gramicidin-a and stearic-acid

gramicidin-a has been researched along with stearic-acid* in 1 studies

Other Studies

1 other study(ies) available for gramicidin-a and stearic-acid

Article	Year
cis-FFA do not alter membrane depolarization but block Ca2+ influx and GH secretion in KCl-stimulated somatotroph cells. Suggestion for a direct cis-FFA perturbation of the Ca2+ channel opening. Biochimica et biophysica acta, 1997, Oct-23, Volume: 1329, Issue:2 It has been reported that cis-unsaturated free fatty acids (cis-FFA) block intracellular Ca2+ rise in EGFR T17 and GH3 cells by perturbing the generation of Ins(1,4,5)P3. In the present work, it was found that cis-FFA did not alter potassium-induced cell depolarization in GH3 cells, while blocking Ca2+ rise and GH secretion. Interestingly enough, saturated or trans-unsaturated FFA exert the opposite actions, i.e., they block cell depolarization without altering Ca2+ rise and hormone secretion. As depolarization activates GH3 cells via direct opening of Ca2+ channels with no generation of intracellular mediators, these results suggest that cis-FFA act by a direct perturbation of the Ca2+ channel opening. Topics: Animals; Calcium; Calcium Channels; Cells, Cultured; Ethanol; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Gramicidin; Growth Hormone; Kinetics; Membrane Potentials; Nimodipine; Oleic Acid; Oleic Acids; Pituitary Gland; Pituitary Neoplasms; Potassium Chloride; Prolactin; Rats; Rats, Sprague-Dawley; Stearic Acids; Stereoisomerism; Tumor Cells, Cultured	1997

Article

Year

cis-FFA do not alter membrane depolarization but block Ca2+ influx and GH secretion in KCl-stimulated somatotroph cells. Suggestion for a direct cis-FFA perturbation of the Ca2+ channel opening.

Biochimica et biophysica acta, 1997, Oct-23, Volume: 1329, Issue:2

It has been reported that cis-unsaturated free fatty acids (cis-FFA) block intracellular Ca2+ rise in EGFR T17 and GH3 cells by perturbing the generation of Ins(1,4,5)P3. In the present work, it was found that cis-FFA did not alter potassium-induced cell depolarization in GH3 cells, while blocking Ca2+ rise and GH secretion. Interestingly enough, saturated or trans-unsaturated FFA exert the opposite actions, i.e., they block cell depolarization without altering Ca2+ rise and hormone secretion. As depolarization activates GH3 cells via direct opening of Ca2+ channels with no generation of intracellular mediators, these results suggest that cis-FFA act by a direct perturbation of the Ca2+ channel opening.

Topics: Animals; Calcium; Calcium Channels; Cells, Cultured; Ethanol; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Gramicidin; Growth Hormone; Kinetics; Membrane Potentials; Nimodipine; Oleic Acid; Oleic Acids; Pituitary Gland; Pituitary Neoplasms; Potassium Chloride; Prolactin; Rats; Rats, Sprague-Dawley; Stearic Acids; Stereoisomerism; Tumor Cells, Cultured

1997