gyki 53655 has been researched along with 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline in 20 studies
| Studies (gyki 53655) | Trials (gyki 53655) | Recent Studies (post-2010) (gyki 53655) | Studies (2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline) | Trials (2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline) | Recent Studies (post-2010) (2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline) |
|---|---|---|---|---|---|
| 111 | 0 | 22 | 1,216 | 0 | 229 |
| Protein | Taxonomy | gyki 53655 (IC50) | 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline (IC50) |
|---|---|---|---|
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | 0.5781 | |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | 0.5781 | |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | 0.5781 | |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | 0.5781 | |
| Glutamate receptor ionotropic, kainate 1 | Rattus norvegicus (Norway rat) | 2.909 | |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | 0.2 | |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | 2.909 | |
| Glutamate receptor 1 | Homo sapiens (human) | 6 | |
| Glutamate receptor 2 | Homo sapiens (human) | 2.5 | |
| Glutamate receptor 3 | Homo sapiens (human) | 1.9 | |
| Glutamate receptor ionotropic, kainate 3 | Rattus norvegicus (Norway rat) | 2.909 | |
| Glutamate receptor 4 | Homo sapiens (human) | 1.1 | |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | 0.2 | |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | 0.2 | |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | 0.2 | |
| Glutamate receptor ionotropic, kainate 4 | Rattus norvegicus (Norway rat) | 2.909 | |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | 0.2 | |
| Glutamate receptor ionotropic, kainate 5 | Rattus norvegicus (Norway rat) | 2.909 | |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | 0.2 | |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | 0.2 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (40.00) | 18.2507 |
| 2000's | 10 (50.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Costa, AM; Hesson, DP; Jones, KA; Pelletier, JC | 1 |
| England, PM; Fleming, JJ | 1 |
| Chizh, BA; Cumberbatch, MJ; Headley, PM | 2 |
| Lodge, D; Palmer, AJ | 1 |
| Borsini, F; Brambilla, A; Grippa, N; Prudentino, A | 1 |
| Kovács, AD; Szabó, G | 1 |
| Jensen, JB; Pickering, DS; Schousboe, A | 1 |
| Ben-Ari, Y; Chevassus-Au-Louis, N; Diabira, D; Gozlan, H; Hennou, S | 1 |
| Bouron, A; Chergui, K; Mulle, C; Normand, E | 1 |
| Dietrich, D; Dybek, A; Schumacher, TB; Seifert, G; Steinhäuser, C; Weiser, T; Wienrich, M; Wilhelm, D; Zhou, M | 1 |
| Durand, J; Ruiz, A | 1 |
| Closier, M; Iop, F; Lestage, P; Lockhart, B | 1 |
| Christensen, KV; Dai, WM; Ebert, B; Egebjerg, J; Lambert, JD | 1 |
| Allgaier, C; Fischer, W; Franke, H; Illes, P; Scheibler, P | 1 |
| Jane, DE; More, JC; Troop, HM | 1 |
| Li, W; Massey, SC; Trexler, EB | 1 |
| Hays, FA; Menuz, K; Nicoll, RA; Stroud, RM | 1 |
| Afzalov, R; Blaesse, P; Huttu, K; Kaila, K; Sipilä, ST; Voipio, J; Yamada, J | 1 |
| Rodríguez-Moreno, A; Sihra, TS | 1 |
20 other study(ies) available for gyki 53655 and 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
| Article | Year |
|---|---|
Substituted 1,2-dihydrophthalazines: potent, selective, and noncompetitive inhibitors of the AMPA receptor.
Topics: Animals; Cells, Cultured; Humans; Kidney Cortex; Phthalazines; Rats; Receptors, AMPA | 1996 |
Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands.
Topics: Allosteric Regulation; Animals; Binding Sites; Ligands; Receptors, AMPA | 2010 |
AMPA receptors have an equal role in spinal nociceptive and non-nociceptive transmission.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Dose-Response Relationship, Drug; Iontophoresis; Male; N-Methylaspartate; Nociceptors; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Spinal Cord; Synapses; Synaptic Transmission | 1994 |
A comparison of intravenous NBQX and GYKI 53655 as AMPA antagonists in the rat spinal cord.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Hot Temperature; Injections, Intravenous; Iontophoresis; Male; N-Methylaspartate; Neurons; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Spinal Cord | 1994 |
Cyclothiazide reverses AMPA receptor antagonism of the 2,3-benzodiazepine, GYKI 53655.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Benzothiadiazines; Cerebral Cortex; Diuretics; Excitatory Amino Acid Antagonists; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, AMPA; Sodium Chloride Symporter Inhibitors | 1993 |
Pharmacological characterization of AMPA-induced biting behaviour in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Benzodiazepines; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Nociceptors; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 1996 |
GYKI 53665, a 2,3-benzodiazepine, non-competitively protects cultured neurones against AMPA toxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Neuroprotective Agents; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 1997 |
Role of desensitization and subunit expression for kainate receptor-mediated neurotoxicity in murine neocortical cultures.
Topics: Animals; Benzodiazepines; Blotting, Western; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Mice; Neocortex; Neuromuscular Depolarizing Agents; Neurotoxins; Quinoxalines; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 1999 |
Late embryonic expression of AMPA receptor function in the CA1 region of the intact hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Aging; Animals; Animals, Newborn; Benzodiazepines; Bicuculline; Cations, Divalent; Electric Stimulation; Embryonic and Fetal Development; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fluorescent Dyes; Hippocampus; Hypoxia; Lysine; Pyramidal Cells; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Synapses; Tetrodotoxin | 1999 |
Functional GluR6 kainate receptors in the striatum: indirect downregulation of synaptic transmission.
Topics: Animals; Benzodiazepines; Corpus Striatum; Down-Regulation; Evoked Potentials; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Gene Expression; GluK2 Kainate Receptor; Kainic Acid; Mice; Mice, Inbred C57BL; Neuromuscular Depolarizing Agents; Neurons; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Kainic Acid; RNA, Messenger; Synaptic Transmission | 2000 |
Developmental regulation of AMPA-receptor properties in CA1 pyramidal neurons of rat hippocampus.
Topics: Alternative Splicing; Animals; Animals, Newborn; Benzodiazepines; Benzothiadiazines; Excitatory Amino Acid Antagonists; Female; Hippocampus; In Vitro Techniques; Kinetics; Patch-Clamp Techniques; Pyramidal Cells; Quinoxalines; Rats; Receptors, AMPA; Receptors, Kainic Acid | 2000 |
Blocking the trigeminal EPSP in rat abducens motoneurons in vivo with the AMPA antagonists NBQX and GYKI 53655.
Topics: Abducens Nerve; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Male; Motor Neurons; N-Methylaspartate; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Trigeminal Nerve | 2000 |
(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release from rat hippocampal and frontal cortex slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Benzothiadiazines; Calcium; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Frontal Lobe; Hippocampus; In Vitro Techniques; Male; Norepinephrine; Pyrrolidinones; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Stereoisomerism; Tetrodotoxin; Tritium | 2000 |
Correlation of the expression of kainate receptor subtypes to responses evoked in cultured cortical and spinal cord neurones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Cells, Cultured; Cerebral Cortex; Concanavalin A; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression; Kainic Acid; Membrane Potentials; Neurons; Patch-Clamp Techniques; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord | 2002 |
AMPA-induced Ca(2+) influx in cultured rat cortical nonpyramidal neurones: pharmacological characterization using fura-2 microfluorimetry.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Benzothiadiazines; Calcium; Cells, Cultured; Cerebral Cortex; Cobalt; Diazoxide; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fluorescence; Fluorometry; Fura-2; gamma-Aminobutyric Acid; Immunohistochemistry; N-Methylaspartate; Neurons; Piperazines; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2002 |
The novel antagonist 3-CBW discriminates between kainate receptors expressed on neonatal rat motoneurones and those on dorsal root C-fibres.
Topics: Alanine; Animals; Animals, Newborn; Benzodiazepines; Benzyl Compounds; Dose-Response Relationship, Drug; Evoked Potentials; Excitatory Amino Acid Antagonists; Motor Neurons; Nerve Fibers; Pyrimidinones; Quinoxalines; Rats; Receptors, AMPA; Receptors, Kainic Acid; Spinal Nerve Roots; Time Factors; Uracil | 2002 |
Simultaneous contribution of two rod pathways to AII amacrine and cone bipolar cell light responses.
Topics: Amacrine Cells; Animals; Benzodiazepines; Benzothiadiazines; Diagnostic Imaging; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Fluorescein; GABA Antagonists; Glycine Agents; In Vitro Techniques; Light; Male; Membrane Potentials; Models, Biological; Neurons; Patch-Clamp Techniques; Picrotoxin; Quinoxalines; Rabbits; Retina; Retinal Rod Photoreceptor Cells; Strychnine; Synapses; Synaptic Transmission; Visual Pathways | 2005 |
TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzodiazepines; Binding, Competitive; Cell Line; Cerebellum; Crystallography, X-Ray; Drug Partial Agonism; Hippocampus; Humans; In Vitro Techniques; Interneurons; Mice; Models, Molecular; Patch-Clamp Techniques; Protein Conformation; Protein Subunits; Pyramidal Cells; Quinoxalines; Receptors, AMPA; Structure-Activity Relationship; Synaptic Transmission; Trichlormethiazide | 2007 |
Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus.
Topics: Action Potentials; Age Factors; Animals; Animals, Newborn; Benzodiazepines; Biophysics; Calcium; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; K Cl- Cotransporters; Mice; Mice, Knockout; Nerve Net; Patch-Clamp Techniques; Pyramidal Cells; Quinoxalines; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Symporters; Up-Regulation | 2009 |
Presynaptic kainate receptor-mediated facilitation of glutamate release involves Ca2+-calmodulin and PKA in cerebrocortical synaptosomes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Benzodiazepines; Calcium; Calmodulin; Cerebral Cortex; Cyclic AMP-Dependent Protein Kinases; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Isoquinolines; Kainic Acid; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Presynaptic; Sulfonamides; Synaptic Transmission; Synaptosomes; Thionucleotides | 2013 |