1
Bégué, P; Grimprel, E; Parez, N; Pillon, V; Quinet, B	1
Hayton, K; Su, XZ	1
Brown, ML; Geyer, JA; Terrell, JC; Trotta, RF	1
Bhattacharjee, AK; Dow, GS; Gerena, L; Hudson, TH; Koenig, ML; Lopez-Sanchez, M; Wolf, L	1
Combes, JC; Garnier, JM; Minodier, P; Noël, G; Retornaz, K; Salles, M; Walters, H	1
Fidock, DA; Sidhu, AB; Valderramos, SG	1
Fidock, DA; Krishna, S; Sidhu, AB; Uhlemann, AC; Valderramos, JC; Valderramos, SG	1
Brockman, A; Chotivanich, K; Day, NP; Stepniewska, K; White, NJ	1
Croft, AM	1
Abuaku, B; Duah, NO; Koram, KA; Quashie, NB	1
Black, J	1
Egan, TJ; Hoppe, HC; Joiner, KA; Roberts, L	1
Borrmann, S; Kiara, SM; Mwai, L; Nzila, A; Ochola, LI; Ohuma, E; Okombo, J; Pole, L; Rono, J	1
Kimura, M; Kinoshita, A; Kotaki, H; Yamada, H	1
Assi, SB; Basco, LK; Bla, KB; Djaman, AJ; Koné, M; Mazabraud, A; Yavo, W	1
Angelino, E; Barnes, KG; Becker, JS; Birren, BW; Cortese, JF; Daniels, RF; Eskin, E; Furlotte, NA; Grossman, SR; Happi, C; Hartl, DL; Johnson, CA; Kang, HM; Karlsson, EK; Lander, ES; Lukens, AK; Mboup, S; Milner, DA; Ndiaye, D; Neafsey, DE; Park, DJ; Rosen, DM; Sabeti, PC; Sarr, O; Schaffner, SF; Shlyakhter, I; Van Tyne, D; Volkman, SK; Wiegand, RC; Wirth, DF; Yamins, D	1
Berger, F; Bertani, S; Bouchier, C; Ekala, MT; Legrand, E; Mercereau-Puijalon, O; Meynard, JB; Musset, L; Péneau, J; Volney, B; Yrinesi, J	1
Al-Farsi, HM; Al-Hashami, ZS; Al-Qahtani, A; Al-Sheikh, AA; Babiker, HA; Bin Dajem, SM	1
Cowman, AF; Healer, J; Uboldi, AD; Van Tyne, D; Wirth, DF	1
Clark, J; Golenser, J; Guiguemde, WA; Guo, J; Guy, RK; Haynes, RK; Hunt, NH; Marciano, A	1

Reviews

9 review(s) available for halofantrine and mefloquine

Article	Year
New antimalarials. A risk-benefit analysis. Drug safety, 1995, Volume: 12, Issue:4 Topics: Animals; Antimalarials; Artemisinins; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum; Pregnancy; Risk Assessment; Sesquiterpenes	1995
Clinical pharmacokinetics in the treatment of tropical diseases. Some applications and limitations. Clinical pharmacokinetics, 1994, Volume: 27, Issue:2 Topics: Chloroquine; Diethylcarbamazine; Drug Resistance; Echinococcosis; Filariasis; Humans; Malaria; Mefloquine; Pharmacokinetics; Phenanthrenes; Pyrimethamine; Quinine; Sulfadoxine; Tropical Medicine	1994
[Correct usage of amino alcohols]. Medecine tropicale : revue du Corps de sante colonial, 1995, Volume: 55, Issue:3 Suppl Topics: Antimalarials; Clinical Protocols; Drug Administration Schedule; Drug Resistance; Humans; Malaria; Mefloquine; Phenanthrenes; Quinine	1995
Pharmacology and pharmacokinetics of new antimalarials. Medecine tropicale : revue du Corps de sante colonial, 1995, Volume: 55, Issue:4 Suppl Topics: Africa; Antimalarials; Artemether; Artemisinins; Drug Costs; Drug Resistance; Humans; Malaria, Falciparum; Mefloquine; Phenanthrenes; Sesquiterpenes; Trimethoprim, Sulfamethoxazole Drug Combination	1995
[The treatment of malaria]. Nederlands tijdschrift voor geneeskunde, 1997, Sep-13, Volume: 141, Issue:37 Topics: Adult; Antimalarials; Chloroquine; Drug Therapy, Combination; Female; Humans; Infant, Newborn; Malaria; Malaria, Falciparum; Malaria, Vivax; Mefloquine; Phenanthrenes; Pregnancy; Primaquine	1997
Comparative efficacy and safety of chloroquine and alternative antimalarial drugs: a meta-analysis from six African countries. East African medical journal, 1999, Volume: 76, Issue:6 Topics: Africa, Eastern; Africa, Western; Amodiaquine; Antimalarials; Chloroquine; Drug Combinations; Drug Costs; Humans; Malaria; Mefloquine; Patient Selection; Phenanthrenes; Pyrimethamine; Quinine; Safety; Sulfadoxine; Treatment Outcome	1999
[Antiprotozoal drugs]. Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 2 Topics: Animals; Antiprotozoal Agents; Drug Combinations; Emetine; Humans; Mefloquine; Metronidazole; Phenanthrenes; Primaquine; Protozoan Infections; Pyrimethamine; Quinine; Sulfadoxine; Tinidazole	2003
Genetic and biochemical aspects of drug resistance in malaria parasites. Current drug targets. Infectious disorders, 2004, Volume: 4, Issue:1 Topics: Animals; Antimalarials; Chloroquine; Dihydropteroate Synthase; Drug Resistance; Drug Resistance, Multiple; Humans; Linkage Disequilibrium; Malaria; Malaria, Falciparum; Malaria, Vivax; Mefloquine; Membrane Proteins; Membrane Transport Proteins; Mutation; Phenanthrenes; Plasmodium falciparum; Plasmodium vivax; Protozoan Proteins; Pyrimethamine; Sulfadoxine; Tetrahydrofolate Dehydrogenase	2004
A lesson learnt: the rise and fall of Lariam and Halfan. Journal of the Royal Society of Medicine, 2007, Volume: 100, Issue:4 Topics: Antimalarials; Drug Industry; Financing, Government; Forecasting; Humans; Interprofessional Relations; Malaria; Mefloquine; Mental Disorders; Military Personnel; Phenanthrenes; Technology, Pharmaceutical; United States; United States Food and Drug Administration	2007

Trials

9 trial(s) available for halofantrine and mefloquine

Article	Year
Comparative trial on the response of Plasmodium falciparum to halofantrine and mefloquine in Trat Province, eastern Thailand. The Southeast Asian journal of tropical medicine and public health, 1992, Volume: 23, Issue:1 Topics: Administration, Oral; Adult; Antimalarials; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Phenanthrenes; Thailand; Treatment Outcome	1992
Malaria: treatment efficacy of halofantrine (WR 171,669) in initial field trials in Thailand. Bulletin of the World Health Organization, 1988, Volume: 66, Issue:2 Topics: Adult; Antimalarials; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Humans; Malaria; Male; Mefloquine; Middle Aged; Phenanthrenes; Quinolines; Random Allocation	1988
Comparison of capillary whole blood, venous whole blood, and plasma concentrations of mefloquine, halofantrine, and desbutyl-halofantrine measured by high-performance liquid chromatography. The American journal of tropical medicine and hygiene, 1994, Volume: 51, Issue:6 Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Linear Models; Malaria, Falciparum; Mefloquine; Middle Aged; Phenanthrenes; Reproducibility of Results	1994
Halofantrine versus mefloquine in treatment of multidrug-resistant falciparum malaria. Lancet (London, England), 1993, Apr-24, Volume: 341, Issue:8852 Topics: Acute Disease; Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Drug Resistance; Female; Follow-Up Studies; Humans; Infant; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Myanmar; Phenanthrenes; Plasmodium falciparum; Prospective Studies; Recurrence; Refugees; Thailand; Treatment Failure	1993
Cardiac effects of antimalarial treatment with halofantrine. Lancet (London, England), 1993, Apr-24, Volume: 341, Issue:8852 Topics: Adolescent; Adult; Antimalarials; Electrocardiography; Female; Heart; Humans; Malaria, Falciparum; Male; Mefloquine; Phenanthrenes; Prospective Studies	1993
Efficacy and tolerance of extended-dose halofantrine for drug-resistant falciparum malaria in Thailand. The American journal of tropical medicine and hygiene, 1994, Volume: 50, Issue:2 Topics: Adult; Animals; Chi-Square Distribution; Diarrhea; Dizziness; Drug Resistance; Drug Therapy, Combination; Humans; Malaria, Falciparum; Male; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Tetracycline; Thailand; Vomiting	1994
Clinical trials with halofantrine in acute uncomplicated falciparum malaria in Thailand. The Southeast Asian journal of tropical medicine and public health, 1993, Volume: 24, Issue:1 Topics: Adolescent; Adult; Antimalarials; Humans; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Phenanthrenes; Thailand	1993
Supportive pentoxifylline in falciparum malaria: no effect on tumor necrosis factor alpha levels or clinical outcome: a prospective, randomized, placebo-controlled study. The American journal of tropical medicine and hygiene, 1997, Volume: 56, Issue:4 Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Antimalarials; Biopterins; Drug Therapy, Combination; Female; Humans; L-Lactate Dehydrogenase; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Neopterin; Parasitemia; Pentoxifylline; Phenanthrenes; Phosphodiesterase Inhibitors; Severity of Illness Index; Single-Blind Method; Treatment Outcome; Tumor Necrosis Factor-alpha	1997
[Mefloquine versus halofantrine in children suffering from acute uncomplicated falciparum malaria]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2005, Volume: 12 Suppl 1 Topics: Adolescent; Antimalarials; Child; Child, Preschool; Female; Humans; Infant; Long QT Syndrome; Malaria, Falciparum; Male; Mefloquine; Phenanthrenes; Treatment Outcome	2005

Other Studies

89 other study(ies) available for halofantrine and mefloquine

Article	Year
Identification and optimization of an aminoalcohol-carbazole series with antimalarial properties. ACS medicinal chemistry letters, 2013, Nov-14, Volume: 4, Issue:11 Topics:	2013
3-Hydroxy-N'-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally. Journal of medicinal chemistry, 2017, 07-27, Volume: 60, Issue:14 Topics: Amides; Animals; Antimalarials; Hep G2 Cells; Humans; Hydrazones; Malaria; Mice; Phenanthrenes; Plasmodium berghei; Stereoisomerism; Structure-Activity Relationship	2017
[Treatment of malaria in children in France]. Pediatrie, 1992, Volume: 47, Issue:5 Topics: Antimalarials; Child; Chloroquine; France; Humans; Malaria, Cerebral; Malaria, Falciparum; Mefloquine; Phenanthrenes; Quinine	1992
Proposals for a new therapeutic strategy for simple Plasmodium falciparum malaria attacks in Cameroon. Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1992, Volume: 43, Issue:2 Topics: Administration, Oral; Aminoquinolines; Amodiaquine; Animals; Antimalarials; Cameroon; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine	1992
Mefloquine-halofantrine cross-resistance in Plasmodium falciparum induced by intermittent mefloquine pressure. The American journal of tropical medicine and hygiene, 1992, Volume: 47, Issue:3 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine	1992
In vitro activity of the enantiomers of mefloquine, halofantrine and enpiroline against Plasmodium falciparum. British journal of clinical pharmacology, 1992, Volume: 33, Issue:5 Topics: Animals; Antimalarials; Dose-Response Relationship, Drug; Mefloquine; Phenanthrenes; Plasmodium falciparum; Pyridines; Stereoisomerism	1992
Emergence of multidrug-resistant Plasmodium falciparum in Thailand: in vitro tracking. The American journal of tropical medicine and hygiene, 1992, Volume: 47, Issue:1 Topics: Animals; Antimalarials; Drug Resistance; Humans; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum; Regression Analysis; Thailand	1992
Susceptibility of Plasmodium falciparum strains to mefloquine in an urban area in Senegal. Bulletin of the World Health Organization, 1992, Volume: 70, Issue:3 Topics: Adolescent; Adult; Aminoquinolines; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Humans; In Vitro Techniques; Infant; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum	1992
Type RI resistance to halofantrine in West Africa. Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1991, Volume: 42, Issue:4 Topics: Animals; Antimalarials; Biological Availability; Chloroquine; Cote d'Ivoire; Drug Resistance; Follow-Up Studies; France; Humans; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Phenanthrenes; Plasmodium falciparum; Quinine; Recurrence; Travel	1991
[Malaria in the republic of São Tomé and Principe. Epidemiologic evaluation and chemoresistance of P. falciparum]. Bulletin de la Societe de pathologie exotique (1990), 1991, Volume: 84, Issue:3 Topics: Age Factors; Animals; Antimalarials; Atlantic Islands; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Seasons; Sex Factors; Splenomegaly	1991
Drug use and design in the nineties. Acta Leidensia, 1991, Volume: 60, Issue:1 Topics: Aminoquinolines; Amodiaquine; Antimalarials; Artemisinins; Calcium Channel Blockers; Chloroquine; Humans; Malaria; Mefloquine; Naphthoquinones; Phenanthrenes; Primaquine; Quinine; Sesquiterpenes; Sulfadoxine	1991
Halofantrine for the treatment of mefloquine chemoprophylaxis failures in Plasmodium falciparum infections. The American journal of tropical medicine and hygiene, 1991, Volume: 45, Issue:4 Topics: Animals; Antimalarials; Drug Resistance; Humans; Malaria, Falciparum; Mefloquine; Military Personnel; Phenanthrenes; Plasmodium falciparum; Recurrence; Thailand	1991
Cross-resistance between mefloquine and halofantrine. Lancet (London, England), 1990, Nov-17, Volume: 336, Issue:8725 Topics: Adult; Animals; Antimalarials; Drug Resistance; Humans; Malaria; Male; Mefloquine; Phenanthrenes; Plasmodium falciparum	1990
In vitro and clinical correlates of mefloquine resistance of Plasmodium falciparum in eastern Thailand. The American journal of tropical medicine and hygiene, 1991, Volume: 44, Issue:5 Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Butylated Hydroxytoluene; Chloroquine; Drug Resistance; Drugs, Chinese Herbal; Mefloquine; Molecular Structure; Phenanthrenes; Plasmodium falciparum; Pyridines; Pyrimethamine; Quinine; Sesquiterpenes; Thailand	1991
[Imported malaria in Bordeaux in 1989. Epidemiologic, clinical and therapeutic study of 71 cases]. Bulletin de la Societe de pathologie exotique (1990), 1990, Volume: 83, Issue:5 Topics: Animals; Antimalarials; Chloroquine; Female; France; Humans; Malaria; Male; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Travel	1990
[Clinical and therapeutic approach in Plasmodium falciparum malaria in non-immune patients]. Presse medicale (Paris, France : 1983), 1990, Apr-14, Volume: 19, Issue:15 Topics: Animals; Drug Resistance, Microbial; Humans; Malaria; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine	1990
[Cross resistance to mefloquine and halofantrine in a case of P. falciparum malaria contracted in Sierra Leone]. Bulletin de la Societe de pathologie exotique (1990), 1990, Volume: 83, Issue:1 Topics: Adult; Animals; Antimalarials; Chloroquine; Cross Reactions; Drug Resistance; Humans; Malaria; Male; Mefloquine; Phenanthrenes; Plasmodium falciparum	1990
[New antiparasitic drugs]. Annales de dermatologie et de venereologie, 1988, Volume: 115, Issue:4 Topics: Amebicides; Anthelmintics; Antifungal Agents; Antimalarials; Artemisinins; Fluconazole; Humans; Itraconazole; Ketoconazole; Mefloquine; Phenanthrenes; Quinolines; Sesquiterpenes; Triazoles	1988
Plasmodium falciparum: induction of resistance to mefloquine in cloned strains by continuous drug exposure in vitro. Experimental parasitology, 1988, Volume: 67, Issue:2 Topics: Animals; Antimalarials; Butylated Hydroxytoluene; Chemical Phenomena; Chemistry; Culture Media; Drug Resistance; Isoenzymes; Mefloquine; Phenanthrenes; Plasmodium falciparum; Pyridines; Quinolines	1988
Hypoglycaemia and antimalarial drugs: quinidine and release of insulin. British medical journal (Clinical research ed.), 1986, May-17, Volume: 292, Issue:6531 Topics: Amodiaquine; Antimalarials; Blood Glucose; Chloroquine; Humans; Hypoglycemia; Insulin; Mefloquine; Phenanthrenes; Quinidine; Quinolines; Thailand	1986
Evaluation of an in vitro assay system for drug susceptibility of field isolates of Plasmodium falciparum from southern Thailand. The American journal of tropical medicine and hygiene, 1988, Volume: 38, Issue:1 Topics: Amodiaquine; Animals; Antimalarials; Butylated Hydroxytoluene; Chloroquine; Humans; Mefloquine; Parasitology; Phenanthrenes; Plasmodium falciparum; Pyridines; Pyrimethamine; Quinine; Quinolines; Thailand; Triazines	1988
Antimalarial drug susceptibility testing of Plasmodium falciparum in Thailand using a microdilution radioisotope method. The American journal of tropical medicine and hygiene, 1985, Volume: 34, Issue:2 Topics: Adult; Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Lethal Dose 50; Malaria; Male; Mefloquine; Microbial Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Quinine; Quinolines; Thailand	1985
Mefloquine failure in a case of falciparum malaria induced with a multidrug-resistant isolate in a non-immune subject. The American journal of tropical medicine and hygiene, 1985, Volume: 34, Issue:4 Topics: Adult; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Mefloquine; Phenanthrenes; Plasmodium falciparum; Pyridines; Quinine; Quinolines	1985
Plasmodium falciparum in Madagascar: in vivo and in vitro sensitivity to seven drugs. Annals of tropical medicine and parasitology, 1985, Volume: 79, Issue:4 Topics: Adolescent; Adult; Aged; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Humans; Infant; Madagascar; Malaria; Mefloquine; Microbial Sensitivity Tests; Middle Aged; Phenanthrenes; Piperazines; Plasmodium falciparum; Quinine; Quinolines	1985
Cloning and characterization of mefloquine-resistant Plasmodium falciparum from Thailand. The American journal of tropical medicine and hygiene, 1985, Volume: 34, Issue:6 Topics: Adult; Animals; Antimalarials; Clone Cells; Drug Resistance; Glucose-6-Phosphate Isomerase; Humans; Isoenzymes; Malaria; Male; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinolines; Thailand	1985
Type II mefloquine resistance in Thailand. Lancet (London, England), 1982, Dec-11, Volume: 2, Issue:8311 Topics: Adult; Antimalarials; Drug Resistance, Microbial; Humans; Malaria; Male; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinolines; Thailand	1982
[Drug sensitivity of Plasmodium falciparum in Madagascar. V. Study of the in vitro activity of quinine, mefloquine and halofantrine]. Archives de l'Institut Pasteur de Madagascar, 1984, Volume: 51, Issue:1 Topics: Antimalarials; Chloroquine; Humans; Mefloquine; Microbial Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Quinine; Quinolines	1984
Quinine resistant falciparum malaria acquired in east Africa. Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1995, Volume: 46, Issue:1 Topics: Adult; Africa, Eastern; Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Male; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Tetracycline	1995
[Variation of cholostase enzymes (5'-nucleotidase and alkaline phosphatase) during a specific treatment for malaria in the Gabonese child]. Bulletin de la Societe de pathologie exotique (1990), 1995, Volume: 88, Issue:1 Topics: 5'-Nucleotidase; Alkaline Phosphatase; Antimalarials; Child; Child, Preschool; Drug Combinations; Gabon; Humans; Infant; Malaria; Mefloquine; Phenanthrenes; Pyrimethamine; Reference Values; Sulfadoxine	1995
Plasmodium falciparum and Plasmodium vivax: lactate dehydrogenase activity and its application for in vitro drug susceptibility assay. Experimental parasitology, 1995, Volume: 80, Issue:2 Topics: Animals; Antimalarials; Chloroquine; Colorimetry; Erythrocytes; Humans; L-Lactate Dehydrogenase; Malaria, Falciparum; Malaria, Vivax; Mefloquine; Parasitemia; Phenanthrenes; Plasmodium falciparum; Plasmodium vivax; Quinine	1995
A strong association between mefloquine and halofantrine resistance and amplification, overexpression, and mutation in the P-glycoprotein gene homolog (pfmdr) of Plasmodium falciparum in vitro. The American journal of tropical medicine and hygiene, 1994, Volume: 51, Issue:5 Topics: Animals; Antimalarials; Artemisinins; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, Northern; Blotting, Southern; Chloroquine; DNA Primers; DNA, Protozoan; Drug Resistance; Gene Amplification; Gene Expression; Genes, Protozoan; Mefloquine; Molecular Sequence Data; Phenanthrenes; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Quinine; RNA, Messenger; Selection, Genetic; Sequence Homology, Nucleic Acid; Sesquiterpenes	1994
In vitro susceptibility of Cambodian isolates of Plasmodium falciparum to halofantrine, pyronaridine and artemisinin derivatives. Annals of tropical medicine and parasitology, 1994, Volume: 88, Issue:2 Topics: Adult; Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Humans; In Vitro Techniques; Mefloquine; Naphthyridines; Phenanthrenes; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinine; Sesquiterpenes; Triazines	1994
In vitro activity of pyrimethamine, cycloguanil, and other antimalarial drugs against African isolates and clones of Plasmodium falciparum. The American journal of tropical medicine and hygiene, 1994, Volume: 50, Issue:2 Topics: Africa; Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Mefloquine; Phenanthrenes; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinine; Triazines	1994
Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine. Proceedings of the National Academy of Sciences of the United States of America, 1994, Feb-01, Volume: 91, Issue:3 Topics: Animals; Chromosome Mapping; Drug Resistance; Gene Amplification; Gene Expression; Genes, Protozoan; Humans; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine	1994
In vitro activity of artemisinin derivatives against African isolates and clones of Plasmodium falciparum. The American journal of tropical medicine and hygiene, 1993, Volume: 49, Issue:3 Topics: Animals; Antimalarials; Artemether; Artemisinins; Chloroquine; Drug Resistance; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Sesquiterpenes	1993
Pharmacological activity and structure-activity relationship of (+/-)-erythro-mefloquine and related compounds on the isolated mouse phrenic nerve diaphragm preparation. Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:7 Topics: Animals; Antimalarials; Bungarotoxins; Electric Stimulation; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Mefloquine; Mice; Models, Molecular; Molecular Conformation; Muscle Contraction; Neuromuscular Junction; Phenanthrenes; Phrenic Nerve; Quinine; Quinolines; Structure-Activity Relationship	1993
Amplification of pfmdr 1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand. Molecular and biochemical parasitology, 1993, Volume: 57, Issue:1 Topics: Animals; Antimalarials; Base Sequence; DNA, Protozoan; Drug Resistance; Gene Amplification; Genes, Protozoan; Humans; Malaria, Falciparum; Mefloquine; Molecular Sequence Data; Phenanthrenes; Plasmodium falciparum; RNA, Messenger; RNA, Protozoan; Thailand	1993
Derivation of highly mefloquine-resistant lines from Plasmodium falciparum in vitro. The American journal of tropical medicine and hygiene, 1993, Volume: 48, Issue:3 Topics: Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Erythrocytes; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Serial Passage; Vacuoles	1993
Plasmodium falciparum: role of absolute stereochemistry in the antimalarial activity of synthetic amino alcohol antimalarial agents. Experimental parasitology, 1993, Volume: 76, Issue:4 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Mefloquine; Phenanthrenes; Plasmodium falciparum; Pyridines; Quinolines; Stereoisomerism; Structure-Activity Relationship	1993
Plasmodium falciparum: molecular characterization of multidrug-resistant Cambodian isolates. Experimental parasitology, 1996, Volume: 82, Issue:2 Topics: Alleles; Animals; Antimalarials; Blotting, Southern; Cambodia; Chloroquine; Codon; DNA Fingerprinting; DNA, Protozoan; Drug Resistance, Multiple; Folic Acid Antagonists; Genes, Protozoan; Genetic Variation; Humans; Mefloquine; Phenanthrenes; Plasmodium falciparum; Polymorphism, Genetic; Proguanil; Pyrimethamine; Triazines	1996
The pfmdr1 gene of Plasmodium falciparum confers cellular resistance to antimalarial drugs in yeast cells. Proceedings of the National Academy of Sciences of the United States of America, 1996, Sep-03, Volume: 93, Issue:18 Topics: Alleles; Animals; Antimalarials; ATP-Binding Cassette Transporters; Dose-Response Relationship, Drug; Drug Resistance; Mefloquine; Mice; Phenanthrenes; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Quinacrine; Quinine	1996
Mefloquine effect on disposition of halofantrine in the isolated perfused rat liver. The Journal of pharmacy and pharmacology, 1996, Volume: 48, Issue:7 Topics: Animals; Antimalarials; Area Under Curve; Drug Interactions; In Vitro Techniques; Liver; Male; Mefloquine; Metabolic Clearance Rate; Perfusion; Phenanthrenes; Rats; Rats, Sprague-Dawley	1996
In vitro selection of halofantrine resistance in Plasmodium falciparum is not associated with increased expression of Pgh1. Molecular and biochemical parasitology, 1996, Dec-02, Volume: 83, Issue:1 Topics: Animals; Antimalarials; ATP-Binding Cassette Transporters; Biological Transport; Chloroquine; DNA Fingerprinting; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Multiple; Gene Dosage; Gene Expression; Immunoblotting; Mefloquine; Phenanthrenes; Plasmodium falciparum; Protozoan Proteins; Quinine; Selection, Genetic; Sequence Analysis, DNA; Verapamil	1996
The chemotherapy of rodent malaria. LIV. Combinations of 'Fenozan B07' (Fenozan-50F), a difluorinated 3,3'-spirocyclopentane 1,2,4-trioxane, with other drugs against drug-sensitive and drug-resistant parasites. Annals of tropical medicine and parasitology, 1997, Volume: 91, Issue:1 Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Drug Antagonism; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Malaria; Mefloquine; Mice; Naphthyridines; Parasitemia; Phenanthrenes; Phenylpropionates; Plasmodium berghei; Plasmodium yoelii	1997
Recrudescence of Plasmodium falciparum malaria contracted in Lombok, Indonesia after quinine/doxycycline and mefloquine: case report. The New Zealand medical journal, 1997, Jul-11, Volume: 110, Issue:1047 Topics: Adult; Animals; Anti-Bacterial Agents; Antimalarials; Doxycycline; Drug Combinations; Drug Resistance, Multiple; Humans; Indonesia; Malaria, Cerebral; Malaria, Falciparum; Male; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Recurrence	1997
In vitro activity of artemether against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial drugs. The American journal of tropical medicine and hygiene, 1998, Volume: 58, Issue:3 Topics: Animals; Antimalarials; Artemether; Artemisinins; Chloroquine; Drug Combinations; Drug Resistance; Erythrocytes; Humans; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Senegal; Sesquiterpenes	1998
Follow-up of the susceptibility of Plasmodium falciparum to antimalarials in Gabon. The American journal of tropical medicine and hygiene, 1998, Volume: 58, Issue:5 Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Follow-Up Studies; Gabon; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Sesquiterpenes; Sulfadoxine	1998
In vitro sensitivity of Plasmodium falciparum to halofantrine compared with chloroquine, quinine and mefloquine in the region of Bobo-Dioulasso, Burkina Faso (West Africa). Tropical medicine & international health : TM & IH, 1998, Volume: 3, Issue:5 Topics: Animals; Antimalarials; Burkina Faso; Chloroquine; Drug Resistance; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine	1998
Recurrence of blackwater fever: triggering of relapses by different antimalarials. Tropical medicine & international health : TM & IH, 1998, Volume: 3, Issue:8 Topics: Adult; Aged; Antimalarials; Belgium; Blackwater Fever; Diagnosis, Differential; Female; Humans; Male; Mefloquine; Middle Aged; Phenanthrenes; Quinine; Recurrence	1998
Central role of hemoglobin degradation in mechanisms of action of 4-aminoquinolines, quinoline methanols, and phenanthrene methanols. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:11 Topics: Amodiaquine; Antimalarials; Chloroquine; Hemoglobins; Humans; Leucine; Mefloquine; Phenanthrenes; Primaquine; Protease Inhibitors	1998
Functional correlation of molecular electronic properties with potency of synthetic carbinolamine antimalarial agents. Bioorganic & medicinal chemistry, 1998, Volume: 6, Issue:10 Topics: Antimalarials; Mefloquine; Models, Molecular; Molecular Conformation; Phenanthrenes; Pyridines; Quinolines; Static Electricity; Structure-Activity Relationship	1998
Submicron oil-in-water emulsion formulations for mefloquine and halofantrine: effect of electric-charge inducers on antimalarial activity in mice. The Journal of pharmacy and pharmacology, 1998, Volume: 50, Issue:11 Topics: Animals; Antimalarials; Drug Interactions; Drug Stability; Emulsions; Excipients; Ions; Male; Mefloquine; Mice; Phenanthrenes; Static Electricity	1998
[The proper use of antimalarial drugs currently available]. Bulletin de la Societe de pathologie exotique (1990), 1998, Volume: 91, Issue:5 Pt 1-2 Topics: Animals; Antimalarials; Chemoprevention; Chloroquine; Contraindications; Drug Combinations; Drug Resistance; Endemic Diseases; Humans; Malaria; Malaria, Falciparum; Malaria, Vivax; Mefloquine; Phenanthrenes; Plasmodium; Plasmodium falciparum; Plasmodium malariae; Plasmodium vivax; Proguanil; Pyrimethamine; Quinine; Sulfadoxine; Travel	1998
[Pulmonary manifestations associated with malaria]. Revue de pneumologie clinique, 1998, Volume: 54, Issue:6 Topics: Adult; Anti-Bacterial Agents; Antimalarials; Bronchitis; Child; Chloroquine; Female; Humans; Infant, Newborn; Lung Diseases; Malaria, Falciparum; Male; Mefloquine; Oxygen Inhalation Therapy; Phenanthrenes; Pleurisy; Pregnancy; Pregnancy Complications, Parasitic; Pulmonary Edema; Quinidine; Quinine; Respiratory Distress Syndrome, Newborn; Travel	1998
In vitro susceptibility of African Plasmodium falciparum isolates to dihydroartemisinin and the risk factors for resistance to qinghaosu. Medecine tropicale : revue du Corps de sante colonial, 1998, Volume: 58, Issue:3 Suppl Topics: Africa; Animals; Antimalarials; Artemisinins; Chloroquine; Cross Reactions; Drug Evaluation, Preclinical; Drug Resistance; France; Humans; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum; Sesquiterpenes; Travel	1998
Risk factors for gametocyte carriage in uncomplicated falciparum malaria. The American journal of tropical medicine and hygiene, 1999, Volume: 60, Issue:6 Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Carrier State; Child; Child, Preschool; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Multivariate Analysis; Parasitemia; Phenanthrenes; Plasmodium falciparum; Prospective Studies; Quinine; Regression Analysis; Risk Factors; Seroepidemiologic Studies; Sesquiterpenes; Thailand	1999
In vitro effects of racemates, separate enantiomers and major metabolites of mefloquine and halofantrine on metoprolol biotransformation by rat liver microsomes. Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:6 Topics: Animals; Antimalarials; Biotransformation; Male; Mefloquine; Metoprolol; Microsomes, Liver; Phenanthrenes; Rats; Rats, Sprague-Dawley; Stereoisomerism	1999
Phenotypic and genotypic characteristics of recently adapted isolates of Plasmodium falciparum from Thailand. The American journal of tropical medicine and hygiene, 1999, Volume: 60, Issue:3 Topics: Animals; Antimalarials; Blotting, Western; Chloroquine; DNA Fingerprinting; DNA, Protozoan; Drug Resistance; Electrophoresis, Agar Gel; Gene Dosage; Genotype; Humans; Malaria, Falciparum; Mefloquine; Penfluridol; Phenanthrenes; Phenotype; Plasmodium falciparum; Polymerase Chain Reaction; Quinine; Thailand; Verapamil	1999
The microculture tetrazolium assay (MTA): another colorimetric method of testing Plasmodium falciparum chemosensitivity. Annals of tropical medicine and parasitology, 1999, Volume: 93, Issue:1 Topics: Animals; Antimalarials; Chloroquine; Colorimetry; Dose-Response Relationship, Drug; Drug Resistance; L-Lactate Dehydrogenase; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Tetrazolium Salts	1999
Inoculum effect leads to overestimation of in vitro resistance for artemisinin derivatives and standard antimalarials: a Gambian field study. Parasitology, 1999, Volume: 119 ( Pt 5) Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Gambia; Hematocrit; Humans; Malaria, Falciparum; Mefloquine; Parasitemia; Phenanthrenes; Plasmodium falciparum; Quinine; Scintillation Counting; Sensitivity and Specificity; Sesquiterpenes	1999
Effects of mefloquine on cardiac contractility and electrical activity in vivo, in isolated cardiac preparations, and in single ventricular myocytes. British journal of pharmacology, 2000, Volume: 129, Issue:2 Topics: Animals; Antimalarials; Blood Pressure; Calcium; Cell Separation; Electrophysiology; Guinea Pigs; Heart; Heart Block; Heart Rate; Heart Ventricles; In Vitro Techniques; Male; Mefloquine; Myocardial Contraction; Myocardium; Papillary Muscles; Patch-Clamp Techniques; Phenanthrenes; Refractory Period, Electrophysiological	2000
Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature, 2000, Feb-24, Volume: 403, Issue:6772 Topics: Amino Acid Substitution; Animals; Antimalarials; Artemisinins; ATP-Binding Cassette Transporters; Chloroquine; Cloning, Molecular; Drug Resistance; Mefloquine; Mutation; Phenanthrenes; Plasmodium falciparum; Protozoan Proteins; Quinine; Sesquiterpenes; Verapamil	2000
In vitro susceptibility of Plasmodium falciparum to four antimalarial drugs in the Central Province of Papua New Guinea. Papua and New Guinea medical journal, 1998, Volume: 41, Issue:2 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Mefloquine; Microbial Sensitivity Tests; Papua New Guinea; Phenanthrenes; Plasmodium falciparum; Quinine	1998
Effect of three structurally related antimalarial drugs on liver microsomal components and lipid peroxidation in rats. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2000, Volume: 126, Issue:3 Topics: Amodiaquine; Animals; Antimalarials; Endoplasmic Reticulum; Lipid Peroxidation; Male; Mefloquine; Microsomes, Liver; Oxidoreductases; Phenanthrenes; Rats; Rats, Wistar; Structure-Activity Relationship	2000
Potentiation of halofantrine-induced QTc prolongation by mefloquine: correlation with blood concentrations of halofantrine. British journal of pharmacology, 2001, Volume: 132, Issue:1 Topics: Action Potentials; Animals; Antimalarials; Blood Gas Analysis; Drug Synergism; Electrocardiography; Female; Hemodynamics; Hydrogen-Ion Concentration; Long QT Syndrome; Mefloquine; Phenanthrenes; Potassium; Rabbits	2001
From the Centers for Disease Control and Prevention. Sudden death in a traveler following halofantrine administration--Togo, 2000. JAMA, 2001, Apr-11, Volume: 285, Issue:14 Topics: Adult; Anti-Bacterial Agents; Antimalarials; Cardiomegaly; Death, Sudden; Drug Interactions; Erythromycin; Humans; Macrolides; Male; Mefloquine; Phenanthrenes; Togo; Travel	2001
Sudden death in a traveller following halofantrine administration--Togo, 2000. Canada communicable disease report = Releve des maladies transmissibles au Canada, 2001, Jul-15, Volume: 27, Issue:14 Topics: Adult; Antimalarials; Cardiomyopathy, Hypertrophic; Contraindications; Death, Sudden, Cardiac; Humans; Long QT Syndrome; Malaria; Male; Mefloquine; Phenanthrenes; Togo; Travel	2001
Antimalarial drugs exacerbate rat liver microsomal lipid peroxidation in the presence of oxidants. Bioscience reports, 2001, Volume: 21, Issue:3 Topics: alpha-Tocopherol; Amodiaquine; Animals; Antimalarials; Antioxidants; Ascorbic Acid; Ferrous Compounds; Hydrogen Peroxide; Lipid Peroxidation; Lipid Peroxides; Liver; Male; Malondialdehyde; Mefloquine; Microsomes, Liver; Oxidants; Phenanthrenes; Rats; Reactive Oxygen Species; Up-Regulation	2001
[Blackwater fever]. Presse medicale (Paris, France : 1983), 2002, Sep-07, Volume: 31, Issue:28 Topics: Adolescent; Adult; Aged; Antimalarials; Atovaquone; Blackwater Fever; Critical Care; Diagnosis, Differential; Drug Combinations; Humans; Mefloquine; Middle Aged; Naphthoquinones; Phenanthrenes; Prognosis; Proguanil; Pyrimethamine; Quinine; Sulfadoxine	2002
The clinical spectrum of severe imported falciparum malaria in the intensive care unit: report of 188 cases in adults. American journal of respiratory and critical care medicine, 2003, Mar-01, Volume: 167, Issue:5 Topics: Adolescent; Adult; Aged; Antimalarials; Community-Acquired Infections; Comorbidity; Cross Infection; Data Interpretation, Statistical; Exchange Transfusion, Whole Blood; Female; France; Glasgow Coma Scale; Humans; Injections, Intravenous; Intensive Care Units; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Phenanthrenes; Quinine; Retrospective Studies; Travel; World Health Organization	2003
In vitro activity of chloroquine, quinine, mefloquine and halofantrine against Gabonese isolates of Plasmodium falciparum. Tropical medicine & international health : TM & IH, 2003, Volume: 8, Issue:1 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Gabon; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Mefloquine; Parasitic Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Quinine	2003
In-vitro sensitivity of Plasmodium falciparum to chloroquine, halofantrine, mefloquine and quinine in Madagascar. East African medical journal, 2002, Volume: 79, Issue:5 Topics: Animals; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Drug Resistance; Hospitals, Public; Hospitals, Urban; Humans; Madagascar; Malaria, Falciparum; Mefloquine; Microbial Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Quinine; Rural Health	2002
[Treatment of uncomplicated Plasmodium falciparum malaria in children: comparison of halofantrine with mefloquine]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2003, Volume: 10 Suppl 5 Topics: Antimalarials; Child; Humans; Malaria, Falciparum; Mefloquine; Phenanthrenes; Retrospective Studies; Treatment Failure	2003
Defective DNA repair as a potential mechanism for the rapid development of drug resistance in Plasmodium falciparum. Biochemistry, 2004, May-04, Volume: 43, Issue:17 Topics: Animals; Antimalarials; Artemisinins; Chloroquine; DNA Damage; DNA Repair; Drug Resistance; Drug Resistance, Multiple; Humans; Malaria, Falciparum; Mefloquine; Parasitic Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Pyrimethamine; Quinine; Sesquiterpenes; Sulfanilamide; Sulfanilamides; Ultraviolet Rays	2004
The antimalarial potential of 4-quinolinecarbinolamines may be limited due to neurotoxicity and cross-resistance in mefloquine-resistant Plasmodium falciparum strains. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:7 Topics: Animals; Antimalarials; Calcium; Cells, Cultured; Drug Resistance; Homeostasis; Mefloquine; Microscopy, Confocal; Models, Molecular; Nervous System Diseases; Neurons; Phenanthrenes; Plasmodium falciparum; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Rats	2004
pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum. Molecular microbiology, 2005, Volume: 57, Issue:4 Topics: Alleles; Animals; Antimalarials; Artemisinins; Asparagine; Aspartic Acid; ATP-Binding Cassette Transporters; Drug Resistance; Mefloquine; Phenanthrenes; Plasmodium falciparum; Point Mutation; Protozoan Proteins; Quinine; Sesquiterpenes	2005
Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin. The Journal of infectious diseases, 2006, Aug-15, Volume: 194, Issue:4 Topics: Animals; Antimalarials; Artemisinins; ATP-Binding Cassette Transporters; DNA, Protozoan; Drug Resistance, Multiple; Ethanolamines; Fluorenes; Genes, MDR; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Mefloquine; Parasitic Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Polymerase Chain Reaction; Protozoan Proteins; Quinine; Sesquiterpenes	2006
Overestimating resistance in field testing of malaria parasites: simple methods for estimating high EC50 values using a Bayesian approach. Malaria journal, 2007, Jan-17, Volume: 6 Topics: Algorithms; Animals; Antimalarials; Artemisinins; Artesunate; Bayes Theorem; Chloroquine; Computer Simulation; Dose-Response Relationship, Drug; Drug Resistance; False Positive Reactions; Inhibitory Concentration 50; Mefloquine; Models, Biological; Phenanthrenes; Plasmodium falciparum; Sesquiterpenes	2007
The in-vitro susceptibilities of Ghanaian Plasmodium falciparum to antimalarial drugs. Annals of tropical medicine and parasitology, 2007, Volume: 101, Issue:5 Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Artesunate; Child, Preschool; Chloroquine; Drug Resistance; Ghana; Humans; Infant; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Sesquiterpenes	2007
Lariam and Halfan. Journal of the Royal Society of Medicine, 2007, Volume: 100, Issue:8 Topics: Antimalarials; Humans; Malaria; Mefloquine; Mental Disorders; Phenanthrenes; Randomized Controlled Trials as Topic; Time Factors	2007
Differential effects of quinoline antimalarials on endocytosis in Plasmodium falciparum. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5 Topics: Amodiaquine; Animals; Antimalarials; Blotting, Western; Chloroquine; Endocytosis; Erythrocytes; Hemoglobins; Humans; Mefloquine; Peroxidase; Phenanthrenes; Plasmodium falciparum; Protein Binding; Protozoan Proteins; Quinolines	2008
In vitro activities of quinine and other antimalarials and pfnhe polymorphisms in Plasmodium isolates from Kenya. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:8 Topics: Amino Acid Sequence; Animals; Antimalarials; Drug Resistance; Humans; Kenya; Mefloquine; Membrane Transport Proteins; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Quinine; Sequence Analysis, DNA; Sodium-Hydrogen Exchangers	2010
Effects of anti-malarial drugs on the electrocardiographic QT interval modelled in the isolated perfused guinea pig heart system. Malaria journal, 2010, Nov-10, Volume: 9 Topics: Animals; Antimalarials; Arrhythmias, Cardiac; Guinea Pigs; Heart; Heart Conduction System; Mefloquine; Phenanthrenes; Quinidine; Quinine; Time Factors	2010
In vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, quinine, mefloquine and halofantrine in Abidjan (Côte d'Ivoire). African health sciences, 2010, Volume: 10, Issue:2 Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Child; Child, Preschool; Cote d'Ivoire; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Microbial Sensitivity Tests; Middle Aged; Phenanthrenes; Plasmodium falciparum; Quinine; Young Adult	2010
Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum. PLoS genetics, 2011, Volume: 7, Issue:4 Topics: Antimalarials; Drug Resistance; Ethanolamines; Fluorenes; Gene Dosage; Gene Expression; Genetic Association Studies; Genetic Loci; Genetic Variation; Genotype; Haplotypes; Linkage Disequilibrium; Lumefantrine; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum; Polymorphism, Single Nucleotide; Selection, Genetic	2011
Discordant temporal evolution of Pfcrt and Pfmdr1 genotypes and Plasmodium falciparum in vitro drug susceptibility to 4-aminoquinolines after drug policy change in French Guiana. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:3 Topics: Aminoquinolines; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Chloroquine; Drug Combinations; Drug Resistance; Ethanolamines; Evolution, Molecular; Fluorenes; French Guiana; Gene Dosage; Haplotypes; Humans; Inhibitory Concentration 50; Longitudinal Studies; Malaria, Falciparum; Mefloquine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Practice Guidelines as Topic; Protozoan Proteins; Quinine	2012
Distribution of drug resistance genotypes in Plasmodium falciparum in an area of limited parasite diversity in Saudi Arabia. The American journal of tropical medicine and hygiene, 2012, Volume: 86, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Female; Genotype; Humans; Infant; Male; Mefloquine; Membrane Transport Proteins; Middle Aged; Multidrug Resistance-Associated Proteins; Mutation; Phenanthrenes; Plasmodium falciparum; Polymorphism, Single Nucleotide; Protozoan Proteins; Pyrimethamine; Saudi Arabia; Sulfadoxine; Tetrahydrofolate Dehydrogenase; Young Adult	2012
Modulation of PF10_0355 (MSPDBL2) alters Plasmodium falciparum response to antimalarial drugs. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:7 Topics: Antimalarials; Base Sequence; DNA Copy Number Variations; Drug Resistance; Ethanolamines; Fluorenes; Gene Dosage; Gene Frequency; Genes, Protozoan; Lumefantrine; Malaria, Falciparum; Mefloquine; Mutation; Parasitic Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Polymorphism, Single Nucleotide; Protozoan Proteins; Sequence Analysis, DNA	2013
Treatment of murine cerebral malaria by artemisone in combination with conventional antimalarial drugs: antiplasmodial effects and immune responses. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:8 Topics: Animals; Antimalarials; Artemisinins; Cell Line; Cell Survival; Cells, Cultured; Chloroquine; Doxycycline; Drug Synergism; Drug Therapy, Combination; Erythrocytes; Humans; Interleukin-10; Interleukin-4; Malaria, Cerebral; Mefloquine; Mice; Mice, Inbred C57BL; Monocytes; Parasitic Sensitivity Tests; Phenanthrenes; Plasmodium berghei; Plasmodium falciparum	2014