gsk-j4 and nephrin

Podocytes are terminally differentiated and highly specialized glomerular cells, which have an essential role as a filtration barrier against proteinuria. Histone methylation has been shown to influence cell development, but its role in podocyte differentiation is less understood. In this study, we first examined the expression pattern of histone demethylase KDM6B at different times of cultured human podocytes

Topics: Benzazepines; Cell Differentiation; Gene Expression Regulation, Enzymologic; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Membrane Proteins; Methylation; Podocytes; Pyrimidines; WT1 Proteins