guanosine-5--o-(2-thiotriphosphate) has been researched along with calmidazolium* in 1 studies
1 other study(ies) available for guanosine-5--o-(2-thiotriphosphate) and calmidazolium
Article | Year |
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Paradoxical facilitation of exocytosis by inhibition of L-type calcium channels of bovine chromaffin cells.
Ca(2+) entry through the L-subtype (α(1D), Ca(v)1,3) of voltage-dependent calcium channels (VDCCs) seems to selectively regulate the endocytotic response after the application of a single depolarizing pulse to voltage-clamped bovine chromaffin cells. Here we have found that L channel blockade with nifedipine transformed the exocytotic responses elicited by a double-pulse protocol, from depression to facilitation. This apparent paradoxical effect was mimicked by pharmacological interventions that directly block endocytosis namely, dynasore, calmidazolium, GTP-γS and GDP-βS. This reinforces our view that Ca(2+) entry through PQ channels (α(1A); Ca(v)2.1) regulates fast exocytosis while Ca(2+) entry through L channels preferentially controls rapid endocytosis. Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cattle; Cells, Cultured; Chromaffin Cells; Exocytosis; Guanosine 5'-O-(3-Thiotriphosphate); Hydrazones; Imidazoles; Nifedipine | 2011 |