gw-4064 and 1-naphthoic-acid

gw-4064 has been researched along with 1-naphthoic-acid* in 1 studies

Other Studies

1 other study(ies) available for gw-4064 and 1-naphthoic-acid

Article	Year
Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064. Bioorganic & medicinal chemistry letters, 2008, 08-01, Volume: 18, Issue:15 Starting from the known FXR agonist GW 4064 1a, a series of stilbene replacements were prepared. The 6-substituted 1-naphthoic acid 1b was an equipotent FXR agonist with improved developability parameters relative to 1a. Analog 1b also reduced the severity of cholestasis in the ANIT acute cholestatic rat model. Topics: Administration, Oral; Animals; Carboxylic Acids; Cholestasis; Crystallography, X-Ray; Disease Models, Animal; DNA-Binding Proteins; Dogs; Gastric Mucosa; Haplorhini; Isoxazoles; Mice; Molecular Conformation; Molecular Structure; Naphthalenes; Rats; Receptors, Cytoplasmic and Nuclear; Stomach; Structure-Activity Relationship; Transcription Factors	2008

Article

Year

Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064.

Bioorganic & medicinal chemistry letters, 2008, 08-01, Volume: 18, Issue:15

Starting from the known FXR agonist GW 4064 1a, a series of stilbene replacements were prepared. The 6-substituted 1-naphthoic acid 1b was an equipotent FXR agonist with improved developability parameters relative to 1a. Analog 1b also reduced the severity of cholestasis in the ANIT acute cholestatic rat model.

Topics: Administration, Oral; Animals; Carboxylic Acids; Cholestasis; Crystallography, X-Ray; Disease Models, Animal; DNA-Binding Proteins; Dogs; Gastric Mucosa; Haplorhini; Isoxazoles; Mice; Molecular Conformation; Molecular Structure; Naphthalenes; Rats; Receptors, Cytoplasmic and Nuclear; Stomach; Structure-Activity Relationship; Transcription Factors

2008