guanosine-triphosphate and 1-stearoyl-2-arachidonoylglycerol

guanosine-triphosphate has been researched along with 1-stearoyl-2-arachidonoylglycerol* in 1 studies

Other Studies

1 other study(ies) available for guanosine-triphosphate and 1-stearoyl-2-arachidonoylglycerol

Article	Year
Inhibitory effect of arachidonic acid on GTPase activating protein is antagonized by 1-stearoyl, 2-arachidonoyl glycerol. Biochemical and biophysical research communications, 1993, Aug-31, Volume: 195, Issue:1 The intrinsic GTPase activity of cellular protein p21ras is strongly increased by cytosolic GTPase activating protein (GAP). The activity of this enzyme has been shown to be inhibited by arachidonic acid. We report here that this inhibition is antagonized by the presence of 1-stearoyl, 2-arachidonoyl glycerol. This effect is structure specific and dose dependent, being maximum at 200 micrograms/ml of diacylglycerol (DG). These results suggest that production of DG in response to hormones or growth factors stimulation could indirectly modulate the interaction between p21ras and GAP. Topics: Animals; Antibodies, Monoclonal; Arachidonic Acid; Diglycerides; Dose-Response Relationship, Drug; GTP Phosphohydrolases; GTPase-Activating Proteins; Guanosine Triphosphate; Kinetics; Proteins; Proto-Oncogene Proteins p21(ras); Rabbits; ras GTPase-Activating Proteins; Rats; Recombinant Proteins	1993

Article

Year

Inhibitory effect of arachidonic acid on GTPase activating protein is antagonized by 1-stearoyl, 2-arachidonoyl glycerol.

Biochemical and biophysical research communications, 1993, Aug-31, Volume: 195, Issue:1

The intrinsic GTPase activity of cellular protein p21ras is strongly increased by cytosolic GTPase activating protein (GAP). The activity of this enzyme has been shown to be inhibited by arachidonic acid. We report here that this inhibition is antagonized by the presence of 1-stearoyl, 2-arachidonoyl glycerol. This effect is structure specific and dose dependent, being maximum at 200 micrograms/ml of diacylglycerol (DG). These results suggest that production of DG in response to hormones or growth factors stimulation could indirectly modulate the interaction between p21ras and GAP.

Topics: Animals; Antibodies, Monoclonal; Arachidonic Acid; Diglycerides; Dose-Response Relationship, Drug; GTP Phosphohydrolases; GTPase-Activating Proteins; Guanosine Triphosphate; Kinetics; Proteins; Proto-Oncogene Proteins p21(ras); Rabbits; ras GTPase-Activating Proteins; Rats; Recombinant Proteins

1993