gw-7647 has been researched along with benzothiazole* in 1 studies
1 other study(ies) available for gw-7647 and benzothiazole
Article | Year |
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Benzothiazole-based N-(phenylsulfonyl)amides as a novel family of PPARα antagonists.
The discovery of PPAR antagonists is emerging as an useful tool for elucidating the biological role of the receptor. Here we report the identification of N-(phenylsulfonyl)amides containing the benzothiazole scaffold, a novel class of potent PPARα antagonists obtained from chemical modification of carboxylic acid agonists. In this work, a group of phenylsulfonamides were synthesized and in vitro evaluated against the agonistic effect of GW7647; they showed an inhibitory effect on PPARα activation, with best compounds revealing a dose-dependent antagonistic profile. Some of these antagonists showed also an inhibitory effect on CPT1A pattern expression. Topics: Benzothiazoles; Butyrates; Carnitine O-Palmitoyltransferase; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Molecular Structure; Phenylurea Compounds; PPAR alpha; Stereoisomerism; Structure-Activity Relationship; Sulfonamides | 2011 |