h-89 and emerin

h-89 has been researched along with emerin* in 1 studies

Other Studies

1 other study(ies) available for h-89 and emerin

Article	Year
New role for EMD (emerin), a key inner nuclear membrane protein, as an enhancer of autophagosome formation in the C16-ceramide autophagy pathway. Autophagy, 2014, Volume: 10, Issue:7 To date, precise roles of EMD (emerin) remain poorly described. In this paper, we investigated the role of EMD in the C16-ceramide autophagy pathway. Ceramides are bioactive signaling molecules acting notably in the regulation of cell growth, differentiation, or cell death. However, the mechanisms by which they mediate these pathways are not fully understood. We found that C16-ceramide induces EMD phosphorylation on its LEM domain through PRKACA. Upon ceramide treatment, phosphorylated EMD binds MAP1LC3B leading to an increase of autophagosome formation. These data suggest a new role of EMD as an enhancer of autophagosome formation in the C16-ceramide autophagy pathway in colon cancer cells. Topics: Apoptosis; Autophagy; Cell Cycle; Ceramides; HCT116 Cells; Humans; Isoquinolines; Membrane Proteins; Microtubule-Associated Proteins; Nuclear Envelope; Nuclear Proteins; Phagosomes; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Signal Transduction; Staurosporine; Sulfonamides	2014

Article

Year

New role for EMD (emerin), a key inner nuclear membrane protein, as an enhancer of autophagosome formation in the C16-ceramide autophagy pathway.

Autophagy, 2014, Volume: 10, Issue:7

To date, precise roles of EMD (emerin) remain poorly described. In this paper, we investigated the role of EMD in the C16-ceramide autophagy pathway. Ceramides are bioactive signaling molecules acting notably in the regulation of cell growth, differentiation, or cell death. However, the mechanisms by which they mediate these pathways are not fully understood. We found that C16-ceramide induces EMD phosphorylation on its LEM domain through PRKACA. Upon ceramide treatment, phosphorylated EMD binds MAP1LC3B leading to an increase of autophagosome formation. These data suggest a new role of EMD as an enhancer of autophagosome formation in the C16-ceramide autophagy pathway in colon cancer cells.

Topics: Apoptosis; Autophagy; Cell Cycle; Ceramides; HCT116 Cells; Humans; Isoquinolines; Membrane Proteins; Microtubule-Associated Proteins; Nuclear Envelope; Nuclear Proteins; Phagosomes; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Signal Transduction; Staurosporine; Sulfonamides

2014