guanosine-monophosphate has been researched along with magnesium-perchlorate* in 2 studies
2 other study(ies) available for guanosine-monophosphate and magnesium-perchlorate
| Article | Year |
|---|---|
The dose rate effects on the in vitro radiolysis products of magnesium-guanosine-5'-monophosphate complexes in aqueous solutions.
This study examined the effects on the radiolysis of magnesium-guanosine-5'-monophosphate complexes in deaerated aqueous solutions, investigated by Fourier transform infrared (FT-IR) spectroscopy. It was found that when the system was irradiated with a dose rate of 500 rad/min (low dose rate), the OH radicals, H atoms and hydrated electrons (eaq-) produced from radiolysis of water reacted mainly by addition to the double bonds C4 = C5 and N7 = C8 of guanine. When the dose rate was 23,800 rad/min (high dose rate) the electrons reacted further with the complex by addition to the carbonyl group, C6 = O, of guanine. Topics: Chemical Phenomena; Chemistry, Physical; Cobalt Radioisotopes; Dose-Response Relationship, Radiation; Fourier Analysis; Gamma Rays; Guanine Nucleotides; Guanosine Monophosphate; Magnesium; Magnesium Compounds; Molecular Structure; Perchlorates; Solutions; Spectrophotometry, Infrared; Water | 1990 |
Magnesium perchlorate and cis-platinum as radiosensitizers in in vitro radiolysis of nucleotides.
The mechanism of the gamma-radiolysis of the nucleotide guanosine-5'-monophosphate (5'-GMP) in the presence of Mg++ ions and cis-platinum was investigated. From high performance liquid chromatography and spectroscopy studies it was found that the OH radicals, produced in irradiated aqueous solutions, reacted with 5'-GMP by addition to the double bonds and that Mg++ as well as cis-Pt sensitized the nucleotide to radiation damage. Furthermore, an important finding was the fact that when the irradiation took place in aerated solutions, the Mg++ ions, contrary to cis-Pt, did not seem to have any effect on the decomposition yield G(-5'-GMP). This result together with the sensitization (100% increase) observed in deaerated solutions led to the conclusion that irradiation in the presence of Mg++ may result in a more effective gamma-radiation therapy for tumours. Topics: Chromatography, High Pressure Liquid; Cisplatin; Gamma Rays; Guanine Nucleotides; Guanosine Monophosphate; Hydroxides; Hydroxyl Radical; Magnesium; Magnesium Compounds; Molecular Structure; Perchlorates; Solutions; Spectrophotometry; Water | 1990 |