guanosine-monophosphate has been researched along with 4-hydroxymethylpyridine* in 1 studies
1 other study(ies) available for guanosine-monophosphate and 4-hydroxymethylpyridine
| Article | Year |
|---|---|
Synthesis, characterization and biological activity of trans-platinum(II) and trans-platinum(IV) complexes with 4-hydroxymethylpyridine.
The synthesis and chemical characterization of two new trans platinum complexes, trans-[PtCl(2)NH(3)(4-hydroxymethylpyridine)] (1) and trans-[PtCl(4)NH(3)(4-hydroxymethylpyridine)] (2) are described. Their ability to interact with 5'-GMP by themselves and in the presence of reducing agents in the case of trans-[PtCl(4)NH(3)(4-hydroxymethylpyridine)] were tested. Circular dichroism, electrophoretic mobility in agarose gel, and atomic force microscopy studies showed that the interaction of complex 1 with DNA is stronger than that of complex 2. Cytotoxicity tests against HL-60 tumor cells also showed higher activity for trans-[PtCl(2)NH(3)(4-hydroxymethylpyridine)] than for trans-[PtCl(4)NH(3)(4-hydroxymethylpyridine)]. Complex 1 presents similar behavior to cisplatin, but with a lower IC(50) at 24 h. Complex 1 also showed high apoptosis induction. Topics: Apoptosis; Cell Line, Tumor; DNA; Guanosine Monophosphate; HL-60 Cells; Humans; Magnetic Resonance Spectroscopy; Microscopy, Atomic Force; Organoplatinum Compounds; Platinum Compounds; Pyridines; Solubility; Water | 2005 |