guanabenz and methyldopa

guanabenz has been researched along with methyldopa in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199013 (59.09)18.7374
1990's2 (9.09)18.2507
2000's3 (13.64)29.6817
2010's4 (18.18)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Campillo, NE; Guerra, A; Páez, JA1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Helfant, RH; Ramanathan, KB; Shah, RS; Vanov, SK; Walker, BR1
Chiummo, R1
Bhandare, PN; D'Souza, RS; Rataboli, PV1
MacLeod, SM; Manmontri, A1
Gehr, M; Goldberg, M1
Kaplan, NM1
Pandhi, P; Sharma, PL1
Giles, TD; Quiroz, AC; Sander, GE; Thomas, MG1
Gehr, M; Goldberg, M; MacCarthy, EP1
Drayer, JI; Weber, MA2
Houston, MC1
Finnerty, FA1
Rosendorff, C1
Deitch, MW; Hare, LE; Schneider, BE; Walker, BR1
Takishita, S; Yamazato, M1
Sica, DA1

Reviews

6 review(s) available for guanabenz and methyldopa

ArticleYear
Centrally acting sympatholytic agents in the treatment of congestive heart failure. A review of the literature.
    Drugs, 1990, Volume: 40, Issue:2

    Topics: Bromocriptine; Clinical Trials as Topic; Clonidine; Guanabenz; Heart Failure; Humans; Methyldopa; Sympatholytics

1990
Centrally acting antihypertensive agents: a brief overview.
    Journal of cardiovascular pharmacology, 1984, Volume: 6 Suppl 5

    Topics: Animals; Antihypertensive Agents; Central Nervous System; Clonidine; Guanabenz; Humans; Hypertension; Methyldopa; Reserpine; Sympathetic Nervous System

1984
Abrupt cessation of treatment in hypertension: consideration of clinical features, mechanisms, prevention and management of the discontinuation syndrome.
    American heart journal, 1981, Volume: 102, Issue:3 Pt 1

    Topics: Acute Disease; Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Bethanidine; Blood Pressure; Clonidine; Guanabenz; Heart Failure; Humans; Hypertension; Methyldopa; Myocardial Infarction; Pressoreceptors; Prospective Studies; Substance Withdrawal Syndrome; Syndrome; Time Factors

1981
Central and peripheral blockade of the sympathetic nervous system.
    The American journal of medicine, 1984, Oct-05, Volume: 77, Issue:4A

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Clonidine; Diuretics; Drug Therapy, Combination; Guanabenz; Humans; Hypertension; Indoramin; Labetalol; Methyldopa; Prazosin; Quinazolines; Reserpine; Sympathetic Nervous System; Sympatholytics

1984
[Centrally-acting antihypertensive drugs].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 3

    Topics: Antihypertensive Agents; Blood Pressure; Clonidine; Guanabenz; Guanfacine; Humans; Hypertension; Imidazoline Receptors; Kidney; Methyldopa; Norepinephrine; Pressoreceptors; Receptors, Drug; Renal Circulation; Sodium; Sympathetic Nervous System; Sympatholytics; Vascular Resistance

2004
Centrally acting antihypertensive agents: an update.
    Journal of clinical hypertension (Greenwich, Conn.), 2007, Volume: 9, Issue:5

    Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Blood Pressure; Clonidine; Contraindications; Guanabenz; Guanfacine; Humans; Hypertension; Imidazoles; Methyldopa; Oxazoles; Rilmenidine

2007

Trials

4 trial(s) available for guanabenz and methyldopa

ArticleYear
Guanabenz and methyldopa on hypertension and cardiac performance.
    Clinical pharmacology and therapeutics, 1977, Volume: 22, Issue:6

    Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Drug Evaluation; Female; Guanabenz; Guanidines; Hemodynamics; Humans; Hypertension; Male; Methyldopa; Middle Aged

1977
Alpha-adrenergic mechanisms in the pathophysiology of left ventricular heart failure--an analysis of their role in systolic and diastolic dysfunction.
    Journal of molecular and cellular cardiology, 1986, Volume: 18 Suppl 5

    Topics: Adrenergic alpha-Antagonists; Autonomic Nervous System; Central Nervous System; Clinical Trials as Topic; Clonidine; Diastole; Guanabenz; Heart Failure; Heart Ventricles; Humans; Methyldopa; Myocardial Contraction; Receptors, Adrenergic, alpha; Stroke Volume; Systole

1986
Guanabenz versus methyldopa in the therapy of mild-to-moderate hypertension.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1982, Sep-18, Volume: 62, Issue:13

    Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Methyldopa; Middle Aged

1982
Comparative antihypertensive effects of guanabenz and methyldopa.
    Clinical therapeutics, 1981, Volume: 4, Issue:4

    Topics: Blood Pressure; Body Weight; Double-Blind Method; Drug Evaluation; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Methyldopa; Posture; Random Allocation

1981

Other Studies

12 other study(ies) available for guanabenz and methyldopa

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics

2011
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
[Antihypertensive activity of a new molecule, 2,6-dichloro-benzylidene aminoguanidine acetate].
    Minerva medica, 1975, Dec-08, Volume: 66, Issue:84

    Topics: Aged; Antihypertensive Agents; Drug Evaluation; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Methyldopa; Middle Aged

1975
Dual action of clonidine on ethanol-induced gastric lesions: is the imidazoline-preferring receptor involved?
    European journal of pharmacology, 1991, Jun-25, Volume: 199, Issue:2

    Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dose-Response Relationship, Drug; Ethanol; Guanabenz; Imidazoline Receptors; Male; Methyldopa; Oxymetazoline; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Drug; Stomach; Yohimbine

1991
Effects of alpha-2 agonists on renal function in hypertensive humans.
    Journal of cardiovascular pharmacology, 1985, Volume: 7 Suppl 8

    Topics: Adrenergic alpha-Agonists; Clonidine; Diuresis; Glomerular Filtration Rate; Guanabenz; Humans; Hypertension; Kidney; Methyldopa; Natriuresis

1985
Alpha 2-adrenoceptor agonists in the treatment of hypertension.
    Journal of cardiovascular pharmacology, 1985, Volume: 7 Suppl 8

    Topics: Adrenergic alpha-Agonists; Clonidine; Diuretics; Drug Therapy, Combination; Guanabenz; Humans; Hypertension; Lipids; Methyldopa

1985
Progress in the treatment of essential hypertension.
    International journal of clinical pharmacology, therapy, and toxicology, 1985, Volume: 23 Suppl 1

    Topics: Adrenergic Agents; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Clonidine; Diuretics; Drug Therapy, Combination; Guanabenz; Humans; Hypertension; Methyldopa; Vasodilator Agents

1985
Natriuretic and water diuretic effects of central alpha 2-adrenoceptor agonists.
    Journal of cardiovascular pharmacology, 1984, Volume: 6 Suppl 5

    Topics: Adrenergic alpha-Agonists; Blood Pressure; Blood Volume; Clonidine; Diuresis; Guanabenz; Homeostasis; Humans; Methyldopa; Natriuresis; Sodium; Water-Electrolyte Balance

1984
Office management of hypertension.
    Comprehensive therapy, 1984, Volume: 10, Issue:2

    Topics: Adrenergic beta-Antagonists; Aged; Ambulatory Care; Antihypertensive Agents; Benzothiadiazines; Captopril; Clonidine; Diuretics; Guanabenz; Humans; Hydralazine; Hypertension; Methyldopa; Middle Aged; Prazosin; Reserpine; Sodium Chloride Symporter Inhibitors

1984
chemdatabank.com