guaiane and gweicurculactone

guaiane has been researched along with gweicurculactone* in 3 studies

Other Studies

3 other study(ies) available for guaiane and gweicurculactone

ArticleYear
Antiinflammation constituents from Curcuma zedoaroides.
    Phytotherapy research : PTR, 2018, Volume: 32, Issue:11

    Curcuma zedoaroides, a Zingiberaceae species, has been used for snake bite antidote and wound care in Thailand. Seven compounds were isolated from the bioactive chloroform extract consisted of one new guaiane sesquiterpene lactone, 5-epiphaeocaulisin A (4) and one new diarylheptanoid, 1,2,3,5-tetrahydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl) heptane (7), together with five known guaiane-type sesquiterpene lactones including gweicurculactone (1), zedoalactone B (2), phaeocaulisin C (3), zedoalactone H (5), and zedoalactone E (6). The antiinflammation was investigated on NO and TNF-α production using RAW264.7 cells. In addition, the expressions of genes involved in inflammation including iNOS, COX-2, and TNF-α were assessed. The results found that Compounds 1-7 presented their antiinflammation against NO production. The most potential effects were demonstrated on Compounds 1 and 7 with IC

    Topics: Animals; Anti-Inflammatory Agents; Azulenes; Curcuma; Cyclooxygenase 2; Inflammation; Lactones; Mice; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase Type II; Plant Extracts; RAW 264.7 Cells; Rhizome; Sesquiterpenes; Sesquiterpenes, Guaiane; Thailand; Tumor Necrosis Factor-alpha

2018
Divergent pathways to furosesquiterpenes: first total syntheses of (+)-zedoarol and (Rac)-gweicurculactone.
    Chemical communications (Cambridge, England), 2015, Feb-11, Volume: 51, Issue:12

    A non-natural hydroxy-elemane was found amenable to divergent transformations, producing either polyunsaturated guaianes under basic, oxygen-free conditions, or oxidized furogermacranes when anionic oxy-Cope reaction quenched by an oxidant is employed. Based on these findings, the first total syntheses of zedoarol and gweicurculactone are reported.

    Topics: Azulenes; Furans; Lactones; Oxidation-Reduction; Sesquiterpenes; Sesquiterpenes, Guaiane; Stereoisomerism

2015
Three new guaiane sesquiterpene lactones from rhizomes of Curcuma wenyujin.
    Journal of Asian natural products research, 2013, Volume: 15, Issue:7

    Three new guaiane sesquiterpene lactones (4S)-4-hydroxy-gweicurculactone (1), zedoalactone G (2), and (1R, 4R, 5S, 10S)-zedoalactone B (3), and three known guaiane sesquiterpene lactones, including zedoarolide B (4), zedoalactone B (5), and a new natural product (+)-zedoalactone A (6), were isolated from the rhizomes of Curcuma wenyujin Y.H. Chen et C. Ling. The structures were elucidated by spectroscopic methods including 1D and 2D NMR and HR-ESI-MS. The absolute configuration of 2 was determined via the calculated electronic circular dichroism (ECD), whereas the absolute configurations of 1 and 3 were determined via the ECD data of the [Rh2(OCOCF3)4] complex and [Mo2(OAc)4] complex, respectively. The inhibitory effects of compounds 1-6 on nitric oxide production in lipopolysaccharide-activated macrophages were evaluated. All of them exhibited weak anti-inflammatory activity.

    Topics: Anti-Inflammatory Agents; Azulenes; Curcuma; Lactones; Lipopolysaccharides; Macrophages; Molecular Structure; Nitric Oxide; Nuclear Magnetic Resonance, Biomolecular; Rhizome; Sesquiterpenes; Sesquiterpenes, Guaiane

2013