Compounds > gyki 52466

gyki 52466 and 4-aminopyridine

gyki 52466 has been researched along with 4-aminopyridine in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (30.00)18.2507
2000's6 (60.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Donevan, SD; Rogawski, MA; Yamaguchi, S1
Blaustein, MP; Juhng, KN; Kim, BY; Kokate, TG; Rogawski, MA; Rogowski, RS; Yamaguchi, S1
Banczerowski-Pelyhe, I; Barna, B; Dóczi, J; Világi, I1
Barna, B; Szász, A; Szente, M; Világi, I1
Gatta, F; Marinelli, S; Sagratella, S1
Banczerowski-Pelyhe, I; Détári, L; Dóczi, J; Gulyás-Kovács, A; Tarnawa, I; Világi, I1
Kardos, J; Lasztóczi, B1
Krisztin-Péva, B; Mihály, A; Weiczner, R1
Bakos, M; Borbély, S; Czégé, D; Dobó, E; Mihály, A; Molnár, E; Szucs, B; Világi, I; Vincze, A1
Borbély, S; Czégé, D; Dobó, E; Mihály, A; Molnár, E; Világi, I1

Other Studies

10 other study(ies) available for gyki 52466 and 4-aminopyridine

ArticleYear
Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models.
    Epilepsy research, 1993, Volume: 15, Issue:3

    Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Hindlimb; Kainic Acid; Male; Mice; Pentylenetetrazole; Quinoxalines; Receptors, AMPA; Receptors, Kainic Acid; Seizures

1993
Induction of seizures by the potent K+ channel-blocking scorpion venom peptide toxins tityustoxin-K(alpha) and pandinustoxin-K(alpha).
    Epilepsy research, 1999, Volume: 34, Issue:2-3

    Topics: 4-Aminopyridine; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Dizocilpine Maleate; Electroencephalography; Excitatory Amino Acid Antagonists; Injections, Intraventricular; Male; Mice; Neuroprotective Agents; Phenytoin; Potassium Channel Blockers; Scorpion Venoms; Seizures

1999
Effect of a glutamate receptor antagonist (GYKI 52466) on 4-aminopyridine-induced seizure activity developed in rat cortical slices.
    Brain research bulletin, 1999, Volume: 49, Issue:6

    Topics: 4-Aminopyridine; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebral Cortex; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; In Vitro Techniques; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, AMPA; Seizures

1999
Anticonvulsive effect of AMPA receptor antagonist GYKI 52466 on 4-aminopyridine-induced cortical ictal activity in rat.
    Brain research bulletin, 2000, Volume: 51, Issue:3

    Topics: 4-Aminopyridine; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Cerebral Cortex; Electroencephalography; Epilepsy; Female; Male; Rats; Rats, Wistar; Receptors, AMPA; Time Factors

2000
Effects of GYKI 52466 and some 2,3-benzodiazepine derivatives on hippocampal in vitro basal neuronal excitability and 4-aminopyridine epileptic activity.
    European journal of pharmacology, 2000, Mar-10, Volume: 391, Issue:1-2

    Topics: 4-Aminopyridine; Animals; Anti-Anxiety Agents; Anticonvulsants; Axons; Benzodiazepines; Calcium Channel Blockers; Convulsants; Electrophysiology; Epilepsy; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Neurons; Neurons, Afferent; Rats; Rats, Wistar; Receptors, Presynaptic; Verapamil

2000
Comparison of spontaneous and evoked epileptiform activity in three in vitro epilepsy models.
    Brain research, 2002, Aug-02, Volume: 945, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Anti-Anxiety Agents; Benzodiazepines; Bicuculline; Convulsants; Electric Stimulation; Electrophysiology; Epilepsy; Excitatory Amino Acid Antagonists; Female; Magnesium Deficiency; Male; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex

2002
Cyclothiazide prolongs low [Mg2+]-induced seizure-like events.
    Journal of neurophysiology, 2006, Volume: 96, Issue:6

    Topics: 4-Aminopyridine; Animals; Benzodiazepines; Benzothiadiazines; Diuretics; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Magnesium Deficiency; Male; Potassium Channel Blockers; Pyramidal Cells; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Presynaptic; Seizures

2006
Blockade of AMPA-receptors attenuates 4-aminopyridine seizures, decreases the activation of inhibitory neurons but is ineffective against seizure-related astrocytic swelling.
    Epilepsy research, 2008, Volume: 78, Issue:1

    Topics: 4-Aminopyridine; Analysis of Variance; Animals; Astrocytes; Behavior, Animal; Benzodiazepines; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Male; Microscopy, Electron, Transmission; Motor Activity; Neural Inhibition; Parvalbumins; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, AMPA; Seizures

2008
Modification of ionotropic glutamate receptor-mediated processes in the rat hippocampus following repeated, brief seizures.
    Neuroscience, 2009, Mar-03, Volume: 159, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Action Potentials; Animals; Benzodiazepines; Biophysics; Calcium; Cobalt; Electric Stimulation; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Male; Neurons; Protein Subunits; Rats; Rats, Wistar; Receptors, Glutamate; Seizures; Synaptic Transmission

2009
Repeated application of 4-aminopyridine provoke an increase in entorhinal cortex excitability and rearrange AMPA and kainate receptors.
    Neurotoxicity research, 2015, Volume: 27, Issue:4

    Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Benzodiazepines; Entorhinal Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Protein Subunits; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Seizures

2015