Page last updated: 2024-09-03

griseolic acid and adenosine

griseolic acid has been researched along with adenosine in 19 studies

Compound Research Comparison

Studies
(griseolic acid)
Trials
(griseolic acid)
Recent Studies (post-2010)
(griseolic acid)
Studies
(adenosine)
Trials
(adenosine)
Recent Studies (post-2010) (adenosine)
190032,5361,0758,930

Protein Interaction Comparison

ProteinTaxonomygriseolic acid (IC50)adenosine (IC50)
high affinity choline transporter 1 isoform aHomo sapiens (human)0.3851
Sodium/nucleoside cotransporter 1Homo sapiens (human)5.5
Sodium/nucleoside cotransporter 2Homo sapiens (human)5.5
Adenosine receptor A3Homo sapiens (human)0.0011
Adenosine receptor A1Homo sapiens (human)0.0023
Equilibrative nucleoside transporter 1Homo sapiens (human)63
Solute carrier family 28 member 3Homo sapiens (human)3.3

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19908 (42.11)18.7374
1990's10 (52.63)18.2507
2000's1 (5.26)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Haruyama, H; Miyakoshi, S; Shioiri, T; Takahashi, S; Torikata, A; Yamazaki, M1
Iijima, Y; Kaneko, M; Yamazaki, M; Yasumoto, T1
Ito, H; Kajinuma, H; Makino, H; Suzuki, T; Yamazaki, M; Yoshida, S1
Mitsui, K; Nagai, Y; Tsuji, S; Yamazaki, M1
Kiuchi, Y; Mishima, HK; Yamazaki, M; Yasumoto, T; Yokoyama, T1
Fukami, S; Iijima, Y; Kaneko, M; Kiuchi, Y; Mishima, H; Yamazaki, M; Yasumoto, T; Yokoyama, T1
Hashimoto, N; Kanatsuka, A; Makino, H; Yamazaki, M; Yoshida, S1
Kiuchi, Y1
Iijima, Y; Kaneko, M; Kimura, M; Murofushi, Y; Yamazaki, M4
Iijima, Y; Kaneko, M; Kimura, M; Kuwano, H; Murofushi, Y; Yamazaki, M1
Iijima, Y; Naito, A; Nakagawa, F; Okazaki, T; Yamazaki, M1
Furukawa, Y; Kawazoe, K; Naito, A; Nakagawa, F; Sato, S; Takahashi, S; Tamura, C1
Handa, S; Iijima, Y; Naito, A; Nakagawa, F; Oda, T; Yamazaki, M1
Kaneko, M; Yamazaki, M1
Ahn, HS; Czarniecki, M; Doll, RJ; Tulshian, D1
Dhavale, DD; Jachak, SM; Karche, NP1

Reviews

1 review(s) available for griseolic acid and adenosine

ArticleYear
[Phosphodiesterase inhibitor: griseolic acid, its' derivatives and their biological activities].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1995, Volume: 40, Issue:10

    Topics: Adenosine; Animals; Cyclic AMP; Cyclic GMP; Drug Design; Phosphodiesterase Inhibitors; Structure-Activity Relationship

1995

Other Studies

18 other study(ies) available for griseolic acid and adenosine

ArticleYear
Biosynthesis of griseolic acids: incorporation of 13C-labeled compounds into griseolic acid A.
    The Journal of antibiotics, 1992, Volume: 45, Issue:3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Carbon Isotopes; Streptomyces

1992
Properties of base-substituted and carboxyl-esterified analogues of griseolic acid, a potent cAMP phosphodiesterase inhibitor.
    Biochemical pharmacology, 1992, May-28, Volume: 43, Issue:10

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3T3 Cells; Adenosine; Adipose Tissue; Animals; Blood Platelets; Cattle; Cells, Cultured; Cyclic AMP; Esters; Mice; Rabbits; Retina; Rod Cell Outer Segment

1992
The role of insulin-sensitive phosphodiesterase in insulin action.
    Advances in second messenger and phosphoprotein research, 1992, Volume: 25

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Adipose Tissue; Animals; Cyclic AMP; Dose-Response Relationship, Drug; Glycerol; In Vitro Techniques; Insulin; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Tritium

1992
Multiple neurite formation in neuroblastoma cell lines by griseolic acid, a potent inhibitor of cyclic nucleotide phosphodiesterases.
    Journal of neurochemistry, 1991, Volume: 57, Issue:2

    Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; Axons; Bucladesine; Butyrates; Butyric Acid; Cell Differentiation; Cell Line; Cyclic AMP; DNA Replication; Neuroblastoma; Tetradecanoylphorbol Acetate; Tretinoin

1991
A cyclic AMP phosphodiesterase inhibitor, 8'-pivaloyloxymethyl ester (POM-ester) of griseolic acid, lowers rabbit intraocular pressure.
    Current eye research, 1991, Volume: 10, Issue:9

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Ciliary Body; Cornea; Cyclic GMP; Intraocular Pressure; Iris; Male; Permeability; Rabbits; Vitreous Body

1991
Griseolic acid, a cAMP phosphodiesterase inhibitor, and its ester: increase in cellular cAMP levels and reduction of intraocular pressure.
    Advances in second messenger and phosphoprotein research, 1990, Volume: 24

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Cattle; Cell Line; Cyclic AMP; Esters; Fibroblasts; Intraocular Pressure; Mice; Molecular Structure; Rabbits; Structure-Activity Relationship

1990
Effects of the new phosphodiesterase inhibitor griseolic acid on insulin release in rat pancreatic islets.
    Arzneimittel-Forschung, 1990, Volume: 40, Issue:10

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Calcium; Calcium Radioisotopes; Cyclic AMP; In Vitro Techniques; Insulin; Islets of Langerhans; Male; Rats; Rats, Inbred Strains

1990
[Changes in ocular hypotensive effect of griseolic acid with isoproterenol, timolol and melanin].
    Nippon Ganka Gakkai zasshi, 1990, Volume: 94, Issue:7

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Depression, Chemical; Drug Synergism; Female; Intraocular Pressure; Isoproterenol; Male; Melanins; Rabbits; Timolol

1990
Studies on griseolic acid derivatives. VI. Synthesis and phosphodiesterase-inhibitory activity of 6- and N1-substituted derivatives of griseolic acid.
    Chemical & pharmaceutical bulletin, 1988, Volume: 36, Issue:4

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Chemical Phenomena; Chemistry; Phosphodiesterase Inhibitors

1988
Studies on griseolic acid derivatives. VII. Synthesis and phosphodiesterase inhibitory activity of the C4'-C5' hydrogenated products of griseolic acid and their base-exchanged derivatives.
    Chemical & pharmaceutical bulletin, 1988, Volume: 36, Issue:10

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Chemical Phenomena; Chemistry; Phosphodiesterase Inhibitors; Structure-Activity Relationship

1988
Griseolic acid, an inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase. I. Taxonomy, isolation and characterization.
    The Journal of antibiotics, 1985, Volume: 38, Issue:7

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Aorta; Chemical Phenomena; Chemistry; Cyclic AMP; In Vitro Techniques; Rats; Streptomyces

1985
Griseolic acid, an inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase. II. The structure of griseolic acid.
    The Journal of antibiotics, 1985, Volume: 38, Issue:7

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Acetylation; Adenosine; Chromatography; Crystallography; Diazomethane; Hydrolysis; Magnetic Resonance Spectroscopy; Methanol; Molecular Conformation

1985
Biological properties of griseolic acid, a cyclic AMP phosphodiesterase inhibitor with an adenine group.
    FEBS letters, 1985, Nov-18, Volume: 192, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Adipose Tissue; Animals; Blood Glucose; Brain; Cerebral Cortex; Cricetinae; Cyclic AMP; Cyclic GMP; Guinea Pigs; In Vitro Techniques; Kinetics; Lipolysis; Liver; Liver Glycogen; Male; Mice; Mice, Inbred Strains; Rats; Rats, Inbred Strains

1985
Studies on griseolic acid derivatives. I. Synthesis of substituted derivatives of griseolic acid at the N1, C6, C2' or C7' position and their biological activities.
    Nucleic acids symposium series, 1985, Issue:16

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine; Animals; Brain; Indicators and Reagents; Rats; Structure-Activity Relationship

1985
Studies on griseolic acid derivatives. IV. Synthesis and phosphodiesterase inhibitory activity of acylated derivatives of griseolic acid.
    Chemical & pharmaceutical bulletin, 1987, Volume: 35, Issue:3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Acylation; Adenosine

1987
Studies on griseolic acid derivatives. V. Synthesis and phosphodiesterase inhibitory activity of substituted derivatives of the hydroxy group at the 2'- or 7'-position in griseolic acid.
    Chemical & pharmaceutical bulletin, 1987, Volume: 35, Issue:11

    Topics: Adenosine; Animals; Chemical Phenomena; Chemistry; In Vitro Techniques; Phosphodiesterase Inhibitors; Rats

1987
Synthesis and phosphodiesterase activity of carboxylic acid mimetics of cyclic guanosine 3',5'-monophosphate.
    Journal of medicinal chemistry, 1993, Apr-30, Volume: 36, Issue:9

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine; Carboxylic Acids; Computer Simulation; Cyclic GMP; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Structure; Structure-Activity Relationship

1993
Synthesis of griseolic acid analogues: regioselective alpha-facial [1,2]-migration in the rhodium acetate catalyzed reaction of D-glucose derived alpha-diazo-beta-keto ester.
    The Journal of organic chemistry, 2003, May-30, Volume: 68, Issue:11

    Topics: Adenosine; Azo Compounds; Catalysis; Chemistry, Organic; Glucose; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Rhodium; Stereoisomerism; Streptomyces

2003