Compounds > halofantrine
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halofantrine and ketoconazole

halofantrine has been researched along with ketoconazole in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19901 (8.33)18.7374
1990's3 (25.00)18.2507
2000's5 (41.67)29.6817
2010's3 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Keserü, GM1
Nagashima, R; Nishikawa, T; Tobita, M1
Jia, L; Sun, H1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Sen, S; Sinha, N1
Coulaud, JP; Ngo Van, P1
Charman, WN; Edwards, GA; Khoo, SM; Porter, JH1
Baune, B; Farinotti, R; Furlan, V; Taburet, AM1
Baune, B; Becquemont, L; Farinotti, R; Flinois, JP; Furlan, V; Gimenez, F; Taburet, AM1
Brocks, DR; El-Kadi, AO; Gharavi, N; Sattari, S; Shayeganpour, A1
Abdel-Aal Sabra, AN; El-Lakkany, NM; Hammam, OA; Seif El-Din, SH1

Trials

1 trial(s) available for halofantrine and ketoconazole

ArticleYear
Metabolism of halofantrine to its equipotent metabolite, desbutylhalofantrine, is decreased when orally administered with ketoconazole.
    Journal of pharmaceutical sciences, 1998, Volume: 87, Issue:12

    Topics: Administration, Oral; Animals; Antimalarials; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dogs; Drug Interactions; Ketoconazole; Male; Mixed Function Oxygenases; Phenanthrenes

1998

Other Studies

11 other study(ies) available for halofantrine and ketoconazole

ArticleYear
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2003
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
    Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11

    Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated

2005
Support vector machines classification of hERG liabilities based on atom types.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve

2008
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
[New antiparasitic drugs].
    Annales de dermatologie et de venereologie, 1988, Volume: 115, Issue:4

    Topics: Amebicides; Anthelmintics; Antifungal Agents; Antimalarials; Artemisinins; Fluconazole; Humans; Itraconazole; Ketoconazole; Mefloquine; Phenanthrenes; Quinolines; Sesquiterpenes; Triazoles

1988
Effect of selected antimalarial drugs and inhibitors of cytochrome P-450 3A4 on halofantrine metabolism by human liver microsomes.
    Drug metabolism and disposition: the biological fate of chemicals, 1999, Volume: 27, Issue:5

    Topics: Adolescent; Adult; Antifungal Agents; Antimalarials; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Ketoconazole; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Phenanthrenes

1999
Halofantrine metabolism in microsomes in man: major role of CYP 3A4 and CYP 3A5.
    The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:4

    Topics: Aryl Hydrocarbon Hydroxylases; Benzoflavones; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Activation; Humans; Isoenzymes; Ketoconazole; Kinetics; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenanthrenes; Saccharomyces cerevisiae; Substrate Specificity

1999
The stereoselective metabolism of halofantrine to desbutylhalofantrine in the rat: evidence of tissue-specific enantioselectivity in microsomal metabolism.
    Chirality, 2007, Volume: 19, Issue:1

    Topics: Animals; Area Under Curve; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Intestinal Mucosa; Ketoconazole; Male; Microsomes; Microsomes, Liver; Organ Specificity; Phenanthrenes; Rats; Rats, Sprague-Dawley; Stereoisomerism

2007
Effect of ketoconazole, a cytochrome P450 inhibitor, on the efficacy of quinine and halofantrine against Schistosoma mansoni in mice.
    The Korean journal of parasitology, 2013, Volume: 51, Issue:2

    Topics: Animals; Anthelmintics; Disease Models, Animal; Drug Synergism; Female; Humans; Intestines; Ketoconazole; Liver; Male; Mice; Parasite Load; Phenanthrenes; Quinine; Schistosoma mansoni; Schistosomiasis mansoni; Treatment Outcome

2013