guanosine-pentaphosphate has been researched along with alpha-ketobutyric-acid* in 1 studies
1 other study(ies) available for guanosine-pentaphosphate and alpha-ketobutyric-acid
| Article | Year |
|---|---|
Serine sensitivity of Escherichia coli K 12: partial characterization of a serine resistnat mutant that is extremely sensitive to 2-ketobutyrate.
E. coli wild type bacteria display sensitivity towards serine. A selection medium is described which allows selection of serine resistant mutants. One such mutant is described which presents pleiotropic alterations: it exhibits a thermosensitive growth pattern, alteration in the metabolism of the pppGpp and ppGpp nucleotides, cAMP intracellular level alteration, extreme sensitivity to 2-ketobutyric acid and a defect in the phosphotransferases permeation system. A conjecture explaining these apparently unrelated defects supposes that serine metabolism interferes via phosphoenol pyruvate with a cytoplasmic control of membrane activity (the mutant would be defective in the coupling between membrane and the protein responsible for its cytoplasmic control) and that 2-ketobutyrate is an effector of this activity. Topics: Butyrates; Culture Media; Cyclic AMP; Drug Resistance, Microbial; Escherichia coli; Guanosine Pentaphosphate; Guanosine Tetraphosphate; Keto Acids; Mutation; Phenotype; Serine | 1980 |