halofantrine has been researched along with 1,3-dichloro-6-trifluoromethyl-9-phenanthryl-3-(n-butyl)aminopropanol in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (10.34) | 18.7374 |
| 1990's | 19 (65.52) | 18.2507 |
| 2000's | 7 (24.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Craig, PN; Fukunaga, JY; Hansch, C; Jow, PY; Kim, KH; Page, J; Steller, EE | 1 |
| Mberu, EK; Muhia, DK; Watkins, WM | 1 |
| Edstein, MD; Kere, N; Parkinson, AD; Rieckmann, KH; Veenendaal, JR | 1 |
| Edwards, G; Karbwang, J; Milton, KA; Na Bangchang, K; Ward, SA | 1 |
| Bunnag, D; Edwards, G; Karbwang, J; Milton, KA; Na Bangchang, K; Ward, SA | 1 |
| Edstein, MD; Keeratithakul, D; Shanks, GD; Teja-Isavadharm, P; Webster, HK | 1 |
| Edwards, G; Milton, KA; Ward, SA | 1 |
| Bursey, JT; Hines, JW; Pellizzari, ED; Voyksner, RD | 1 |
| Fasanmade, AA; Jusko, WJ | 1 |
| Chaulet, JF; Cheminel, V; Gaillard, Y; Prévosto, JM; Soares, O | 1 |
| Charman, WN; Currie, GJ; Humberstone, AJ; Porter, CJ; Scanlon, MJ | 1 |
| Bernard, J; Bertherat, E; Keundjian, A; Soares, JL; Touze, JE | 1 |
| Dolan, G; Edstein, MD; Keeratithakul, D; Nosten, F; Phaipun, L; Teja-Isavatharm, P; Ter Kuile, FO; Webster, HK; White, NJ | 1 |
| Blaschke, G; Terefe, H | 2 |
| Bernard, J; Chaudet, H; Doury, JC; Imbert, P; Keundjian, A; Touze, JE; Viguier, A | 1 |
| Bernard, J; Giudicelli, CP; Touze, JE | 1 |
| Edwards, G; Gundersen, SG; Myrvang, B; Platou, ES; Rostrup, M; von der Lippe, E | 1 |
| Aideloje, SO; Onyeji, CO | 1 |
| Bangchang, KN; Farinotti, R; Gimenez, F; Gorichon, E; Karbwang, J; Martin, C; Thuillier, A | 1 |
| Bhattacharjee, AK; Karle, JM | 1 |
| Charman, WN; Edwards, GA; Khoo, SM; Porter, JH | 1 |
| Schuster, BG; Wang, WX; Wesche, DL; Woosley, RL | 1 |
| Brocks, DR | 1 |
| January, CT; Mbai, M; Rajamani, S | 1 |
| Babalola, CP; Kolade, YT; Scriba, GK | 1 |
| Daniyan, MO; Omoruyi, SI; Onyeji, CO | 1 |
| Babalola, CP; Kolade, YT; Olaniyi, AA; Scriba, GK | 1 |
| Brocks, DR; Fleischer, JG; Patel, JP; Wasan, KM | 1 |
1 review(s) available for halofantrine and 1,3-dichloro-6-trifluoromethyl-9-phenanthryl-3-(n-butyl)aminopropanol
| Article | Year |
|---|---|
Mechanism of cardiotoxicity of halofantrine.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Animals; Antimalarials; Cardiovascular Diseases; Cats; Child; Child, Preschool; Disease Models, Animal; Female; Heart Conduction System; Humans; Infant; Male; Middle Aged; Myocardium; Phenanthrenes | 2000 |
4 trial(s) available for halofantrine and 1,3-dichloro-6-trifluoromethyl-9-phenanthryl-3-(n-butyl)aminopropanol
| Article | Year |
|---|---|
Comparison of capillary whole blood, venous whole blood, and plasma concentrations of mefloquine, halofantrine, and desbutyl-halofantrine measured by high-performance liquid chromatography.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Linear Models; Malaria, Falciparum; Mefloquine; Middle Aged; Phenanthrenes; Reproducibility of Results | 1994 |
Metabolism of halofantrine to its equipotent metabolite, desbutylhalofantrine, is decreased when orally administered with ketoconazole.
Topics: Administration, Oral; Animals; Antimalarials; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dogs; Drug Interactions; Ketoconazole; Male; Mixed Function Oxygenases; Phenanthrenes | 1998 |
Effects of prior administration of amodiaquine on the disposition of halofantrine in healthy volunteers.
Topics: Adult; Amodiaquine; Antimalarials; Area Under Curve; Chromatography, High Pressure Liquid; Cross-Over Studies; Drug Interactions; Electrocardiography; Half-Life; Humans; Male; Metabolic Clearance Rate; Phenanthrenes | 2007 |
Effect of kolanut on the pharmacokinetics of the antimalarial drug halofantrine.
Topics: Administration, Oral; Adult; Antimalarials; Area Under Curve; Caffeine; Chromatography, High Pressure Liquid; Cola; Cross-Over Studies; Drug Interactions; Half-Life; Humans; Male; Nuts; Phenanthrenes | 2008 |
24 other study(ies) available for halofantrine and 1,3-dichloro-6-trifluoromethyl-9-phenanthryl-3-(n-butyl)aminopropanol
| Article | Year |
|---|---|
Quantitative structure-activity relationships in 1-aryl-2-(alkylamino)ethanol antimalarials.
Topics: Animals; Antimalarials; Ethanolamines; Malaria; Mice; Models, Biological; Phenanthrenes; Plasmodium berghei; Pyridines; Quinolines; Structure-Activity Relationship | 1979 |
Measurement of halofantrine and its major metabolite desbutylhalofantrine in plasma and blood by high-performance liquid chromatography: a new methodology.
Topics: Antimalarials; Chromatography, High Pressure Liquid; Humans; Male; Phenanthrenes; Reference Values; Reproducibility of Results | 1992 |
Pharmacokinetics of halofantrine and n-desbutylhalofantrine in patients with falciparum malaria following a multiple dose regimen of halofantrine.
Topics: Antimalarials; Chromatography, High Pressure Liquid; Drug Administration Schedule; Humans; Malaria, Falciparum; Melanesia; Phenanthrenes | 1991 |
Pharmacokinetics of halofantrine in healthy Thai volunteers.
Topics: Adolescent; Adult; Antimalarials; Humans; Malaria; Male; Middle Aged; Phenanthrenes; Thailand | 1991 |
Pharmacokinetics of halofantrine in Thai patients with acute uncomplicated falciparum malaria.
Topics: Acute Disease; Adolescent; Adult; Animals; Antimalarials; Humans; Malaria; Middle Aged; Phenanthrenes; Plasmodium falciparum | 1991 |
An improved high-performance liquid chromatographic method for the simultaneous measurement of halofantrine and desbutylhalofantrine in human serum.
Topics: Antimalarials; Chromatography, High Pressure Liquid; Humans; Malaria; Phenanthrenes; Ultraviolet Rays | 1991 |
Determination of halofantrine and its principal metabolite desbutylhalofantrine in biological fluids by reversed-phase high-performance liquid chromatography.
Topics: Adult; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Male; Phenanthrenes; Spectrophotometry, Ultraviolet | 1988 |
A comparison of thermospray and direct liquid introduction high-performance liquid chromatography/mass spectrometry for the analysis of candidate antimalarials.
Topics: Animals; Antimalarials; Chromatography, High Pressure Liquid; Dogs; Mass Spectrometry; Phenanthrenes | 1984 |
Effect of halofantrine and its desbutyl metabolite on lymphocyte proliferation dynamics.
Topics: Adult; Analysis of Variance; Animals; Antimalarials; Cell Division; Chloroquine; Humans; In Vitro Techniques; Lymphocytes; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley | 1995 |
New solid-phase extraction for an improved high-performance liquid chromatographic procedure for the quantitation of halofantrine and monodesbutylhalofantrine in blood or plasma.
Topics: Antimalarials; Chromatography, High Pressure Liquid; Humans; Phenanthrenes; Reference Standards; Reproducibility of Results; Spectrometry, Fluorescence | 1995 |
A simplified liquid chromatography assay for the quantitation of halofantrine and desbutylhalofantrine in plasma and identification of a degradation product of desbutylhalofantrine formed under alkaline conditions.
Topics: Animals; Antimalarials; Biotransformation; Chromatography, Liquid; Dogs; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Male; Phenanthrenes | 1995 |
[Plasma levels of halofantrine during two therapeutic sessions at a 7 day interval].
Topics: Adult; Antimalarials; Dose-Response Relationship, Drug; Humans; Malaria, Falciparum; Phenanthrenes | 1995 |
Direct determination of the enantiomers of the antimalarial drug halofantrine and its active metabolite N-desbutylhalofantrine in human plasma.
Topics: Adult; Antimalarials; Chromatography, High Pressure Liquid; Humans; Kinetics; Male; Middle Aged; Phenanthrenes; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism | 1994 |
Direct determination of the enantiomers of halofantrine and its pharmacologically active metabolite N-desbutylhalofantrine by high-performance liquid chromatography.
Topics: Animals; Antimalarials; Biotransformation; Chromatography, High Pressure Liquid; In Vitro Techniques; Liver; Microsomes, Liver; Phenanthrenes; Rats; Stereoisomerism | 1993 |
Electrocardiographic changes and halofantrine plasma level during acute falciparum malaria.
Topics: Acute Disease; Adult; Antimalarials; Electrocardiography; Heart; Humans; Malaria, Falciparum; Male; Middle Aged; Phenanthrenes | 1996 |
[Electrocardiographic changes due to halofantrine in the treatment of malaria: therapeutic implications].
Topics: Adult; Antimalarials; Data Interpretation, Statistical; Electrocardiography; Heart; Humans; Malaria, Falciparum; Male; Middle Aged; Phenanthrenes; Prospective Studies; Time Factors | 1996 |
Halofantrine-associated ventricular fibrillation in a young woman with no predisposing QTc prolongation.
Topics: Adult; Antimalarials; Female; Humans; Long QT Syndrome; Phenanthrenes; Ventricular Fibrillation | 1997 |
Ion-pair reversed-phase high-performance liquid chromatographic analysis of halofantrine and desbutylhalofantrine in human plasma.
Topics: Administration, Oral; Antimalarials; Chromatography, High Pressure Liquid; Humans; Phenanthrenes | 1997 |
Chiral chromatographic method to determine the enantiomers of halofantrine and its main chiral desbutyl metabolite in erythrocytes.
Topics: Administration, Oral; Antimalarials; Chromatography, Liquid; Erythrocytes; Humans; Malaria; Phenanthrenes; Reproducibility of Results; Stereoisomerism | 1998 |
Functional correlation of molecular electronic properties with potency of synthetic carbinolamine antimalarial agents.
Topics: Antimalarials; Mefloquine; Models, Molecular; Molecular Conformation; Phenanthrenes; Pyridines; Quinolines; Static Electricity; Structure-Activity Relationship | 1998 |
Stereoselective halofantrine and desbutylhalofantrine disposition in the rat: cardiac and plasma concentrations and plasma protein binding.
Topics: Animals; Antimalarials; Blood Proteins; Male; Myocardium; Phenanthrenes; Protein Binding; Rats; Rats, Sprague-Dawley; Stereoisomerism | 2002 |
The anti-malarial drug halofantrine and its metabolite N-desbutylhalofantrine block HERG potassium channels.
Topics: Action Potentials; Antimalarials; Arrhythmias, Cardiac; Cation Transport Proteins; Cell Line; DNA-Binding Proteins; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Inhibitory Concentration 50; Kidney; Patch-Clamp Techniques; Phenanthrenes; Potassium Channels; Potassium Channels, Voltage-Gated; Trans-Activators; Transcriptional Regulator ERG; Transfection | 2002 |
Analysis of the antimalarial drug halofantrine and its major metabolite N-desbutylhalofantrine in human plasma by high performance liquid chromatography.
Topics: Antimalarials; Calibration; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Phenanthrenes; Reproducibility of Results; Technology, Pharmaceutical; Time Factors | 2006 |
The effect of experimental hyperlipidemia on the stereoselective tissue distribution, lipoprotein association and microsomal metabolism of (+/-)-halofantrine.
Topics: Animals; Antimalarials; Hyperlipidemias; Lipoproteins; Male; Microsomes, Liver; Phenanthrenes; Protein Binding; Rats; Rats, Sprague-Dawley; Stereoisomerism | 2009 |