gyki 53655 has been researched along with gyki 52466 in 9 studies
| Studies (gyki 53655) | Trials (gyki 53655) | Recent Studies (post-2010) (gyki 53655) | Studies (gyki 52466) | Trials (gyki 52466) | Recent Studies (post-2010) (gyki 52466) |
|---|---|---|---|---|---|
| 111 | 0 | 22 | 312 | 0 | 38 |
| Protein | Taxonomy | gyki 53655 (IC50) | gyki 52466 (IC50) |
|---|---|---|---|
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | 10 | |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | 10 | |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | 10 | |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | 10 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Costa, AM; Hesson, DP; Jones, KA; Pelletier, JC | 1 |
| Baraldi, M; De Micheli, C; De Sarro, A; De Sarro, G; Grasso, S; Micale, N; Puia, G; Zappalà, M | 1 |
| Huettner, JE; Wilding, TJ | 1 |
| Lerma, J; Morales, M; Paternain, AV | 1 |
| Ballyk, BA; Bath, CP; Bleakman, D; Bufton, HR; Kamboj, RK; Lodge, D; Palmer, AJ; Schoepp, DD; Sharpe, EF; Tarnawa, I; Woolley, ML | 1 |
| Gacsályi, I; Gigler, G; Gyertyán, I; Lévay, G; Szabados, T | 2 |
| Ciprian-Ollivier, J; Perret, L; Sebban, C; Spedding, M; Tesolin-Decros, B | 1 |
| Nowak, LM; Oswald, RE; Ptak, CP; Shi, EY; Sipple, MT; Srinivasan, J; Yuan, CL | 1 |
9 other study(ies) available for gyki 53655 and gyki 52466
| Article | Year |
|---|---|
Substituted 1,2-dihydrophthalazines: potent, selective, and noncompetitive inhibitors of the AMPA receptor.
Topics: Animals; Cells, Cultured; Humans; Kidney Cortex; Phthalazines; Rats; Receptors, AMPA | 1996 |
Synthesis and anticonvulsant activity of novel and potent 2,3-benzodiazepine AMPA/kainate receptor antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Cells, Cultured; Convulsants; Drug Evaluation, Preclinical; Electroshock; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Mice; Mice, Inbred DBA; Motor Activity; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Seizures | 1999 |
Differential antagonism of alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid-preferring and kainate-preferring receptors by 2,3-benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzothiadiazines; Binding, Competitive; Cerebral Cortex; Concanavalin A; Electrophysiology; Ganglia, Spinal; Kainic Acid; Membrane Potentials; Neurons; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Kainic Acid; Substrate Specificity | 1995 |
Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Cells, Cultured; Electric Conductivity; Hippocampus; Kainic Acid; Neuronal Plasticity; Neurons; Rats; Receptors, AMPA; Receptors, Kainic Acid; Synaptic Transmission | 1995 |
Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: stereospecificity and selectivity profiles.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzothiadiazines; Cell Line; Cerebellum; Cerebral Cortex; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Humans; Kidney; Membrane Potentials; Molecular Structure; Neurons; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Recombinant Proteins; Spinal Cord; Structure-Activity Relationship; Transfection | 1996 |
Duration of action of GYKI 52466 and its analogues in antiepileptic, anti-ischaemic and muscle relaxant tests.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Mice; Muscle Relaxants, Central | 1999 |
Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Brain Ischemia; Dose-Response Relationship, Drug; Electroshock; Magnesium Chloride; Male; Mice; Mice, Inbred Strains; Neuroprotective Agents; Seizures; Survival Analysis; Time Factors | 2001 |
Effects of phencyclidine (PCP) and MK 801 on the EEGq in the prefrontal cortex of conscious rats; antagonism by clozapine, and antagonists of AMPA-, alpha(1)- and 5-HT(2A)-receptors.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Carbonic Anhydrase Inhibitors; Clozapine; Consciousness; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Fluorobenzenes; Hallucinogens; Male; Models, Biological; Phencyclidine; Piperidines; Prazosin; Prefrontal Cortex; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, AMPA; Receptors, Serotonin; Serotonin Antagonists | 2002 |
Noncompetitive antagonists induce cooperative AMPA receptor channel gating.
Topics: Benzodiazepines; Binding Sites; Excitatory Amino Acid Antagonists; HEK293 Cells; Humans; Ion Channel Gating; Protein Binding; Receptors, AMPA | 2019 |