guanosine-diphosphate and 2-aminoisobutyric-acid

Brown adipose tissue (Na(+)-K+)-ATPase activity, in vitro glucose uptake and 2-aminoisobutyric acid uptake, as well as mitochondrial GDP-binding and succinate dehydrogenase activity were determined in order to study the relationship between these parameters in control, cold acclimated and cafeteria-fed rats. GDP-binding, (Na(+)-K+)-ATPase and glucose uptake were increased in interscapular brown adipose tissue from cold-acclimated and cafeteria-fed rats, whereas 2-aminoisobutyric acid uptake was only increased in cafeteria-fed rats. GDP-binding and (Na(+)-K+)-ATPase activity showed a high correlation coefficient suggesting a parallel modulation of both systems, which would probably share a common regulation mechanism.

Topics: Adipose Tissue, Brown; Aminoisobutyric Acids; Animals; Body Temperature Regulation; Body Weight; Cold Temperature; Female; Glucose; Guanosine Diphosphate; Insulin; Mitochondria; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase; Succinate Dehydrogenase