ha 1004 has been researched along with 1-(5-isoquinolinesulfonyl)-2-methylpiperazine in 160 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (20.00) | 18.7374 |
| 1990's | 123 (76.88) | 18.2507 |
| 2000's | 5 (3.13) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Felipo, V; Grisolía, S; Miñana, MD | 2 |
| Kotoyori, J; Kozawa, O; Miwa, M; Oiso, Y; Tokuda, H | 1 |
| Felipo, V; Grisolía, S; Hermenegildo, C; Miñana, MD | 1 |
| Baldassare, JJ; Burns, D; Ceska, M; Fisher, GJ; Hammerberg, C; Henderson, PA; Voorhees, JJ; Zhang, QY | 1 |
| Bandekar, JR; Castagna, R; Sultzer, BM | 1 |
| Friesel, RE; Peifley, KA; Winkles, JA | 1 |
| Glembotski, CC; Hidaka, H; Irons, CE; Sei, CA | 1 |
| Amano, S; Hanazawa, S; Kitami, H; Kitano, S; Murakami, Y; Ohta, K; Takeshita, A | 1 |
| Brown, EJ; Zheleznyak, A | 1 |
| Del Vecchio, PJ; Goligorsky, MS; Malik, AB; Siflinger-Birnboim, A | 1 |
| Amador, M; Dani, JA; Moorman, JR; Pinkham, J; Reuhl, TO | 1 |
| Petcoff, DW; Platt, JE | 1 |
| Beauchamp, RD; Ishizuka, J; Sheng, HM; Thompson, JC; Townsend, CM | 1 |
| Aumailley, M; Gimond, C | 1 |
| Meltzer, M; Mufson, RA; Myers, C; Turpin, JA | 1 |
| Chrest, FJ; Gabrielson, EW; Lin, Y | 1 |
| Baldari, CT; Macchia, G; Telford, JL | 1 |
| Frangos, JA; Hsieh, HJ; Li, NQ | 1 |
| Katayama, N; Komada, F; Minami, N; Nishikawa, M; Sekine, T; Shimizu, N; Shirakawa, S | 1 |
| Citi, S | 1 |
| Felipo, V; Grisolía, S; Llopis, J; Miñana, MD; Romá, J; Romero, FJ | 1 |
| Couchman, JR; Woods, A | 1 |
| Chow, AW; See, RH | 1 |
| Hurme, M; Matikainen, S; Serkkola, E | 1 |
| Kumegawa, M; Oshima, T; Tanabe, T; Yamamoto, S; Yokoyama, C; Yoshimoto, T | 1 |
| Hartfield, PJ; Robinson, JM | 1 |
| Leahy, JC; Vallano, ML | 1 |
| Cotman, CW; Koh, JY; Palmer, E | 1 |
| Andrade, J; Folch, H; Guarda, MI; Maldonado, C; Ojeda, F | 1 |
| Kennedy, MS; Maddon, PJ; McDougal, JS; Orloff, GM; Orloff, SL | 1 |
| Chipkin, SR; Goodman, HM; Tai, LR | 1 |
| Brown, JH; Glembotski, CC; Irons, CE; McDonough, PM; Sei, CA; Sprenkle, AB | 1 |
| Norman-O'Guin, K; Shafit-Zagardo, B; Sharma, N | 1 |
| Autieri, MV; Coffman, FD; Cohen, S; Fresa, KL; Katz, ME | 1 |
| Cao, XM; Guy, GR; Sukhatme, VP; Tan, YH | 1 |
| Bernstein, SH; Kharbanda, SM; Kufe, DW; Sherman, ML; Stone, RM | 1 |
| Chong, P; Jordan, SC; Klinenberg, JR; Matzner, WL; Wallace, D; Yamiguchi, D | 1 |
| Caldwell, CW; Patterson, WP; Yesus, YW | 1 |
| Boyer, JE; Burch, RM; Hubbell, HR; Roane, P | 1 |
| Doré, M; Neilsen, NR; Slauson, DO | 1 |
| Hallahan, DE; Huberman, E; Kufe, DW; Sherman, ML; Virudachalam, S; Weichselbaum, RR | 1 |
| Datta, R; Kharbanda, S; Kufe, D | 1 |
| Kavaliers, M; Ossenkopp, KP; Tysdale, DM | 1 |
| Grove, DS; Mastro, AM | 1 |
| Chuang, ST; Grunstein, MM; Pawlowski, NA; Schramm, CM | 1 |
| Lin, PS; Mikkelsen, RB; Schmidt-Ullrich, R; Stedman, T | 1 |
| Beermann, ML; Shea, TB | 1 |
| Hurme, M; Serkkola, E | 1 |
| Car, BD; Doré, M; Slauson, DO; Suyemoto, MM | 1 |
| Leszczynski, D; Ustinov, J | 1 |
| Emoto, T; Hattori, Y; Hiraiwa, M; Kasai, K; Kuroda, H; Shimoda, S; Yamazaki, A | 1 |
| Manganel, M; Turner, RJ | 1 |
| Kondratyev, AD; Posypanova, GA; Severin, SE | 1 |
| Boyce, MA; Forester, LD; Hager, CC; Oeltmann, TN; Petroni, KC | 1 |
| Dinarello, CA; Morse, C; Zucali, JR | 1 |
| Badwey, JA; Heyworth, PG; Robinson, JM | 1 |
| Mattila, P; Renkonen, R; Turunen, JP | 1 |
| Fujiwara, K; Hirata, K | 1 |
| Folch, H; Guarda, MI; Maldonado, C; Ojeda, F | 1 |
| Atluru, D; Atluru, S; Blecha, F; Minocha, HC; Polam, S; Sarraju, L | 1 |
| Atluru, D; Atluru, S; Polam, S; Woloschak, GE | 1 |
| Lieberman, AP; Pitha, PM; Shin, ML | 1 |
| Clark, RB; Lingenheld, EG; Love, JT; Sgroi, D; Sha'afi, RI | 1 |
| Faltynek, CR; Gusella, GL; Princler, GL; Radzioch, D; Varesio, L | 1 |
| Alonso, M; Cárdenas, L; Carrera, AC; de Landázuri, MO; Sánchez-Madrid, F; Tugores, A | 1 |
| Levin, EG; Marotti, KR; Santell, L | 1 |
| Shen, SS | 1 |
| Badwey, JA; Heyworth, PG; Karnovsky, ML | 1 |
| Badwey, JA; Heyworth, PG; Horn, W; Karnovsky, ML; Robinson, JM | 1 |
| Akerlind, G; Akerman, KE; Heikkilä, JE | 1 |
| Berg, KL; Foster, DA; Joseph, C; Qureshi, SA; Spangler, R | 1 |
| Corradetti, R; Pugliese, AM; Ropert, N | 1 |
| Clark, MR; Eyster, KM; Hummel, WP | 1 |
| Duffie, GP; Ellis, NK; Wepsic, HT | 1 |
| Asami, K; Fujiwara, A; Kobayashi, H; Yasumasu, I | 1 |
| Katayama, N; Minami, N; Nishikawa, M; Shirakawa, S | 1 |
| Andersson, LC; Hölttä, E; Legraverend, C; Potter, A | 1 |
| Barile, G; Faggioni, A; Frati, L; Grimaldi, S; Lazdins, J; Venanzoni, M; Zompetta, C | 1 |
| Gomez-Cambronero, J; Huang, CK; Molski, TF; Sha'afi, RI | 1 |
| Badwey, JA; Horn, W; Karnovsky, MJ; Karnovsky, ML; Robinson, JM; Soberman, RJ | 1 |
| Fujita, T; Fukase, M; Hishikawa, R; Kinoshita, Y | 1 |
| Adamo, S; Cavallo, G; Frati, L; Gismondi, A; Paolini, R; Piccoli, M; Procopio, AD; Santoni, A | 1 |
| Hidaka, H; Inagaki, M; Tanaka, T | 1 |
| Ida, E; Onoue, K; Sakata, A; Tominaga, M | 1 |
| Berlin, RD; Pearson, CM; Preston, SF; Volpi, M | 1 |
| Ito, M; Sato, A; Shigeta, S; Takami, Y; Tanabe, F | 1 |
| Inariba, H; Inoue, T; Itoh, S; Kanayama, Y; Takaori, K; Takeda, T | 1 |
| Cosgrove, JM; Howcroft, TK; Lindquist, RR; Tatum, SM | 1 |
| Brahmi, Z; Steele, TA | 1 |
| Koide, T; Niki, A; Niki, H; Niki, I; Sakamoto, N; Tamagawa, T | 1 |
| Hsu, T; Martell, RE; Simpson, RU | 1 |
| Hidaka, H; Nishikawa, M; Shirakawa, S; Uemura, Y | 1 |
| Baba, H; Fujimi, T; Fujita, T; Fukase, M; Kinoshita, Y; Yamaguchi, T | 1 |
| Asano, T; Hidaka, H; Kageyama, N; Kanamori, M; Okada, T; Shibuya, M; Suzuki, Y; Takayasu, M | 1 |
| Berns, CM; Cho, JM; Corry, PM; Erdos, G; Galoforo, S; Lee, YJ | 1 |
| Carter, DA | 1 |
| Evans, DL; Jaso-Friedmann, L; Leary, JH | 2 |
| Benishin, CG; Ren, J | 1 |
| Faris, M; Fu, SM; Gaskin, F; Parsons, JT | 1 |
| Allen, JM; Balbi, D | 1 |
| Walters, JD; Wojcik, MS | 1 |
| Cheng, JF; Leu, SJ; Singh, VK | 1 |
| Chik, CL; Ho, AK; Karpinski, E; Li, B; Liu, QY | 1 |
| Clegg, JM; McKenna, TM; Williams, TJ | 1 |
| Ren, Y; Smith, A | 1 |
| Chen, SL; Huang, CH; Lin, YK; Tsao, YP | 1 |
| Niedbala, MJ; Stein-Picarella, M | 1 |
| Marmé, D; May, WS; Qatsha, KA; Rudolph, C; Schächtele, C | 1 |
| Cazaux, CA; Cremaschi, GA; Gorelik, G; Sterin-Borda, L | 1 |
| Imanaga, I; Inoue, M | 1 |
| Falk, LA; Halder, S; Mufson, RA; Rinaudo, MS; Su, K | 1 |
| Glass, DB; Habermacher, G; Howard, DR; Sale, WS; Smith, EF | 1 |
| Ahn, CH; Berns, CM; Borrelli, MJ; Corry, PM; Erdos, G; Lee, YJ | 1 |
| Aloyo, VJ | 1 |
| Zhang, L | 1 |
| Hirai, H; Okada, Y | 1 |
| Kosaka, C; Masuda, J; Ogata, J; Sasaguri, T; Zen, K | 1 |
| Arola, J; Heikkilä, P; Kahri, AI; Voutilainen, R | 1 |
| Burighel, P; Citi, S; Denisenko, N | 1 |
| Chapes, SK; Woods, KM | 1 |
| Berns, CM; Corry, PM; Erdos, G; Lee, YJ | 1 |
| Dahmer, MK; Penberthy, WT | 1 |
| Kubota, C; Murata, Y; Shinagawa, T; Shinohara, O | 1 |
| Mosher, DF; Somers, CE | 1 |
| Enger, MD; Tang, N | 1 |
| Leu, SJ; Singh, VK | 1 |
| Beezhold, DH; Chang, ZL; Personius, CD; Shen, ZL | 1 |
| Frangos, JA; Reich, KM | 1 |
| Nozawa, Y; Sakai, N; Yamada, H; Zhang, W | 1 |
| Carpentier, G; Climent, F; Lagord, C; Martelly, I; Moraczewski, J; Pons, G | 1 |
| Harada, H; Motomura, A; Suketa, Y; Suzuki, S; Tai, H | 1 |
| Bosche, MC; Levine, RA; Nandi, J; Rotker, JD; Strapko, A | 1 |
| Hirose, K; Isogai, E; Miura, H; Mizugai, H; Ueda, I | 1 |
| Gubitz, AK; Kirkpatrick, KA; Kurokawa, M; Richardson, PJ; Widdowson, L | 1 |
| Chiaramonte, M; Gazzinelli, RT; Grunvald, E; Hieny, S; Sher, A; Trinchieri, G; Vogel, SN; Wysocka, M | 1 |
| Chen, SL; Huang, CH; Lu, KY; Tsai, TC; Tsao, YP | 1 |
| Cohen, S; Li, W; Liu, X; Yanoff, M; Ye, X | 1 |
| Gerritsen, ME; Moatter, T | 1 |
| Carpentier, G; Lagord, C; Leibovitch, MP; Leibovitch, SA; Martelly, I | 1 |
| Byers, DM; Cook, HW; Mandla, SG; Ridgway, ND | 1 |
| Fink, BD; Grunwald, GB; Lee, MM | 1 |
| Hirata, C; Kizaki, H; Onishi, Y; Sakurai, Y; Tanimoto, Y; Yamada, T | 1 |
| McCaig, C; Rajnicek, A | 1 |
| Chapman, BM; Soares, MJ; Yamamoto, T | 1 |
| Kohno, K; Koike, K; Kuwano, M; Ohga, T; Toh, S; Uchiumi, T; Wada, M | 1 |
| Fujishima, M; Ibayashi, S; Kitazono, T; Nakane, H; Ooboshi, H; Uchimura, H; Yao, H | 1 |
| Barnum, SR; Carlino, JA; Drouin, SM; Kiley, SC | 1 |
| Mufson, RA; Shi, Y; Wang, R; Yin, D; Zhang, L | 1 |
| Adler, MR; Botsford, SA; Gronau, RT; Light, DB; Ter Beest, JK | 1 |
| Kada, K; Kamiya, K; Kodama, I; Naruse, K; Toyama, J; Yasui, K | 1 |
| Hayakawa, A; Nakashima, I; Okamoto, T; Tajiri, H; Yokoyama, I | 1 |
| Boudouresque, F; Delfino, C; Fraboulet, S; Girard, B; Oliver, C; Ouafik, L | 1 |
| Jett, M; Yan, Z; Yang, DC | 1 |
| Fernandez, MC; Marucha, PT; Rojas, IG; Walters, JD | 1 |
| Fukui, H; Horio, S | 1 |
| Esuvaranathan, K; Khoo, HE; Mahendran, R; Yap, LL; Zhang, Y | 1 |
| Belaunzarán, ML; Florin-Christensen, J; Florin-Christensen, M; Isola, EL; Lammel, EM; Wainszelbaum, MJ | 1 |
| Johnson, SW; Shen, KZ | 1 |
2 review(s) available for ha 1004 and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine
| Article | Year |
|---|---|
[Molecular pharmacology on intracellular calcium messenger system].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actomyosin; Binding Sites; Calcium; Calcium Channel Blockers; Calmodulin; Calmodulin-Binding Proteins; Extracellular Space; Humans; Isoquinolines; Muscle Contraction; Phosphotransferases; Piperazines; Sulfonamides | 1986 |
Receptor associated phosphorylation following monoclonal antibody or synthetic peptide binding to nonspecific cytotoxic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antibodies, Monoclonal; Cytotoxicity, Immunologic; Genistein; Ictaluridae; Isoquinolines; Killer Cells, Natural; Molecular Sequence Data; Oxazolone; Peptides; Phosphorylation; Phosphoserine; Protein Kinase C; Quinolines; Serine; Sulfonamides; Tetradecanoylphorbol Acetate | 1998 |
158 other study(ies) available for ha 1004 and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine
| Article | Year |
|---|---|
Differential effects of the protein kinase C inhibitors H7 and calphostin C on the cell cycle of neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Cycle; Cell Membrane Permeability; Cell Survival; DNA; Isoquinolines; Light; Naphthalenes; Neuroblastoma; Piperazines; Polycyclic Compounds; Protein Kinase C; Sulfonamides; Tumor Cells, Cultured | 1992 |
Cross-talk regulation between cyclic AMP production and phosphoinositide hydrolysis induced by prostaglandin E2 in osteoblast-like cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Inositol Phosphates; Isoquinolines; Kinetics; Mice; Osteoblasts; Piperazines; Protein Kinase C; Second Messenger Systems; Sulfonamides; Tetradecanoylphorbol Acetate | 1992 |
Inhibition of protein kinase C restores Na+,K(+)-ATPase activity in sciatic nerve of diabetic mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Isoquinolines; Male; Mice; Mice, Inbred Strains; Piperazines; Protein Kinase C; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sulfonamides | 1992 |
Retinoic acid and phorbol ester synergistically up-regulate IL-8 expression and specifically modulate protein kinase C-epsilon in human skin fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Western; Cells, Cultured; Cyclic AMP; Drug Synergism; Enzyme Activation; Fibroblasts; Gene Expression; Humans; In Vitro Techniques; Interleukin 1 Receptor Antagonist Protein; Interleukin-8; Isoquinolines; Phosphoproteins; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Proteins; RNA, Messenger; Sialoglycoproteins; Skin; Sulfonamides; Tetradecanoylphorbol Acetate; Tretinoin | 1992 |
Roles of protein kinase C and G proteins in activation of murine resting B lymphocytes by endotoxin-associated protein.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; B-Lymphocytes; Bacterial Proteins; DNA Replication; Dose-Response Relationship, Drug; Endotoxins; Female; GTP-Binding Proteins; Isoquinolines; Lipid A; Lymphocyte Activation; Male; Mice; Mice, Inbred C3H; Pertussis Toxin; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; RNA; Staurosporine; Sulfonamides; Virulence Factors, Bordetella | 1992 |
Tumor promoters induce basic fibroblast growth factor gene expression in human dermal fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinogens; Cell Line; Diterpenes; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Fibroblasts; Gene Expression; Isoquinolines; Phorbol Esters; Piperazines; RNA, Messenger; Skin; Sulfonamides; Terpenes; Tetradecanoylphorbol Acetate | 1992 |
Protein kinase C and calmodulin kinase are required for endothelin-stimulated atrial natriuretic factor secretion from primary atrial myocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Atrial Natriuretic Factor; Cells, Cultured; Endothelins; Heart; Heart Atria; Isoquinolines; Kinetics; Myocardium; Nifedipine; Phorbol 12,13-Dibutyrate; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Sulfonamides | 1992 |
Porphyromonas gingivalis fimbriae induce expression of the neutrophil chemotactic factor KC gene of mouse peritoneal macrophages: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Bucladesine; Chemotaxis, Leukocyte; Colforsin; Dose-Response Relationship, Drug; Fimbriae, Bacterial; Gene Expression Regulation, Bacterial; Interleukin-8; Isoquinolines; Macrophages; Mice; Mice, Inbred BALB C; Neutrophils; Piperazines; Porphyromonas gingivalis; Protein Kinase C; RNA; Sulfonamides; Tetradecanoylphorbol Acetate | 1992 |
Immunoglobulin-mediated phagocytosis by human monocytes requires protein kinase C activation. Evidence for protein kinase C translocation to phagosomes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaline Phosphatase; Alkaloids; Amino Acid Sequence; Biological Transport; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Eye Proteins; Humans; Immunoglobulin G; Isoquinolines; Kinetics; Molecular Sequence Data; Monocytes; Naphthalenes; Phagocytosis; Phagosomes; Piperazines; Polycyclic Compounds; Protein Kinase C; Rod Opsins; Signal Transduction; Staurosporine; Sulfonamides | 1992 |
Activation of protein kinase C pathway contributes to hydrogen peroxide-induced increase in endothelial permeability.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Animals; Cattle; Cell Survival; Culture Techniques; Endothelium, Vascular; Enzyme Activation; Hydrogen Peroxide; Isoquinolines; Microscopy, Fluorescence; Naphthalenes; Permeability; Piperazines; Polycyclic Compounds; Protein Kinase C; Sulfonamides | 1992 |
Nicotinic acetylcholine receptors are directly affected by agents used to study protein phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cells, Cultured; Ion Channels; Isoquinolines; Membrane Potentials; Nicotinic Antagonists; Oocytes; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Proteins; Receptors, Nicotinic; RNA, Messenger; Sulfonamides; Xenopus | 1992 |
Inhibition of protein kinase C antagonizes in vitro tadpole tail fin regression induced by thyroxine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Dose-Response Relationship, Drug; In Vitro Techniques; Isoquinolines; Metamorphosis, Biological; Piperazines; Prolactin; Protein Kinase C; Rana pipiens; Sulfonamides; Thyroxine | 1992 |
Transforming growth factor (TGF)-beta stimulates hepatic jun-B and fos-B proto-oncogenes and decreases albumin mRNA.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Albumins; Animals; Cells, Cultured; Down-Regulation; Gene Expression Regulation; Genes, fos; Genes, jun; Isoquinolines; Liver; Mice; Piperazines; Protein Kinase Inhibitors; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 1992 |
Cellular interactions with the extracellular matrix are coupled to diverse transmembrane signaling pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calmodulin; Cell Adhesion; Collagen; Extracellular Matrix; Extracellular Matrix Proteins; Fibronectins; Humans; Isoquinolines; Laminin; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Staurosporine; Sulfonamides; Tumor Cells, Cultured | 1992 |
Phorbol ester reduces constitutive nuclear NF kappa B and inhibits HIV-1 production in mature human monocytic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Cell Line; Cell Nucleus; Cells, Cultured; Enhancer Elements, Genetic; HIV-1; Humans; Isoquinolines; Kinetics; Molecular Sequence Data; Monocytes; NF-kappa B; Oligonucleotide Probes; Piperazines; Protein Kinase C; Repetitive Sequences, Nucleic Acid; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Virus Replication | 1992 |
Reversible G1 arrest of a human lung epithelial cell line by staurosporine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Division; Cell Line; DNA; Dose-Response Relationship, Drug; G1 Phase; Genistein; Humans; Isoflavones; Isoquinolines; Phenols; Piperazines; Protein Kinase C; Staurosporine; Sulfonamides | 1992 |
Interleukin-2 promoter activation in T-cells expressing activated Ha-ras.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Chloramphenicol O-Acetyltransferase; Interleukin-2; Isoquinolines; Lymphocyte Activation; Mice; NF-kappa B; Piperazines; Plasmids; Promoter Regions, Genetic; Protein Kinase C; Proto-Oncogene Proteins p21(ras); Receptors, Antigen, T-Cell; RNA, Neoplasm; Sulfonamides; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1992 |
Shear-induced platelet-derived growth factor gene expression in human endothelial cells is mediated by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cells, Cultured; Egtazic Acid; Endothelium, Vascular; Gene Expression Regulation; Guanosine Diphosphate; Humans; Ibuprofen; Indomethacin; Isoquinolines; Neomycin; Piperazines; Platelet-Derived Growth Factor; Protein Kinase C; RNA, Messenger; Signal Transduction; Staurosporine; Stress, Mechanical; Sulfonamides; Transcriptional Activation | 1992 |
A role for protein kinase C in the growth of human erythroid progenitor cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Bone Marrow Cells; Cell Division; Erythroid Precursor Cells; Erythropoiesis; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Isoquinolines; Piperazines; Protein Kinase C; Recombinant Proteins; Staurosporine; Sulfonamides | 1992 |
Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Azepines; Calcium; Cell Communication; Cell Line; Dogs; Egtazic Acid; Epithelium; Fluorescent Antibody Technique; Intercellular Junctions; Isoquinolines; Kidney; Kinetics; Naphthalenes; Piperazines; Protein Kinase Inhibitors; Staurosporine; Sulfonamides | 1992 |
H7, a protein kinase C inhibitor, increases the glutathione content of neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Enzyme Activation; Glutathione; Isoquinolines; Mice; Neuroblastoma; Piperazines; Protein Kinase C; Sphingosine; Staurosporine; Sulfonamides; Tumor Cells, Cultured | 1992 |
Protein kinase C involvement in focal adhesion formation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Adhesion; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Fibroblasts; Fibronectins; Humans; Isoquinolines; Microscopy, Interference; Peptide Fragments; Phorbol Esters; Piperazines; Protein Kinase C; Protein Kinases; Rats; Sulfonamides | 1992 |
Staphylococcal toxic shock syndrome toxin 1-induced tumor necrosis factor alpha and interleukin-1 beta secretion by human peripheral blood monocytes and T lymphocytes is differentially suppressed by protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bacterial Toxins; Cells, Cultured; Enterotoxins; Genistein; Humans; Interleukin-1; Isoflavones; Isoquinolines; Lipopolysaccharides; Monocytes; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Staphylococcus aureus; Sulfonamides; Superantigens; T-Lymphocytes; Tumor Necrosis Factor-alpha | 1992 |
Retinoic acid enhances IL-1 beta expression in myeloid leukemia cells and in human monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Bucladesine; Gene Expression; Humans; Interleukin-1; Isoquinolines; Leukemia, Myeloid; Lipopolysaccharides; Monocytes; Piperazines; Protein Kinase Inhibitors; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tretinoin; Tumor Cells, Cultured | 1991 |
cAMP-dependent induction of fatty acid cyclooxygenase mRNA in mouse osteoblastic cells (MC3T3-E1).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Blotting, Western; Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; Dinoprostone; Enzyme Induction; Epinephrine; Gene Expression; Isoquinolines; Mice; Osteoblasts; Piperazines; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides | 1991 |
ATP gamma S activates the respiratory burst in electropermeabilized neutrophils: the role of protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Alkaloids; Animals; Guinea Pigs; In Vitro Techniques; Isoquinolines; Kinetics; Neutrophils; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Sulfonamides; Superoxides | 1991 |
Differential effects of isoquinolinesulfonamide protein kinase inhibitors on CA1 responses in hippocampal slices.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Hippocampus; In Vitro Techniques; Isoquinolines; Osmolar Concentration; Piperazines; Protein Kinase C; Protein Kinases; Rats; Rats, Inbred Strains; Sulfonamides; Synapses | 1991 |
Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Animals; Carbachol; Cells, Cultured; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Isoquinolines; Mice; N-Methylaspartate; Neurons; Neurotoxins; Piperazines; Protein Kinase C; Receptors, Glutamate; Receptors, Neurotransmitter; Sulfonamides | 1991 |
Radiation-induced surface IgG modulation: protein kinase C involvement.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; B-Lymphocytes; Immunoglobulin G; In Vitro Techniques; Isoquinolines; Mice; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Receptors, Antigen, B-Cell; Sulfonamides; Tetradecanoylphorbol Acetate | 1991 |
Penetration of CD4 T cells by HIV-1. The CD4 receptor does not internalize with HIV, and CD4-related signal transduction events are not required for entry.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Calcium Channel Blockers; Calmodulin; CD4 Antigens; CD4-Positive T-Lymphocytes; Cells, Cultured; Cyclosporins; Cytochalasins; Egtazic Acid; HIV-1; Humans; In Vitro Techniques; Isoquinolines; Lymphocyte Activation; Nerve Tissue Proteins; Pertussis Toxin; Piperazines; Polymerase Chain Reaction; Protein Kinase C; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1991 |
The isoquinoline sulfonamide inhibitors of protein phosphorylation, H-7, H-8, and HA-1004, also inhibit RNA synthesis: studies on responses of adipose tissue to growth hormone.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adipose Tissue; Animals; Growth Hormone; Insulin; Isoquinolines; Lipolysis; Male; Phosphorylation; Piperazines; Protein Kinase C; Proteins; Rats; Rats, Inbred Strains; RNA; Sulfonamides | 1990 |
The alpha-adrenergic stimulation of atrial natriuretic factor expression in cardiac myocytes requires calcium influx, protein kinase C, and calmodulin-regulated pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Agonists; Animals; Atrial Natriuretic Factor; Calcium; Calmodulin; Cells, Cultured; Gene Expression; Heart; Hydrolysis; Isoquinolines; Myocardium; Nifedipine; Phenylephrine; Phosphatidylinositols; Piperazines; Protein Kinase C; Rats; Sulfonamides | 1991 |
Phorbol-12-myristate-13-acetate (PMA) and inhibitors of protein kinase C alter glial fibrillary acidic protein (GFAP) mRNA levels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Astrocytoma; Dactinomycin; Glial Fibrillary Acidic Protein; Humans; Isoquinolines; Piperazines; Protein Kinase C; RNA; RNA, Messenger; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1991 |
Induction of a cytoplasmic activator of DNA synthesis in lymphocytes is mediated through a membrane-associated protein kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaline Phosphatase; Amino Acid Sequence; Aprotinin; Cell Nucleus; Gene Expression Regulation, Enzymologic; Humans; Isoquinolines; Leukemia, Lymphoid; Lymphocytes; Membrane Proteins; Membranes; Peptides; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Protein Precursors; Serine Endopeptidases; Signal Transduction; Subcellular Fractions; Sulfonamides | 1990 |
Regulation of the Egr-1 gene by tumor necrosis factor and interferons in primary human fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Blotting, Northern; Blotting, Western; DNA; Epidermal Growth Factor; Fibroblasts; Gene Expression Regulation; HeLa Cells; Humans; Interferon-gamma; Isoquinolines; Kinetics; Mice; Phosphorylation; Piperazines; RNA, Messenger; Staurosporine; Sulfonamides; Thymidine; Tumor Necrosis Factor-alpha | 1992 |
Inhibition of protein kinase C is associated with a decrease in c-myc expression in human myeloid leukemia cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Cell Line; Enzyme Activation; Gene Expression; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; Isoquinolines; Kinetics; Leukemia, Myeloid; Piperazines; Protein Kinase C; Pyrimidine Nucleosides; RNA, Messenger; RNA, Neoplasm; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 1991 |
Inhibition of protein-kinase C in peripheral blood mononuclear cells of patients with systemic lupus erythematosus: effect on spontaneous immunoglobulin production.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Autoantibodies; Cells, Cultured; Female; Humans; Immunoglobulin G; Isoquinolines; Lupus Erythematosus, Systemic; Male; Monocytes; Piperazines; Pokeweed Mitogens; Protein Kinase C; Sulfonamides | 1991 |
Translocation of CD45RA in neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Differentiation; Calcimycin; Calcium; Calcium Channel Blockers; Calmodulin; Cell Membrane; Flow Cytometry; Gene Expression Regulation; Histocompatibility Antigens; Humans; Isoantigens; Isoquinolines; Leukocyte Common Antigens; Neutrophils; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Up-Regulation | 1991 |
Cyclic AMP mediates the direct antiproliferative action of mismatched double-stranded RNA.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Astrocytoma; Base Composition; Carcinoma, Transitional Cell; Cell Division; Cell Line; Cyclic AMP; Enzyme Induction; Humans; Interferon Type I; Interferon-gamma; Isoquinolines; Piperazines; Poly I-C; Poly U; Polyribonucleotides; Protein Kinase Inhibitors; Recombinant Proteins; RNA, Double-Stranded; Signal Transduction; Sulfonamides; Urinary Bladder Neoplasms | 1991 |
Decreased respiratory burst activity in neonatal bovine neutrophils stimulated by protein kinase C agonists.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Cattle; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Female; Isoquinolines; Neutrophils; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate | 1991 |
Tumor necrosis factor gene expression is mediated by protein kinase C following activation by ionizing radiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line; Down-Regulation; Enzyme Activation; Gene Expression Regulation; Isoquinolines; Phosphorylation; Piperazines; Protein Kinase C; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1991 |
Regulation of c-jun gene expression in HL-60 leukemia cells by 1-beta-D-arabinofuranosylcytosine. Potential involvement of a protein kinase C dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aphidicolin; Cell Line; Cell Nucleus; Cycloheximide; Cytarabine; Dactinomycin; Diterpenes; DNA-Binding Proteins; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Isoquinolines; Kinetics; Leukemia, Promyelocytic, Acute; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; RNA, Neoplasm; Sulfonamides; Transcription Factors; Transcription, Genetic | 1991 |
Evidence for the involvement of protein kinase C in the modulation of morphine-induced 'analgesia' and the inhibitory effects of exposure to 60-Hz magnetic fields in the snail, Cepaea nemoralis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analgesia; Animals; Enzyme Activation; Hot Temperature; Isoquinolines; Magnetics; Morphine; Naloxone; Piperazines; Protein Kinase C; Snails; Sulfonamides | 1991 |
Differential activation and inhibition of lymphocyte proliferation by modulators of protein kinase C: diacylglycerols, "rationally designed" activators and inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbazoles; Cattle; Diglycerides; Down-Regulation; Enzyme Activation; Genistein; Indole Alkaloids; Isoflavones; Isoquinolines; Lymphocyte Activation; Piperazines; Protease Inhibitors; Protein Kinase C; Sphingosine; Sulfonamides; Type C Phospholipases | 1991 |
Role of endothelin 1 in regulating rabbit airway contractility.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Dinoprostone; Endothelins; Epithelium; Epoprostenol; In Vitro Techniques; Indomethacin; Isometric Contraction; Isoquinolines; Kinetics; Muscle, Smooth; Piperazines; Protein Kinase Inhibitors; Rabbits; Reference Values; Staurosporine; Sulfonamides; Trachea | 1991 |
Effects of tamoxifen and protein kinase C inhibitors on hyperthermic cell killing.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Survival; Hot Temperature; Humans; Isoquinolines; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Sulfonamides; Tamoxifen | 1991 |
Staurosporine-induced morphological differentiation of human neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Axons; Cell Differentiation; Colchicine; Cycloheximide; Humans; Isoquinolines; Microtubules; Neuroblastoma; Neurons; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Sulfonamides; Tumor Cells, Cultured | 1991 |
Different activation signals are required for the expression of interleukin-1 alpha and beta genes in human monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Enzyme-Linked Immunosorbent Assay; Gene Expression; Humans; Interleukin-1; Isoquinolines; Lipopolysaccharides; Lymphocyte Activation; Monocytes; Piperazines; Protein Kinase Inhibitors; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate | 1991 |
Endotoxin-mediated bovine alveolar macrophage procoagulant induction is dependent on protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Coagulation Factors; Cattle; Endotoxins; Enzyme Activation; Isoquinolines; Lipopolysaccharides; Macrophages; Phenylbutazone; Piperazines; Protein Kinase C; Pulmonary Alveoli; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Thromboplastin | 1990 |
Protein kinase C-regulated production of prostacyclin by rat endothelium is increased in the presence of lipoxin A4.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Cells, Cultured; Endothelium; Epoprostenol; Homeostasis; Hydroxyeicosatetraenoic Acids; Isoquinolines; Kinetics; Lipoxins; Myocardium; Piperazines; Protein Kinase C; Rats; Sulfonamides | 1990 |
Inhibition by protein kinase-C inhibitor and cycloheximide of phorbol ester- and epidermal growth factor-induced arachidonic acid metabolism in cultured porcine thyroid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Cycloheximide; Dinoprostone; Epidermal Growth Factor; Isoquinolines; Kinetics; Male; Mice; Piperazines; Protein Kinase C; Sulfonamides; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland | 1990 |
Agonist-induced activation of Na+/H+ exchange in rat parotid acinar cells is dependent on calcium but not on protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Calcium Channel Blockers; Calmodulin; Carbachol; Carrier Proteins; Diglycerides; Epinephrine; Isoquinolines; Male; Parotid Gland; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Sodium-Hydrogen Exchangers; Sulfonamides; Trifluoperazine | 1990 |
Effect of protein kinase modulators on the induction of morphological differentiation of pheochromocytoma PC12 cells by nerve and fibroblast growth factors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Cell Differentiation; Cyclic AMP; Cyclic GMP; Drug Synergism; Fibroblast Growth Factors; Isoquinolines; Nerve Growth Factors; Pheochromocytoma; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Sulfonamides; Tumor Cells, Cultured | 1990 |
A possible role for protein kinase C activity but not cyclic nucleotide-dependent protein kinases in human natural killer cell lytic activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Calcium Channel Blockers; Cyclic AMP; Cytotoxicity Tests, Immunologic; Glycosylation; Humans; Isoquinolines; Killer Cells, Natural; Piperazines; Protein Biosynthesis; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Sulfonamides | 1990 |
The role of protein kinase C in interleukin 1 and tumor necrosis factor alpha induction of fibroblasts to produce and release granulocyte-macrophage colony-stimulating activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Alkaloids; Bone Marrow Cells; Bucladesine; Calcium Channel Blockers; Calmodulin; Cell Line; Colforsin; Colony-Forming Units Assay; Colony-Stimulating Factors; Cyclic AMP; Fibroblasts; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Humans; Interleukin-1; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Staurosporine; Sulfonamides; Tumor Necrosis Factor-alpha | 1990 |
Utility of staurosporine in uncovering differences in the signal transduction pathways for superoxide production in neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Diglycerides; Guinea Pigs; In Vitro Techniques; Isoquinolines; Models, Chemical; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Staurosporine; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
cAMP mediates IL-1-induced lymphocyte penetration through endothelial monolayers.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cell Movement; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Cycloheximide; Dactinomycin; Endothelium, Vascular; Gene Expression; In Vitro Techniques; Inflammation; Interleukin-1; Isoquinolines; Lymphocytes; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Signal Transduction; Sulfonamides | 1990 |
Possible contribution of protein kinase C activation to priming for DNA synthesis induced by epidermal growth factor with insulin and its inhibition by plasma membrane in primary cultured rat hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Cell Membrane; Cells, Cultured; DNA; DNA Replication; Enzyme Activation; Epidermal Growth Factor; Insulin; Isoquinolines; Liver; Male; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Sulfonamides; Tetradecanoylphorbol Acetate; Thymidine; Vasopressins | 1990 |
Protein kinase-C involvement in thymocyte apoptosis induced by hydrocortisone.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Survival; DNA; Hydrocortisone; Isoquinolines; Mice; Piperazines; Protein Kinase C; Sulfonamides; T-Lymphocytes | 1990 |
Inhibition of phytohemagglutinin-stimulated bovine mononuclear cell proliferation, interleukin-2 production and protein kinase C activity by a protein kinase C inhibitor, H-7.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Cattle; Cell Division; Cell Survival; Cells, Cultured; Cytosol; Interleukin-2; Isoquinolines; Leukocytes, Mononuclear; Lymphocyte Activation; Phytohemagglutinins; Piperazines; Protein Kinase C; Recombinant Proteins; Sulfonamides | 1990 |
A specific inhibitor of protein kinase C induces differentiation of neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Cell Differentiation; Cell Membrane; Cytosol; Isoquinolines; Kinetics; Mice; Neuroblastoma; Piperazines; Protein Kinase C; Sulfonamides; Tumor Cells, Cultured | 1990 |
Regulation of mitogen-stimulated human T-cell proliferation, interleukin-2 production, and interleukin-2 receptor expression by protein kinase C inhibitor, H-7.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Division; Humans; In Vitro Techniques; Interleukin-2; Interleukin-4; Isoquinolines; Lymphocyte Activation; Phytohemagglutinins; Piperazines; Protein Kinase C; Receptors, Interleukin-2; RNA, Messenger; Sulfonamides; T-Lymphocytes; Thymidine; Tritium | 1990 |
Protein kinase regulates tumor necrosis factor mRNA stability in virus-stimulated astrocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amanitins; Animals; Astrocytes; Blotting, Northern; Cell Nucleus; Cell Transformation, Viral; Cells, Cultured; Diglycerides; Isoquinolines; Newcastle disease virus; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rats; RNA, Messenger; Staurosporine; Sulfonamides; Tumor Necrosis Factor-alpha | 1990 |
The protein kinase C inhibitor H-7, inhibits antigen and IL-2-induced proliferation of murine T cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Division; Cell Line; Cell Survival; Interleukin-2; Isoquinolines; Lymphocyte Activation; Mice; Myelin Basic Protein; Piperazines; Protein Kinase C; Sulfonamides; T-Lymphocytes | 1987 |
A functional protein kinase C is required for induction of 2-5A synthetase by recombinant interferon-alpha A in Daudi cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2',5'-Oligoadenylate Synthetase; Cell Line; Endocytosis; Humans; Interferon Type I; Isoquinolines; Phorbol Esters; Piperazines; Protein Biosynthesis; Protein Kinase C; Recombinant Proteins; RNA; RNA, Messenger; Sulfonamides; Transcription, Genetic; Tumor Cells, Cultured | 1989 |
Activators of protein kinase C up-regulate the cell surface expression of CD2 and CD5 T cell glycoproteins.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Antigens, Differentiation; Antigens, Differentiation, T-Lymphocyte; Calcium Channel Blockers; CD2 Antigens; CD5 Antigens; Cell Membrane; Cells, Cultured; Cycloheximide; Diglycerides; Dinoprostone; Enzyme Activation; Flow Cytometry; Humans; Isoquinolines; Membrane Glycoproteins; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Receptors, Immunologic; RNA, Messenger; Sulfonamides; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1989 |
Protein kinase C and the stimulation of tissue plasminogen activator release from human endothelial cells. Dependence on the elevation of messenger RNA.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Calcium Channel Blockers; Cells, Cultured; Cloning, Molecular; Colforsin; Cycloheximide; DNA; Endothelium, Vascular; Humans; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; RNA, Messenger; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator | 1989 |
Na+-H+ antiport during fertilization of the sea urchin egg is blocked by W-7 but is insensitive to K252a and H-7.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Carbazoles; Carrier Proteins; Female; Fertilization; Indole Alkaloids; Isoquinolines; Kinetics; Ovum; Piperazines; Protein Kinase C; Sea Urchins; Sodium-Hydrogen Exchangers; Sulfonamides; Tetradecanoylphorbol Acetate | 1989 |
Protein phosphorylation associated with synergistic stimulation of neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Diterpenes; Drug Synergism; Guinea Pigs; Hydroxyeicosatetraenoic Acids; Isoquinolines; Molecular Weight; Neutrophils; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Piperazines; Sulfonamides; Superoxides; Terpenes | 1989 |
Paradoxical effects of retinal in neutrophil stimulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Fractionation; Cell Membrane; Egtazic Acid; Guinea Pigs; Isoquinolines; Neutrophils; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Retinaldehyde; Retinoids; Solubility; Sulfonamides; Superoxides | 1989 |
Protein kinase C activation and down-regulation in relation to phorbol ester-induced differentiation of SH-SY5Y human neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Calcium Channels; Cell Compartmentation; Cell Differentiation; Diglycerides; Enzyme Activation; Humans; Isoquinolines; Membrane Potentials; Neuroblastoma; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Receptors, Muscarinic; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1989 |
Evidence that v-src and v-fps gene products use a protein kinase C-mediated pathway to induce expression of a transformation-related gene.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Calcium Channel Blockers; Cell Transformation, Neoplastic; Chick Embryo; Gene Products, gag; Isoquinolines; Kinetics; Oncogene Protein pp60(v-src); Oncogenes; Phorbol Esters; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Retroviridae Proteins; RNA, Messenger; Signal Transduction; Sulfonamides; Transcription, Genetic | 1989 |
The protein kinase C inhibitor 1-(5-isoquinolinesulphonyl)-2-methylpiperazine (H-7) disinhibits CA1 pyramidal cells in rat hippocampal slices.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Animals; Calcium Channel Blockers; Electric Stimulation; Hippocampus; In Vitro Techniques; Isoquinolines; Male; Piperazines; Protein Kinase C; Pyramidal Tracts; Rats; Rats, Inbred Strains; Sphingosine; Sulfonamides | 1989 |
Suppression of LH-stimulated prostaglandin and progesterone accumulation in rat granulosa cells by isoquinolinesulfonamide protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Female; Granulosa Cells; Isoquinolines; Luteinizing Hormone; Piperazines; Progesterone; Prostaglandins E; Protein Kinase C; Protein Kinase Inhibitors; Rats; Sulfonamides | 1989 |
The effects of protein kinase inhibitors on lymphocyte blastogenesis and GVHD-induced splenomegaly.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Graft vs Host Disease; Immunosuppressive Agents; In Vitro Techniques; Isoquinolines; Lymphocyte Activation; Male; Mice; Mice, Inbred Strains; Phenothiazines; Piperazines; Protein Kinase Inhibitors; Splenomegaly; Sulfonamides | 1989 |
Changes in the nuclear protein kinase activities in the regenerating liver of partially irradiated rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Nucleus; Histones; Isoquinolines; Liver; Liver Regeneration; Male; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Inbred Strains; Sulfonamides | 1989 |
Putative involvement of protein kinase C in proliferation of human myeloid progenitor cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Alkaloids; Bone Marrow; Cell Division; Cell Line; Clone Cells; Colony-Forming Units Assay; Colony-Stimulating Factors; Growth Inhibitors; Hematopoietic Stem Cells; Humans; Isoquinolines; Leukemia, Erythroblastic, Acute; Piperazines; Protein Kinase C; Staurosporine; Sulfonamides | 1989 |
Interleukin-2 regulates the activity of ornithine decarboxylase in a cloned murine T lymphocytic cell line: evidence for a protein kinase C-dependent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Division; Clone Cells; Enzyme Induction; Interleukin-2; Isoquinolines; Mice; Ornithine Decarboxylase; Piperazines; Protein Kinase C; Sulfonamides; T-Lymphocytes | 1989 |
TPA induction of Epstein-Barr virus early antigens in Raji cells is blocked by selective protein kinase-C inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Neoplasm; Antigens, Viral; Burkitt Lymphoma; Calmodulin; Gene Expression Regulation; Herpesvirus 4, Human; Humans; Isoquinolines; Piperazines; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Verapamil | 1987 |
Dissociation of the 47-kilodalton protein phosphorylation from degranulation and superoxide production in neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylglucosaminidase; Animals; Cytochalasin B; Cytoplasmic Granules; Drug Interactions; Hexosaminidases; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate | 1988 |
Synergistic stimulation of neutrophils. Possible involvement of 5-hydroxy-6,8,11,14-eicosatetraenoate in superoxide release.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Cations, Divalent; Drug Synergism; Guinea Pigs; Hydroxyeicosatetraenoic Acids; Isoquinolines; Neutrophils; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Sphingosine; Sulfonamides; Superoxides | 1988 |
Calcitonin-induced increase in phosphate accumulation in LLC-PK1 cells probably through protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Calcitonin; Cells, Cultured; Cyclic AMP; Diglycerides; Isoquinolines; Kidney; Phorbol Esters; Phosphates; Piperazines; Protein Kinase C; Sulfonamides; Swine; Tetradecanoylphorbol Acetate | 1988 |
Effects of protein kinase C (PK-C) activators and inhibitors on human large granular lymphocytes (LGL): role of PK-C on natural killer (NK) activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Diglycerides; Enzyme Activation; Ethers; Humans; Immunity, Innate; Ionomycin; Isoquinolines; Killer Cells, Natural; Molecular Weight; Phosphoproteins; Piperazines; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate | 1989 |
Arachidonic acid acts as an intracellular activator of NADPH-oxidase in Fc gamma receptor-mediated superoxide generation in macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Enzyme Activation; Guinea Pigs; Isoquinolines; Macrophages; NADH, NADPH Oxidoreductases; NADPH Oxidases; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Receptors, Fc; Receptors, IgG; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate | 1987 |
Regulation of cell shape in the Cloudman melanoma cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-MSH; Animals; Axons; Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; Fluorescent Antibody Technique; Isoquinolines; Melanocyte-Stimulating Hormones; Melanoma; Mice; Microscopy, Electron; Piperazines; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic | 1987 |
A potent inhibitor of protein kinase C inhibits natural killer activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line, Transformed; Humans; Isoquinolines; Killer Cells, Natural; Piperazines; Protein Kinase C; Sulfonamides | 1988 |
Intracellular pH in platelets from spontaneously hypertensive rats and Wistar-Kyoto rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Platelets; Hydrogen-Ion Concentration; Hypertension; Isoquinolines; Piperazines; Protein Kinase C; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Sulfonamides | 1988 |
Protein kinase C (PKC) inhibitors inhibit primary (1-0) but not secondary (1-1) or cloned cytotoxic T lymphocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Clone Cells; Cytotoxicity, Immunologic; Isoquinolines; Mice; Piperazines; Protein Kinase C; Sulfonamides; T-Lymphocytes, Cytotoxic | 1988 |
Inhibition of human natural killer cell activity by the protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine is an early but post-binding event.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Antibody-Dependent Cell Cytotoxicity; Binding, Competitive; Cytotoxicity Tests, Immunologic; Cytotoxicity, Immunologic; Humans; Immunosuppressive Agents; Interferon Type I; Interleukin-2; Isoquinolines; Killer Cells, Natural; Kinetics; Lymphocyte Activation; Piperazines; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate | 1988 |
Possible involvement of diacylglycerol-activated, Ca2+-dependent protein kinase in glucose memory of the rat pancreatic B-cell.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Colforsin; Enzyme Activation; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Isoquinolines; Male; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Sulfonamides; Tetradecanoylphorbol Acetate | 1988 |
Effects of protein kinase inhibitors 1(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) and N-[2-guanidinoethyl]-5-isoquinolinesulfonamide hydrochloride (HA1004) on calcitriol-induced differentiation of HL-60 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcitriol; Cell Differentiation; Cell Survival; DNA, Neoplasm; Humans; Isoquinolines; Leukemia, Myeloid, Acute; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Sulfonamides; Tumor Cells, Cultured | 1988 |
1-(5-Isoquinolinesulfonyl)-2-methylpiperazine(H-7), a potent inhibitor of protein kinases, inhibits the differentiation of HL-60 cells induced by phorbol diester.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Differentiation; Cell Division; Cell Line; Depression, Chemical; Humans; Isoquinolines; Leukemia, Myeloid, Acute; Male; Phosphorylation; Piperazines; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate | 1986 |
Possible involvement of protein kinase C in parathyroid hormone degradation by osteoblast-like rat osteosarcoma cell line UMR106.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Diglycerides; Isoquinolines; Osteoblasts; Osteosarcoma; Parathyroid Hormone; Piperazines; Protein Kinase C; Rats; Sarcoma, Experimental; Sulfonamides; Tetradecanoylphorbol Acetate | 1987 |
The effects of HA compound calcium antagonists on delayed cerebral vasospasm in dogs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Dogs; In Vitro Techniques; Ischemic Attack, Transient; Isoquinolines; Subarachnoid Hemorrhage; Sulfonamides; Vasoconstriction; Vasodilation | 1986 |
Differential effect of 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) on alpha B-crystallin and hsp70 gene expression in murine cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Base Sequence; Cell Line; Crystallins; Enzyme Inhibitors; Gene Expression; HSP70 Heat-Shock Proteins; Isoquinolines; Mice; Molecular Sequence Data; Piperazines; Protein Kinase C; RNA, Messenger; Sulfonamides; Transcription, Genetic | 1995 |
Noradrenergic regulation of c-jun expression in the rat pineal gland in culture: positive and negative components.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Gene Expression Regulation; Isoquinolines; Male; Norepinephrine; Organ Culture Techniques; Phorbol 12,13-Dibutyrate; Pineal Gland; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; RNA, Messenger; Sulfonamides | 1993 |
Pathways of signaling in nonspecific cytotoxic cells: effects of protein kinase and phosphatase inhibitors and evidence for membrane tyrosine phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Catfishes; Cell Membrane; Cytotoxicity, Immunologic; Female; Immunity, Cellular; Isoquinolines; Male; Phosphoprotein Phosphatases; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Sulfonamides; Tyrosine | 1994 |
Evidence that prostaglandin E2 can block calcium-activated 86Rb efflux from rat brain synaptosomes via a protein kinase C-dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Calcium Channel Blockers; Charybdotoxin; Cyclic AMP; Dinoprostone; Isoquinolines; Kinetics; Male; Phorbol 12,13-Dibutyrate; Piperazines; Prosencephalon; Protein Kinase C; Rats; Rats, Sprague-Dawley; Rubidium; Scorpion Venoms; Staurosporine; Sulfonamides; Synaptosomes; Thionucleotides | 1994 |
CD40 signaling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated protein
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Benzoquinones; Burkitt Lymphoma; CD40 Antigens; Cell Line; Cell Line, Transformed; Enzyme Precursors; Genistein; Herpesvirus 4, Human; Humans; Intracellular Signaling Peptides and Proteins; Isoflavones; Isoquinolines; Lactams, Macrocyclic; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Weight; Palatine Tonsil; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Quinones; Rifabutin; Sulfonamides; Syk Kinase; Tumor Cells, Cultured; Tyrosine | 1994 |
Role of protein kinase C in mediating NGF effect on neuropeptide Y expression in PC12 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Binding Sites; Blotting, Northern; Bucladesine; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Gene Expression; Isoquinolines; Kinetics; Molecular Sequence Data; Naphthalenes; Nerve Growth Factors; Neuropeptide Y; Oligodeoxyribonucleotides; PC12 Cells; Piperazines; Polycyclic Compounds; Promoter Regions, Genetic; Protein Kinase C; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1994 |
Polyamine transport in human promyelocytic leukemia cells and polymorphonuclear leukocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Biological Transport; Cell Line; Genistein; Gramicidin; Humans; In Vitro Techniques; Ionomycin; Isoflavones; Isoquinolines; Kinetics; Leukemia, Promyelocytic, Acute; Neutrophils; Piperazines; Protein Kinase Inhibitors; Putrescine; Spermidine; Spermine; Sulfonamides; Temperature; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Effect of substance P and protein kinase inhibitors on beta-amyloid peptide-induced proliferation of cultured brain cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amyloid beta-Peptides; Animals; Animals, Newborn; Brain; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Isoquinolines; Kinetics; Piperazines; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Substance P; Sulfonamides; Thymidine | 1994 |
cGMP inhibits L-type Ca2+ channel currents through protein phosphorylation in rat pinealocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Isoquinolines; Male; Nifedipine; Nitroprusside; Norepinephrine; Patch-Clamp Techniques; Phosphorylation; Pineal Gland; Piperazines; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Sulfonamides; Thionucleotides | 1995 |
Protein kinase C is a mediator of lipopolysaccharide-induced vascular suppression in the rat aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Oxidoreductases; Animals; Aorta; Arginine; Cell Membrane; Citrulline; Cycloheximide; Cytosol; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Isoquinolines; Kinetics; Lipopolysaccharides; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phorbol 12,13-Dibutyrate; Piperazines; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; Stereoisomerism; Sulfonamides | 1994 |
Mechanism of metallothionein gene regulation by heme-hemopexin. Roles of protein kinase C, reactive oxygen species, and cis-acting elements.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Line; Enzyme Inhibitors; Gene Expression Regulation; Heme; Hemopexin; Hydrogen Peroxide; Isoquinolines; Kinetics; Liver Neoplasms; Metallothionein; Mice; Molecular Sequence Data; Piperazines; Promoter Regions, Genetic; Protein Kinase C; Rabbits; Reactive Oxygen Species; RNA, Messenger; Sequence Deletion; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Xanthine; Xanthines | 1995 |
Protein kinase C-and ras-dependent activation of c-jun gene by human papillomavirus type 11 E5a oncoprotein.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Blotting, Western; Cells, Cultured; Cyclic AMP; Genes, jun; Humans; In Vitro Techniques; Isoquinolines; Keratinocytes; Mice; Oncogene Proteins, Viral; Papillomaviridae; Piperazines; Protein Kinase C; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins p21(ras); Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Transfection | 1995 |
Role of protein kinase C in tumor necrosis factor induction of endothelial cell urokinase-type plasminogen activator.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Cells, Cultured; Culture Media, Conditioned; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Enzyme Induction; Extracellular Matrix; Humans; Isoquinolines; Kinetics; Molecular Sequence Data; Molecular Weight; Naphthalenes; Oligodeoxyribonucleotides; Piperazines; Plasminogen Activator Inhibitor 1; Polycyclic Compounds; Protein Kinase C; RNA; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Necrosis Factor-alpha; Umbilical Veins; Urokinase-Type Plasminogen Activator | 1993 |
Gö 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bryostatins; Carbazoles; Enzyme Induction; HIV-1; Humans; In Vitro Techniques; Indoles; Isoquinolines; Lactones; Macrolides; Piperazines; Protein Kinase C; Retroviridae Proteins; RNA-Directed DNA Polymerase; RNA, Viral; Sulfonamides; Transcription, Genetic; Tumor Cells, Cultured; Virus Replication | 1993 |
Down-regulation of beta-adrenergic receptors induced by mitogen activation of intracellular signaling events in lymphocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Concanavalin A; Cyclic AMP; Down-Regulation; Genistein; In Vitro Techniques; Interleukin-2; Intracellular Fluid; Isoflavones; Isoquinolines; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Neuroimmunomodulation; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Receptors, Adrenergic, beta; Signal Transduction; Sulfonamides; T-Lymphocytes | 1995 |
Phosphatase is responsible for run down, and probably G protein-mediated inhibition of inwardly rectifying K+ currents in guinea pig chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adenylyl Imidodiphosphate; Alkaline Phosphatase; Aluminum Compounds; Animals; Chromaffin System; Down-Regulation; Electrophysiology; Female; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Guinea Pigs; Isoquinolines; Marine Toxins; Membrane Potentials; Oxazoles; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Potassium Channel Blockers; Potassium Channels; Protein Phosphatase 1; Sulfonamides | 1995 |
Human interleukin-3 receptor modulates bcl-2 mRNA and protein levels through protein kinase C in TF-1 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Base Sequence; Dactinomycin; Gene Expression Regulation, Leukemic; Humans; Interleukin-3; Isoquinolines; Leukemia, Erythroblastic, Acute; Molecular Sequence Data; Naphthalenes; Neoplasm Proteins; Piperazines; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Receptors, Interleukin-3; RNA, Messenger; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1995 |
Regulation of Chlamydomonas flagellar dynein by an axonemal protein kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Chlamydomonas reinhardtii; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Dyneins; Flagella; Isoquinolines; Microtubules; Movement; Peptide Fragments; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Sulfonamides | 1994 |
Effect of 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) on HSP70 and HSP28 gene expression and thermotolerance development in human colon carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Gene Expression; Hot Temperature; HSP70 Heat-Shock Proteins; Humans; Isoquinolines; Piperazines; Protein Kinase C; RNA, Messenger; Sulfonamides; Tumor Cells, Cultured | 1994 |
Modulation of mu opioid binding by protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analgesics; Animals; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; Receptors, Opioid, mu; Sulfonamides; Tritium | 1995 |
The role of protein kinase C in inducing Alzheimer's A68 protein expression in the culture of human neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Humans; Immunoblotting; Immunochemistry; Isoquinolines; Nerve Tissue Proteins; Neuroblastoma; Piperazines; Protein Kinase C; Sulfonamides; tau Proteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Adenosine facilitates glutamate release in a protein kinase-dependent manner in superior colliculus slices.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Animals; Calcium; Electric Stimulation; Electrophysiology; Glutamates; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Isoquinolines; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Sulfonamides; Superior Colliculi; Tetrodotoxin | 1994 |
Gene expression of monocyte chemoattractant protein-1 in human monocytes is regulated by cell density through protein tyrosine kinase and protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzoquinones; Blotting, Northern; Cell Division; Cell Nucleus; Cells, Cultured; Chemokine CCL2; Chemotactic Factors; Cytokines; Gene Expression Regulation; Genistein; Humans; Isoflavones; Isoquinolines; Lactams, Macrocyclic; Monocytes; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; RNA, Messenger; Sulfonamides; Transcription, Genetic; Vanadates | 1994 |
Protein kinase C signal transduction pathway in ACTH-induced growth effect of rat adrenocortical cells in primary culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Cortex; Adrenocorticotropic Hormone; Alkaloids; Animals; Cell Division; Cells, Cultured; Corticosterone; Isoquinolines; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Stimulation, Chemical; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 1994 |
Different effects of protein kinase inhibitors on the localization of junctional proteins at cell-cell contact sites.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Actins; Alkaloids; Animals; Cadherins; Calcium; Cell Line; Cytoskeletal Proteins; Cytoskeleton; Desmoplakins; Dogs; Epithelium; Intercellular Junctions; Isoquinolines; Kidney; Membrane Proteins; Phosphoproteins; Piperazines; Protein Kinase Inhibitors; Staurosporine; Sulfonamides; Zonula Occludens-1 Protein | 1994 |
Abrogation of TNF-mediated cytotoxicity by space flight involves protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Death; Cell Line; Dose-Response Relationship, Drug; Fibroblasts; Humans; Isoquinolines; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Space Flight; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1994 |
Effect of isoquinolinesulfonamides on heat shock gene expression during heating at 41 degrees C in human carcinoma cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Breast Neoplasms; Cyclic AMP-Dependent Protein Kinases; Female; Gene Expression Regulation, Neoplastic; Heat-Shock Proteins; Hot Temperature; Humans; Isoquinolines; Kinetics; Leucine; Male; Piperazines; Prostatic Neoplasms; Protein Kinase C; RNA, Messenger; Sulfonamides; Tumor Cells, Cultured | 1994 |
Insulin-like growth factor-I-enhanced secretion is abolished in protein kinase C-deficient chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Amino Acid Sequence; Analysis of Variance; Animals; Brain; Calcium; Catecholamines; Cattle; Cells, Cultured; Insulin-Like Growth Factor I; Isoquinolines; Kinetics; Molecular Sequence Data; Peptide Fragments; Phorbol Esters; Piperazines; Potassium; Protein Kinase C; Protein Kinase Inhibitors; Rats; Substrate Specificity; Sulfonamides; Tetradecanoylphorbol Acetate | 1994 |
Protein kinase C inhibitors enhance differentiation of rat adipocyte precursor cells in serum-free culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adipose Tissue; Alkaloids; Animals; Cell Differentiation; Cells, Cultured; Culture Media, Serum-Free; Glycerolphosphate Dehydrogenase; Isoquinolines; Male; Piperazines; Protein Kinase C; Rats; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 1994 |
Protein kinase C modulation of fibronectin matrix assembly.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Cricetinae; Enzyme Activation; Fetus; Fibroblasts; Fibronectins; Humans; Infant, Newborn; Isoquinolines; Kidney; Kinetics; Lung; Phorbol Esters; Piperazines; Protein Binding; Protein Kinase C; Sulfonamides | 1993 |
Cd(2+)-induced c-myc mRNA accumulation in NRK-49F cells is blocked by the protein kinase inhibitor H7 but not by HA1004, indicating that protein kinase C is a mediator of the response.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Cadmium; Cell Line; DNA Probes; Gene Expression; Genes, fos; Genes, jun; Genes, myc; Isoquinolines; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; RNA, Messenger; Sulfonamides | 1993 |
Corticotropin-releasing factor-induced production of cyclic AMP by human peripheral blood immunocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Calcium Channel Blockers; Corticotropin-Releasing Hormone; Cyclic AMP; Humans; Isoquinolines; Leukocytes, Mononuclear; Lymphocytes; Monocytes; Piperazines; Protein Kinase Inhibitors; Signal Transduction; Sulfonamides | 1993 |
Fibronectin cell-binding domain triggered transmembrane signal transduction in human monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cell Division; Cells, Cultured; Chymotrypsin; Dactinomycin; Fibronectins; Humans; Isoquinolines; Kinetics; L Cells; Lipopolysaccharides; Mice; Monocytes; Peptide Fragments; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Signal Transduction; Sulfonamides; Time Factors; Tumor Necrosis Factor-alpha | 1993 |
Protein kinase C mediates flow-induced prostaglandin E2 production in osteoblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bone Remodeling; Cells, Cultured; Dinoprostone; Extracellular Space; Isoquinolines; Osteoblasts; Piperazines; Protein Biosynthesis; Protein Kinase C; Rats; Regression Analysis; Sulfonamides | 1993 |
Sensitization of C6 glioma cells to radiation by staurosporine, a potent protein kinase C inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Dose-Response Relationship, Radiation; Glioma; Isoquinolines; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Radiation Tolerance; Radiation-Sensitizing Agents; Rats; Staurosporine; Sulfonamides; Tumor Cells, Cultured | 1993 |
Satellite cell myogenesis is highly stimulated by the kinase inhibitor iso-H7: comparison with HA1004 and staurosporine effects.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Differentiation; Cell Fusion; Cells, Cultured; Creatine Kinase; In Vitro Techniques; Isoquinolines; Muscles; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Staurosporine; Sulfonamides | 1993 |
Extracellular ATP-induced regulation of epidermal growth factor signaling in cultured renal LLC-PK1 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Adenosine Triphosphate; Animals; Cell Line; Cell Membrane; Cytosol; Epidermal Growth Factor; ErbB Receptors; Inositol 1,4,5-Trisphosphate; Isoquinolines; Kidney; Kinetics; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate | 1993 |
Effects of cyclic adenosine monophosphate-dependent protein kinase and calcium-dependent protein kinase modulators on stimulated gastric acid secretion in the perfused rat stomach.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Oral; Animals; Calcium; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Gastric Acid; Histamine; Injections, Intravenous; Isoquinolines; Male; Naphthalenes; Pentagastrin; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetradecanoylphorbol Acetate | 1995 |
Inductive effect of Porphyromonas gingivalis fimbriae on differentiation of human monocytic tumor cell line U937.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Bacterial; Antigens, CD; Cell Differentiation; Enzyme Inhibitors; Fimbriae, Bacterial; Hematopoietic Stem Cells; Humans; Interleukin-1; Isoquinolines; Macrophage-1 Antigen; Macrophages; Monocytes; Naphthalenes; Neoplastic Stem Cells; Piperazines; Porphyromonas gingivalis; Protein Kinase C; Receptors, Fc; Rosette Formation; Second Messenger Systems; Signal Transduction; Sulfonamides; Tumor Cells, Cultured | 1996 |
Dual signalling by the adenosine A2a receptor involves activation of both N- and P-type calcium channels by different G proteins and protein kinases in the same striatal nerve terminals.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Adenosine; Agatoxins; Alkaloids; Animals; Antihypertensive Agents; Benzophenanthridines; Calcium Channel Blockers; Calcium Channels; Cholera Toxin; Cholinergic Fibers; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; GTP-Binding Proteins; Isoquinolines; Neostriatum; Neurons; Phenanthridines; Phenethylamines; Piperazines; Potassium; Presynaptic Terminals; Protein Kinase C; Protein Kinases; Rats; Rats, Wistar; Receptors, Purinergic P1; Signal Transduction; Spider Venoms; Stereoisomerism; Sulfonamides; Tritium; Xanthines | 1996 |
Biochemical characterization and protein kinase C dependency of monokine-inducing activities of Toxoplasma gondii.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antigens, Protozoan; Endopeptidases; Female; Gene Expression; Interleukin-1; Isoquinolines; Mice; Mice, Inbred C3H; Monokines; Oxidation-Reduction; Piperazines; Polymerase Chain Reaction; Protein Kinase C; Sulfonamides; Toxoplasma; Tumor Necrosis Factor-alpha | 1996 |
The regulation mechanism of c-jun and junB by human papillomavirus type 16 E5 oncoprotein.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Division; Cells, Cultured; Gene Expression Regulation; Genes, jun; Humans; Isoquinolines; Keratinocytes; Oncogene Proteins, Viral; Piperazines; Simian virus 40; Sulfonamides | 1996 |
Cultured retinal capillary pericytes die by apoptosis after an abrupt fluctuation from high to low glucose levels: a comparative study with retinal capillary endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Bucladesine; Calcimycin; Capillaries; Cattle; Cell Survival; Cells, Cultured; Coculture Techniques; DNA; Endothelium, Vascular; Enzyme Inhibitors; Glucose; Isoquinolines; Kinetics; Microscopy, Electron; Muscle, Smooth, Vascular; Niacinamide; Piperazines; Retinal Vessels; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 1996 |
Acidic fibroblast factor induction of cyclooxygenase II in rabbit cardiac muscle microvessel endothelial cells: mediation by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Blotting, Northern; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Fibroblast Growth Factor 1; Inositol Phosphates; Isoenzymes; Isoquinolines; Microcirculation; Myocardium; Naphthalenes; Piperazines; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Rabbits; RNA, Messenger; Staurosporine; Sulfonamides | 1994 |
The kinase inhibitor iso-H7 stimulates rat satellite cell differentiation through a non-protein kinase C pathway by increasing myogenin expression level.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Cell Differentiation; Creatine Kinase; Enzyme Inhibitors; Indoles; Isoquinolines; Maleimides; Muscle, Skeletal; Myogenin; Myosin Light Chains; Protein Kinase C; Rats; Rats, Wistar; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate | 1996 |
Differential alterations of ethanolamine and choline phosphoglyceride metabolism by clofibrate and retinoic acid in human fibroblasts are not mediated by phorbol ester-sensitive protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinogens; Clofibrate; Enzyme Inhibitors; Ethanolamine; Ethanolamines; Fibroblasts; Humans; Hypolipidemic Agents; Isoquinolines; Phosphatidylcholines; Phospholipids; Protein Kinase C; Skin; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1996 |
Evidence that tyrosine phosphorylation regulates N-cadherin turnover during retinal development.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Cadherins; Chick Embryo; Enzyme Inhibitors; Heart; Hydrogen Peroxide; Isoquinolines; Lens, Crystalline; Myocardium; Organ Culture Techniques; Peptide Mapping; Phosphorylation; Phosphoserine; Protein Kinase C; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Retina; Sulfonamides; Tyrosine; Vanadates | 1997 |
Preincubation of thymocytes with 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) induces apoptosis in non-stimulated thymocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dactinomycin; Enzyme Inhibitors; Isoenzymes; Isoquinolines; Lactams, Macrocyclic; Male; Mice; Mice, Inbred BALB C; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Quinones; Rifabutin; RNA; Sulfonamides; T-Lymphocytes; Thymus Gland | 1997 |
Guidance of CNS growth cones by substratum grooves and ridges: effects of inhibitors of the cytoskeleton, calcium channels and signal transduction pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Cytochalasin B; Cytoskeleton; Embryo, Mammalian; Embryo, Nonmammalian; Enzyme Inhibitors; Gadolinium; GTP-Binding Proteins; Hippocampus; Indoles; Isoquinolines; Maleimides; Microtubules; Neurites; Neurons; Nocodazole; Paclitaxel; Pertussis Toxin; Protein Kinase Inhibitors; Rats; Spinal Cord; Staurosporine; Sulfonamides; Virulence Factors, Bordetella; Xenopus laevis | 1997 |
Protein kinase C dependent and independent mechanisms controlling rat trophoblast cell DNA synthesis and differentiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzophenanthridines; Blotting, Northern; Blotting, Western; Cell Differentiation; Cholesterol Side-Chain Cleavage Enzyme; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Isoquinolines; Male; Phenanthridines; Pregnancy; Progesterone; Protein Kinase C; Rats; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Trophoblasts; Tumor Cells, Cultured | 1997 |
Nuclear translocation of the Y-box binding protein by ultraviolet irradiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; CCAAT-Enhancer-Binding Proteins; Cell Nucleus; COS Cells; DNA-Binding Proteins; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Green Fluorescent Proteins; Humans; Isoquinolines; KB Cells; Luminescent Proteins; NFI Transcription Factors; Nuclear Proteins; Protein Kinase Inhibitors; Recombinant Fusion Proteins; Sulfonamides; Transcription Factors; Transfection; Tumor Cells, Cultured; Ultraviolet Rays; Urinary Bladder Neoplasms; Y-Box-Binding Protein 1 | 1997 |
Protein kinase C modulates ischemia-induced amino acids release in the striatum of hypertensive rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acids; Animals; Brain Ischemia; Corpus Striatum; Enzyme Inhibitors; Extracellular Space; Hypertension; Isoquinolines; Male; Osmolar Concentration; Protein Kinase C; Rats; Rats, Inbred SHR; Sulfonamides | 1998 |
Transforming growth factor-beta2 regulates C3 secretion in monocytes through a protein kinase C-dependent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Complement C3; Drug Interactions; Humans; Inflammation; Isoenzymes; Isoquinolines; Monocytes; Naphthalenes; Protein Kinase C; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 1998 |
Protein kinase C regulates Fas (CD95/APO-1) expression.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antibodies; Apoptosis; Biological Transport; Calcium; Enzyme Activation; fas Receptor; Humans; Hybridomas; Isoquinolines; Lymphocyte Activation; Mice; Protein Kinase C; Sulfonamides; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription Factors | 1998 |
Protein kinase C and regulatory volume decrease in mudpuppy red blood cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzophenanthridines; Calcium; Cell Size; Enzyme Inhibitors; Erythrocytes; Gramicidin; Hematocrit; Hypotonic Solutions; Indoles; Ion Channel Gating; Ion Transport; Isoquinolines; Maleimides; Models, Biological; Necturus; Osmotic Fragility; Osmotic Pressure; Patch-Clamp Techniques; Phenanthridines; Potassium Channels; Protein Kinase C; Sulfonamides | 1998 |
Orientation change of cardiocytes induced by cyclic stretch stimulation: time dependency and involvement of protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actinin; Actins; Animals; Benzoquinones; Cells, Cultured; Egtazic Acid; Enzyme Inhibitors; Gadolinium; Immunoblotting; Isoquinolines; Lactams, Macrocyclic; Muscle Spindles; Myocardium; Myofibrils; Physical Stimulation; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Wistar; Rifabutin; Signal Transduction; Sulfonamides; Time Factors | 1999 |
Protein kinase C-dependent anti-apoptotic mechanism that is associated with high sensitivity to anti-Fas antibody in ovarian cancer cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies; Apoptosis; Calcimycin; Cell Division; Ceramides; Cyclic AMP-Dependent Protein Kinases; DNA Fragmentation; Enzyme Inhibitors; fas Receptor; Female; Flow Cytometry; Humans; Isoquinolines; Ovarian Neoplasms; Protein Kinase C; Signal Transduction; Sphingomyelin Phosphodiesterase; Sulfonamides; Tetradecanoylphorbol Acetate; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1999 |
Alpha1-adrenergic regulation of peptidylglycine alpha-amidating monooxygenase gene expression in cultured rat cardiac myocytes: transcriptional studies and messenger ribonucleic acid stability.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-1 Receptor Agonists; Animals; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Gene Expression Regulation; Isoquinolines; Kinetics; Mixed Function Oxygenases; Multienzyme Complexes; Myocardium; Phenylephrine; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; RNA Stability; RNA, Messenger; Sulfonamides; Transcription, Genetic | 1999 |
Cholera toxin induces tumor necrosis factor alpha production in human monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Diphosphate; Benzamides; Cells, Cultured; Cholera Toxin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Isoquinolines; Lymphocytes; Monocytes; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Protein Kinase C; Signal Transduction; Sphingosine; Sulfonamides; Transcription, Genetic; Tumor Necrosis Factor-alpha; Type C Phospholipases | 1999 |
The role of protein kinase C and calcium in induction of human polymorphonuclear leukocyte IL-1 beta gene expression by GM-CSF.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Benzophenanthridines; Calcium; Cells, Cultured; Enzyme Inhibitors; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-1; Intracellular Fluid; Isoquinolines; Neutrophils; Phenanthridines; Protein Kinase C; Recombinant Proteins; Sulfonamides; Transcription, Genetic | 2000 |
Inhibition of oxotremorine-induced desensitization of guinea-pig ileal longitudinal muscle in Ca2+-free conditions.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Calcium; Enzyme Inhibitors; Guinea Pigs; Ileum; In Vitro Techniques; Isoquinolines; Male; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Oxotremorine; Potassium; Protein Kinase Inhibitors; Sulfonamides | 2001 |
The signalling pathway for BCG-induced interleukin-6 production in human bladder cancer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenine; Antibodies; BCG Vaccine; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; Imidazoles; Interleukin-6; Isoquinolines; Phosphodiesterase Inhibitors; Protein Denaturation; RNA, Messenger; Signal Transduction; Sulfonamides; Time Factors; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2002 |
Free fatty acids induce cell differentiation to infective forms in Trypanosoma cruzi.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Cell Differentiation; Cell Division; Cyclic AMP-Dependent Protein Kinases; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Fatty Acids, Nonesterified; Intestines; Isoquinolines; Oleic Acid; Phosphorylation; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate; Triatoma; Trypanosoma cruzi | 2003 |
Group II metabotropic glutamate receptor modulation of excitatory transmission in rat subthalamic nucleus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenylyl Cyclase Inhibitors; Amino Acids; Amino Acids, Dicarboxylic; Animals; Colforsin; Cyclopropanes; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glycine; Imines; In Vitro Techniques; Isoquinolines; Male; Picrotoxin; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Subthalamic Nucleus; Sulfonamides; Synaptic Transmission; Tetradecanoylphorbol Acetate; Xanthenes | 2003 |