guanosine-monophosphate and selenazofurin

guanosine-monophosphate has been researched along with selenazofurin* in 1 studies

Other Studies

1 other study(ies) available for guanosine-monophosphate and selenazofurin

Article	Year
Synergistic cytotoxic effect of tiazofurin and ribavirin in hepatoma cells. Biochemical and biophysical research communications, 1988, May-31, Volume: 153, Issue:1 Tiazofurin, an anti-cancer drug, which induces remissions in human leukemia, and ribavirin, an anti-viral agent, bind at separate sites (NADH and IMP-XMP sites, respectively) on the target enzyme, IMP dehydrogenase. Now we show that the binding to IMP dehydrogenase of these drugs at two separate sites is translated into synergistic inhibition of de novo guanylate biosynthesis and synergistic toxicity in rat hepatoma 3924A cells. These results may be utilized in the chemotherapy of neoplastic diseases and in the treatment of hepatitis virus infection and hepatocellular carcinoma. Topics: Animals; Cell Line; Cell Survival; Drug Synergism; Guanosine Monophosphate; IMP Dehydrogenase; Liver Neoplasms, Experimental; Organoselenium Compounds; Purines; Rats; Ribavirin; Ribonucleosides; Selenium	1988

Article

Year

Synergistic cytotoxic effect of tiazofurin and ribavirin in hepatoma cells.

Biochemical and biophysical research communications, 1988, May-31, Volume: 153, Issue:1

Tiazofurin, an anti-cancer drug, which induces remissions in human leukemia, and ribavirin, an anti-viral agent, bind at separate sites (NADH and IMP-XMP sites, respectively) on the target enzyme, IMP dehydrogenase. Now we show that the binding to IMP dehydrogenase of these drugs at two separate sites is translated into synergistic inhibition of de novo guanylate biosynthesis and synergistic toxicity in rat hepatoma 3924A cells. These results may be utilized in the chemotherapy of neoplastic diseases and in the treatment of hepatitis virus infection and hepatocellular carcinoma.

Topics: Animals; Cell Line; Cell Survival; Drug Synergism; Guanosine Monophosphate; IMP Dehydrogenase; Liver Neoplasms, Experimental; Organoselenium Compounds; Purines; Rats; Ribavirin; Ribonucleosides; Selenium

1988