guanylyl-(3--5-)-guanosine and tetramethylammonium

guanylyl-(3--5-)-guanosine has been researched along with tetramethylammonium* in 2 studies

Other Studies

2 other study(ies) available for guanylyl-(3--5-)-guanosine and tetramethylammonium

Article	Year
Cation-dependence of the self-association behavior of guanylyl-(3'-5')-guanosine. Journal of biomolecular structure & dynamics, 1992, Volume: 10, Issue:3 The aggregation behavior of guanylyl-(3'-5')-guanosine, GpG, in the form of the tetramethylammonium (TMA), Li, Na, and K salts in aqueous solution has been investigated by NMR and FTIR techniques. The salts were prepared by a cation-exchange method. The ability of the cations to induce aggregate formation is TMA+ < Li+ < Na+ < K+, where TMA+ has only a weakly promoting action and K+ has a very strong effect. Three types of aggregates have been observed: (a) small aggregates which are in rapid exchange with respect to the NMR time scale; (b) intermediate-sized aggregates which are slow to exchange; (c) very large aggregates which can only be observed by FTIR. In all cases the aggregated species are held together by base stacking and guanine-guanine hydrogen bonding. A stoichiometry of 2 GpG per K+ has been determined by a 1H NMR titration of TMAGpG with KCl. Models have been proposed for the various-sized species. These include stacked dimers, stacked tetramers (similar to G-tetrads), and species in which K+ ion bridges between phosphates in separate tetramers. Topics: Cations, Monovalent; Chromatography, Ion Exchange; Dinucleoside Phosphates; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Quaternary Ammonium Compounds	1992
The preparation and spectroscopic characterization of a weakly self-associating salt of guanylyl-(3'-5')-guanosine. Biochemical and biophysical research communications, 1988, Feb-29, Volume: 151, Issue:1 The tetramethylammonium salt of guanylyl-(3'-5')-guanosine has been prepared by a cation-exchange technique and it has been found that the tetramethylammonium ion drastically reduces the self-association of GpG in solution. This has allowed the characterization of GpG by FTIR and 1-D and 2-D NMR spectroscopy. A complete, well-resolved 1H NMR spectrum in D2O has been obtained and all resonances have been assigned. A weak, essentially non-cooperative intermolecular association is observed in solution (15-20 mM) below 40 degrees C. The association occurs via base stacking and base-base hydrogen bonding. Topics: Chemical Phenomena; Chemistry; Dinucleoside Phosphates; Guanine Nucleotides; Guanosine; Guanosine Monophosphate; Magnetic Resonance Spectroscopy; Quaternary Ammonium Compounds; Salts; Spectrophotometry, Infrared; Temperature	1988

Article

Year

Cation-dependence of the self-association behavior of guanylyl-(3'-5')-guanosine.

Journal of biomolecular structure & dynamics, 1992, Volume: 10, Issue:3

The aggregation behavior of guanylyl-(3'-5')-guanosine, GpG, in the form of the tetramethylammonium (TMA), Li, Na, and K salts in aqueous solution has been investigated by NMR and FTIR techniques. The salts were prepared by a cation-exchange method. The ability of the cations to induce aggregate formation is TMA+ < Li+ < Na+ < K+, where TMA+ has only a weakly promoting action and K+ has a very strong effect. Three types of aggregates have been observed: (a) small aggregates which are in rapid exchange with respect to the NMR time scale; (b) intermediate-sized aggregates which are slow to exchange; (c) very large aggregates which can only be observed by FTIR. In all cases the aggregated species are held together by base stacking and guanine-guanine hydrogen bonding. A stoichiometry of 2 GpG per K+ has been determined by a 1H NMR titration of TMAGpG with KCl. Models have been proposed for the various-sized species. These include stacked dimers, stacked tetramers (similar to G-tetrads), and species in which K+ ion bridges between phosphates in separate tetramers.

Topics: Cations, Monovalent; Chromatography, Ion Exchange; Dinucleoside Phosphates; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Quaternary Ammonium Compounds

1992

The preparation and spectroscopic characterization of a weakly self-associating salt of guanylyl-(3'-5')-guanosine.

Biochemical and biophysical research communications, 1988, Feb-29, Volume: 151, Issue:1

The tetramethylammonium salt of guanylyl-(3'-5')-guanosine has been prepared by a cation-exchange technique and it has been found that the tetramethylammonium ion drastically reduces the self-association of GpG in solution. This has allowed the characterization of GpG by FTIR and 1-D and 2-D NMR spectroscopy. A complete, well-resolved 1H NMR spectrum in D2O has been obtained and all resonances have been assigned. A weak, essentially non-cooperative intermolecular association is observed in solution (15-20 mM) below 40 degrees C. The association occurs via base stacking and base-base hydrogen bonding.

Topics: Chemical Phenomena; Chemistry; Dinucleoside Phosphates; Guanine Nucleotides; Guanosine; Guanosine Monophosphate; Magnetic Resonance Spectroscopy; Quaternary Ammonium Compounds; Salts; Spectrophotometry, Infrared; Temperature

1988