guanosine-monophosphate has been researched along with thiophenol* in 1 studies
1 other study(ies) available for guanosine-monophosphate and thiophenol
| Article | Year |
|---|---|
Furoxans as nitric oxide donors. 4-Phenyl-3-furoxancarbonitrile: thiol-mediated nitric oxide release and biological evaluation.
4-Phenyl-3-furoxancarbonitrile (2) affords nitric oxide under the action of thiol cofactors. Two principal products were isolated in the reaction with thiophenol: the phenylcyanoglyoxime (6) and 5-amino-3-phenyl-4-(phenylthio)isoxazole (7). Mechanisms which could account for the formation of these two products are discussed. Compound 2 is an efficient activator of the rat lung soluble guanylate cyclase, displays high vasodilatory activity on strips of rat thoracic aorta precontracted with noradrenaline, and is a potent inhibitor of platelet aggregation. Topics: Animals; Aorta, Thoracic; Enzyme Activation; Guanosine Monophosphate; Guanylate Cyclase; Humans; Lung; Male; Mass Spectrometry; Nitric Oxide; Norepinephrine; Oxadiazoles; Phenols; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Sulfhydryl Compounds; Vasodilation; Vasodilator Agents | 1994 |