granisetron has been researched along with tropisetron in 98 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (3.06) | 18.7374 |
| 1990's | 53 (54.08) | 18.2507 |
| 2000's | 28 (28.57) | 29.6817 |
| 2010's | 10 (10.20) | 24.3611 |
| 2020's | 4 (4.08) | 2.80 |
| Authors | Studies |
|---|---|
| Andrews, PL; Bhandari, P | 1 |
| Higgins, GA; Jones, BJ; Oakley, NR; Tyers, MB | 1 |
| de Mulder, PH; Seynaeve, C; Verweij, J | 1 |
| Jantunen, I; Johansson, R | 1 |
| Gamse, R; Humpel, C; Javorsky, F; Saria, A | 2 |
| Itoh, Z; Iwanaga, Y; Mizumoto, A; Yoshida, N | 1 |
| Gandara, DR; Hesketh, PJ | 1 |
| Costall, B; Domeney, AM; Naylor, RJ | 1 |
| Cutler, MG | 1 |
| Moss, HE; Sanger, GJ | 1 |
| Brown, GW; Butcher, ME; Kidgell, AE | 1 |
| Chen, HI | 1 |
| Ashby, CR; Edwards, E; Harkins, K; Wang, RY | 1 |
| Ito, A; Ito, T; Iwanaga, H; Karasawa, T; Mizumoto, A; Yoshida, N | 1 |
| Blaney, FE; Edge, C; Phippen, RW | 1 |
| Allison, K; Arnold, B; Greenshaw, AJ; Ivanová, S; Paetsch, PR; Paslawski, T | 1 |
| Perez, EA | 1 |
| Sanger, GJ; Wardle, KA | 1 |
| Hansen, MB; Skadhauge, E | 1 |
| Ayrton, AD; Baldwin, SJ; Bloomer, JC; Chenery, RJ; Clarke, SE; Smith, GJ | 1 |
| Del Favero, A; Roila, F; Tonato, M | 1 |
| Beubler, E; Gamse, R; Schirgi-Degen, A | 1 |
| Grahame-Smith, DG; Leslie, RA; Pei, Q; Zetterström, T | 1 |
| Aapro, MS | 2 |
| Flander, MK; Jantunen, IT; Kataja, VV; Muhonen, TT; Teerenhovi, L | 1 |
| Blackburn, TP; Grahame-Smith, DG; Leslie, RA; Newberry, NR; Sprosen, TS; Watkins, CJ | 1 |
| de Bruijn, KM; Kataja, V | 1 |
| Bianchi, A; Curreli, L; Ghiani, M; Macciò, A; Mantovani, G; Proto, E; Santona, MC | 1 |
| Hickok, JT; Morrow, GR; Rosenthal, SN | 1 |
| Barbato, F; La Rotonda, MI; Quaglia, F | 1 |
| Galindo, JR | 1 |
| Alon, E; Biro, P | 1 |
| Appadu, BL; Lambert, DG | 1 |
| Ionta, MT; Massidda, B | 1 |
| Attia, M; Channa, AB; el Bakry, AK; el Gammal, K; el Gammal, M; Elhattab, YS; Jaroudi, R; Khoshim, MH; Naguib, M; Saddique, A | 1 |
| Jordan, D; Ramage, AG; Wang, Y | 1 |
| Teixeira, GM; Tremont-Lukats, IW | 1 |
| Kobayashi, S; Kumai, T; Nakura, H; Tanaka, M; Tateishi, T; Watanabe, M | 1 |
| Grondahi, ML; Hansen, MB; Jensen, GM; Skadhauge, E | 1 |
| Dahl, SG; Junien, JL; Langlois, A; Pascaud, X; Rivière, PJ | 1 |
| Sun, Y; Zhang, H; Zhang, P | 1 |
| Basurto, C; Ciccarese, G; Palladino, MA; Roila, F | 1 |
| Alloui, A; Bardin, L; Eschalier, A; Jourdan, D; Lavarenne, J | 1 |
| Maksay, G | 1 |
| Baltali, E; Barişta, I; Ozişik, Y; Tekuzman, G; Yalçin, S | 1 |
| Bacci, G; Beghelli, C; Biolchini, A; Ferrari, S; Forni, C; Loro, L; Mazzei, T; Puggioli, C; Simoni, P; Strazzari, S; Tremosini, M | 1 |
| Alkiş, N; Kartum, A; Oge, A; Oge, O | 1 |
| Chan, R; Chua, DT; Foo, YC; Kwok, CC; Kwong, DL; Sham, JS; Yue, A | 1 |
| Akutagawa, N; Ishioka, S; Ito, E; Kiya, T; Kudo, R; Sagae, S; Saito, T; Sugimura, M; Umemura, K | 1 |
| Barrajon, E; de las Peñas, R | 1 |
| Bertrand, PP; Bornstein, JC; Furness, JB; Kunze, WA | 1 |
| Klener, P; Procházka, B; Slabý, J; Trnený, M | 1 |
| Araújo Pereira, ME; Carmo, JA; Juncal, C; Lacerda, JF; Lacerda, JM; Lourenço, MF; Martins, C; Rodrigues, A | 1 |
| Naylor, RJ; Tuladhar, BR; Womack, MD | 1 |
| Horikoshi, K; Ishii, A; Karasawa, A; Kishibayashi, N; Ohmori, K; Yokoyama, T | 1 |
| Akman, SA; Aksoylar, S; Kansoy, S; Ozgenç, F | 1 |
| Cui, C; Wang, J; Yang, L | 1 |
| Allgar, V; Goss, I; Overend, M; Pedley, I; Riley, M; Watters, J; Whitehead, A | 1 |
| Endo, T; Hamaue, N; Hirafuji, M; Minami, M | 1 |
| Grothey, A; Hinke, A; Jordan, K; Schmoll, HJ | 1 |
| Olver, IN | 1 |
| Abali, H; Aynacioglu, AS; Babaoglu, MO; Bayar, B; Bozkurt, A; Celik, I; Kerb, R | 1 |
| Nylander, O; Pihl, L | 1 |
| Beaune, P; Dubray, C; Eschalier, A; Libert, F; Loriot, MA; Pickering, G | 1 |
| Neufeld, SM; Newburn-Cook, CV | 1 |
| Arnold, D; Grothey, A; Hinke, A; Jordan, K; Schmoll, HJ; Voigt, W; Wolf, HH | 1 |
| Quan, X; Ye, TH; Zhu, B | 1 |
| Barbaud, A; Bursztejn, AC; Cuny, JF; Schmutz, JL; Tréchot, P | 1 |
| Du Bois, A | 1 |
| Ayuhara, H; Okuyama, K; Ozeki, T; Takayanagi, R; Yamada, Y; Yokoyama, H; Yoshimoto, K | 1 |
| Askitopoulou, H; Chatzimichali, A; Metaxari, M; Papaioannou, A; Petrou, A; Pharmakalidou, E | 1 |
| Hu, X; Liu, S; Liu, Z; Wang, Y; Yang, J | 1 |
| Aminian, A; Dehpour, AR; Ghazi-Khansari, M; Hassanzadeh, G; Javadi, S; Kafami, L; Mehr, SE; Noorbakhsh, F; Rahimian, R | 1 |
| Iwata, N; Kishi, T; Matsuda, Y; Mukai, T | 1 |
| Du, Y; Lin, X; Liu, J; Ni, J; Tang, Y; Zeng, K; Zhou, J | 1 |
| Alimoradi, H; Asadi, F; Asgari, M; Barzegar-Fallah, A; Dehpour, AR; Shafiei, M | 1 |
| Liu, Z; Ruan, L; Zhou, C; Zhu, Y | 1 |
| Leuenberger, M; Lochner, M; Ruepp, MD; Thompson, AJ; Wei, H | 1 |
| Huang, C; Li, J; Sun, Y; Wan, H; Wang, Q; Zhang, H; Zhang, J; Zhong, H | 1 |
| Barakat, GH; El-Bagary, RI; Hassib, ST; Taha, EA | 1 |
| Hayes, AW; Jafarian, AH; Karimi, G; Mehri, S; Rahimian, R; Zirak, MR | 1 |
| Amiri, S; Divanbeigi, A; Nasehi, M; Vaseghi, S; Zarrindast, MR | 1 |
| Dehpour, AR; Fasihi Harandi, M; Kia, EB; Motevaseli, E; Naderi, M; Nekoeian, S; Shiee, MR; Zahabiun, F | 1 |
| Bloomquist, W; Cohen, ML; Reid, LR; Robertson, DW; Schenck, K; Wong, DT | 1 |
| Carr, AA; Hibert, MF; Hoffmann, R; Miller, RC | 1 |
| Bloomquist, WE; Cohen, ML; Deeter, JB; Evrard, DA; Fludzinski, P; Jones, ND; Lacefield, WB; Pfeifer, W | 1 |
| Berger, J; Bonhaus, DW; Clark, RD; Eglen, RM; Kowalczyk, BA; Lee, CH; Michel, AD; Miller, AB; Repke, DB; Weinhardt, KK | 1 |
| Labeaga, L; Mosquera, R; Orjales, A; Rodes, R | 1 |
| Arrigoni, C; Bolis, G; Caccia, C; Dho, L; Heidempergher, F; McArthur, R; Pillan, A; Pinciroli, V; Vaghi, F; Varasi, M | 1 |
| Bourguignon, JJ; Didier, B; Hoffmann, R; Rival, Y; Rybaltchenko, V; Wermuth, CG | 1 |
| Bloomquist, WE; Calligaro, DO; Cohen, ML; Schaus, JM; Susemichel, AD; Thompson, DC | 1 |
| Gordon, JC; Gurley, D; Lanthorn, T; Loch, J; Mack, RA; Macor, JE; Mullen, G; Tran, O; Wright, N | 1 |
| Gálvez, E; Innerarity, A; Iriepa, I; Labeaga, L; Orjales, A; Villasante, FJ | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC | 1 |
17 review(s) available for granisetron and tropisetron
| Article | Year |
|---|---|
5-HT3 receptor antagonists, a new approach in emesis: a review of ondansetron, granisetron and tropisetron.
Topics: Animals; Antiemetics; Granisetron; Humans; Imidazoles; Indazoles; Indoles; Ondansetron; Serotonin Antagonists; Tropisetron; Vomiting | 1991 |
[Chemotherapy-induced emesis and serotonin antagonists].
Topics: Antiemetics; Antineoplastic Agents; Granisetron; Humans; Indoles; Ondansetron; Serotonin Antagonists; Tropisetron; Vomiting | 1991 |
Antiemetic control: 5-HT3 antagonists: review of clinical results, with particular emphasis on ondansetron.
Topics: Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Granisetron; Headache; Humans; Imidazoles; Indazoles; Indoles; Nausea; Ondansetron; Radiation Injuries; Radiotherapy; Serotonin Antagonists; Tropisetron; Vomiting | 1990 |
Review of the preclinical pharmacology and comparative efficacy of 5-hydroxytryptamine-3 receptor antagonists for chemotherapy-induced emesis.
Topics: Antiemetics; Antineoplastic Agents; Cisplatin; Granisetron; Humans; Indoles; Ondansetron; Prognosis; Selective Serotonin Reuptake Inhibitors; Tropisetron; Vomiting | 1995 |
Are there differences among the serotonin antagonists?
Topics: Animals; Antiemetics; Cisplatin; Clinical Trials as Topic; Dose-Response Relationship, Drug; Granisetron; Humans; Indoles; Neoplasms; Ondansetron; Serotonin Antagonists; Tropisetron; Vomiting | 1994 |
Progress in reducing nausea and emesis. Comparisons of ondansetron (Zofran), granisetron (Kytril), and tropisetron (Navoban).
Topics: Antiemetics; Antineoplastic Agents; Granisetron; Humans; Indoles; Nausea; Ondansetron; Serotonin Antagonists; Tropisetron; Vomiting | 1995 |
[Anti-5-HT-3: a new group of antiemetics].
Topics: Adult; Antiemetics; Granisetron; Humans; Indoles; Ondansetron; Serotonin Antagonists; Time Factors; Tropisetron | 1996 |
[Prevention and treatment of postoperative nausea and vomiting with 5-HT3-receptor blockers].
Topics: Antiemetics; Clinical Trials as Topic; Dose-Response Relationship, Drug; Granisetron; Humans; Indoles; Infusions, Intravenous; Nausea; Ondansetron; Postoperative Complications; Quinolizines; Serotonin Antagonists; Tropisetron; Vomiting | 1996 |
[Recent improvements in antiemetic therapy].
Topics: Antiemetics; Antineoplastic Agents; Cisplatin; Dexamethasone; Drug Therapy, Combination; Granisetron; Humans; Indoles; Metoclopramide; Nausea; Ondansetron; Phenothiazines; Serotonin Antagonists; Tropisetron; Vomiting | 1997 |
[Serotonin and anticancer drug-induced emesis].
Topics: Animals; Antiemetics; Antineoplastic Agents; Cisplatin; Enterochromaffin Cells; Granisetron; Humans; Indoles; Ondansetron; Receptors, Serotonin, 5-HT3; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Serotonin 5-HT4 Receptor Antagonists; Serotonin Antagonists; Tropisetron; Vagus Nerve; Vomiting | 2004 |
Granisetron versus tropisetron for prophylaxis of acute chemotherapy-induced emesis: a pooled analysis.
Topics: Antiemetics; Antineoplastic Agents; Granisetron; Humans; Indoles; Serotonin Antagonists; Tropisetron; Vomiting | 2005 |
Update on anti-emetics for chemotherapy-induced emesis.
Topics: Administration, Oral; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Australia; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Granisetron; Humans; Indoles; Isoquinolines; Male; Neoplasms; Ondansetron; Palonosetron; Patient Satisfaction; Prognosis; Quality of Life; Quinolizines; Quinuclidines; Treatment Outcome; Tropisetron; Vomiting | 2005 |
The efficacy of 5-HT3 receptor antagonists for the prevention of postoperative nausea and vomiting after craniotomy: a meta-analysis.
Topics: Antiemetics; Craniotomy; Data Interpretation, Statistical; Granisetron; Humans; Indoles; Ondansetron; Postoperative Nausea and Vomiting; Randomized Controlled Trials as Topic; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Treatment Outcome; Tropisetron | 2007 |
A meta-analysis comparing the efficacy of four 5-HT3-receptor antagonists for acute chemotherapy-induced emesis.
Topics: Antiemetics; Antineoplastic Agents; Granisetron; Humans; Indoles; Ondansetron; Quinolizines; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Treatment Outcome; Tropisetron; Vomiting | 2007 |
[Management of chemotherapy-induced emesis: what is the standard after 20 years of clinical research].
Topics: Antineoplastic Combined Chemotherapy Protocols; Benchmarking; Dexamethasone; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Granisetron; Humans; Indoles; Metoclopramide; Nausea; Ondansetron; Premedication; Randomized Controlled Trials as Topic; Research; Serotonin 5-HT3 Receptor Antagonists; Tropisetron; Vomiting | 1998 |
Selective serotonin 3 receptor antagonist treatment for schizophrenia: meta-analysis and systematic review.
Topics: Antipsychotic Agents; Constipation; Double-Blind Method; Drug Therapy, Combination; Granisetron; Haloperidol; Humans; Indoles; Nausea; Ondansetron; Randomized Controlled Trials as Topic; Receptors, Serotonin, 5-HT3; Risperidone; Schizophrenia; Serotonin 5-HT3 Receptor Antagonists; Severity of Illness Index; Symptom Assessment; Treatment Outcome; Tropisetron; Vomiting | 2014 |
5-HT3 receptor antagonists for the prevention of postoperative shivering: a meta-analysis.
Topics: Analgesics, Opioid; Granisetron; Humans; Indoles; Isoquinolines; Meperidine; Ondansetron; Palonosetron; Postoperative Complications; Postoperative Period; Quinuclidines; Randomized Controlled Trials as Topic; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Antagonists; Shivering; Surgical Procedures, Operative; Tropisetron | 2016 |
21 trial(s) available for granisetron and tropisetron
| Article | Year |
|---|---|
5-HT3 receptor antagonists in the prophylaxis of acute vomiting induced by moderately emetogenic chemotherapy--a randomised study.
Topics: Adult; Aged; Aged, 80 and over; Antiemetics; Antineoplastic Agents; Female; Granisetron; Humans; Indoles; Male; Middle Aged; Neoplasms; Ondansetron; Patient Satisfaction; Prospective Studies; Receptors, Serotonin; Serotonin Antagonists; Tropisetron; Vomiting | 1993 |
Comparison of granisetron, ondansetron, and tropisetron in the prophylaxis of acute nausea and vomiting induced by cisplatin for the treatment of head and neck cancer: a randomized controlled trial.
Topics: Adult; Aged; Antiemetics; Antineoplastic Agents; Cisplatin; Drug Administration Schedule; Female; Granisetron; Head and Neck Neoplasms; Humans; Indoles; Male; Middle Aged; Nausea; Ondansetron; Prospective Studies; Serotonin Antagonists; Tropisetron; Vomiting | 1996 |
Prevention of delayed emesis by a single intravenous bolus dose of 5-HT3-receptor-antagonist in moderately emetogenic chemotherapy.
Topics: Adolescent; Adult; Aged; Antiemetics; Antineoplastic Agents; Breast Neoplasms; Cisplatin; Cost-Benefit Analysis; Cyclophosphamide; Epirubicin; Female; Fluorouracil; Granisetron; Granulocyte Colony-Stimulating Factor; Humans; Indoles; Injections, Intravenous; Methotrexate; Middle Aged; Ondansetron; Serotonin Antagonists; Tropisetron; Vomiting | 1996 |
Prophylactic antiemetic therapy with ondansetron, tropisetron, granisetron and metoclopramide in patients undergoing laparoscopic cholecystectomy: a randomized, double-blind comparison with placebo.
Topics: Adult; Aged; Antiemetics; Cholecystectomy, Laparoscopic; Double-Blind Method; Female; Granisetron; Humans; Indoles; Male; Metoclopramide; Middle Aged; Nausea; Ondansetron; Postoperative Complications; Prospective Studies; Serotonin Antagonists; Tropisetron; Vomiting | 1996 |
Comparison of Granisetron, ondansetron, and tropisetron in the prophylaxis of acute nausea and vomiting induced by cisplatin for the treatment of head and neck cancer. A randomized controlled trial.
Topics: Acute Disease; Antiemetics; Antineoplastic Agents; Cisplatin; Data Interpretation, Statistical; Granisetron; Humans; Indoles; Nausea; Ondansetron; Randomized Controlled Trials as Topic; Tropisetron | 1996 |
[A randomized trial of tropisetron in the prophylaxis of nausea and vomiting induced by chemotherapy].
Topics: Adult; Aged; Antiemetics; Antineoplastic Agents; Breast Neoplasms; Cisplatin; Female; Granisetron; Humans; Indoles; Lung Neoplasms; Lymphoma; Male; Middle Aged; Tropisetron; Vomiting | 1996 |
Serotonin receptor antagonists in prophylaxis of acute and delayed emesis induced by moderately emetogenic, single-day chemotherapy: a randomized study.
Topics: Adult; Aged; Antiemetics; Antineoplastic Agents; Female; Granisetron; Humans; Indoles; Male; Middle Aged; Ondansetron; Prospective Studies; Serotonin Antagonists; Tropisetron; Vomiting | 1999 |
Granisetron, tropisetron, and ondansetron in the prevention of acute emesis induced by a combination of cisplatin-Adriamycin and by high-dose ifosfamide delivered in multiple-day continuous infusions.
Topics: Acute Disease; Adolescent; Adult; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Doxorubicin; Drug Administration Schedule; Extremities; Female; Granisetron; Humans; Ifosfamide; Indoles; Male; Ondansetron; Osteosarcoma; Tropisetron; Vomiting | 2000 |
Comparison of granisetron, ondansetron and tropisetron for control of vomiting and nausea induced by cisplatin.
Topics: Adult; Antiemetics; Antineoplastic Agents; Cisplatin; Cost-Benefit Analysis; Female; Granisetron; Humans; Indoles; Injections, Intravenous; Male; Middle Aged; Nausea; Neoplasms; Ondansetron; Treatment Outcome; Tropisetron; Vomiting, Anticipatory | 2000 |
Comparative efficacy of three 5-HT3 antagonists (granisetron, ondansetron, and tropisetron) plus dexamethasone for the prevention of cisplatin-induced acute emesis: a randomized crossover study.
Topics: Adult; Aged; Antiemetics; Antineoplastic Agents; Cisplatin; Cross-Over Studies; Dexamethasone; Female; Granisetron; Head and Neck Neoplasms; Humans; Indoles; Injections, Intravenous; Male; Middle Aged; Ondansetron; Patient Satisfaction; Treatment Outcome; Tropisetron; Vomiting | 2000 |
[Effects of oral 5-HT3 antagonists on chemotherapy-induced emesis in patients with gynecologic cancers].
Topics: Administration, Oral; Antiemetics; Benzimidazoles; Carboplatin; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Genital Neoplasms, Female; Granisetron; Humans; Indoles; Middle Aged; Nausea; Ondansetron; Paclitaxel; Serotonin Antagonists; Tropisetron; Vomiting | 2000 |
Randomised double blind crossover study comparing ondansetron, granisetron and tropisetron. A cost-benefit analysis.
Topics: Adult; Aged; Antiemetics; Antineoplastic Agents; Cost-Benefit Analysis; Cross-Over Studies; Drug Costs; Female; Granisetron; Health Care Costs; Humans; Indoles; Male; Middle Aged; Nausea; Neoplasms; Ondansetron; Treatment Outcome; Tropisetron; Vomiting | 2000 |
Antiemetic efficacy of three serotonin antagonists during high-dose chemotherapy and autologous stem cell transplantation in malignant lymphoma.
Topics: Adult; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Combined Modality Therapy; Cytarabine; Etoposide; Female; Granisetron; Hematopoietic Stem Cell Transplantation; Humans; Indoles; Lymphoma; Male; Melphalan; Nausea; Ondansetron; Serotonin Antagonists; Transplantation, Autologous; Tropisetron; Vomiting | 2000 |
Randomized trial of ondansetron, granisetron, and tropisetron in the prevention of acute nausea and vomiting.
Topics: Adult; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Granisetron; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppression Therapy; Indoles; Leukemia; Male; Multiple Myeloma; Myelodysplastic Syndromes; Nausea; Ondansetron; Transplantation, Autologous; Transplantation, Homologous; Tropisetron; Vomiting | 2000 |
Comparison of tropisetron and granisetron in the control of nausea and vomiting in children receiving combined cancer chemotherapy.
Topics: Adolescent; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Granisetron; Humans; Indoles; Infant; Male; Nausea; Prospective Studies; Therapeutic Equivalency; Treatment Outcome; Tropisetron; Vomiting | 2001 |
[The clinical effect of Tropisetron in the prevention of nausea and vomiting induced by anti-cancer drugs].
Topics: Adolescent; Adult; Aged; Antiemetics; Antineoplastic Agents; Cross-Over Studies; Drug Administration Schedule; Female; Granisetron; Humans; Indoles; Male; Middle Aged; Nausea; Tropisetron; Vomiting | 2001 |
The development of a protocol for the use of 5-HT3 antagonists in chemotherapy-induced nausea and vomiting.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Clinical Protocols; Female; Granisetron; Humans; Indoles; Male; Middle Aged; Nausea; Neoplasms; Ondansetron; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Treatment Outcome; Tropisetron; Vomiting | 2001 |
Association of the ABCB1 3435C>T polymorphism with antiemetic efficacy of 5-hydroxytryptamine type 3 antagonists.
Topics: Adult; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; ATP-Binding Cassette Transporters; Female; Gene Frequency; Genotype; Granisetron; Humans; Indoles; Male; Middle Aged; Nausea; Neoplasms; Ondansetron; Polymorphism, Single Nucleotide; Prospective Studies; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Time Factors; Treatment Outcome; Tropisetron; Vomiting | 2005 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Granisetron; Humans; Indoles; Male; Pain; Pain Measurement; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Tropisetron | 2006 |
[A randomized double-blind study of prevention of postoperative nausea and vomiting with ondansetron, tropisetron, or granisetron in patients undergoing general anesthesia].
Topics: Adolescent; Adult; Aged; Anesthesia, General; Antiemetics; Double-Blind Method; Female; Granisetron; Humans; Indoles; Male; Middle Aged; Ondansetron; Postoperative Nausea and Vomiting; Tropisetron; Young Adult | 2007 |
Antiemetic prophylaxis in thyroid surgery: a randomized, double-blind comparison of three 5-HT3 agents.
Topics: Adult; Aged; Antiemetics; Double-Blind Method; Female; Granisetron; Humans; Indoles; Male; Middle Aged; Ondansetron; Postoperative Nausea and Vomiting; Preanesthetic Medication; Serotonin 5-HT3 Receptor Antagonists; Thyroidectomy; Tropisetron; Young Adult | 2011 |
60 other study(ies) available for granisetron and tropisetron
| Article | Year |
|---|---|
Preliminary evidence for the involvement of the putative 5-HT4 receptor in zacopride- and copper sulphate-induced vomiting in the ferret.
Topics: Analysis of Variance; Animals; Antiemetics; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Copper; Copper Sulfate; Female; Ferrets; Granisetron; Imidazoles; Indazoles; Indoles; Loperamide; Male; Ondansetron; Receptors, Serotonin; Serotonin Antagonists; Tropisetron; Vomiting | 1991 |
Evidence that the amygdala is involved in the disinhibitory effects of 5-HT3 receptor antagonists.
Topics: Amygdala; Animals; Anxiety; Conflict, Psychological; Granisetron; Imidazoles; Indazoles; Indoles; Lighting; Male; Ondansetron; Raphe Nuclei; Rats; Serotonin; Serotonin Antagonists; Social Behavior; Tropanes; Tropisetron | 1991 |
5-HT3 receptor antagonists inhibit sensory neuropeptide release from the rat spinal cord.
Topics: Animals; Calcitonin Gene-Related Peptide; Granisetron; In Vitro Techniques; Indazoles; Indoles; Neurokinin A; Neurons, Afferent; Neuropeptides; Potassium; Rats; Rats, Inbred Strains; Serotonin Antagonists; Spinal Cord; Substance P; Tropisetron | 1990 |
Endogenous 5-hydroxytryptamine modulates the release of tachykinins and calcitonin gene-related peptide from the rat spinal cord via 5-HT3 receptors.
Topics: Animals; Calcitonin Gene-Related Peptide; Granisetron; In Vitro Techniques; Indazoles; Indoles; Neurokinin A; Potassium Chloride; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spinal Cord; Substance P; Tachykinins; Tropisetron | 1991 |
Effects of 5-hydroxytryptamine 3 receptor antagonists on gastrointestinal motor activity in conscious dogs.
Topics: Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Digestion; Dogs; Dose-Response Relationship, Drug; Female; Gastrointestinal Motility; Granisetron; Imidazoles; Indazoles; Indoles; Infusions, Intravenous; Injections, Intravenous; Male; Motilin; Motor Activity; Muscle Contraction; Muscle, Smooth; Ondansetron; Serotonin Antagonists; Time Factors; Tropisetron | 1991 |
Serotonin antagonists: a new class of antiemetic agents.
Topics: Antiemetics; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Granisetron; Humans; Imidazoles; Indazoles; Indoles; Metoclopramide; Ondansetron; Quinolizines; Receptors, Serotonin; Serotonin Antagonists; Tropanes; Tropisetron; Vomiting | 1991 |
5-HT3 receptor antagonists attenuate dopamine-induced hyperactivity in the rat.
Topics: Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dopamine; Dopamine Antagonists; Female; Granisetron; Indazoles; Indoles; Injections; Motor Activity; Nucleus Accumbens; Rats; Rats, Inbred Strains; Serotonin Antagonists; Tropisetron | 1990 |
Behavioural effects in gerbils of the 5-HT3 receptor antagonists, BRL 43694 and ICS 205-930, under circumstances of high and low light intensity.
Topics: Animals; Behavior, Animal; Gerbillinae; Granisetron; Indazoles; Indoles; Light; Male; Pyrazoles; Serotonin Antagonists; Social Behavior; Tropisetron | 1990 |
The effects of granisetron, ICS 205-930 and ondansetron on the visceral pain reflex induced by duodenal distension.
Topics: Animals; Blood Pressure; Duodenum; Granisetron; Imidazoles; Indazoles; Indoles; Male; Morphine; Muscle Contraction; Muscle, Smooth; Ondansetron; Pain; Pyrazoles; Rats; Rats, Inbred Strains; Reflex; Serotonin Antagonists; Stomach; Tropisetron; Vagotomy | 1990 |
Evidence for the presynaptic action of 5-hydroxytryptamine and the involvement of purinergic innervation in the rabbit lower urinary tract.
Topics: Adenosine Triphosphate; Animals; Atropine; Electric Stimulation; Female; Granisetron; In Vitro Techniques; Indazoles; Indoles; Male; Muscle Contraction; Muscle, Smooth; Purines; Rabbits; Serotonin; Serotonin Antagonists; Synapses; Tropanes; Tropisetron; Urethra; Urinary Tract | 1990 |
Characterization of 5-hydroxytryptamine3 receptors in the medial prefrontal cortex: a microiontophoretic study.
Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Granisetron; Indazoles; Indoles; Iontophoresis; Magnesium Chloride; Male; Metergoline; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tropisetron | 1989 |
[Effect of 5-HT3 receptor antagonists on gastrointestinal motility].
Topics: Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dogs; Gastrointestinal Motility; Granisetron; Imidazoles; In Vitro Techniques; Indazoles; Indoles; Motilin; Ondansetron; Rabbits; Serotonin Antagonists; Tropisetron | 1989 |
Molecular surface comparison. 2. Similarity of electrostatic vector fields in drug design.
Topics: Anti-Anxiety Agents; Benzamides; Benzazepines; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Diazepam; Drug Design; Electricity; GABA-A Receptor Agonists; Granisetron; Indoles; Isomerism; Molecular Conformation; Ondansetron; Pharmaceutical Preparations; Protein Binding; Pyrazoles; Pyridazines; Receptors, Drug; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Structure-Activity Relationship; Surface Properties; Triazolam; Tropisetron | 1995 |
5HT3 receptor antagonists do not block nicotine induced hyperactivity in rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Granisetron; Haloperidol; Indoles; Male; Motor Activity; Nicotine; Ondansetron; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Time Factors; Tropanes; Tropisetron | 1995 |
Constipation evoked by 5-HT3-receptor antagonism: evidence for heterogeneous efficacy among different antagonists in guinea-pigs.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Clonidine; Colon; Constipation; Defecation; Drug Interactions; Granisetron; Guinea Pigs; In Vitro Techniques; Indoles; Injections, Intraperitoneal; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Serotonin Antagonists; Tropisetron | 1994 |
Ketanserin and granisetron reduce cholera toxin-induced hypersecretion in pig jejunum.
Topics: Animals; Animals, Newborn; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cholera Toxin; Diarrhea; Dose-Response Relationship, Drug; Drug Therapy, Combination; Granisetron; Indoles; Intestinal Secretions; Jejunum; Ketanserin; Methysergide; Serotonin Antagonists; Swine; Tropisetron | 1994 |
Characterisation of the cytochrome P450 enzymes involved in the in vitro metabolism of granisetron.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Granisetron; Humans; Hydroxylation; In Vitro Techniques; Indoles; Isoenzymes; Kinetics; Microsomes, Liver; Ondansetron; Serotonin Antagonists; Tropisetron | 1994 |
Inhibition of 5-hydroxytryptamine- and enterotoxin-induced fluid secretion by 5-HT receptor antagonists in the rat jejunum.
Topics: Animals; Bacterial Toxins; Body Fluids; Cholera Toxin; Enterotoxins; Escherichia coli; Escherichia coli Proteins; Female; Granisetron; Indoles; Jejunum; Ketanserin; Ondansetron; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tropisetron | 1993 |
5-HT3 receptor antagonists inhibit morphine-induced stimulation of mesolimbic dopamine release and function in the rat.
Topics: Animals; Behavior, Animal; Dialysis; Dopamine; Dose-Response Relationship, Drug; Granisetron; Indazoles; Indoles; Limbic System; Male; Morphine; Ondansetron; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Tropisetron | 1993 |
'... setron': are 5-HT3 receptor antagonists different?
Topics: Antiemetics; Antineoplastic Agents; Female; Granisetron; Humans; Indoles; Male; Ondansetron; Receptors, Serotonin; Serotonin Antagonists; Tropisetron; Vomiting | 1993 |
BRL 46470 potently antagonizes neural responses activated by 5-HT3 receptors.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Electrophysiology; Glioma; Granisetron; In Vitro Techniques; Indoles; Kinetics; Male; Neuroblastoma; Neurons; Ondansetron; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Tropisetron; Tubocurarine; Tumor Cells, Cultured; Vagus Nerve | 1993 |
Hypersensitivity reactions associated with 5- hydroxytryptamine(3)-receptor antagonists: a class effect?
Topics: Aged; Antiemetics; Drug Hypersensitivity; Female; Granisetron; Humans; Indoles; Middle Aged; Ondansetron; Serotonin Antagonists; Tropisetron | 1996 |
Retention behaviour of anti-emetic serotonin antagonists in reversed phase high performance liquid chromatography.
Topics: Antiemetics; Chromatography, High Pressure Liquid; Granisetron; Indoles; Ondansetron; Serotonin Antagonists; Tropisetron | 1995 |
Interaction of i.v. anaesthetic agents with 5-HT3 receptors.
Topics: Anesthetics, Intravenous; Animals; Antiemetics; Binding, Competitive; Dose-Response Relationship, Drug; Etomidate; Granisetron; Indoles; Ketamine; Mice; Propofol; Receptors, Serotonin; Serotonin Antagonists; Thiopental; Tropisetron; Tumor Cells, Cultured | 1996 |
Mediation by 5-HT3 receptors of an excitatory effect of 5-HT on dorsal vagal preganglionic neurones in anaesthetized rats: an ionophoretic study.
Topics: Anesthesia, General; Animals; Biguanides; Extracellular Space; Granisetron; Indoles; Iontophoresis; Male; Motor Neurons; Nerve Fibers; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tropisetron; Vagus Nerve | 1996 |
The activity of dihydropyrimidine dehydrogenase from rat liver was not affected by any of five 5-hydroxytryptamine antagonists.
Topics: Animals; Antiemetics; Antimetabolites, Antineoplastic; Biotransformation; Bridged Bicyclo Compounds, Heterocyclic; Cytosol; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Granisetron; Indoles; Liver; Male; Ondansetron; Oxazines; Oxidoreductases; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Tropisetron | 1996 |
Effect of 5-HT2 and 5-HT3 receptor antagonists on cholera toxin-induced fluid hypersecretion in the pig jejunum.
Topics: Analysis of Variance; Animals; Cholera Toxin; Dose-Response Relationship, Drug; Granisetron; Indoles; Jejunal Diseases; Jejunum; Ketanserin; Ondansetron; Serotonin Antagonists; Swine; Swine Diseases; Tropisetron | 1996 |
Response heterogeneity of 5-HT3 receptor antagonists in a rat visceral hypersensitivity model.
Topics: Animals; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Colon; Granisetron; Indoles; Male; Muscle Contraction; Muscle, Smooth; Ondansetron; Pain; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Tropisetron | 1996 |
Always more "setrons": how many do we need?
Topics: Antiemetics; Antineoplastic Agents; Drug Costs; Granisetron; Humans; Indoles; Nausea; Ondansetron; Serotonin Antagonists; Tropisetron; Vomiting | 1997 |
Differential influence of two serotonin 5-HT3 receptor antagonists on spinal serotonin-induced analgesia in rats.
Topics: Animals; Biguanides; Dose-Response Relationship, Drug; Granisetron; Indoles; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord; Tropisetron | 1997 |
Bidirectional allosteric modulation of strychnine-sensitive glycine receptors by tropeines and 5-HT3 serotonin receptor ligands.
Topics: Allosteric Regulation; Animals; Benzofurans; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Glycine; Granisetron; Indoles; Ligands; Male; Medulla Oblongata; Ondansetron; Pons; Rats; Rats, Wistar; Receptors, Glycine; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord; Strychnine; Tropanes; Tropisetron; Tubocurarine | 1998 |
The terminals of myenteric intrinsic primary afferent neurons of the guinea-pig ileum are excited by 5-hydroxytryptamine acting at 5-hydroxytryptamine-3 receptors.
Topics: 5-Methoxytryptamine; Action Potentials; Animals; Dioxanes; Granisetron; Guinea Pigs; Ileum; Indoles; Myenteric Plexus; Neurons, Afferent; Piperidines; Presynaptic Terminals; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin; Signal Transduction; Tropisetron | 2000 |
Pharmacological characterization of the 5-HT receptor-mediated contraction in the mouse isolated ileum.
Topics: Animals; Atropine; Dioxanes; Dose-Response Relationship, Drug; Female; Granisetron; Ileum; In Vitro Techniques; Indoles; Ketanserin; Male; Mice; Muscle Contraction; Ondansetron; Piperidines; Receptors, Serotonin; Ritanserin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tetrodotoxin; Tropanes; Tropisetron | 2000 |
Possible involvement of 5-HT4 receptors, in addition to 5-HT3 receptors, in the emesis induced by high-dose cisplatin in Suncus murinus.
Topics: Animals; Antiemetics; Antineoplastic Agents; Cisplatin; Granisetron; Indoles; Male; Ondansetron; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Receptors, Serotonin, 5-HT4; Serotonin Antagonists; Shrews; Sulfonamides; Tropisetron; Vomiting | 2001 |
5HT3-receptor antagonists as antiemetics in cancer.
Topics: Adult; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Child; Granisetron; Humans; Indoles; Isoquinolines; Nausea; Neoplasms; Ondansetron; Palonosetron; Practice Guidelines as Topic; Quinolizines; Quinuclidines; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Tropisetron; Vomiting | 2005 |
Luminal hypotonicity increases duodenal mucosal permeability by a mechanism involving 5-hydroxytryptamine.
Topics: Anesthetics, Local; Animals; Cyclooxygenase Inhibitors; Duodenum; Granisetron; Indoles; Indomethacin; Intestinal Mucosa; Lidocaine; Male; Ondansetron; Osmotic Pressure; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Serotonin 5-HT4 Receptor Antagonists; Serotonin Agents; Serotonin Antagonists; Tetrodotoxin; Tropisetron | 2006 |
Cutaneous adverse drug reactions during chemotherapy: consider non-antineoplastic drugs.
Topics: Adult; Antiemetics; Antineoplastic Agents; Breast Neoplasms; Cross Reactions; Drug Eruptions; Female; Glucocorticoids; Granisetron; Humans; Indoles; Male; Middle Aged; Ondansetron; Pancreatic Neoplasms; Prednisolone; Skin Tests; Tropisetron; Urticaria | 2008 |
Receptor occupancy theory-based analysis of interindividual differences in antiemetic effects of 5-HT3 receptor antagonists.
Topics: Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Drug Administration Schedule; Granisetron; Humans; Indoles; Models, Theoretical; Ondansetron; Oxazines; Serotonin 5-HT3 Receptor Antagonists; Treatment Outcome; Tropisetron; Vomiting | 2009 |
Study on the interactions of antiemetic drugs and 12-tungstophosphoric acid by absorption and resonance Rayleigh scattering spectra and their analytical applications.
Topics: Antiemetics; Granisetron; Indoles; Light; Limit of Detection; Models, Molecular; Nanoparticles; Phosphoric Acids; Scattering, Radiation; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tropisetron; Tungsten Compounds | 2013 |
Tropisetron diminishes demyelination and disease severity in an animal model of multiple sclerosis.
Topics: Animals; Biguanides; Cell Proliferation; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Encephalomyelitis, Autoimmune, Experimental; Granisetron; Indoles; Leukocytes, Mononuclear; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Agonists; Serotonin 5-HT3 Receptor Antagonists; Spinal Cord; Spleen; Treatment Outcome; Tropisetron | 2013 |
5-HT3 receptor antagonists do not alter spontaneous contraction of pregnant myometrium in vitro.
Topics: Female; Granisetron; Humans; In Vitro Techniques; Indoles; Ondansetron; Pregnancy; Serotonin Antagonists; Tropisetron; Uterine Contraction | 2015 |
Tropisetron ameliorates early diabetic nephropathy in streptozotocin-induced diabetic rats.
Topics: Albuminuria; Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glomerular Filtration Rate; Granisetron; Indoles; Inflammation Mediators; Kidney; Male; Oxidative Stress; Rats, Wistar; Serotonin 5-HT3 Receptor Antagonists; Time Factors; Tropisetron; Tumor Necrosis Factor-alpha | 2015 |
The binding orientations of structurally-related ligands can differ; A cautionary note.
Topics: Binding Sites; Binding, Competitive; Crystallography, X-Ray; Granisetron; HEK293 Cells; Humans; Indoles; Ligands; Models, Molecular; Molecular Structure; Mutation; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Structure-Activity Relationship; Tritium; Tropisetron | 2017 |
Quantification of ondansetron, granisetron and tropisetron in goat plasma using hydrophilic interaction liquid chromatography-solid phase extraction coupled with hydrophilic interaction liquid chromatography-triple quadrupole tandem mass spectrometry.
Topics: Acetonitriles; Animals; Chromatography, Liquid; Formates; Goats; Granisetron; Hydrophobic and Hydrophilic Interactions; Indoles; Linear Models; Ondansetron; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry; Tropisetron | 2018 |
Determination of some antiemetic drugs through its native fluorescence or fluorescence quenching of cerrous ammonium sulphate.
Topics: Ammonium Sulfate; Antiemetics; Chemistry, Pharmaceutical; Fluorometry; Granisetron; Hydrolysis; Ondansetron; Quantum Theory; Radiotherapy; Reproducibility of Results; Spectrometry, Fluorescence; Tropisetron | 2020 |
Tropisetron ameliorates cyclophosphamide-induced hemorrhagic cystitis in rats.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Cyclophosphamide; Cystitis; Disease Models, Animal; Female; Granisetron; Hemorrhage; Inflammation Mediators; Lipid Peroxidation; Nicotinic Agonists; Ondansetron; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Poly(ADP-ribose) Polymerases; Rats, Wistar; Serotonin 5-HT3 Receptor Antagonists; Signal Transduction; STAT3 Transcription Factor; Tropisetron; Urinary Bladder | 2020 |
Tropisetron But Not Granisetron Ameliorates Spatial Memory Impairment Induced by Chronic Cerebral Hypoperfusion.
Topics: Animals; Arterial Occlusive Diseases; CA1 Region, Hippocampal; Carotid Artery, Common; Cerebrovascular Disorders; Granisetron; Interleukin-6; Male; Maze Learning; Memory Disorders; Neurons; Rats, Wistar; RNA-Binding Proteins; Serotonin 5-HT3 Receptor Antagonists; Spatial Memory; Tropisetron | 2020 |
In vitro effects of tropisetron and granisetron against Echinococcus granulosus (s.s.) protoscoleces by involvement of calcineurin and calmodulin.
Topics: Animals; Anthelmintics; Calcineurin; Calmodulin; Drug Evaluation, Preclinical; Echinococcosis; Echinococcus granulosus; Granisetron; Helminth Proteins; Larva; Sheep; Sheep Diseases; Tropisetron | 2021 |
Synthesis and biochemical evaluation of tritium-labeled 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1H-indazole-3-carboxa mide, a useful radioligand for 5HT3 receptors.
Topics: Animals; Cell Membrane; Cerebral Cortex; Guinea Pigs; Heart Rate; Ileum; Indazoles; Male; Methylation; Myocardium; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Tritium; Tropanes | 1990 |
Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site.
Topics: Animals; Binding Sites; Guinea Pigs; Mice; Protein Conformation; Rabbits; Rats; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship | 1990 |
Indazoles as indole bioisosteres: synthesis and evaluation of the tropanyl ester and amide of indazole-3-carboxylate as antagonists at the serotonin 5HT3 receptor.
Topics: Amides; Animals; Esters; Heart Rate; Indazoles; Magnetic Resonance Spectroscopy; Models, Molecular; Pyrazoles; Rats; Receptors, Serotonin; Reflex; Serotonin; Serotonin Antagonists; Tropanes | 1987 |
2-(Quinuclidin-3-yl)pyrido[4,3-b]indol-1-ones and isoquinolin-1-ones. Potent conformationally restricted 5-HT3 receptor antagonists.
Topics: Animals; Cisplatin; Computer Simulation; Dogs; Ferrets; Isoquinolines; Male; Models, Molecular; Molecular Structure; Palonosetron; Pyridones; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Stereoisomerism; Structure-Activity Relationship; Vomiting | 1993 |
New 2-piperazinylbenzimidazole derivatives as 5-HT3 antagonists. Synthesis and pharmacological evaluation.
Topics: Animals; Benzimidazoles; Guinea Pigs; Indazoles; Male; Models, Chemical; Piperazines; Piperidines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Receptors, Serotonin, 5-HT3; Receptors, Serotonin, 5-HT4; Serotonin Antagonists; Tropanes | 1997 |
Phenylimidazolidin-2-one derivatives as selective 5-HT3 receptor antagonists and refinement of the pharmacophore model for 5-HT3 receptor binding.
Topics: Animals; Binding, Competitive; Brain; Guinea Pigs; Heart Rate; Ileum; Imidazoles; Models, Molecular; Molecular Structure; Muscles; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists | 1997 |
5-HT3 antagonists derived from aminopyridazine-type muscarinic M1 agonists.
Topics: Animals; Brain Stem; Hippocampus; In Vitro Techniques; Models, Molecular; Muscarinic Agonists; Myocardium; Protein Conformation; Pyridazines; Rats; Receptors, Muscarinic; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists | 1998 |
Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: indazole and benzimidazolone derivatives.
Topics: Adamantane; Administration, Oral; Adrenergic alpha-Antagonists; Animals; Aorta; Brain; Drug Evaluation, Preclinical; Esophagus; Guinea Pigs; Ileum; In Vitro Techniques; Indazoles; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Adrenergic, alpha-1; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Receptors, Serotonin, 5-HT4; Serotonin Antagonists; Structure-Activity Relationship | 1998 |
The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cell Membrane; Hippocampus; Indoles; Inhibitory Concentration 50; Intestine, Small; Ligands; Membrane Potentials; Mice; Nicotinic Agonists; Oocytes; Protein Binding; Rats; Receptors, Nicotinic; Serotonin Antagonists; Structure-Activity Relationship; Tropisetron; Xenopus | 2001 |
Synthesis and pharmacology of isoquinuclidine derivatives as 5-HT(3) ligands.
Topics: Ligands; Quinuclidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Stereoisomerism | 2002 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility | 2010 |