guanabenz and guanoxabenz

guanabenz has been researched along with guanoxabenz in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19906 (35.29)18.7374
1990's10 (58.82)18.2507
2000's1 (5.88)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Uhlén, S; Wikberg, JE1
Dugarin, J; Gorceix, A; Pommier, F1
Berridge, TL; Gadie, B; Roach, AG; Tulloch, IF1
Dettmar, PW; Lynn, AG; Tulloch, IF1
Cavero, I; Doxey, JC; Roach, AG; Strachan, DA1
Bourdon, R; Hoffelt, J1
Cavellat, M; Chapillon, M; Delhumeau, A; Leboulanger, J1
García-Sevilla, JA; Sastre, M1
Cloix, JF; Dausse, JP; Le Jossec, M1
Clement, B; Demesmaeker, M; Linne, S1
Clement, B; Demesmaeker, M1
Dambrova, M; Uhlén, S; Welch, CJ; Wikberg, JE1
Dambrova, M; Oliver, DW; Tiger, G; Uhlén, S; Wikberg, JE1
Dambrova, M; Prusis, P; Uhlén, S; Welch, CJ; Wikberg, JE1
Dambrova, M; Uhlén, S; Wikberg, JE1
Cirule, H; Dambrova, M; Kalvinsh, I; Meirena, D; Veveris, M; Wikberg, JE1
Clement, B; Deters, S; Havemeyer, A; Mau, S1

Other Studies

17 other study(ies) available for guanabenz and guanoxabenz

ArticleYear
Delineation of three pharmacological subtypes of alpha 2-adrenoceptor in the rat kidney.
    British journal of pharmacology, 1991, Volume: 104, Issue:3

    Topics: Animals; Binding, Competitive; Computer Simulation; Dioxanes; Guanabenz; Idazoxan; In Vitro Techniques; Kidney; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine

1991
[Use of presynaptic alpha-mimetics for withdrawal in heroin addicts].
    Annales de medecine interne, 1985, Volume: 136, Issue:5

    Topics: Adrenergic alpha-Agonists; Adult; Female; Guanabenz; Guanfacine; Guanidines; Heroin Dependence; Hospitalization; Humans; Length of Stay; Male; Phenylacetates; Recurrence; Substance Withdrawal Syndrome; Time Factors

1985
alpha 2-Adrenoceptor agonists induced mydriasis in the rat by an action within the central nervous system.
    British journal of pharmacology, 1983, Volume: 78, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Atropine; Brain; Dioxins; Epinephrine; Guanabenz; Idazoxan; Injections, Intraventricular; Male; Mydriatics; Physostigmine; Pupil; Rats; Rats, Inbred Strains

1983
Neuropharmacological studies in rodents on the action of RX 781094, a new selective alpha 2-adrenoceptor antagonist.
    Neuropharmacology, 1983, Volume: 22, Issue:6

    Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Cerebral Cortex; Clonidine; Dioxins; Drug Antagonism; Electroencephalography; Guanabenz; Idazoxan; Male; Parietal Lobe; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Sleep; Wakefulness

1983
Sleeping times evoked by alpha adrenoceptor agonists in two-day-old chicks: an experimental model to evaluate full and partial agonists at central alpha-2 adrenoceptors.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 227, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain; Brimonidine Tartrate; Chickens; Clonidine; Guanabenz; Guanfacine; Guanidines; Imidazoles; Phenylacetates; Quinoxalines; Receptors, Adrenergic, alpha; Sleep; Thiophenes; Time Factors; Xylazine

1983
[Estimation of guanoxabenz in biological fluids (author's transl)].
    Annales de biologie clinique, 1980, Volume: 38, Issue:6

    Topics: Body Fluids; Chromatography, Gas; Guanabenz; Guanidines; Humans

1980
[Single dose of thiopental or fentanyl. Hemodynamic effects after treatment by an anti-hypertensive drug: guanoxabenz (author's transl)].
    Anesthesie, analgesie, reanimation, 1981, Volume: 38, Issue:3-4

    Topics: Aged; Antihypertensive Agents; Craniocerebral Trauma; Drug Interactions; Fentanyl; Guanabenz; Guanidines; Hemodynamics; Humans; Hypertension; Middle Aged; Thiopental

1981
Alpha 2-adrenoceptor subtypes identified by [3H]RX821002 binding in the human brain: the agonist guanoxabenz does not discriminate different forms of the predominant alpha 2A subtype.
    Journal of neurochemistry, 1994, Volume: 63, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Binding, Competitive; Brain; Dioxanes; Edetic Acid; Female; Guanabenz; Guanylyl Imidodiphosphate; Humans; Idazoxan; Imidazoles; Indoles; Isoindoles; Isoquinolines; Male; Piperazines; Receptors, Adrenergic, alpha; Sodium Chloride; Tritium

1994
[Evidence for two alpha 2B-adrenoreceptor isoforms in the renal cortex of salt-sensitive and salt resistant Sabra rats. Effect of salt loading].
    Archives des maladies du coeur et des vaisseaux, 1995, Volume: 88, Issue:8

    Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Binding, Competitive; Guanabenz; Hypertension; Kidney Cortex; Male; Oxymetazoline; Prazosin; Rats; Receptors, Adrenergic, alpha-2; Sodium, Dietary; Yohimbine

1995
Microsomal catalyzed N-hydroxylation of guanabenz and reduction of the N-hydroxylated metabolite: characterization of the two reactions and genotoxic potential of guanoxabenz.
    Chemical research in toxicology, 1996, Volume: 9, Issue:4

    Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Female; Guanabenz; Humans; Hydroxylation; Inactivation, Metabolic; Male; Mass Spectrometry; Microsomes, Liver; Mutagenicity Tests; NAD; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Rabbits; Spectrophotometry, Ultraviolet; Swine

1996
Formation of guanoxabenz from guanabenz in human liver. A new metabolic marker for CYP1A2.
    Drug metabolism and disposition: the biological fate of chemicals, 1997, Volume: 25, Issue:11

    Topics: Antihypertensive Agents; Biomarkers; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Guanabenz; Humans; Hydroxylation; In Vitro Techniques; Liver; Microsomes, Liver

1997
Identification of an N-hydroxyguanidine reducing activity of xanthine oxidase.
    European journal of biochemistry, 1998, Oct-01, Volume: 257, Issue:1

    Topics: Animals; Catalysis; Cattle; Guanabenz; Guanidines; Hydroxylamines; Kinetics; Milk; NAD; Oxidation-Reduction; Oxygen; Rats; Xanthine Oxidase

1998
Characterization of the enzymatic activity for biphasic competition by guanoxabenz (1-(2,6-dichlorobenzylidene-amino)-3-hydroxyguanidine) at alpha2-adrenoceptors. I. Description of an enzymatic activity in spleen membranes.
    Biochemical pharmacology, 1998, Nov-01, Volume: 56, Issue:9

    Topics: Animals; Antihypertensive Agents; Binding, Competitive; Cerebral Cortex; Guanabenz; Idazoxan; Magnesium; Male; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spleen; Xanthine Oxidase

1998
Characterization of the enzymatic activity for biphasic competition by guanoxabenz (1-(2,6-dichlorobenzylidene-amino)-3-hydroxyguanidine) at alpha2-adrenoceptors. II. Description of a xanthine-dependent enzymatic activity in spleen cytosol.
    Biochemical pharmacology, 1998, Nov-01, Volume: 56, Issue:9

    Topics: Allopurinol; Animals; Antihypertensive Agents; Binding, Competitive; Cytosol; Guanabenz; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spleen; Xanthine; Xanthine Oxidase

1998
Characterization of guanoxabenz reducing activity in rat brain.
    Pharmacology & toxicology, 1998, Volume: 83, Issue:4

    Topics: Allopurinol; Animals; Antihypertensive Agents; Binding, Competitive; Cerebral Cortex; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Guanabenz; Male; NAD; NADP; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Synaptic Membranes; Xanthine

1998
Cardioprotective effects of N-hydroxyguanidine PR5 in myocardial ischaemia and reperfusion in rats.
    British journal of pharmacology, 1999, Volume: 128, Issue:5

    Topics: Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Cardiovascular Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanabenz; Guanidines; Hydroxylamines; Male; Malondialdehyde; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Oxidation-Reduction; Rats; Rats, Wistar; Reperfusion Injury; Xanthine Oxidase

1999
Hepatic, extrahepatic, microsomal, and mitochondrial activation of the N-hydroxylated prodrugs benzamidoxime, guanoxabenz, and Ro 48-3656 ([[1-[(2s)-2-[[4-[(hydroxyamino)iminomethyl]benzoyl]amino]-1-oxopropyl]-4-piperidinyl]oxy]-acetic acid).
    Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:11

    Topics: Animals; Benzamidines; Cytochrome P-450 Enzyme System; Cytochrome-B(5) Reductase; Cytochromes b5; Guanabenz; Heterocyclic Compounds; Humans; In Vitro Techniques; Kidney; Kinetics; Liver; Microsomes, Liver; Mitochondria; Oximes; Prodrugs; Swine

2005