Page last updated: 2024-08-25

grepafloxacin and carbostyril

grepafloxacin has been researched along with carbostyril in 81 studies

Research

Studies (81)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	76 (93.83)	18.2507
2000's	5 (6.17)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Goto, S; Imada, T; Miyazaki, S; Nishida, M; Yamaguchi, K	1
Erwin, ME; Jones, RN; Sader, HS	1
Chin, NX; Fang, W; Gu, JW; Neu, HC	1
Fang, W; Gu, JW; Neu, HC	1
Mitsuhashi, S; Wakebe, H	1
Mikami, Y; Yazawa, K	1
Allen, SD; Barry, AL; Fuchs, PC; Jorgensen, JH; Sewell, DL; Tenover, F	1
Andrews, JM; Child, J; Wise, R	1
Andrews, JM; Cook, PJ; Honeybourne, D; Moudgil, H; Wise, R	1
Finegold, SM; Molitoris, E; Wexler, HM	1
Sanders, CC; Thomson, KS	1
Arduino, RC; Frosolono, M; Murray, BE	1
Imada, T; Mukai, F; Ohguro, K; Ohmori, K; Tamaoka, H; Wakebe, H; Yabuuchi, Y; Yoneda, H	1
Appelbaum, PC; Jacobs, MR; Spangler, SK	1
Bale, MJ; Erwin, ME; Jones, RN	1
Frei, R; Hoban, DJ; Jones, RN; Marco, F; Pignatari, AC; Yamane, N	1
Andrews, JM; Honeybourne, D; Wise, R; Woodcock, JM	1
Hammerschlag, MR; Montalban, G; Roblin, PM	1
Allen, SD; Gerlach, EH; Jones, RN; Murray, PR; Sader, HS; Washington, JA	1
Jones, RN; Sanford, MD	1
Cartwright, FD; Kenny, GE	1
Koga, H; Kohno, S; Taira, K	1
Neumann, T; Patton, M; Reichart, C; Zenilman, JM	1
Akiyama, H; Nakano, M; Nakashima, M; Uematsu, T	1
Andrews, JM; Brenwald, N; Wise, R	1
Kashiwagi, H; Tanimura, H; Uchiyama, K	1
Matsuda, S	1
Kawano, Y; Matsubara, J; Morita, S; Ohguro, K; Ohmori, K; Ohtani, T; Otsubo, K; Uchida, M	1
Allen, SD; Barry, AL; Fuchs, PC; Murray, PR; Sewell, DL; Tenover, FC	1
Hecht, DW; Wexler, HM	1
Goldstein, EJ	1
Barry, AL; Fuchs, PC	1
Kanamaru, M; Kozawa, O; Matsuno, H; Nagashima, S; Niwa, M; Uematsu, T	1
Balfour, JA; Wagstaff, AJ	1
Barry, AL; Brown, SD; Fuchs, PC	1
Sasabe, H; Sugiyama, Y; Terasaki, T; Tsuji, A	1
Bean, K; Hook, EW; Jones, RB; Maroli, AN; Martin, D; McCormack, WM	1
Johnson, AP; Parsons, T; Warner, M	1
Bramer, SL; Efthymiopoulos, C; Maroli, A	3
Bass, N; Bramer, SL; Efthymiopoulos, C; Flaherty, JF; Maroli, A; Somberg, K; Wolfe, E	1
Bramer, SL; Efthymiopoulos, C; Gambertoglio, JG; Maroli, A	1
Blum, B; Bramer, SL; Efthymiopoulos, C; Maroli, A	1
Breisch, S; Chodosh, S; Lakshminarayan, S; Swarz, H	1
Kato, Y; Sasabe, H; Sugiyama, Y; Tsuji, A	1
Geddes, AM	1
Goldsmith, CE; Moore, JE; Murphy, PG	1
Heisig, P; Wiedemann, B	1
Andrews, JM; Wise, R	1
Dencer, C; Felmingham, D; Ridgway, GL; Robbins, MJ; Salman, H	1
Efthymiopoulos, C	1
Amantea, MA; Chodosh, S; Collins, DA; Forrest, A; Schentag, JJ	1
Breisch, S; Cranfield, R; Langan, CE; Pettit, R	1
Dutchman, DA; Maroli, A; O'Doherty, B; Pettit, R	1
Schwabe, R; Stahlmann, R	1
Dawe, R; Ferguson, J	1
Norrby, SR	1
Sasabe, H; Sugiyama, Y; Tsuji, A	1
Appelbaum, PC; Jacobs, MR; Pankuch, GA	1
Friis, HM	1
Maskell, JP; Sefton, AM; Whiley, AC	1
Owen, K	1
Hook, EW; Jones, RB; Martin, DH; McCormack, WM	1
Deschilder, I; Liekens, K; Lontie, M	1
Hashimoto, Y; Inui, K; Ito, T; Matsuo, Y; Yano, I	1
Lexchin, J	1
Heisig, P; Jones, ME; Klootwijk, M; Schmitz, FJ; Verhoef, J; Visser, MR	1
Hasimoto, K; Itoh, N; Owen, K; Takizawa, T; Yamashita, S	1
Elies, W; Lode, H; Vogel, F	1
Bagby, B; Bettis, R; Collins, JJ; DeAbate, CA; Fleming, H; Giguere, G; Munk, ZM; Munn, NJ; Riffer, E	1
Kato, Y; Sasabe, H; Sugiyama, Y; Terasaki, T; Tsuji, A	1
Frimpong, EK; Honda, T; Voravuthikunchai, SP; Yoh, M	1
Otsubo, K	1
Ikejima, H; Ishida, K; Kaku, M; Shimada, J; Yamamoto, H	1
Sato, K	1
Baumann-Wilschke, I; Rücker, M; Shakibaei, M; Stahlmann, R	1
Cai, SH; Hasegawa, T; Kitaichi, K; Nadai, M; Takagi, K; Tatsumi, Y; Wang, L; Yoshizumi, H; Zhao, YL	1

Reviews

9 review(s) available for grepafloxacin and carbostyril

Article	Year
Possible role for the new fluoroquinolones (levofloxacin, grepafloxacin, trovafloxacin, clinafloxacin, sparfloxacin, and DU-6859a) in the treatment of anaerobic infections: review of current information on efficacy and safety. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1996, Volume: 23 Suppl 1 Topics: Anti-Infective Agents; Bacteria, Anaerobic; Bacterial Infections; Fluoroquinolones; Humans; Levofloxacin; Naphthyridines; Ofloxacin; Piperazines; Quinolones; Safety; Syndrome	1996
Grepafloxacin. Drugs, 1997, Volume: 53, Issue:5 Topics: Anti-Infective Agents; Bacterial Infections; Fluoroquinolones; Humans; Multicenter Studies as Topic; Piperazines; Quinolones; Randomized Controlled Trials as Topic	1997
Grepafloxacin--focus on respiratory infections. The Journal of antimicrobial chemotherapy, 1997, Volume: 40 Suppl A Topics: Anti-Infective Agents; Fluoroquinolones; Humans; Piperazines; Quinolones; Respiratory Tract Infections	1997
Antibacterial activity of grepafloxacin. The Journal of antimicrobial chemotherapy, 1997, Volume: 40 Suppl A Topics: Anti-Infective Agents; Bacterial Infections; Fluoroquinolones; Humans; Piperazines; Quinolones	1997
Pharmacokinetics of grepafloxacin. The Journal of antimicrobial chemotherapy, 1997, Volume: 40 Suppl A Topics: Administration, Oral; Anti-Infective Agents; Biological Availability; Drug Interactions; Fluoroquinolones; Humans; Piperazines; Quinolones	1997
Safety profile of grepafloxacin compared with other fluoroquinolones. The Journal of antimicrobial chemotherapy, 1997, Volume: 40 Suppl A Topics: Animals; Anti-Infective Agents; Bacterial Infections; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Evaluation; Fluoroquinolones; Humans; Piperazines; Quinolones	1997
Grepafloxacin in respiratory tract infections: are we ready to accept a quinolone for empirical treatment? The Journal of antimicrobial chemotherapy, 1997, Volume: 40 Suppl A Topics: Anti-Infective Agents; Bacterial Infections; Drug Resistance, Microbial; Fluoroquinolones; Humans; Piperazines; Quinolones; Respiratory Tract Infections	1997
Grepafloxacin: a review of its safety profile based on clinical trials and postmarketing surveillance. Clinical therapeutics, 1999, Volume: 21, Issue:1 Topics: Animals; Anti-Infective Agents; Clinical Trials as Topic; Drug Interactions; Fluoroquinolones; Humans; Piperazines; Product Surveillance, Postmarketing; Quinolones; Respiratory Tract Infections	1999
[Studies on the efficient syntheses of the drug metabolites]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2000, Volume: 120, Issue:11 Topics: Animals; Anti-Infective Agents; Benzazepines; Chemistry, Organic; Cytochrome P-450 Enzyme System; Fluoroquinolones; Imidazoles; Indans; Lipase; Organic Chemistry Phenomena; Piperazines; Piperidines; Platelet Aggregation Inhibitors; Quinolones; Stereoisomerism; Sulfur Compounds	2000

Trials

16 trial(s) available for grepafloxacin and carbostyril

Article	Year
The measurement of a new antimicrobial quinolone in hair as an index of drug exposure. British journal of clinical pharmacology, 1993, Volume: 35, Issue:2 Topics: Adult; Anti-Infective Agents; Diffusion; Fluoroquinolones; Hair; Humans; Male; Piperazines; Quinolones; Scalp; Tissue Distribution	1993
Gallbladder tissue concentrations, biliary excretion and pharmacokinetics of OPC-17116. Drugs, 1995, Volume: 49 Suppl 2 Topics: Anti-Infective Agents; Bile; Biotransformation; Fluoroquinolones; Gallbladder; Humans; Piperazines; Quinolones	1995
Clinical experience with OPC-17116 in the treatment of gynaecological infections and its penetration into gynaecological tissues. Japanese Collaborative Study Group of OPC-17116 in Gynaecology. Drugs, 1995, Volume: 49 Suppl 2 Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Female; Fluoroquinolones; Genital Diseases, Female; Genitalia, Female; Humans; Middle Aged; Piperazines; Quinolones	1995
Comparative study of pharmacokinetics of two new fluoroquinolones, balofloxacin and grepafloxacin, in elderly subjects. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:12 Topics: Aged; Aging; Anti-Infective Agents; Female; Fluoroquinolones; Humans; Male; Piperazines; Quinolones	1996
Comparison of single-dose oral grepafloxacin with cefixime for treatment of uncomplicated gonorrhea in men. The STD Study Group. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:8 Topics: Administration, Oral; Adolescent; Anti-Infective Agents; beta-Lactam Resistance; Cefixime; Cefotaxime; Cephalosporins; Fluoroquinolones; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Penicillin Resistance; Piperazines; Quinolones	1997
Pharmacokinetics of grepafloxacin after oral administration of single and repeat doses in healthy young males. Clinical pharmacokinetics, 1997, Volume: 33 Suppl 1 Topics: Administration, Oral; Adult; Anti-Infective Agents; Area Under Curve; Chromatography, High Pressure Liquid; Double-Blind Method; Fluoroquinolones; Half-Life; Humans; Male; Piperazines; Quinolones; Tissue Distribution	1997
Effect of food and gastric pH on the bioavailability of grepafloxacin. Clinical pharmacokinetics, 1997, Volume: 33 Suppl 1 Topics: Adult; Anti-Infective Agents; Area Under Curve; Biological Availability; Cross-Over Studies; Diet; Drug Interactions; Famotidine; Fasting; Fluoroquinolones; Food-Drug Interactions; Gastric Acid; Histamine H2 Antagonists; Humans; Male; Piperazines; Quinolones	1997
Grepafloxacin pharmacokinetics in individuals with hepatic dysfunction. Clinical pharmacokinetics, 1997, Volume: 33 Suppl 1 Topics: Administration, Oral; Adult; Aged; Anti-Infective Agents; Area Under Curve; Drug Monitoring; Female; Fluoroquinolones; Humans; Liver Diseases; Male; Middle Aged; Piperazines; Quinolones	1997
Theophylline and warfarin interaction studies with grepafloxacin. Clinical pharmacokinetics, 1997, Volume: 33 Suppl 1 Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Anti-Infective Agents; Area Under Curve; Chromatography, High Pressure Liquid; Drug Interactions; Female; Fluoroquinolones; Humans; Male; Piperazines; Quinolones; Single-Blind Method; Theophylline; Warfarin	1997
Efficacy and safety of a 10-day course of 400 or 600 milligrams of grepafloxacin once daily for treatment of acute bacterial exacerbations of chronic bronchitis: comparison with a 10-day course of 500 milligrams of ciprofloxacin twice daily. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:1 Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Bronchitis; Bronchodilator Agents; Chronic Disease; Ciprofloxacin; Double-Blind Method; Drug Administration Schedule; Female; Fluoroquinolones; Humans; Male; Middle Aged; Piperazines; Prospective Studies; Quinolones; Theophylline; Treatment Outcome	1998
Pharmacokinetics and pharmacodynamics of oral grepafloxacin in patients with acute bacterial exacerbations of chronic bronchitis. The Journal of antimicrobial chemotherapy, 1997, Volume: 40 Suppl A Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analysis of Variance; Anti-Infective Agents; Bacteria; Bacterial Infections; Bronchitis; Chronic Disease; Dose-Response Relationship, Drug; Female; Fluoroquinolones; Humans; Male; Middle Aged; Models, Biological; Piperazines; Quinolones; Time Factors	1997
Randomized, double-blind study of grepafloxacin versus amoxycillin in patients with acute bacterial exacerbations of chronic bronchitis. The Journal of antimicrobial chemotherapy, 1997, Volume: 40 Suppl A Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Infective Agents; Bacteria; Bacterial Infections; Bronchitis; Chronic Disease; Double-Blind Method; Female; Fluoroquinolones; Hematologic Tests; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Penicillins; Piperazines; Quinolones; Treatment Outcome	1997
Randomized, double-blind, comparative study of grepafloxacin and amoxycillin in the treatment of patients with community-acquired pneumonia. The Journal of antimicrobial chemotherapy, 1997, Volume: 40 Suppl A Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Infective Agents; Bacteria; Community-Acquired Infections; Double-Blind Method; Female; Fluoroquinolones; Hematologic Tests; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Patient Dropouts; Penicillins; Piperazines; Pneumonia, Bacterial; Quinolones; Treatment Outcome	1997
Phototoxicity in quinolones: comparison of ciprofloxacin and grepafloxacin. The Journal of antimicrobial chemotherapy, 1997, Volume: 40 Suppl A Topics: Adolescent; Adult; Anti-Infective Agents; Ciprofloxacin; Dermatitis, Phototoxic; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Double-Blind Method; Drug Administration Schedule; Erythema; Female; Fluoroquinolones; Humans; Male; Middle Aged; Piperazines; Placebos; Quinolones; Reference Standards; Skin Pigmentation; Ultraviolet Rays	1997
Daily oral grepafloxacin vs. twice daily oral doxycycline in the treatment of Chlamydia trachomatis endocervical infection. Infectious diseases in obstetrics and gynecology, 1998, Volume: 6, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Chlamydia Infections; Chlamydia trachomatis; Double-Blind Method; Doxycycline; Drug Administration Schedule; Female; Fluoroquinolones; Humans; Middle Aged; Piperazines; Quinolones; Treatment Outcome; Uterine Cervicitis	1998
Effectiveness of short-course therapy (5 days) with grepafloxacin in the treatment of acute bacterial exacerbations of chronic bronchitis. Clinical therapeutics, 1999, Volume: 21, Issue:1 Topics: Acute Disease; Adult; Aged; Anti-Infective Agents; Bacterial Infections; Bronchitis; Chronic Disease; Double-Blind Method; Drug Administration Schedule; Female; Fluoroquinolones; Humans; Male; Middle Aged; Piperazines; Quinolones	1999

Other Studies

56 other study(ies) available for grepafloxacin and carbostyril

Article	Year
In vitro and in vivo antibacterial activities of a new quinolone, OPC-17116. Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:3 Topics: Administration, Oral; Animals; Anti-Infective Agents; Bacterial Infections; Female; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Piperazines; Quinolones; Tissue Distribution	1992
In vitro activity of OPC-17116 compared to other broad-spectrum fluoroquinolones. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1992, Volume: 11, Issue:4 Topics: Anti-Infective Agents; Drug Evaluation, Preclinical; Drug Resistance, Microbial; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Mutation; Piperazines; Quinolones	1992
In vitro activity of OPC-17116. Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:6 Topics: Anti-Infective Agents; Bacteria; Drug Resistance, Microbial; Fluoroquinolones; Microbial Sensitivity Tests; Piperazines; Quinolones	1992
Plasma bactericidal activity of a new C-5 methyl fluoroquinolone after oral doses of 400 and 800 mg. Journal of clinical pharmacology, 1992, Volume: 32, Issue:9 Topics: Administration, Oral; Anti-Infective Agents; Bacteria; Drug Administration Schedule; Fluoroquinolones; Humans; Male; Microbial Sensitivity Tests; Piperazines; Quinolones	1992
Comparative in vitro activities of a new quinolone, OPC-17116, possessing potent activity against gram-positive bacteria. Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:10 Topics: Anti-Infective Agents; Ciprofloxacin; DNA Topoisomerases, Type II; Fluoroquinolones; Gram-Positive Bacteria; Microbial Sensitivity Tests; Norfloxacin; Ofloxacin; Piperazines; Quinolones; Staphylococcus aureus	1992
In-vitro antimicrobial activity of the new fluoroquinolone, grepafloxacin, against pathogenic Nocardia spp. The Journal of antimicrobial chemotherapy, 1995, Volume: 35, Issue:4 Topics: Anti-Infective Agents; Fluoroquinolones; Microbial Sensitivity Tests; Nocardia; Piperazines; Quinolones	1995
Tentative criteria for determining the in vitro susceptibilities of Haemophilus influenzae, including quality control parameters, to two fluoroquinolones (grepafloxacin and PD 131628). Diagnostic microbiology and infectious disease, 1995, Volume: 21, Issue:3 Topics: Anti-Infective Agents; Fluoroquinolones; Haemophilus influenzae; Humans; Microbial Sensitivity Tests; Naphthyridines; Piperazines; Quality Control; Quinolones	1995
Pharmacokinetics and tissue penetration of the new fluoroquinolone grepafloxacin. Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:2 Topics: Adult; Anti-Infective Agents; Blister; Fluoroquinolones; Humans; Male; Piperazines; Quinolones	1995
Concentrations of OPC-17116, a new fluoroquinolone antibacterial, in serum and lung compartments. The Journal of antimicrobial chemotherapy, 1995, Volume: 35, Issue:2 Topics: Adult; Aged; Anti-Infective Agents; Bacterial Infections; Bronchoalveolar Lavage Fluid; Female; Fluoroquinolones; Humans; Lung; Macrophages, Alveolar; Male; Middle Aged; Mucous Membrane; Piperazines; Quinolones; Tissue Distribution	1995
In vitro activity of grepafloxacin (OPC-17116) against anaerobic bacteria. Diagnostic microbiology and infectious disease, 1994, Volume: 19, Issue:2 Topics: Anti-Infective Agents; Bacteria, Anaerobic; Fluoroquinolones; Microbial Sensitivity Tests; Piperazines; Quinolones	1994
Dissociated resistance among fluoroquinolones. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:9 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Mutation; Ofloxacin; Piperazines; Quinolones	1994
In-vitro activity of OPC-17116 against bacterial enteric pathogens. The Journal of antimicrobial chemotherapy, 1994, Volume: 34, Issue:3 Topics: Anti-Infective Agents; Ciprofloxacin; Enterobacteriaceae; Escherichia coli; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Piperazines; Quinolones; Tetracycline; Trimethoprim	1994
Evaluation of OPC-17116 against important pathogens that cause respiratory tract infections. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:10 Topics: Animals; Anti-Infective Agents; Bacteria; Bacterial Infections; Fluoroquinolones; Male; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Piperazines; Pneumonia; Quinolones; Rats; Rats, Sprague-Dawley; Respiratory Tract Infections	1994
Activity of CP 99,219 compared with those of ciprofloxacin, grepafloxacin, metronidazole, cefoxitin, piperacillin, and piperacillin-tazobactam against 489 anaerobes. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:10 Topics: Anti-Infective Agents; Bacteria, Anaerobic; Cefoxitin; Ciprofloxacin; Fluoroquinolones; Metronidazole; Microbial Sensitivity Tests; Naphthyridines; Penicillanic Acid; Piperacillin; Piperazines; Quinolones; Tazobactam	1994
Minimum inhibitory concentration quality-control guidelines for biapenem, DU-6859a, FK-037, levofloxacin, grepafloxacin, and ceftizoxime when using various National Committee for Clinical Laboratory Standards susceptibility test methods. Quality Control S Diagnostic microbiology and infectious disease, 1994, Volume: 19, Issue:1 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Ceftizoxime; Fluoroquinolones; Levofloxacin; Microbial Sensitivity Tests; Ofloxacin; Piperazines; Quality Control; Quinolones; Reference Values; Spiro Compounds; Thienamycins	1994
In-vitro activity of OPC-17116 against more than 6000 consecutive clinical isolates: a multicentre international study. The Journal of antimicrobial chemotherapy, 1994, Volume: 33, Issue:3 Topics: Anti-Infective Agents; Bacteria; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Piperazines; Quinolones	1994
Determination of OPC-17116, a new fluoroquinolone, in human alveolar macrophages and other biological matrices by high performance liquid chromatography (HPLC). FEMS microbiology letters, 1994, Jun-15, Volume: 119, Issue:3 Topics: Anti-Infective Agents; Bronchoalveolar Lavage Fluid; Chromatography, High Pressure Liquid; Fluoroquinolones; Humans; Macrophages, Alveolar; Piperazines; Quinolones	1994
In vitro activities of OPC-17116, a new quinolone; ofloxacin; and sparfloxacin against Chlamydia pneumoniae. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:6 Topics: Anti-Infective Agents; Chlamydophila pneumoniae; Fluoroquinolones; Microbial Sensitivity Tests; Ofloxacin; Piperazines; Quinolones	1994
In vitro comparison activity of OPC-17116, a new fluoroquinolone, against more than 5,000 recent clinical isolates from five medical centers. Journal of chemotherapy (Florence, Italy), 1993, Volume: 5, Issue:5 Topics: Anti-Infective Agents; Bacteria; Drug Resistance, Microbial; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Piperazines; Quinolones	1993
Postantibiotic effects of E-4868 and OPC-17116. The Journal of antimicrobial chemotherapy, 1993, Volume: 32, Issue:6 Topics: Anti-Infective Agents; Enterococcus faecalis; Escherichia coli; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Piperazines; Pseudomonas aeruginosa; Quinolones; Staphylococcus aureus	1993
Susceptibilities of Mycoplasma hominis, Mycoplasma pneumoniae, and Ureaplasma urealyticum to a new quinolone, OPC 17116. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:8 Topics: Anti-Infective Agents; Fluoroquinolones; Microbial Sensitivity Tests; Mycoplasma; Mycoplasma pneumoniae; Ofloxacin; Piperazines; Quinolones; Ureaplasma urealyticum	1993
Accumulation of a newly developed fluoroquinolone, OPC-17116, by human polymorphonuclear leukocytes. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:9 Topics: Adult; Anti-Infective Agents; Chemical Phenomena; Chemistry, Physical; Fluoroquinolones; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Neutrophils; Piperazines; Quinolones; Spectrometry, Fluorescence; Temperature	1993
Antibacterial activities of OPC-17116, ofloxacin, and ciprofloxacin against 200 isolates of Neisseria gonorrhoeae. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:10 Topics: Anti-Infective Agents; Ciprofloxacin; Fluoroquinolones; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Ofloxacin; Penicillin Resistance; Piperazines; Quinolones; Tetracycline Resistance	1993
The in-vitro activity of OPC-17116, a new 5-methyl substituted quinolone. The Journal of antimicrobial chemotherapy, 1993, Volume: 31, Issue:4 Topics: Amoxicillin; Anti-Infective Agents; Bacteroides fragilis; Cefaclor; Chlamydia trachomatis; Chlamydophila pneumoniae; Ciprofloxacin; Fluoroquinolones; Haemophilus influenzae; Humans; Microbial Sensitivity Tests; Norfloxacin; Piperazines; Protein Binding; Quinolones; Staphylococcus	1993
Synthesis of possible metabolites of 1-cyclopropyl-1,4-dihydro-6-fluoro-5-methyl-7-(3-methyl-1-piperazinyl)- 4-oxo-3-quinolinecarboxylic acid (Grepafloxacin, OPC-17116). Chemical & pharmaceutical bulletin, 1995, Volume: 43, Issue:12 Topics: Animals; Anti-Infective Agents; Biotransformation; Chemical Phenomena; Chemistry, Physical; Dogs; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; Piperazines; Quinolones; Rats	1995
Tentative interpretive criteria and quality control parameters for in-vitro susceptibility testing of Neisseria gonorrhoeae to two fluoroquinolones (PD 131628 and grepafloxacin (OPC 17116)). The Journal of antimicrobial chemotherapy, 1996, Volume: 37, Issue:1 Topics: Anti-Infective Agents; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Naphthyridines; Neisseria gonorrhoeae; Piperazines; Quality Control; Quinolones	1996
In vitro susceptibility of anaerobes to quinolones in the United States. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1996, Volume: 23 Suppl 1 Topics: Anti-Infective Agents; Bacteria, Anaerobic; Culture Media; Drug Resistance, Microbial; Evaluation Studies as Topic; Fluoroquinolones; Humans; In Vitro Techniques; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Piperazines; Quinolones; United States	1996
Antibacterial activities of grepafloxacin, ciprofloxacin, ofloxacin and fleroxacin. Journal of chemotherapy (Florence, Italy), 1997, Volume: 9, Issue:1 Topics: Anti-Infective Agents; Bacteria, Anaerobic; Ciprofloxacin; Drug Evaluation, Preclinical; Drug Resistance, Microbial; Enterobacteriaceae; Fleroxacin; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Mutation; Ofloxacin; Piperazines; Quinolones	1997
Is Escherichia coli ATCC 25922 useful for monitoring broth microdilution tests of fluoroquinolones? The Journal of antimicrobial chemotherapy, 1997, Volume: 39, Issue:4 Topics: Anti-Infective Agents; Ciprofloxacin; Dose-Response Relationship, Drug; Escherichia coli; Fluoroquinolones; Microbial Sensitivity Tests; Ofloxacin; Piperazines; Quinolones; Reproducibility of Results	1997
Carrier-mediated hepatic uptake of quinolone antibiotics in the rat. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:1 Topics: Animals; Anti-Infective Agents; Biological Transport; Carrier Proteins; Dose-Response Relationship, Drug; Fluoroquinolones; Hydrogen-Ion Concentration; Liver; Male; Piperazines; Quinolones; Rats; Rats, Sprague-Dawley	1997
Activity of grepafloxacin against respiratory isolates of Streptococcus pneumoniae. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1997, Volume: 16, Issue:8 Topics: Anti-Infective Agents; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Piperazines; Pneumococcal Infections; Quinolones; Respiratory Tract Infections; Sputum; Streptococcus pneumoniae	1997
[Grepafloxacin (Vaxar)--innovative antibiotic for therapy of respiratory tract infections. Symposium: "Grepafloxacin--a new quinolone designed for respiratory tract infection. Lausanne/Switzerland, 25 May 1997]. Pneumologie (Stuttgart, Germany), 1997, Volume: 51, Issue:9 Suppl Topics: Anti-Infective Agents; Fluoroquinolones; Humans; Piperazines; Quinolones; Respiratory Tract Infections; Switzerland	1997
Effect of age and gender on the pharmacokinetics of grepafloxacin. Clinical pharmacokinetics, 1997, Volume: 33 Suppl 1 Topics: Administration, Oral; Adult; Age Factors; Aged; Anti-Infective Agents; Area Under Curve; Female; Fluoroquinolones; Half-Life; Humans; Male; Middle Aged; Piperazines; Quinolones; Sex Factors	1997
Effect of renal impairment on the pharmacokinetics of grepafloxacin. Clinical pharmacokinetics, 1997, Volume: 33 Suppl 1 Topics: Administration, Oral; Adult; Aged; Anti-Infective Agents; Area Under Curve; Chromatography, High Pressure Liquid; Creatinine; Female; Fluoroquinolones; Humans; Kidney Diseases; Male; Middle Aged; Piperazines; Quinolones	1997
Stereoselective hepatobiliary transport of the quinolone antibiotic grepafloxacin and its glucuronide in the rat. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:2 Topics: Animals; Anti-Infective Agents; Bile Ducts; Biological Transport, Active; Cell Membrane; Cell-Free System; Cells, Cultured; Fluoroquinolones; Glucuronates; Hyperbilirubinemia; Kinetics; Liver; Male; Piperazines; Quinolones; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Stereoisomerism	1998
Grepafloxacin--a new fluoroquinolone. The Medical letter on drugs and therapeutics, 1998, Jan-30, Volume: 40, Issue:1019 Topics: Administration, Oral; Anti-Infective Agents; Chlamydophila pneumoniae; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Interactions; Fluoroquinolones; Haemophilus; Half-Life; Humans; Legionella pneumophila; Moraxella catarrhalis; Mycoplasma pneumoniae; Piperazines; Pneumonia; Quinolones; Staphylococcus aureus; Streptococcus pneumoniae	1998
New antibiotic approved for community-acquired infections. The Nurse practitioner, 1998, Volume: 23, Issue:1 Topics: Anti-Infective Agents; Bronchitis; Community-Acquired Infections; Contraindications; Fluoroquinolones; Humans; Piperazines; Pneumonia; Quinolones; Sexually Transmitted Diseases; United States; United States Food and Drug Administration	1998
Pneumococcal resistance in the UK. The Journal of antimicrobial chemotherapy, 1997, Volume: 40 Suppl A Topics: Anti-Bacterial Agents; Anti-Infective Agents; Cephalosporins; Chloramphenicol; Ciprofloxacin; Drug Resistance, Multiple; Fluoroquinolones; Humans; Macrolides; Microbial Sensitivity Tests; Northern Ireland; Ofloxacin; Oxacillin; Penicillin Resistance; Penicillins; Piperazines; Pneumococcal Infections; Quinolones; Retrospective Studies; Streptococcus pneumoniae; Tetracycline	1997
The activity of grepafloxacin against respiratory pathogens in the UK. The Journal of antimicrobial chemotherapy, 1997, Volume: 40 Suppl A Topics: Anti-Infective Agents; Bacterial Infections; Ciprofloxacin; Drug Resistance, Microbial; England; Fluoroquinolones; Haemophilus influenzae; Humans; Microbial Sensitivity Tests; Moraxella catarrhalis; Penicillin Resistance; Penicillins; Piperazines; Quinolones; Respiratory Tract Infections; Retrospective Studies; Streptococcus pneumoniae	1997
The in-vitro activity of grepafloxacin against Chlamydia spp., Mycoplasma spp., Ureaplasma urealyticum and Legionella spp. The Journal of antimicrobial chemotherapy, 1997, Volume: 40 Suppl A Topics: Anti-Bacterial Agents; Anti-Infective Agents; Chlamydia; Clarithromycin; Dose-Response Relationship, Drug; Doxycycline; Fluoroquinolones; Gram-Negative Bacteria; Legionella; Mycoplasma; Ofloxacin; Piperazines; Quinolones; Ureaplasma urealyticum	1997
Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:3 Topics: Animals; Anti-Infective Agents; Bile; Biological Transport, Active; Fluoroquinolones; Glucuronates; Glutathione; Hyperbilirubinemia; Male; Piperazines; Quinolones; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley	1998
Antipneumococcal activity of grepafloxacin compared to that of other agents by time-kill methodology. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:5 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Fluoroquinolones; Humans; Macrolides; Microbial Sensitivity Tests; Piperazines; Quinolones; Streptococcus pneumoniae	1998
[Grepafloxacin (Raxar)]. Ugeskrift for laeger, 1998, Jul-20, Volume: 160, Issue:30 Topics: Anti-Infective Agents; Bronchitis; Contraindications; Female; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Piperazines; Pneumonia; Quinolones; Urethritis; Uterine Cervicitis	1998
In vitro activity of grepafloxacin against Haemophilus influenzae and Moraxella catarrhalis. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1998, Volume: 17, Issue:4 Topics: Anti-Infective Agents; Fluoroquinolones; Haemophilus influenzae; Microbial Sensitivity Tests; Moraxella catarrhalis; Piperazines; Quinolones	1998
Comparative grepafloxacin phototoxicity in mouse skin. The Journal of antimicrobial chemotherapy, 1998, Volume: 42, Issue:2 Topics: Alopecia; Animals; Anti-Infective Agents; Dermatitis, Phototoxic; Edema; Erythema; Female; Fluoroquinolones; Mice; Mice, Inbred BALB C; Piperazines; Quinolones; Skin; Ultraviolet Rays	1998
In vitro activity of newer quinolones on Streptococcus pneumoniae isolated from outpatients. Acta clinica Belgica, 1998, Volume: 53, Issue:4 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Infective Agents; Cefuroxime; Cephalosporins; Doxycycline; Drug Therapy, Combination; Fluoroquinolones; Humans; Naphthyridines; Ofloxacin; Outpatients; Penicillin G; Penicillins; Piperazines; Pneumococcal Infections; Quinolones; Roxithromycin; Streptococcus pneumoniae	1998
Transport of quinolone antibacterial drugs in a kidney epithelial cell line, LLC-PK1. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:2 Topics: 4-Chloromercuribenzenesulfonate; Animals; Anti-Infective Agents; Cyclosporine; Epithelial Cells; Fluoroquinolones; Hydrogen-Ion Concentration; Kidney; Levofloxacin; LLC-PK1 Cells; Ofloxacin; Piperazines; Quinolones; Swine	1998
Drug not considered a first-line agent. Canadian family physician Medecin de famille canadien, 1998, Volume: 44 Topics: Anti-Infective Agents; Community-Acquired Infections; Drug Prescriptions; Drug Resistance, Microbial; Fluoroquinolones; Humans; Piperazines; Pneumonia; Practice Guidelines as Topic; Quinolones	1998
Comparative activities of clinafloxacin, grepafloxacin, levofloxacin, moxifloxacin, ofloxacin, sparfloxacin, and trovafloxacin and nonquinolones linozelid, quinupristin-dalfopristin, gentamicin, and vancomycin against clinical isolates of ciprofloxacin-re Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:2 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Aza Compounds; Ciprofloxacin; Drug Resistance, Microbial; Fluoroquinolones; Gentamicins; Humans; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Ofloxacin; Piperazines; Quinolines; Quinolones; Staphylococcus aureus; Vancomycin; Virginiamycin	1999
A comparative study of the repeat dose toxicity of grepafloxacin and a number of other fluoroquinolones in rats. Human & experimental toxicology, 1999, Volume: 18, Issue:1 Topics: Animals; Anti-Infective Agents; Blood Cells; Body Weight; Eating; Female; Fluoroquinolones; Humans; Infant, Newborn; Joint Diseases; Male; Organ Size; Piperazines; Quinolones; Rats; Survival Rate; Time Factors	1999
Differences in the hepatobiliary transport of two quinolone antibiotics, grepafloxacin and lomefloxacin, in the rat. Biopharmaceutics & drug disposition, 1999, Volume: 20, Issue:3 Topics: Animals; Anti-Infective Agents; Biliary Tract; Biological Transport; Cells, Cultured; Fluoroquinolones; Liver; Male; Piperazines; Quinolones; Rats; Rats, Sprague-Dawley	1999
Effect of subinhibitory concentrations of antimicrobial agents (quinolones and macrolide) on the production of verotoxin by enterohemorrhagic Escherichia coli O157:H7. Canadian journal of microbiology, 1999, Volume: 45, Issue:9 Topics: Animals; Anti-Infective Agents; Azithromycin; Bacterial Toxins; Chlorocebus aethiops; Clarithromycin; Dose-Response Relationship, Drug; Enterotoxins; Erythromycin; Escherichia coli O157; Fluoroquinolones; Humans; Macrolides; Norfloxacin; Piperazines; Quinolones; Shiga Toxin 1; Time Factors; Vero Cells	1999
Evaluation of in-vitro activity of new quinolones, macrolides, and minocycline against Mycoplasma pneumoniae. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2000, Volume: 6, Issue:3 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Drug Evaluation; Drug Resistance, Bacterial; Fluoroquinolones; Macrolides; Minocycline; Mycoplasma pneumoniae; Piperazines; Quinolones	2000
Evaluation of in-vitro activity of new quinolones, macrolides, and minocycline against Mycoplasma pneumoniae. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2000, Volume: 6, Issue:3 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Drug Evaluation; Drug Resistance, Bacterial; Fluoroquinolones; Macrolides; Minocycline; Mycoplasma pneumoniae; Piperazines; Quinolones	2000
Ultrastructural characterization of murine limb buds after in vitro exposure to grepafloxacin and other fluoroquinolones. Archives of toxicology, 2002, Volume: 75, Issue:11-12 Topics: Abnormalities, Drug-Induced; Animals; Anti-Infective Agents; Calcium; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Fluoroquinolones; In Vitro Techniques; Levofloxacin; Limb Buds; Magnesium; Male; Mice; Mice, Inbred Strains; Ofloxacin; Piperazines; Pregnancy; Quinolones	2002
Possible involvement of P-glycoprotein in the biliary excretion of grepafloxacin. Clinical and experimental pharmacology & physiology, 2002, Volume: 29, Issue:3 Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Biliary Tract; Doxorubicin; Drug Resistance, Neoplasm; Fluoroquinolones; Leukemia P388; Male; Mice; Piperazines; Quinolones; Rats; Rats, Wistar; Tumor Cells, Cultured	2002