gramicidin-a and mesoxalonitrile

Two diamines were prepared to investigate the structure-activity relationship required for an increase in the permeability of the outer membrane of Escherichia coli. It was found that diamine (a), bis[4-(2-methylaminoethoxy)phenyl]methane dihydrochloride, increased the permeability of the membrane, while diamine (b), 1,4-bis(2-methylaminoethoxy)benzene dihydrochloride, did not. The result indicated that the existence of bulky hydrophobic moiety is important to cause an increase in the permeability.

Topics: Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Membrane Permeability; Diamines; Escherichia coli; Gramicidin; Kinetics; Nitriles; Onium Compounds; Organophosphorus Compounds; Potassium