Compounds > guanabenz

guanabenz and sephin1

guanabenz has been researched along with sephin1 in 11 studies

Research

Studies (11)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	7 (63.64)	24.3611
2020's	4 (36.36)	2.80

Authors

Authors	Studies
Barry, N; Bertolotti, A; D'Antonio, M; Das, I; Krzyzosiak, A; Schneider, K; Sigurdardottir, A; Wrabetz, L	1
Clayton, BLL; Popko, B	1
Chambers, JE; Crespillo-Casado, A; Fischer, PM; Marciniak, SJ; Ron, D	1
Bertolotti, A; Carrara, M; Sigurdardottir, A	1
Bollen, M; Choy, MS; Claes, Z; Crespillo-Casado, A; Peti, W; Ron, D	1
Chen, Y; Jones, J; Kunjamma, RB; Lin, W; Miller, SD; Podojil, JR; Popko, B; Weiner, M	1
Beck, C; Bertagnoli, S; Bessière, P; Dupré, G; Eléouët, JF; Fusade-Boyer, M; Gallardo, F; Khiar, S; Lajoie, B; Lecollinet, S; Quentin-Froignant, C; Rameix-Welti, MA; Tangy, F; Vidalain, PO; Volmer, R	1
Abdelaziz, DH; Abdulrahman, BA; Schatzl, HM; Thapa, S	1
Andreopoulou, E; Callejo, G; Chakrabarti, S; Greenhalgh, JC; Hockley, JRF; Pattison, LA; Rahman, T; Smith, ESJ	1
Alberdi, E; Luchena, C; Matute, C; Ortiz-Sanz, C; Ruiz, A; Zuazo, J	1
Abbink, TEM; Bartelink, I; Bugiani, M; de Veij Mestdagh, CF; Hoogterp, L; Hu-A-Ng, GV; Krzywańska, AM; Marinus, K; Oudejans, E; van der Knaap, MS; Witkamp, D; Žnidaršič, M	1

Reviews

1 review(s) available for guanabenz and sephin1

Article	Year
Endoplasmic reticulum stress and the unfolded protein response in disorders of myelinating glia. Brain research, 2016, 10-01, Volume: 1648, Issue:Pt B Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Demyelinating Diseases; Endoplasmic Reticulum Stress; Guanabenz; Humans; Neuroglia; Unfolded Protein Response	2016

Other Studies

10 other study(ies) available for guanabenz and sephin1

Article	Year
Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science (New York, N.Y.), 2015, Apr-10, Volume: 348, Issue:6231 Topics: Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Charcot-Marie-Tooth Disease; Disease Models, Animal; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Guanabenz; HeLa Cells; Humans; Mice; Mice, Transgenic; Molecular Targeted Therapy; Phosphorylation; Protein Folding; Protein Phosphatase 1; Proteostasis Deficiencies; Signal Transduction	2015
PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz. eLife, 2017, 04-27, Volume: 6 Topics: Enzyme Inhibitors; Eukaryotic Initiation Factor-2; Guanabenz; Protein Phosphatase 1; Protein Processing, Post-Translational	2017
Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors. Nature structural & molecular biology, 2017, Volume: 24, Issue:9 Topics: Eukaryotic Initiation Factor-2; Guanabenz; Humans; Membrane Proteins; Protein Binding; Protein Conformation; Protein Phosphatase 1; Recombinant Proteins	2017
A Sephin1-insensitive tripartite holophosphatase dephosphorylates translation initiation factor 2α. The Journal of biological chemistry, 2018, 05-18, Volume: 293, Issue:20 Topics: Actins; Animals; Catalytic Domain; Drug Resistance; Eukaryotic Initiation Factor-2; Gene Expression Regulation; Guanabenz; HeLa Cells; Humans; Phosphorylation; Protein Isoforms; Protein Phosphatase 1; Proteolysis; Rabbits	2018
Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis. Brain : a journal of neurology, 2019, 02-01, Volume: 142, Issue:2 Topics: Animals; Cells, Cultured; Encephalomyelitis, Autoimmune, Experimental; Female; Guanabenz; Humans; Immunity, Innate; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendroglia; Rats	2019
Evaluation of the Antiviral Activity of Sephin1 Treatment and Its Consequences on eIF2α Phosphorylation in Response to Viral Infections. Frontiers in immunology, 2019, Volume: 10 Topics: Animals; Antiviral Agents; Cell Line; DNA Viruses; Eukaryotic Initiation Factor-2; Guanabenz; Humans; Mice; Phosphorylation; Poxviridae Infections; Rabbits; RNA Viruses; Tumor Virus Infections; Virus Replication	2019
Sephin1 Reduces Prion Infection in Prion-Infected Cells and Animal Model. Molecular neurobiology, 2020, Volume: 57, Issue:5 Topics: Animals; Cell Line, Tumor; Drug Evaluation, Preclinical; Drug Synergism; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Guanabenz; Metformin; Mice; Neuroblastoma; Neuroprotective Agents; Phosphorylation; Prions; Protein Phosphatase 1; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; PrPC Proteins; PrPSc Proteins; Scrapie; Unfolded Protein Response	2020
In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3. Biochemical pharmacology, 2020, Volume: 174 Topics: Acid Sensing Ion Channels; Allosteric Regulation; Animals; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Guanabenz; Guanidines; Protein Structure, Secondary; Quinazolines	2020
Sephin1 Protects Neurons against Excitotoxicity Independently of the Integrated Stress Response. International journal of molecular sciences, 2020, Aug-24, Volume: 21, Issue:17 Topics: Animals; Calcium; Cells, Cultured; Cytoprotection; Embryo, Mammalian; Endoplasmic Reticulum Stress; Guanabenz; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Signal Transduction; Stress, Physiological	2020
Guanabenz ameliorates disease in vanishing white matter mice in contrast to sephin1. Annals of clinical and translational neurology, 2022, Volume: 9, Issue:8 Topics: Adrenergic Agents; Animals; Eukaryotic Initiation Factor-2B; Guanabenz; Mice; White Matter	2022