guanosine and purine

guanosine has been researched along with purine* in 1 studies

Other Studies

1 other study(ies) available for guanosine and purine

Article	Year
Activation and inhibition of CTP synthase from Trypanosoma brucei, the causative agent of African sleeping sickness. Bioorganic & medicinal chemistry letters, 2011, Sep-15, Volume: 21, Issue:18 CTP Synthase from Trypanosoma brucei (TbCTPS) catalyzes the conversion of UTP to CTP and is a recognized target for the development of antiprotozoal agents. GTP activates glutamine-dependent CTP formation catalyzed by TbCTPS at concentrations below 0.2 mM, but inhibits this activity at concentrations above 0.2 mM. TbCTPS catalyzes ammonia-dependent CTP formation, which is inhibited by purine derivatives such as GTP, guanosine, caffeine, and uric acid with IC(50) values of 460, 380, 480, and 100 μM, respectively. These observations suggest that the purine ring may serve as a useful scaffold for the development of inhibitors of trypanosomal CTP synthase. Topics: Antiprotozoal Agents; Biocatalysis; Carbon-Nitrogen Ligases; Dose-Response Relationship, Drug; Enzyme Activation; Purines; Recombinant Proteins; Structure-Activity Relationship; Trypanosoma brucei brucei; Trypanosomiasis, African	2011

Article

Year

Activation and inhibition of CTP synthase from Trypanosoma brucei, the causative agent of African sleeping sickness.

Bioorganic & medicinal chemistry letters, 2011, Sep-15, Volume: 21, Issue:18

CTP Synthase from Trypanosoma brucei (TbCTPS) catalyzes the conversion of UTP to CTP and is a recognized target for the development of antiprotozoal agents. GTP activates glutamine-dependent CTP formation catalyzed by TbCTPS at concentrations below 0.2 mM, but inhibits this activity at concentrations above 0.2 mM. TbCTPS catalyzes ammonia-dependent CTP formation, which is inhibited by purine derivatives such as GTP, guanosine, caffeine, and uric acid with IC(50) values of 460, 380, 480, and 100 μM, respectively. These observations suggest that the purine ring may serve as a useful scaffold for the development of inhibitors of trypanosomal CTP synthase.

Topics: Antiprotozoal Agents; Biocatalysis; Carbon-Nitrogen Ligases; Dose-Response Relationship, Drug; Enzyme Activation; Purines; Recombinant Proteins; Structure-Activity Relationship; Trypanosoma brucei brucei; Trypanosomiasis, African

2011