gyki 52466 has been researched along with 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline in 60 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 37 (61.67) | 18.2507 |
| 2000's | 21 (35.00) | 29.6817 |
| 2010's | 2 (3.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Costa, AM; Hesson, DP; Jones, KA; Pelletier, JC | 1 |
| Chenard, BL; Ewing, FE; Menniti, FS; Pagnozzi, MJ; Shenk, KD; Welch, WM | 1 |
| Costagli, C; De Micheli, C; Galli, A; Grasso, S; Menniti, FS; Micale, N; Zappalà, M | 1 |
| Elger, B; Huth, A; Neuhaus, R; Ottow, E; Schneider, H; Seilheimer, B; Turski, L | 1 |
| Cagnotto, A; Colleoni, S; Diana, V; Grasso, S; Lazzaro, J; Mennini, T; Micale, N; Pellicanò, A; Postorino, G; Zappalà, M | 1 |
| Chapman, AG; Craggs, MD; Dürmüller, N; Meldrum, BS; Smith, SE | 1 |
| Arvin, B; Le Peillet, E; Meldrum, BS; Moncada, C | 2 |
| Dürmüller, N; Meldrum, BS; Smith, SE | 1 |
| Chapman, AG; Meldrum, BS; Smith, SE | 1 |
| Barnes, KA; Buchan, AM; Huang, ZG; Lesiuk, H; Li, H; Smith, KE; Xue, D | 1 |
| Barnes, K; Buchan, AM; Huang, ZG; Lesiuk, HJ; Smith, KE; Xue, D | 1 |
| Gruner, R; Parsons, CG; Rozental, J | 1 |
| Balázs, R; Hack, N | 1 |
| Buchan, AM; Li, H | 1 |
| Donevan, SD; Rogawski, MA; Yamaguchi, S | 1 |
| Mennerick, S; Zorumski, CF | 1 |
| Croucher, MJ; Patel, DR; Sturt, NJ | 1 |
| Hönack, D; Löscher, W | 1 |
| Schmidt, WJ; Zadow, B | 1 |
| Champagnat, J; Denavit-Saubié, M; Foutz, AS; Pierrefiche, O | 1 |
| Craggs, M; Dürmüller, N; Meldrum, BS | 1 |
| Steppuhn, KG; Turski, L | 1 |
| al-Zubaidy, Z; Chapman, AG; Meldrum, BS | 1 |
| Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Turski, WA; Tutka, P; Zarnowski, T | 1 |
| Anzilotti, KF; Jackson, PF; Rissolo, KC; Stauch Slusher, B | 1 |
| Benz, A; Mennerick, S; Zorumski, CF | 1 |
| Turetsky, DM; Yamada, KA | 1 |
| Cole, BJ; Stephens, DN | 1 |
| Croucher, MJ; Patel, DR | 1 |
| Brown, G; Jackson, A; Stephens, DN | 1 |
| Fontana, G; Gemignani, A; Marchese, S; Raiteri, M | 1 |
| Lu, Y; Wehner, JM | 1 |
| Członkowska, A; Płaźnik, A; Siemiatkowski, M | 1 |
| Ohno-Shosaku, T; Sawada, S; Yamamoto, C | 1 |
| Vanover, KE | 1 |
| Bleuel, Z; Clifford, MM; Ellis, GJ; Humbel, U; Klingelschmidt, A; Messer, J; Mutel, V; Richards, JG; Trube, G | 1 |
| Chimirri, A; De Sarro, A; De Sarro, G; Gitto, R; Rizzo, M; Sinopoli, VA; Zappala, M | 1 |
| Gigler, G; Gyertyán, I; Simó, A | 1 |
| Matsumoto, RR; Nour, M; Pouw, B | 1 |
| Brown, G; Stephens, DN | 1 |
| Kohda, K; Wang, Y; Yuzaki, M | 1 |
| Durand, J; Kapus, G; Ruiz, A; Székely, JI; Tarnawa, I | 1 |
| Croucher, MJ; Patel, DR; Young, AM | 1 |
| Goldberg, MP; Tekkök, SB | 1 |
| Brenner, M; Löscher, W; Palluk, R; Pieper, M; Potschka, H; Weiser, T; Wienrich, M | 1 |
| Kristensen, BW; Noraberg, J; Zimmer, J | 1 |
| Farkas, S; Kocsis, P; Szombathelyi, Z; Tarnawa, I | 1 |
| Camins, A; Canudas, AM; Folch, J; Jiménez, A; Jordà, EG; Pallàs, M; Rimbau, V; Verdaguer, E | 1 |
| Barkoczy, J; Gigler, G; Gressens, P; Harsing, LG; Kapus, G; Kertesz, S; Levay, G; Medja, F; Spedding, M; Szenasi, G; Villa, P; Williamson, T | 1 |
| Cadetti, L; Thoreson, WB; Tranchina, D | 1 |
| Gudz, TI; Komuro, H; Macklin, WB | 1 |
| Kandefer-Szerszeń, M; Majdan, M; Parada-Turska, J; Rzeski, W; Turski, WA | 1 |
| Bespalov, AY; Gross, G; Harich, S; Jongen-Rêlo, AL; van Gaalen, MM | 1 |
| Chen, G; Dow, ER; Du, J; Gould, TD; Manji, HK; O'Donnell, KC | 1 |
| Barkóczy, J; Bilkei-Gorzó, A; Gacsályi, I; Hársing, LG; Hegedus, E; Kapus, GL; Kompagne, H; Lévay, G; Leveleki, C; Vegh, M | 1 |
| Barbour, B; Brunel, N; Buisseret, P; de Solages, C; Hakim, V; Isope, P; Léna, C; Rousseau, C; Szapiro, G | 1 |
| DeSilva, TM; Goldhoff, PE; Kabakov, AY; Rosenberg, PA; Volpe, JJ | 1 |
| Gray, WP; Pringle, A; Sadek, AR; Seifert, G; Shtaya, A; Steinhäuser, C; Zaben, M | 1 |
| Folbergrová, J; Haugvicová, R; Kubová, H; Mareš, P | 1 |
60 other study(ies) available for gyki 52466 and 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
| Article | Year |
|---|---|
Substituted 1,2-dihydrophthalazines: potent, selective, and noncompetitive inhibitors of the AMPA receptor.
Topics: Animals; Cells, Cultured; Humans; Kidney Cortex; Phthalazines; Rats; Receptors, AMPA | 1996 |
Methaqualone derivatives are potent noncompetitive AMPA receptor antagonists.
Topics: Animals; Cells, Cultured; Cerebellum; Cytoplasmic Granules; Excitatory Amino Acid Antagonists; Methaqualone; Rats; Receptors, AMPA | 2000 |
Characterization of the mechanism of anticonvulsant activity for a selected set of putative AMPA receptor antagonists.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Azepines; Benzodiazepines; Binding, Competitive; Excitatory Amino Acid Antagonists; Mice; Mice, Inbred DBA; Quinazolines; Receptors, AMPA; Receptors, Glycine; Receptors, Kainic Acid; Structure-Activity Relationship | 2003 |
Novel alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor antagonists of 2,3-benzodiazepine type: chemical synthesis, in vitro characterization, and in vivo prevention of acute neurodegeneration.
Topics: Acute Disease; Animals; Benzodiazepines; Binding, Competitive; Brain Infarction; Cells, Cultured; Dioxoles; Hippocampus; In Vitro Techniques; Ischemic Attack, Transient; Kainic Acid; Male; Mice; Nerve Degeneration; Neuroprotective Agents; Patch-Clamp Techniques; Prosencephalon; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, AMPA | 2005 |
Structure-activity study of 2,3-benzodiazepin-4-ones noncompetitive AMPAR antagonists: identification of the 1-(4-amino-3-methylphenyl)-3,5-dihydro-7,8-ethylenedioxy-4H-2,3-benzodiazepin-4-one as neuroprotective agent.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Calcium; Cells, Cultured; Hippocampus; Inhibitory Concentration 50; Kainic Acid; Ligands; Mice; Molecular Structure; Neurons; Neuroprotective Agents; Protein Binding; Receptors, AMPA; Structure-Activity Relationship | 2008 |
The effects of AMPA receptor antagonists on kindled seizures and on reflex epilepsy in rodents and primates.
Topics: Acoustic Stimulation; Amygdala; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Cerebral Cortex; Electroencephalography; Epilepsies, Myoclonic; Epilepsy; Evoked Potentials; Excitatory Amino Acid Antagonists; Hippocampus; Kindling, Neurologic; Mice; Mice, Inbred DBA; Neural Pathways; Papio; Photic Stimulation; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Glutamate; Reflex; Synaptic Transmission | 1992 |
The non-NMDA antagonists, NBQX and GYKI 52466, protect against cortical and striatal cell loss following transient global ischaemia in the rat.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Cell Death; Cerebral Cortex; Corpus Striatum; Excitatory Amino Acid Antagonists; Glutamic Acid; Ischemic Attack, Transient; Male; Quinoxalines; Rats; Rats, Inbred Strains | 1992 |
The non-N-methyl-D-aspartate receptor antagonists, GYKI 52466 and NBQX are anticonvulsant in two animal models of reflex epilepsy.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepines; Dose-Response Relationship, Drug; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Tonic-Clonic; Female; Male; Papio; Photic Stimulation; Quinoxalines; Rats; Rats, Inbred Strains; Reflex | 1991 |
The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in mice.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Female; Ibotenic Acid; Male; Mice; Mice, Inbred DBA; Postural Balance; Quinoxalines; Seizures | 1991 |
Non-NMDA antagonists protect against kainate more than AMPA toxicity in the rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Hippocampus; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Pyramidal Tracts; Quinoxalines; Rats; Rats, Inbred Strains | 1991 |
AMPA antagonists: do they hold more promise for clinical stroke trials than NMDA antagonists?
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebral Infarction; Cerebrovascular Disorders; Dizocilpine Maleate; Drug Administration Schedule; Injections, Intraperitoneal; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Wistar; Reperfusion | 1993 |
Delayed treatment with AMPA, but not NMDA, antagonists reduces neocortical infarction.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebral Cortex; Cerebral Infarction; Cerebrovascular Circulation; Injections, Intraperitoneal; Injections, Intravenous; Kidney; Male; N-Methylaspartate; Pilot Projects; Quinoxalines; Rats; Rats, Inbred SHR; Sodium Chloride | 1994 |
Comparative patch clamp studies on the kinetics and selectivity of glutamate receptor antagonism by 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) and 1-(4-amino-phenyl)-4-methyl-7,8-methyl-endioxyl-5H-2,3-benzodiaze pine (GYKI 52466).
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cells, Cultured; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Quinoxalines; Rats; Receptors, AMPA; Superior Colliculi | 1994 |
Properties of AMPA receptors expressed in rat cerebellar granule cell cultures: Ca2+ influx studies.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzothiadiazines; Calcium; Calcium Radioisotopes; Cell Survival; Cells, Cultured; Cerebellum; Cobalt; Concanavalin A; Excitatory Amino Acids; Kainic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, AMPA; Wheat Germ Agglutinins | 1995 |
Treatment with an AMPA antagonist 12 hours following severe normothermic forebrain ischemia prevents CA1 neuronal injury.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Brain Diseases; Dizocilpine Maleate; Hippocampus; Ischemic Attack, Transient; Male; Neurons; Prosencephalon; Quinoxalines; Rats; Rats, Wistar | 1993 |
Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Hindlimb; Kainic Acid; Male; Mice; Pentylenetetrazole; Quinoxalines; Receptors, AMPA; Receptors, Kainic Acid; Seizures | 1993 |
Presynaptic influence on the time course of fast excitatory synaptic currents in cultured hippocampal cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Anti-Anxiety Agents; Benzodiazepines; Benzothiadiazines; Calcium; Cells, Cultured; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kinetics; Magnesium; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors | 1995 |
Modulation of D-[2,3 3H]aspartate release from rat forebrain slices by non-NMDA receptor agonists and antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Aspartic Acid; Benzodiazepines; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Kinetics; Kynurenic Acid; Male; Prosencephalon; Quinoxalines; Rats; Rats, Wistar; Tritium | 1995 |
Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Excitatory Amino Acid Antagonists; Flumazenil; Male; Mice; Muscle Relaxants, Central; Pentylenetetrazole; Quinoxalines; Receptors, AMPA; Reflex; Seizures; Synaptic Transmission | 1994 |
The AMPA antagonists NBQX and GYKI 52466 do not counteract neuroleptic-induced catalepsy.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Catalepsy; Dizocilpine Maleate; Drug Interactions; Ergolines; Haloperidol; Levodopa; Male; Pilot Projects; Quinoxalines; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 1994 |
NMDA and non-NMDA receptors may play distinct roles in timing mechanisms and transmission in the feline respiratory network.
Topics: Action Potentials; Anesthesia; Animals; Anti-Anxiety Agents; Benzodiazepines; Blood Pressure; Carbon Dioxide; Cats; Dizocilpine Maleate; N-Methylaspartate; Neurons; Phrenic Nerve; Pulmonary Alveoli; Quinoxalines; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Reflex; Respiration; Synaptic Transmission; Time Factors | 1994 |
The effect of the non-NMDA receptor antagonist GYKI 52466 and NBQX and the competitive NMDA receptor antagonist D-CPPene on the development of amygdala kindling and on amygdala-kindled seizures.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Electric Stimulation; Kindling, Neurologic; Male; Piperazines; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures | 1994 |
Diazepam dependence prevented by glutamate antagonists.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Drug Tolerance; Electroencephalography; Electromyography; Excitatory Amino Acid Antagonists; Male; Mice; Mice, Inbred Strains; Motor Activity; Muscle Tonus; Piperazines; Quinoxalines; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1993 |
Aniracetam reverses the anticonvulsant action of NBQX and GYKI 52466 in DBA/2 mice.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Dose-Response Relationship, Drug; Mice; Mice, Inbred DBA; Piperazines; Pyrrolidinones; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
Influence of combined treatment with NMDA and non-NMDA receptor antagonists on electroconvulsions in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Drug Combinations; Electroshock; Male; Mice; Mice, Inbred Strains; Motor Activity; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures | 1995 |
Centrally-administered AMPA antagonists increase locomotion in parkinsonian rats.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Excitatory Amino Acid Antagonists; Male; Mesencephalon; Microinjections; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Substantia Nigra | 1995 |
Components of glial responses to exogenous and synaptic glutamate in rat hippocampal microcultures.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Cells, Cultured; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Microglia; Neurons; Neurotoxins; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Tacrine | 1996 |
Allosteric interactions between cyclothiazide and AMPA/kainate receptor antagonists.
Topics: Allosteric Regulation; Animals; Anti-Anxiety Agents; Antihypertensive Agents; Benzodiazepines; Benzothiadiazines; Drug Interactions; Electrophysiology; Excitatory Amino Acid Antagonists; Hippocampus; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid | 1996 |
AMPA antagonists differ from NMDA antagonists in their effects on operant DRL and delayed matching to position tasks.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Conditioning, Operant; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Wistar; Reinforcement, Psychology | 1996 |
A role for presynaptic AMPA receptors in the enhancement of neuronal glutamate release by kainic acid.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Neurons; Prosencephalon; Quinoxalines; Rats; Receptors, AMPA; Receptors, Presynaptic | 1996 |
N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4- isoxazoleproprionate (AMPA) glutamate-receptor antagonists have different interactions with the discriminative stimuli of abused drugs.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Conditioning, Operant; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Ketamine; Male; Morphine; Narcotic Antagonists; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule | 1996 |
Neuropeptide Y release from cultured hippocampal neurons: stimulation by glutamate acting at N-methyl-D-aspartate and AMPA receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Antibody Specificity; Antihypertensive Agents; Benzodiazepines; Benzothiadiazines; Calcium; Cells, Cultured; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kainic Acid; Magnesium; Neurons; Neuropeptide Y; Quinoxalines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 1997 |
Enhancement of contextual fear-conditioning by putative (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor modulators and N-methyl-D-aspartate (NMDA) receptor antagonists in DBA/2J mice.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Benzodiazepines; Conditioning, Classical; Cues; Excitatory Amino Acid Antagonists; Fear; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Nootropic Agents; Pyrrolidines; Pyrrolidinones; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 1997 |
Some behavioral effects of AMPA/kainate receptor agonist and antagonists.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzodiazepines; Conflict, Psychological; Drinking Behavior; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exploratory Behavior; Male; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid | 1997 |
Distribution and properties of kainate receptors distinct in the CA3 region of the hippocampus of the guinea pig.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Anti-Anxiety Agents; Benzodiazepines; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Guinea Pigs; Hippocampus; Kainic Acid; Microinjections; Pressure; Quinoxalines; Receptors, AMPA; Receptors, Kainic Acid; Time Factors | 1998 |
Effects of AMPA receptor antagonists on dopamine-mediated behaviors in mice.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Dopamine; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Mice; Motor Activity; Quinoxalines; Receptors, AMPA; Stereotyped Behavior; Tetrazoles | 1998 |
Binding characteristics of a potent AMPA receptor antagonist [3H]Ro 48-8587 in rat brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Brain Chemistry; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Imidazoles; In Situ Hybridization; Kainic Acid; Kinetics; Male; N-Methylaspartate; Quinazolines; Quinoxalines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, AMPA; RNA, Messenger; Tritium | 1998 |
Relationship between anticonvulsant activity and plasma level of some 2,3-benzodiazepines in genetically epilepsy-prone rats.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Epilepsy; Motor Activity; Motor Skills Disorders; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 1998 |
The neuroprotective and hypothermic effect of GYKI-52466, a non-competitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-antagonist on histological and behavioural variables in the gerbil global ischemia model.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Body Temperature; Chlorpromazine; Excitatory Amino Acid Antagonists; Gerbillinae; Ischemic Attack, Transient; Male; Maze Learning; Motor Activity; Neuroprotective Agents; Quinoxalines; Receptors, AMPA; Time Factors | 1999 |
Effects of AMPA/kainate glutamate receptor antagonists on cocaine-induced convulsions and lethality in mice.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Cocaine; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Male; Mice; Quinoxalines; Receptors, AMPA; Receptors, Kainic Acid; Seizures | 1999 |
Disruption of operant oral self-administration of ethanol, sucrose, and saccharin by the AMPA/kainate antagonist, NBQX, but not the AMPA antagonist, GYKI 52466.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Central Nervous System Depressants; Conditioning, Operant; Ethanol; Male; Motor Activity; Quinoxalines; Rats; Receptors, AMPA; Saccharin; Self Administration; Sucrose; Sweetening Agents | 1999 |
Mutation of a glutamate receptor motif reveals its role in gating and delta2 receptor channel properties.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Anti-Anxiety Agents; Antihypertensive Agents; Benzodiazepines; Benzothiadiazines; Cell Line; Conserved Sequence; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ion Channel Gating; Kainic Acid; Kidney; Mice; Mice, Neurologic Mutants; Molecular Sequence Data; Mutagenesis; Neuromuscular Depolarizing Agents; Patch-Clamp Techniques; Purkinje Cells; Quinoxalines; Receptors, Glutamate; Transfection | 2000 |
AMPA receptor antagonists, GYKI 52466 and NBQX, do not block the induction of long-term potentiation at therapeutically relevant concentrations.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Male; Memory; Neurodegenerative Diseases; Neurons; Organ Culture Techniques; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 2000 |
Presynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor-mediated stimulation of glutamate and GABA release in the rat striatum in vivo: a dual-label microdialysis study.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Antihypertensive Agents; Benzodiazepines; Benzothiadiazines; Calcium; Carbon Radioisotopes; Corpus Striatum; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Kynurenic Acid; Male; Microdialysis; Nootropic Agents; Potassium; Presynaptic Terminals; Pyrrolidinones; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Tritium | 2001 |
Ampa/kainate receptor activation mediates hypoxic oligodendrocyte death and axonal injury in cerebral white matter.
Topics: Action Potentials; Animals; Anti-Anxiety Agents; Axons; Benzodiazepines; Calcium; Cell Death; Cell Hypoxia; Corpus Callosum; Excitatory Amino Acid Antagonists; Female; Glucose; Hypoxia, Brain; In Vitro Techniques; Mice; Models, Biological; Nerve Fibers, Myelinated; Oligodendroglia; Oxygen; Propidium; Quinoxalines; Receptors, AMPA; Sodium Channel Blockers | 2001 |
In vivo pharmacology of BIIR 561 CL, a novel combined antagonist of AMPA receptors and voltage-dependent Na(+) channels.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Death; Dose-Response Relationship, Drug; Electric Stimulation; Female; Lethal Dose 50; Male; Mexiletine; Mice; Neuroprotective Agents; Oxadiazoles; Quinoxalines; Rabbits; Rats; Rats, Wistar; Receptors, AMPA; Sodium Channel Blockers | 2001 |
Comparison of excitotoxic profiles of ATPA, AMPA, KA and NMDA in organotypic hippocampal slice cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Isoxazoles; Kainic Acid; Microtubule-Associated Proteins; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Nissl Bodies; Nuclear Proteins; Propidium; Propionates; Quinoxalines; Rats; Rats, Wistar | 2001 |
Participation of AMPA- and NMDA-type excitatory amino acid receptors in the spinal reflex transmission, in rat.
Topics: Action Potentials; Animals; Animals, Newborn; Anti-Anxiety Agents; Benzodiazepines; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; In Vitro Techniques; Magnesium; Models, Neurological; Piperazines; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Reflex, Monosynaptic; Spinal Cord; Synapses; Time Factors; Valine | 2003 |
p21(WAF1/Cip1) is not involved in kainic acid-induced apoptosis in murine cerebellar granule cells.
Topics: Animals; Apoptosis; Benzodiazepines; Cell Cycle; Cell Cycle Proteins; Cells, Cultured; Cerebellum; Cyclin-Dependent Kinase Inhibitor p21; Excitatory Amino Acid Antagonists; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Neurons; Quinoxalines; Receptors, AMPA | 2004 |
The effects of AMPA receptor antagonists in models of stroke and neurodegeneration.
Topics: Animals; Animals, Newborn; Anticonvulsants; Benzodiazepines; Brain; Brain Ischemia; Cell Survival; Chickens; Cortical Spreading Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Excitatory Amino Acid Antagonists; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred Strains; Motor Neurons; Nerve Degeneration; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Retina; Seizures; Stroke | 2005 |
A comparison of release kinetics and glutamate receptor properties in shaping rod-cone differences in EPSC kinetics in the salamander retina.
Topics: Animals; Benzodiazepines; Benzothiadiazines; Calcium; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Kinetics; Models, Biological; Neurotransmitter Agents; Quinoxalines; Receptors, AMPA; Receptors, Glutamate; Retinal Bipolar Cells; Retinal Cone Photoreceptor Cells; Retinal Horizontal Cells; Retinal Rod Photoreceptor Cells; Synaptic Transmission; Synaptic Vesicles; Urodela | 2005 |
Glutamate stimulates oligodendrocyte progenitor migration mediated via an alphav integrin/myelin proteolipid protein complex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Genetically Modified; Animals, Newborn; Benzodiazepines; Blotting, Western; Calcium; Carbachol; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Movement; Cells, Cultured; Chelating Agents; Cholinergic Agonists; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fibronectins; Glutamic Acid; Immunohistochemistry; Immunoprecipitation; Integrin alphaV; Ionophores; Kainic Acid; Models, Biological; Myelin Proteolipid Protein; Myelin Sheath; Oligodendroglia; Pertussis Toxin; Quinoxalines; Rats; Receptor, Platelet-Derived Growth Factor alpha; Receptors, AMPA; Ruthenium Red; Stem Cells; Thapsigargin | 2006 |
Effect of glutamate receptor antagonists and antirheumatic drugs on proliferation of synoviocytes in vitro.
Topics: Animals; Antirheumatic Agents; Benzodiazepines; Benzodiazepinones; Celecoxib; Cell Line; Cell Proliferation; Cell Survival; Diclofenac; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Inhibitory Concentration 50; Methotrexate; Naproxen; Pyrazoles; Quinoxalines; Sulfasalazine; Sulfonamides; Synovial Membrane | 2006 |
AMPA receptor antagonists reverse effects of extended habit training on signaled food approach responding in rats.
Topics: Animals; Appetitive Behavior; Behavior, Animal; Benzazepines; Benzodiazepines; Conditioning, Classical; Conditioning, Operant; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Food; Habits; Injections, Intraperitoneal; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Dopamine D1; Sound; Time Factors | 2007 |
Involvement of AMPA receptors in the antidepressant-like effects of lithium in the mouse tail suspension test and forced swim test.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Benzodiazepines; Brain; Depression; Disease Models, Animal; Drug Administration Routes; Excitatory Amino Acid Antagonists; Exploratory Behavior; Hindlimb Suspension; Injections, Intraventricular; Lithium Compounds; Mice; Mice, Inbred C57BL; Protein Transport; Quinoxalines; Receptors, AMPA; Swimming; Time Factors | 2008 |
Antagonism of AMPA receptors produces anxiolytic-like behavior in rodents: effects of GYKI 52466 and its novel analogues.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Conflict, Psychological; Data Interpretation, Statistical; Diazepam; Electrophysiology; Excitatory Amino Acid Antagonists; Hippocampus; Male; Membrane Potentials; Mice; Motor Activity; Neurons; Patch-Clamp Techniques; Piperazines; Quinoxalines; Radioligand Assay; Rats; Rats, Wistar; Receptors, AMPA; Telencephalon | 2008 |
High-frequency organization and synchrony of activity in the purkinje cell layer of the cerebellum.
Topics: Action Potentials; Anesthesia; Animals; Benzodiazepines; Benzoxazines; Biological Clocks; Cannabinoids; Cerebellum; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Inhibitory Postsynaptic Potentials; Male; Models, Neurological; Morpholines; Naphthalenes; Picrotoxin; Piperidines; Purkinje Cells; Pyrazoles; Quinoxalines; Rats; Rats, Wistar; Reaction Time | 2008 |
Regulation of glutamate transport in developing rat oligodendrocytes.
Topics: Animals; Animals, Newborn; Aspartic Acid; Benzodiazepines; Bicuculline; Brain; Cells, Cultured; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Female; Fibroblast Growth Factors; GABA Antagonists; Gangliosides; Gene Expression Regulation, Developmental; Glutamic Acid; Kainic Acid; Membrane Potentials; Neurons; O Antigens; Oligodendroglia; Patch-Clamp Techniques; Platelet-Derived Growth Factor; Pregnancy; Quinoxalines; Rats; Rats, Long-Evans; Sodium Channel Blockers; Tetrodotoxin; Tritium | 2009 |
AMPA receptors and seizures mediate hippocampal radial glia-like stem cell proliferation.
Topics: Animals; Animals, Newborn; Benzodiazepines; Cell Death; Cell Proliferation; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Ki-67 Antigen; Male; Membrane Potentials; Nerve Tissue Proteins; Neuroglia; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Seizures; Stem Cells | 2018 |
Do stereoisomers of homocysteic acid exhibit different convulsant action in immature rats?
Topics: 2-Amino-5-phosphonovalerate; Animals; Benzodiazepines; Dizocilpine Maleate; Homocysteine; Male; Quinoxalines; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Stereoisomerism | 2019 |