Compounds > gyki 53655
Page last updated: 2024-09-03

gyki 53655 and n-methylaspartate

gyki 53655 has been researched along with n-methylaspartate in 10 studies

Compound Research Comparison

Studies
(gyki 53655)		Trials
(gyki 53655)		Recent Studies (post-2010)
(gyki 53655)		Studies
(n-methylaspartate)		Trials
(n-methylaspartate)		Recent Studies (post-2010) (n-methylaspartate)
11102210,408591,902

Protein Interaction Comparison

ProteinTaxonomygyki 53655 (IC50)n-methylaspartate (IC50)
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)5.175
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)5.175
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)5.175
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)5.175
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)5.175
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)5.175
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)5.175

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (60.00)18.2507
2000's4 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chizh, BA; Cumberbatch, MJ; Headley, PM2
Lodge, D; Palmer, AJ1
Kombian, SB; Pittman, QJ; Saleh, TM; Zidichouski, JA1
Barks, JD; Liu, XH; Wang, P1
Shen, Y; Yang, XL; Zhou, Y1
Durand, J; Ruiz, A1
Bardoul, M; Drian, MJ; König, N1
Allgaier, C; Fischer, W; Franke, H; Illes, P; Scheibler, P1
Adamcio, B; Belozertseva, I; Bespalov, A; Dravolina, O; Zvartau, E1

Other Studies

10 other study(ies) available for gyki 53655 and n-methylaspartate

ArticleYear
AMPA receptors have an equal role in spinal nociceptive and non-nociceptive transmission.
    Neuroreport, 1994, Apr-14, Volume: 5, Issue:8

    Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Dose-Response Relationship, Drug; Iontophoresis; Male; N-Methylaspartate; Nociceptors; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Spinal Cord; Synapses; Synaptic Transmission

1994
A comparison of intravenous NBQX and GYKI 53655 as AMPA antagonists in the rat spinal cord.
    British journal of pharmacology, 1994, Volume: 112, Issue:3

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Hot Temperature; Injections, Intravenous; Iontophoresis; Male; N-Methylaspartate; Neurons; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Spinal Cord

1994
Cyclothiazide reverses AMPA receptor antagonism of the 2,3-benzodiazepine, GYKI 53655.
    European journal of pharmacology, 1993, Jan-15, Volume: 244, Issue:2

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Benzothiadiazines; Cerebral Cortex; Diuretics; Excitatory Amino Acid Antagonists; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, AMPA; Sodium Chloride Symporter Inhibitors

1993
Cholecystokinin and neurotensin inversely modulate excitatory synaptic transmission in the parabrachial nucleus in vitro.
    Neuroscience, 1997, Volume: 77, Issue:1

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Benzodiazepinones; Cholecystokinin; Devazepide; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Hormone Antagonists; Interneurons; N-Methylaspartate; Neural Inhibition; Neurons, Afferent; Neurotensin; Patch-Clamp Techniques; Phenylurea Compounds; Pons; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Receptors, Neurotensin; Synaptic Transmission; Tetrodotoxin

1997
The non-competitive AMPA antagonist LY 300168 (GYKI 53655) attenuates AMPA-induced hippocampal injury in neonatal rodents.
    Neuroscience letters, 1997, Oct-10, Volume: 235, Issue:1-2

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Newborn; Atrophy; Benzodiazepines; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hippocampus; Injections, Intraperitoneal; N-Methylaspartate; Pyramidal Cells; Rats; Rats, Sprague-Dawley

1997
Characterization of AMPA receptors on isolated amacrine-like cells in carp retina.
    The European journal of neuroscience, 1999, Volume: 11, Issue:12

    Topics: Alternative Splicing; Animals; Antihypertensive Agents; Benzodiazepines; Benzothiadiazines; Cell Separation; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Goldfish; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Phenoxyacetates; Receptors, AMPA; Retina

1999
Blocking the trigeminal EPSP in rat abducens motoneurons in vivo with the AMPA antagonists NBQX and GYKI 53655.
    Brain research bulletin, 2000, May-15, Volume: 52, Issue:2

    Topics: Abducens Nerve; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Male; Motor Neurons; N-Methylaspartate; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Trigeminal Nerve

2000
Blockade of AMPA/kainate receptors can either decrease or increase the survival of cultured neocortical cells depending on the stage of maturation.
    Neurochemistry international, 2001, Volume: 38, Issue:6

    Topics: Animals; Benzodiazepines; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Kainic Acid; N-Methylaspartate; Neocortex; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid

2001
AMPA-induced Ca(2+) influx in cultured rat cortical nonpyramidal neurones: pharmacological characterization using fura-2 microfluorimetry.
    European journal of pharmacology, 2002, Mar-01, Volume: 438, Issue:1-2

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Benzothiadiazines; Calcium; Cells, Cultured; Cerebral Cortex; Cobalt; Diazoxide; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fluorescence; Fluorometry; Fura-2; gamma-Aminobutyric Acid; Immunohistochemistry; N-Methylaspartate; Neurons; Piperazines; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate

2002
Lowered brain stimulation reward thresholds in rats treated with a combination of caffeine and N-methyl-D-aspartate but not alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate or metabotropic glutamate receptor-5 receptor antagonists.
    Behavioural pharmacology, 2006, Volume: 17, Issue:4

    Topics: Animals; Benzodiazepines; Brain; Caffeine; Central Nervous System Stimulants; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Excitatory Amino Acid Antagonists; Male; N-Methylaspartate; Piperazines; Pyridines; Quinolones; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Reward; Self Stimulation; Ventral Tegmental Area

2006