guanine-ribonucleotidyl-(3--5-)-adenosine has been researched along with guanylyl-(3--5-)-guanosine* in 1 studies
1 other study(ies) available for guanine-ribonucleotidyl-(3--5-)-adenosine and guanylyl-(3--5-)-guanosine
| Article | Year |
|---|---|
High-performance liquid chromatographic investigations on the time-dependent reaction of cis-Pt(NH3)2Cl2, Pt(en)Cl2 and Pt(pn)Cl2 with RNA fragments.
The reaction of three platinum compounds, Pt(NH3)2Cl2, Pt(en)Cl2 and Pt(pn)Cl2 with nucleic acid fragments (Ade, Gua; GpG, GpA and ApA), both reactants (1:1, 1 X 10(-2) M; 1 X 10(-3) M) being dissolved in water, has been studied. UV measurements have been used to characterize the products. Kinetics and adduct formation in the nucleoside-Pt compound system were studied by reversed-phase high-performance liquid chromatography [gradient 0-30% methanol in 30 min, ammonium acetate buffer (0.1 M) at pH 4.25] at fixed intervals of time and the product formation was examined by measuring the peak heights. After 10 h, the reaction was complete for guanosine and showed a steady state for adenosine. The increasing lipophilicity in the sequence of the platinum compounds resulted in a shift to longer retention times. Topics: Adenosine; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Dinucleoside Phosphates; Drug Interactions; Guanine Nucleotides; Guanosine; Guanosine Monophosphate; Hydrogen-Ion Concentration; Kinetics; Organoplatinum Compounds; RNA | 1984 |