guanidine has been researched along with proline in 81 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (9.88) | 18.7374 |
| 1990's | 39 (48.15) | 18.2507 |
| 2000's | 27 (33.33) | 29.6817 |
| 2010's | 5 (6.17) | 24.3611 |
| 2020's | 2 (2.47) | 2.80 |
| Authors | Studies |
|---|---|
| Baldwin, RL; Schmid, FX | 1 |
| Kiefhaber, T; Rudolph, R; Siebendritt, R | 1 |
| Baldwin, RL; Schmid, FX; Schultz, DA | 1 |
| Briggs, MS; Roder, H | 1 |
| Kiefhaber, T; Schmid, FX | 1 |
| Jerala, R; Lenarcic, B; Turk, V; Zerovnik, E | 1 |
| Fersht, AR; Jackson, SE | 1 |
| Hayashi, S; Ogasahara, K; Sugisaki, Y; Yutani, K | 1 |
| Hahn, U; Kiefhaber, T; Quaas, R; Schmid, FX | 1 |
| Lang, K; Schmid, FX | 1 |
| Pandit, MW; Sagar, AJ; Subbiah, V | 1 |
| Nall, BT; Ramdas, L; White, TB; Wood, LC | 1 |
| Nall, BT; Ramdas, L; Sherman, F | 1 |
| Nall, BT; Ramdas, L | 1 |
| Kelley, RF; Richards, FM | 1 |
| Chang, D; Crouch, E; Quinones, F | 1 |
| Jaenicke, R; Rudolph, R; Zettlmeissl, G | 1 |
| Ahmad, F; Taneja, S | 1 |
| Dodge, RW; Laity, JH; Rothwarf, DM; Scheraga, HA; Shimotakahara, S | 1 |
| Hamada, S; Moriyama, Y; Takeda, K; Yamaguchi, K | 1 |
| Rajendrakumar, CS; Reddy, AR; Reddy, BV | 1 |
| Fothergill-Gilmore, LA; Kelly, SM; Price, NC; White, MF | 1 |
| Bächinger, HP; Davis, JM | 1 |
| Nall, BT; Veeraraghavan, S | 1 |
| Antonino, LC; Fink, AL; Fox, RO; Nakano, T | 1 |
| Hahn, U; Landt, O; Mayr, LM; Schmid, FX | 1 |
| Markley, JL; Royer, CA; Truckses, DM; Vidugiris, GJ | 1 |
| Dodge, RW; Scheraga, HA | 1 |
| Hashimoto, Y; Imoto, T; Motoshima, H; Tsutsumi, M; Ueda, T | 1 |
| Frère, JM; Pain, RH; Palzkill, T; Raquet, X; Vanhove, M | 1 |
| Houry, WA; Scheraga, HA | 2 |
| Burton, LE; De Young, LR; Liu, J; Powell, MF; Schmelzer, CH; Skelton, NJ | 1 |
| Ogasahara, K; Yutani, K | 1 |
| Aronsson, G; Brorsson, AC; Jonsson, BH; Sahlman, L | 1 |
| Campbell, ID; Dobson, CM; Guijarro, JI; Morton, CJ; Pitkeathly, M; Plaxco, KW | 1 |
| Ford, C; Li, Y; Reilly, PJ | 1 |
| Bizounok, M; Griffin, RG; Hatcher, ME; Herzfeld, J; Hu, JG; Lansing, JC; Lugtenburg, J; Raap, J; Sun, BQ; Verdegem, PJ | 1 |
| Chaffotte, AF; Georgescu, RE; Goldberg, ME; Li, JH; Tasayco, ML | 1 |
| Bartolucci, S; Cannio, R; Fiorentino, G; Rossi, M | 1 |
| Birolo, L; Capitani, G; De Luca, F; Jansonius, JN; Malashkevich, VN; Marino, G; Moretta, A | 1 |
| Cooper, A; Kelly, SM; Littlechild, JA; McHarg, J; Price, NC | 1 |
| Gehrig, P; Plückthun, A; Ramm, K | 1 |
| Bhuyan, AK; Udgaonkar, JB | 1 |
| Chakrabarti, A; Srivastava, S; Surolia, A; Swaminathan, CP; Varadarajan, R | 1 |
| Laity, JH; Montelione, GT; Scheraga, HA | 1 |
| Nall, BT; Pierce, MM | 1 |
| Eastman, P; Fink, AL; Nishimura, C; Riley, R | 1 |
| Bennett, AD; Bocking, SP; Davies, KG; Gill, AC; Hope, J; Hunt, LG; Rhie, AG; Ritchie, MA; Steane, SE | 1 |
| Myers, JK; Oas, TG | 1 |
| Han, G; Hruby, VJ; Tamaki, M | 1 |
| Masotti, L; Neyroz, P; Simeoni, F | 1 |
| Gahunia, HK; Grynpas, MD; Hartmann, D; Pritzker, KP; Tupy, JH; Yuan, J | 1 |
| Maier, R; Schmid, FX; Scholz, C | 1 |
| Fersht, AR; Galani, D; Perrett, S | 1 |
| Kamen, DE; Woody, RW | 1 |
| Bhat, R; Scheraga, HA; Wedemeyer, WJ | 1 |
| Chiba, T; Goto, Y; Hagihara, Y; Hasegawa, K; Higurashi, T; Naiki, H | 1 |
| Artigues, A; Bengoechea-Alonso, MT; Iriarte, A; Martinez-Carrión, M; Osés-Prieto, JA | 1 |
| Andreotti, G; Motta, A | 1 |
| Jiménez, B; Piccioli, M; Poggi, L | 1 |
| Chilson, AE; Chilson, OP | 1 |
| Al-Mourabit, A; Travert, N | 1 |
| Bofill, R; Crespo, MD; Platt, GW; Searle, MS | 1 |
| Chebotareva, NA; Eronina, TB; Kurganov, BI | 1 |
| Baddam, S; Bowler, BE | 1 |
| Kim, SH; Yan, YB; Zhou, HM | 1 |
| Meng, FG; Mu, H; Park, YD; Wang, XY; Xia, Y; Zhou, HM | 1 |
| Chalovich, JM; Kenney, JM; Khaymina, SS; Schroeter, MM | 1 |
| Chugh, J; Hosur, RV; Sharma, S | 1 |
| Coon, SL; Ganguly, S; Hassan, SA; Klein, DC; Pavlicek, J; Sackett, DL; Weller, JL | 1 |
| Li, F; Wang, XY; Wu, QY | 1 |
| Biernat, J; Chinnathambi, S; Hascher, A; Jeganathan, S; Mandelkow, E; Mandelkow, EM | 1 |
| Alemán, C; Calaza, MI; Cativiela, C; Flores-Ortega, A; Jiménez, AI; Nussinov, R; Ruoslahti, E; Zanuy, D | 1 |
| Concellón, C; del Amo, V; Martínez-Castañeda, Á; Poladura, B; Rodríguez-Solla, H | 2 |
| Ganesh, KN; Nanda, M; Sonar, M; Umashankara, M | 1 |
| Concellón, C; del Amo, V; Kędziora, K; Lavandera, I; Martínez-Castañeda, Á; Rodríguez-Solla, H | 1 |
| Hermansen, JR; Jas, GS; Johnson, CK; Kuczera, K; Middaugh, CR; Rentchler, EC; Słowicka, AM | 1 |
| Katrusiak, A; Rozwadowski, Z; Tabisz, Ł; Łęska, B | 1 |
| Childs, EW; Jas, GS; Kuczera, K; Middaugh, CR | 1 |
1 review(s) available for guanidine and proline
| Article | Year |
|---|---|
4(R/S)-Amino/guanidino-substituted proline peptides: design, synthesis and DNA transfection properties.
Topics: Amines; DNA; Guanidine; Molecular Conformation; Peptides; Proline; Stereoisomerism; Transfection | 2012 |
80 other study(ies) available for guanidine and proline
| Article | Year |
|---|---|
The rate of interconversion between the two unfolded forms of ribonuclease A does not depend on guanidinium chloride concentration.
Topics: Endonucleases; Guanidine; Guanidines; Isomerism; Proline; Protein Conformation; Protein Denaturation; Ribonuclease, Pancreatic; Ribonucleases | 1979 |
Reversible unfolding and refolding behavior of a monomeric aldolase from Staphylococcus aureus.
Topics: Enzyme Reactivators; Enzyme Stability; Fructose-Bisphosphate Aldolase; Guanidine; Guanidines; Hot Temperature; Isomerism; Models, Chemical; Proline; Protein Conformation; Protein Denaturation; Protein Folding; Staphylococcus aureus; Time Factors | 1992 |
Cis proline mutants of ribonuclease A. II. Elimination of the slow-folding forms by mutation.
Topics: Amino Acid Sequence; Animals; Cattle; Guanidine; Guanidines; Kinetics; Mutagenesis, Site-Directed; Proline; Protein Denaturation; Protein Folding; Recombinant Proteins; Ribonuclease, Pancreatic; Structure-Activity Relationship | 1992 |
Early hydrogen-bonding events in the folding reaction of ubiquitin.
Topics: Amino Acid Sequence; Calorimetry; Guanidine; Guanidines; Hydrogen Bonding; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Proline; Protein Conformation; Protein Denaturation; Ubiquitins | 1992 |
Kinetic coupling between protein folding and prolyl isomerization. II. Folding of ribonuclease A and ribonuclease T1.
Topics: Exoribonucleases; Guanidine; Guanidines; Kinetics; Proline; Protein Conformation; Ribonuclease, Pancreatic | 1992 |
Folding studies of the cysteine proteinase inhibitor--human stefin A.
Topics: Chromatography, High Pressure Liquid; Circular Dichroism; Cystatin A; Cystatins; Cysteine Proteinase Inhibitors; Guanidine; Guanidines; Humans; Kinetics; Pregnancy Proteins; Proline; Protein Conformation; Protein Denaturation; Spectrometry, Fluorescence; Stereoisomerism; Ultraviolet Rays | 1991 |
Folding of chymotrypsin inhibitor 2. 2. Influence of proline isomerization on the folding kinetics and thermodynamic characterization of the transition state of folding.
Topics: Catalysis; Chymotrypsin; Guanidine; Guanidines; Hydrogen-Ion Concentration; Isomerism; Kinetics; Peptides; Plant Proteins; Proline; Protein Conformation; Temperature; Thermodynamics | 1991 |
Role of conserved proline residues in stabilizing tryptophan synthase alpha subunit: analysis by mutants with alanine or glycine.
Topics: Alanine; Calorimetry; Circular Dichroism; Enzyme Stability; Glycine; Guanidine; Guanidines; Mutagenesis, Site-Directed; Proline; Protein Conformation; Protein Denaturation; Thermodynamics; Tryptophan Synthase | 1991 |
Folding of ribonuclease T1. 1. Existence of multiple unfolded states created by proline isomerization.
Topics: Endoribonucleases; Escherichia coli; Genes, Synthetic; Guanidine; Guanidines; Isomerism; Kinetics; Proline; Protein Conformation; Recombinant Proteins; Ribonuclease T1; Urea | 1990 |
Role of two proline-containing turns in the folding of porcine ribonuclease.
Topics: Ammonium Sulfate; Animals; Enzyme Stability; Guanidine; Guanidines; Kinetics; Proline; Protein Conformation; Protein Denaturation; Ribonuclease, Pancreatic; Swine; Temperature | 1990 |
Studies on the enzymatic and physicochemical behaviour of the trichloroacetic acid-treated and untreated bovine pancreatic ribonuclease.
Topics: Binding Sites; Chemical Phenomena; Chemistry, Physical; Circular Dichroism; Cyclic CMP; Enzyme Activation; Guanidine; Guanidines; Histidine; Hot Temperature; Hydrolysis; Kinetics; Magnetic Resonance Spectroscopy; Proline; Protein Conformation; Protein Denaturation; Ribonuclease, Pancreatic; RNA, Ribosomal; Thermodynamics; Trichloroacetic Acid | 1989 |
Replacement of a conserved proline eliminates the absorbance-detected slow folding phase of iso-2-cytochrome c.
Topics: Cytochrome c Group; Cytochromes c; Glycine; Guanidine; Guanidines; Kinetics; Models, Molecular; Proline; Protein Conformation; Saccharomyces cerevisiae; Spectrometry, Fluorescence | 1988 |
Guanidine hydrochloride induced equilibrium unfolding of mutant forms of iso-1-cytochrome c with replacement of proline-71.
Topics: Cytochrome c Group; Cytochromes c; Guanidine; Guanidines; Kinetics; Mutation; Proline; Protein Conformation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thermodynamics | 1986 |
Folding/unfolding kinetics of mutant forms of iso-1-cytochrome c with replacement of proline-71.
Topics: Cytochrome c Group; Cytochromes c; Guanidine; Guanidines; Kinetics; Mutation; Proline; Protein Conformation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 1986 |
Replacement of proline-76 with alanine eliminates the slowest kinetic phase in thioredoxin folding.
Topics: Alanine; Bacterial Proteins; Escherichia coli; Guanidine; Guanidines; Kinetics; Models, Molecular; Mutation; Proline; Protein Conformation; Protein Denaturation; Thioredoxins | 1987 |
Synthesis of type IV procollagen in lung explants.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Guanidine; Guanidines; Lung; Male; Organ Culture Techniques; Procollagen; Proline; Rats; Rats, Inbred Strains; Tritium | 1986 |
The yield of reactivation of lactic dehydrogenase after guanidine HCl denaturation is not determined by proline cis in equilibrium trans isomerization.
Topics: Animals; Enzyme Reactivators; Guanidine; Guanidines; In Vitro Techniques; Kinetics; L-Lactate Dehydrogenase; Muscles; Proline; Protein Denaturation; Stereoisomerism; Swine | 1982 |
Increased thermal stability of proteins in the presence of amino acids.
Topics: Amino Acids; Animals; Arginine; Cytochrome c Group; Drug Stability; Guanidine; Guanidines; Horses; Hot Temperature; Kinetics; Mitochondria, Heart; Proline; Protein Denaturation; Proteins; Thermodynamics | 1994 |
Folding pathway of guanidine-denatured disulfide-intact wild-type and mutant bovine pancreatic ribonuclease A.
Topics: Alanine; Animals; Binding Sites; Cattle; Cytidine Monophosphate; Disulfides; Guanidine; Guanidines; Kinetics; Mutagenesis, Site-Directed; Point Mutation; Proline; Protein Denaturation; Protein Folding; Recombinant Proteins; Ribonuclease, Pancreatic; Tyrosine | 1994 |
Conformational stability of alpha-lactalbumin missing a peptide bond between Asp66 and Pro67.
Topics: Amino Acid Sequence; Aspartic Acid; Circular Dichroism; Disulfides; Drug Stability; Ethanol; Formates; Guanidine; Guanidines; Lactalbumin; Proline; Protein Conformation; Protein Denaturation; Protein Structure, Secondary; Spectrometry, Fluorescence; Thermodynamics; Urea | 1994 |
Proline-protein interactions: protection of structural and functional integrity of M4 lactate dehydrogenase.
Topics: Animals; Binding Sites; Circular Dichroism; Enzyme Stability; Guanidine; Guanidines; Isoenzymes; Kinetics; L-Lactate Dehydrogenase; Muscles; Proline; Protein Binding; Protein Conformation; Rabbits; Spectrometry, Fluorescence | 1994 |
Dissociation of the tetrameric phosphoglycerate mutase from yeast by a mutation in the subunit contact region.
Topics: Circular Dichroism; Enzyme Stability; Guanidine; Guanidines; Kinetics; Lysine; Macromolecular Substances; Mutagenesis, Site-Directed; Mutation; Phosphoglycerate Mutase; Proline; Protein Conformation; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Saccharomyces cerevisiae | 1993 |
Hysteresis in the triple helix-coil transition of type III collagen.
Topics: Amino Acid Sequence; Animals; Calorimetry, Differential Scanning; Cattle; Cells, Cultured; Collagen; Cysteine; Ehlers-Danlos Syndrome; Fetus; Fibroblasts; Guanidine; Guanidines; Humans; Kinetics; Methionine; Molecular Sequence Data; Proline; Protein Denaturation; Protein Folding; Skin; Sulfur Radioisotopes; Thermodynamics; Tritium | 1993 |
Characterization of folding intermediates using prolyl isomerase.
Topics: Amino Acid Isomerases; Carrier Proteins; Catalysis; Cytochrome c Group; Cytochromes c; Guanidine; Guanidines; Models, Chemical; Mutation; Peptidylprolyl Isomerase; Proline; Protein Denaturation; Protein Folding; Saccharomyces cerevisiae; Time Factors | 1994 |
Effect of proline mutations on the stability and kinetics of folding of staphylococcal nuclease.
Topics: Amino Acid Sequence; Enzyme Stability; Guanidine; Guanidines; Kinetics; Micrococcal Nuclease; Mutagenesis; Proline; Protein Folding; Recombinant Proteins; Spectrometry, Fluorescence | 1993 |
Stability and folding kinetics of ribonuclease T1 are strongly altered by the replacement of cis-proline 39 with alanine.
Topics: Alanine; Base Sequence; Circular Dichroism; DNA; Enzyme Stability; Guanidine; Guanidines; Kinetics; Molecular Sequence Data; Proline; Protein Denaturation; Protein Folding; Ribonuclease T1 | 1993 |
High-pressure denaturation of staphylococcal nuclease proline-to-glycine substitution mutants.
Topics: Enzyme Stability; Escherichia coli; Fluorescence; Glycine; Guanidine; Guanidines; Kinetics; Micrococcal Nuclease; Models, Molecular; Mutagenesis; Point Mutation; Pressure; Proline; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Thermodynamics; Tryptophan | 1996 |
Folding and unfolding kinetics of the proline-to-alanine mutants of bovine pancreatic ribonuclease A.
Topics: Alanine; Animals; Cattle; Genes, Synthetic; Guanidine; Guanidines; Isomerism; Kinetics; Models, Chemical; Mutation; Pancreas; Proline; Protein Denaturation; Protein Folding; Recombinant Proteins; Ribonuclease, Pancreatic | 1996 |
Correlation between the differences in the free energy change and conformational energy in the folded state of hen lysozymes with Gly-Pro and Pro-Gly sequences introduced to the same site.
Topics: Amino Acid Sequence; Animals; Base Sequence; Chickens; Glycine; Guanidine; Guanidines; Kinetics; Models, Structural; Molecular Sequence Data; Muramidase; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Point Mutation; Proline; Protein Conformation; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Thermodynamics | 1995 |
The rate-limiting step in the folding of the cis-Pro167Thr mutant of TEM-1 beta-lactamase is the trans to cis isomerization of a non-proline peptide bond.
Topics: Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Enzyme Stability; Guanidine; Guanidines; Isomerism; Kinetics; Models, Molecular; Mutation; Proline; Protein Conformation; Protein Denaturation; Protein Folding; Spectrometry, Fluorescence; Thermodynamics | 1996 |
Nature of the unfolded state of ribonuclease A: effect of cis-trans X-Pro peptide bond isomerization.
Topics: Animals; Cattle; Cytidine Monophosphate; Enzyme Inhibitors; Guanidine; Guanidines; Hydrogen-Ion Concentration; Isomerism; Kinetics; Models, Chemical; Models, Molecular; Peptides; Proline; Protein Binding; Protein Conformation; Protein Denaturation; Protein Folding; Ribonuclease, Pancreatic; Spectrophotometry | 1996 |
Structure of a hydrophobically collapsed intermediate on the conformational folding pathway of ribonuclease A probed by hydrogen-deuterium exchange.
Topics: Amides; Amino Acid Sequence; Animals; Cattle; Deuterium; Guanidine; Guanidines; Hydrogen; Hydrogen Bonding; Hydrogen-Ion Concentration; Isomerism; Kinetics; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Proline; Protein Conformation; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Ribonuclease, Pancreatic | 1996 |
RhNGF slow unfolding is not due to proline isomerization: possibility of a cystine knot loop-threading mechanism.
Topics: Chromatography, High Pressure Liquid; Cystine; Dimerization; Guanidine; Guanidines; Humans; Magnetic Resonance Spectroscopy; Nerve Growth Factors; Osmolar Concentration; Proline; Protein Conformation; Protein Denaturation; Protein Folding; Protons; Recombinant Proteins; Spectrometry, Fluorescence; Temperature; Time Factors; Ultracentrifugation | 1996 |
Equilibrium and kinetic analyses of unfolding and refolding for the conserved proline mutants of tryptophan synthase alpha subunit.
Topics: Conserved Sequence; Enzyme Stability; Escherichia coli; Guanidine; Guanidines; Kinetics; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; Point Mutation; Proline; Protein Conformation; Protein Denaturation; Protein Folding; Thermodynamics; Tryptophan Synthase | 1997 |
Remarkably slow folding of a small protein.
Topics: Bacterial Proteins; Carrier Proteins; Circular Dichroism; Guanidine; Guanidines; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Proline; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Proteins; Spectrometry, Fluorescence; Temperature | 1997 |
The folding kinetics and thermodynamics of the Fyn-SH3 domain.
Topics: Amino Acid Sequence; Escherichia coli; Guanidine; Humans; In Vitro Techniques; Kinetics; Models, Molecular; Molecular Sequence Data; Proline; Protein Denaturation; Protein Folding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Spectrometry, Fluorescence; src Homology Domains; Thermodynamics; Tryptophan | 1998 |
Effect of introducing proline residues on the stability of Aspergillus awamori.
Topics: Aspergillus; Base Sequence; Enzyme Stability; Glucan 1,4-alpha-Glucosidase; Guanidine; Mutagenesis, Site-Directed; Osmolar Concentration; Proline; Protein Folding; Protein Structure, Tertiary; Temperature | 1997 |
Early and late M intermediates in the bacteriorhodopsin photocycle: a solid-state NMR study.
Topics: Bacteriorhodopsins; Carbon Isotopes; Guanidine; Halobacterium salinarum; Light; Lysine; Magnetic Resonance Spectroscopy; Nitrogen Isotopes; Photochemistry; Proline; Protein Conformation; Protons; Schiff Bases; Spectrophotometry | 1998 |
Proline isomerization-independent accumulation of an early intermediate and heterogeneity of the folding pathways of a mixed alpha/beta protein, Escherichia coli thioredoxin.
Topics: Circular Dichroism; Escherichia coli; Guanidine; Isomerism; Kinetics; Oxidation-Reduction; Proline; Protein Folding; Protein Structure, Secondary; Spectrometry, Fluorescence; Temperature; Thioredoxins | 1998 |
Decreasing the stability and changing the substrate specificity of the Bacillus stearothermophilus alcohol dehydrogenase by single amino acid replacements.
Topics: Alcohol Dehydrogenase; Alcohols; Amino Acid Substitution; Binding Sites; Catalytic Domain; Enzyme Stability; Escherichia coli; Geobacillus stearothermophilus; Glutamic Acid; Guanidine; Hydrogen-Ion Concentration; Kinetics; Mutagenesis, Site-Directed; NAD; Proline; Protein Denaturation; Recombinant Proteins; Substrate Specificity; Temperature | 1998 |
Functional and structural analysis of cis-proline mutants of Escherichia coli aspartate aminotransferase.
Topics: Alanine; Amino Acid Substitution; Aspartate Aminotransferases; Crystallography, X-Ray; Enzyme Activation; Escherichia coli; Guanidine; Hot Temperature; Kinetics; Ligands; Mutagenesis, Site-Directed; Proline; Protein Conformation; Protein Denaturation; Protein Folding; Spectrophotometry; Structure-Activity Relationship | 1999 |
Site-directed mutagenesis of proline 204 in the 'hinge' region of yeast phosphoglycerate kinase.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Calorimetry, Differential Scanning; Circular Dichroism; Enzyme Stability; Guanidine; Kinetics; Mutagenesis, Site-Directed; Mutation; Phosphoglycerate Kinase; Proline; Protein Denaturation; Protein Structure, Secondary; Protein Structure, Tertiary; Saccharomyces cerevisiae; Spectrometry, Fluorescence; Sulfates; Trypanosoma | 1999 |
Removal of the conserved disulfide bridges from the scFv fragment of an antibody: effects on folding kinetics and aggregation.
Topics: Conserved Sequence; Deuterium; Disulfides; Guanidine; Humans; Hydrogen; Immunoglobulin Fragments; Immunoglobulin Variable Region; Isomerism; Kinetics; Mass Spectrometry; Mutation; Proline; Protein Conformation; Protein Denaturation; Protein Folding; Solubility; Spectrometry, Fluorescence; Thermodynamics | 1999 |
Observation of multistate kinetics during the slow folding and unfolding of barstar.
Topics: Bacillus; Bacterial Proteins; Circular Dichroism; Dose-Response Relationship, Drug; Guanidine; Isoenzymes; Kinetics; Nuclear Magnetic Resonance, Biomolecular; Proline; Protein Folding; Ribonucleases; Spectrometry, Fluorescence; Temperature | 1999 |
Thermodynamics of replacing an alpha-helical Pro residue in the P40S mutant of Escherichia coli thioredoxin.
Topics: Amino Acid Substitution; Calorimetry; Escherichia coli; Guanidine; Mutagenesis, Site-Directed; Oxidation-Reduction; Proline; Protein Denaturation; Protein Structure, Secondary; Recombinant Proteins; Thermodynamics; Thioredoxins | 1999 |
Comparison of local and global stability of an analogue of a disulfide-folding intermediate with those of the wild-type protein in bovine pancreatic ribonuclease A: identification of specific regions of stable structure along the oxidative folding pathway
Topics: Amides; Animals; Cattle; Disulfides; Enzyme Stability; Guanidine; Hydrogen-Ion Concentration; Isoenzymes; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Proline; Protein Folding; Protons; Recombinant Proteins; Reproducibility of Results; Ribonuclease, Pancreatic; Temperature | 1999 |
Coupled kinetic traps in cytochrome c folding: His-heme misligation and proline isomerization.
Topics: Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Cytochrome c Group; Cytochromes c; Enzyme Stability; Fluorescence; Guanidine; Heme; Histidine; Hydrogen-Ion Concentration; Isomerism; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation; Proline; Protein Conformation; Protein Denaturation; Protein Folding; Protein Renaturation; Saccharomyces cerevisiae; Sequence Alignment; Thermodynamics | 2000 |
Fluorescence energy transfer indicates similar transient and equilibrium intermediates in staphylococcal nuclease folding.
Topics: Amino Acid Substitution; Anilino Naphthalenesulfonates; Anions; Circular Dichroism; Cysteine; Energy Transfer; Fluorescence; Guanidine; Hydrogen-Ion Concentration; Kinetics; Micrococcal Nuclease; Models, Molecular; Pliability; Proline; Protein Binding; Protein Denaturation; Protein Folding; Protein Renaturation; Protein Structure, Secondary; Thermodynamics; Titrimetry; Tryptophan; Urea | 2000 |
Post-translational hydroxylation at the N-terminus of the prion protein reveals presence of PPII structure in vivo.
Topics: Amino Acid Sequence; Animals; CHO Cells; Circular Dichroism; Cricetinae; Guanidine; Hydroxylation; Mice; Molecular Sequence Data; Osmolar Concentration; Oxidation-Reduction; Peptide Fragments; Peptides; Prions; Proline; Protein Denaturation; Protein Processing, Post-Translational; Protein Structure, Secondary; Protein Structure, Tertiary; PrPSc Proteins; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization; Temperature; Transfection | 2000 |
Preorganized secondary structure as an important determinant of fast protein folding.
Topics: Circular Dichroism; Diffusion; Guanidine; Isomerism; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Proline; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Staphylococcal Protein A; Thermodynamics | 2001 |
Practical and efficient synthesis of orthogonally protected constrained 4-guanidinoprolines.
Topics: Guanidine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Proline | 2001 |
Structural role of the proline residues of the beta-hinge region of p13suc1 as revealed by site-directed mutagenesis and fluorescence studies.
Topics: Cell Cycle Proteins; Cyclin-Dependent Kinases; Fungal Proteins; Guanidine; Mutagenesis, Site-Directed; Peptide Fragments; Proline; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Spectrometry, Fluorescence; Thermodynamics | 2001 |
Analysis of collagens solubilized from cartilage of normal and spontaneously osteoarthritic rhesus monkeys.
Topics: Animals; Cartilage, Articular; Collagen; Electrophoresis, Agar Gel; Guanidine; Macaca mulatta; Osteoarthritis, Knee; Proline | 1994 |
Dynamic association of trigger factor with protein substrates.
Topics: Amino Acid Substitution; Apoproteins; Bacterial Proteins; Circular Dichroism; Citrate (si)-Synthase; Escherichia coli Proteins; Gene Deletion; Genes, Lethal; Guanidine; Half-Life; HSP70 Heat-Shock Proteins; Isomerism; Kinetics; Lactalbumin; Molecular Chaperones; Oxidation-Reduction; Peptidylprolyl Isomerase; Proline; Protein Binding; Protein Conformation; Protein Denaturation; Protein Folding; Proteins; Ribonuclease T1; Spectrometry, Fluorescence; Thermodynamics | 2001 |
Folding of the yeast prion protein Ure2: kinetic evidence for folding and unfolding intermediates.
Topics: Amyloidosis; Dimerization; Fluorescence; Glutathione Peroxidase; Guanidine; Isomerism; Kinetics; Models, Biological; Mutation; Prions; Proline; Protein Denaturation; Protein Folding; Protein Renaturation; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Solutions; Thermodynamics; Water | 2002 |
Identification of proline residues responsible for the slow folding kinetics in pectate lyase C by mutagenesis.
Topics: Base Sequence; Calorimetry; DNA Primers; Escherichia coli; Guanidine; Isoenzymes; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmids; Polysaccharide-Lyases; Proline; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Recombinant Proteins; Spectrophotometry, Ultraviolet; Thermodynamics; X-Ray Diffraction | 2002 |
Proline isomerization in bovine pancreatic ribonuclease A. 2. Folding conditions.
Topics: Animals; Cattle; Guanidine; In Vitro Techniques; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Proline; Protein Conformation; Protein Denaturation; Protein Folding; Recombinant Proteins; Ribonuclease, Pancreatic; Stereoisomerism; Temperature | 2003 |
Amyloid fibril formation in the context of full-length protein: effects of proline mutations on the amyloid fibril formation of beta2-microglobulin.
Topics: Amyloid; beta 2-Microglobulin; Dimerization; Guanidine; Humans; Hydrogen-Ion Concentration; Mutagenesis, Site-Directed; Mutation, Missense; Proline; Protein Denaturation | 2003 |
The nature of the rate-limiting steps in the refolding of the cofactor-dependent protein aspartate aminotransferase.
Topics: Animals; Aspartate Aminotransferases; Cyclophilins; Escherichia coli; Guanidine; Hydrogen-Ion Concentration; Kinetics; Liver; Mass Spectrometry; Microscopy, Fluorescence; Models, Chemical; Peptides; Proline; Protein Binding; Protein Folding; Pyridoxal Phosphate; Rats; Spectrometry, Fluorescence; Temperature; Time Factors; Ultraviolet Rays | 2003 |
Modulating calcitonin fibrillogenesis: an antiparallel alpha-helical dimer inhibits fibrillation of salmon calcitonin.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Animals; Arginine; Calcitonin; Chromatography, Gel; Circular Dichroism; Dimerization; Dose-Response Relationship, Drug; Guanidine; Hydrogen Bonding; Hydrogen-Ion Concentration; Leucine; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Peptides; Proline; Protein Folding; Protein Structure, Secondary; Salmon; Sequence Homology, Amino Acid | 2004 |
Monitoring the early steps of unfolding of dicalcium and mono-Ce3+-substituted forms of P43M calbindin D9k.
Topics: Amides; Amino Acid Substitution; Animals; Calbindins; Calcium; Cations, Divalent; Cattle; Cerium; Guanidine; Methionine; Nuclear Magnetic Resonance, Biomolecular; Proline; Protein Conformation; Protein Denaturation; Protein Folding; Protons; S100 Calcium Binding Protein G; Solutions; Thermodynamics | 2003 |
Perturbation of folding and reassociation of lactate dehydrogenase by proline and trimethylamine oxide.
Topics: Animals; Catalysis; Cattle; Dose-Response Relationship, Drug; Guanidine; Hydrogen-Ion Concentration; Kinetics; L-Lactate Dehydrogenase; Methylamines; Myocardium; Proline; Protein Conformation; Protein Denaturation; Protein Folding; Protein Isoforms; Protein Renaturation; Swine; Time Factors | 2003 |
A likely biogenetic gateway linking 2-aminoimidazolinone metabolites of sponges to proline: spontaneous oxidative conversion of the pyrrole-proline-guanidine pseudo-peptide to dispacamide A.
Topics: Amination; Animals; Biomimetic Materials; Guanidine; Imidazoles; Oxidation-Reduction; Peptides; Porifera; Proline; Pyrroles | 2004 |
Context-dependent effects of proline residues on the stability and folding pathway of ubiquitin.
Topics: Amino Acid Substitution; Escherichia coli; Guanidine; Humans; Kinetics; Models, Molecular; Proline; Protein Denaturation; Protein Folding; Protein Renaturation; Recombinant Proteins; Spectrometry, Fluorescence; Temperature; Thermodynamics; Tryptophan; Ubiquitin | 2004 |
Influence of osmolytes on inactivation and aggregation of muscle glycogen phosphorylase b by guanidine hydrochloride. Stimulation of protein aggregation under crowding conditions.
Topics: Animals; Betaine; Dose-Response Relationship, Drug; Glycine; Glycogen Phosphorylase, Muscle Form; Guanidine; Kinetics; Methylamines; Muscle, Skeletal; Proline; Rabbits | 2005 |
Thermodynamics and kinetics of formation of the alkaline state of a Lys 79-->Ala/Lys 73-->His variant of iso-1-cytochrome c.
Topics: Alanine; Cytochromes c; Guanidine; Histidine; Hydrogen-Ion Concentration; Kinetics; Lysine; Mutagenesis, Site-Directed; Proline; Protein Denaturation; Saccharomyces cerevisiae Proteins; Static Electricity; Thermodynamics | 2005 |
Role of osmolytes as chemical chaperones during the refolding of aminoacylase.
Topics: Amidohydrolases; Anilino Naphthalenesulfonates; Animals; Circular Dichroism; Glycerol; Guanidine; Molecular Chaperones; Osmosis; Proline; Protein Folding; Protein Structure, Quaternary; Spectrometry, Fluorescence; Swine; Time Factors | 2006 |
The protective effects of osmolytes on arginine kinase unfolding and aggregation.
Topics: Anilino Naphthalenesulfonates; Animals; Arginine Kinase; Dimethyl Sulfoxide; Enzyme Activation; Fluorescence; Glycerol; Grasshoppers; Guanidine; Kinetics; Proline; Protein Denaturation; Protein Folding; Protein Structure, Quaternary; Spectrometry, Fluorescence; Sucrose | 2007 |
Fesselin is a natively unfolded protein.
Topics: Amino Acids; Animals; Chickens; Environment; Guanidine; Hot Temperature; Hydrogen-Ion Concentration; Membrane Proteins; Microfilament Proteins; Myosin Subfragments; Proline; Protein Binding; Protein Denaturation; Protein Folding; Spectrometry, Fluorescence; Tryptophan | 2007 |
Pockets of short-range transient order and restricted topological heterogeneity in the guanidine-denatured state ensemble of GED of dynamin.
Topics: Amino Acid Sequence; Circular Dichroism; Cloning, Molecular; Deuterium; DNA, Complementary; Dynamin I; Escherichia coli; Guanidine; Humans; Hydrogen-Ion Concentration; Models, Molecular; Molecular Sequence Data; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Plasmids; Proline; Protein Conformation; Protein Denaturation; Protein Structure, Tertiary; Spectrometry, Fluorescence; Temperature; Time Factors | 2007 |
Evidence that proline focuses movement of the floppy loop of arylalkylamine N-acetyltransferase (EC 2.3.1.87).
Topics: Animals; Arylalkylamine N-Acetyltransferase; Gene Expression; Guanidine; Models, Molecular; Mutation; Proline; Protein Denaturation; Protein Structure, Tertiary; Sheep; Substrate Specificity | 2008 |
Evidence that the amino acid residue P272 of arginine kinase is involved in its activity, structure and stability.
Topics: Animals; Arginine Kinase; Enzyme Stability; Grasshoppers; Guanidine; Mutation; Proline; Protein Folding; Protein Structure, Quaternary; Protein Structure, Tertiary; Spectrometry, Fluorescence; Structure-Activity Relationship; Temperature | 2008 |
Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation.
Topics: Alzheimer Disease; Antibodies; Circular Dichroism; Epitopes; Guanidine; Microscopy, Electron, Transmission; Mutation; Phosphorylation; Proline; Protein Conformation; Protein Denaturation; Protein Folding; Protein Structure, Secondary; tau Proteins | 2008 |
In silico molecular engineering for a targeted replacement in a tumor-homing peptide.
Topics: Amino Acid Sequence; Amino Acid Substitution; Arginine; Computer Simulation; Guanidine; Models, Molecular; Oligopeptides; Proline; Protein Conformation | 2009 |
Direct aldol reactions catalyzed by a heterogeneous guanidinium salt/proline system under solvent-free conditions.
Topics: Aldehydes; Azabicyclo Compounds; Catalysis; Guanidine; Molecular Structure; Proline; Salts; Stereoisomerism | 2011 |
Highly enantioselective proline-catalysed direct aldol reaction of chloroacetone and aromatic aldehydes.
Topics: Acetone; Aldehydes; Catalysis; Guanidine; Molecular Structure; Proline; Stereoisomerism | 2012 |
Highly enantioselective synthesis of α-azido-β-hydroxy methyl ketones catalyzed by a cooperative proline-guanidinium salt system.
Topics: Azides; Catalysis; Guanidine; Ketones; Methylation; Molecular Structure; Proline; Stereoisomerism | 2014 |
Reorientation Motion and Preferential Interactions of a Peptide in Denaturants and Osmolyte.
Topics: Fluorescence Polarization; Guanidine; Molecular Dynamics Simulation; Motion; Osmolar Concentration; Peptides; Proline; Protein Denaturation; Urea; Water | 2016 |
Exploring ion-ion preferences through structure-property correlations: amino acid-derived, bis(guanidinium) disiloxane salts.
Topics: Amino Acids; Anions; beta-Alanine; Butyric Acid; Crystallization; Glycine; Guanidine; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Ions; Proline; Silanes; Solubility; Solutions; Structure-Activity Relationship; Water | 2020 |
Probing the Internal Dynamics and Shape of Simple Peptides in Urea, Guanidinium Hydrochloride, and Proline Solutions with Time-Resolved Fluorescence Anisotropy and Atomistic Cosolvent Simulations.
Topics: Fluorescence Polarization; Guanidine; Peptides; Proline; Urea | 2021 |