guanosine-triphosphate and phorbol-12-13-diacetate

guanosine-triphosphate has been researched along with phorbol-12-13-diacetate* in 1 studies

Other Studies

1 other study(ies) available for guanosine-triphosphate and phorbol-12-13-diacetate

Article	Year
Serotonin-induced inward current in rat facial motoneurons: evidence for mediation by G proteins but not protein kinase C. Brain research, 1990, Jul-30, Volume: 524, Issue:1 The 5-HT-induced inward current in rat facial motoneurons was rendered irreversible by intracellular GTP gamma S, an hydrolysis-resistant analog of guanosine 5'-triphosphate which sustains G protein activation. Conversely, the 5-HT response was reduced by GDP beta S, an analog of guanosine 5'-diphosphate which interferes with G protein activation. Inhibitors of protein kinase C enhanced the 5-HT-induced inward current. Thus, the slow inward current induced by 5-HT in facial motoneurons appears to be mediated by G proteins but modulated negatively by protein kinase C. Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Electric Conductivity; Facial Nerve; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; In Vitro Techniques; Isoquinolines; Male; Motor Neurons; Phorbol Esters; Piperazines; Protein Kinase C; Rats; Serotonin; Thionucleotides	1990

Article

Year

Serotonin-induced inward current in rat facial motoneurons: evidence for mediation by G proteins but not protein kinase C.

Brain research, 1990, Jul-30, Volume: 524, Issue:1

The 5-HT-induced inward current in rat facial motoneurons was rendered irreversible by intracellular GTP gamma S, an hydrolysis-resistant analog of guanosine 5'-triphosphate which sustains G protein activation. Conversely, the 5-HT response was reduced by GDP beta S, an analog of guanosine 5'-diphosphate which interferes with G protein activation. Inhibitors of protein kinase C enhanced the 5-HT-induced inward current. Thus, the slow inward current induced by 5-HT in facial motoneurons appears to be mediated by G proteins but modulated negatively by protein kinase C.

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Electric Conductivity; Facial Nerve; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; In Vitro Techniques; Isoquinolines; Male; Motor Neurons; Phorbol Esters; Piperazines; Protein Kinase C; Rats; Serotonin; Thionucleotides

1990