guanosine-monophosphate has been researched along with oxanosine* in 1 studies
1 other study(ies) available for guanosine-monophosphate and oxanosine
Article | Year |
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Mode of action of oxanosine, a novel nucleoside antibiotic.
Oxanosine, a novel nucleoside, inhibits the growth of Escherichia coli K-12 on peptone agar, but not on Nutrient agar. This antibiotic activity was found to be bacteriostatic and was antagonized by guanine, guanosine, and guanylic acid. The growth of leukemia L 1210 cell was also inhibited by oxanosine, and the inhibition was reversed by guanylic acid. Oxanosine was confirmed to be a competitive inhibitor of GMP synthetase (E.C. 6.3.5.2) and the Ki value was 7.4 X 10(-4) M. Topics: Animals; Anti-Bacterial Agents; Carbon-Nitrogen Ligases; Escherichia coli; Guanosine; Guanosine Monophosphate; Leukemia L1210; Ligases; Ribonucleosides | 1982 |