halichondrin-b and tetrabutylammonium

halichondrin-b has been researched along with tetrabutylammonium* in 1 studies

Other Studies

1 other study(ies) available for halichondrin-b and tetrabutylammonium

Article	Year
Operationally simple and efficient workup procedure for TBAF-mediated desilylation: application to halichondrin synthesis. Organic letters, 2007, Feb-15, Volume: 9, Issue:4 An operationally simple and efficient workup method for tetrabutylammonium fluoride (TBAF)-mediated t-butyldimethylsilyl (TBS) deprotection has been developed. The procedure includes addition of a sulfonic acid resin and calcium carbonate, followed by filtration and evaporation. This method eliminates the tedious aqueous-phase extraction process to remove excess TBAF and materials derived from TBAF, thereby making the protocol highly amenable to multiple TBS deprotections. Its efficiency and usefulness were demonstrated by using the transformation of 1a to 3a in the halichondrin synthesis. [reaction: see text]. Topics: Calcium Carbonate; Ethers, Cyclic; Filtration; Indicators and Reagents; Ion Exchange Resins; Macrolides; Magnetic Resonance Spectroscopy; Quaternary Ammonium Compounds; Sulfonic Acids	2007

Article

Year

Operationally simple and efficient workup procedure for TBAF-mediated desilylation: application to halichondrin synthesis.

Organic letters, 2007, Feb-15, Volume: 9, Issue:4

An operationally simple and efficient workup method for tetrabutylammonium fluoride (TBAF)-mediated t-butyldimethylsilyl (TBS) deprotection has been developed. The procedure includes addition of a sulfonic acid resin and calcium carbonate, followed by filtration and evaporation. This method eliminates the tedious aqueous-phase extraction process to remove excess TBAF and materials derived from TBAF, thereby making the protocol highly amenable to multiple TBS deprotections. Its efficiency and usefulness were demonstrated by using the transformation of 1a to 3a in the halichondrin synthesis. [reaction: see text].

Topics: Calcium Carbonate; Ethers, Cyclic; Filtration; Indicators and Reagents; Ion Exchange Resins; Macrolides; Magnetic Resonance Spectroscopy; Quaternary Ammonium Compounds; Sulfonic Acids

2007