gramicidin-a has been researched along with pinocembrin* in 1 studies
1 other study(ies) available for gramicidin-a and pinocembrin
| Article | Year |
|---|---|
Effect of plant flavonoids on the volume regulation of rat thymocytes under hypoosmotic stress.
Cell volume regulation and volume-regulated anion channels are critical for cell survival in non-isosmotic conditions, and dysregulation of this system is detrimental. Although genes and proteins underlying this basic cellular machinery were recently identified, the pharmacology remains poorly explored.. We examined effects of 16 flavonoids on the regulatory volume decrease (RVD) of thymocytes under hypoosmotic stress assessed by light transmittance and on the activity of volume-sensitive chloride channel by patch-clamp technique.. Comparison of effects of flavonoids on RVD revealed a group of four active substances with lehmannin being the strongest inhibitor (IC. Lehmannin, pinocembrin, and possibly hispidulin and pulicarin may serve as leads for developing effective low-toxic immunomodulators. Topics: Alkaloids; Animals; Cell Size; Chloride Channels; Flavanones; Flavonoids; Gramicidin; Osmotic Pressure; Patch-Clamp Techniques; Quinolizidines; Rats; Thymocytes | 2019 |