gramicidin-a and carbene

gramicidin-a has been researched along with carbene* in 1 studies

Other Studies

1 other study(ies) available for gramicidin-a and carbene

Article	Year
Preparation and properties of novel gramicidin S analogs possessing a tri-, tetra- or pentamethylene bridge between ornithine side chains. The journal of peptide research : official journal of the American Peptide Society, 1999, Volume: 53, Issue:6 Gramicidin S (GS) analogs in which the Ndelta atoms of the two Orn side chains are linked by an oligomethylene bridge [-(CH2)n-; n=3-5] were prepared via the bis(p-nitrobenzenesulfonyl) derivative [Orn(NBS)2,2']GS. For comparison the nonbridged secondary amino group-containing analog [Orn(Me)2,2']GS was also prepared. 1H NMR and CD spectral analysis indicated that these analogs adopt the same beta-sheet conformation as GS. The antimicrobial activities of these analogs were very similar, but were slightly dependent on the bridge chain length, the trimethylene-bridged analog being the most potent. Topics: Anti-Bacterial Agents; Bacillus subtilis; Circular Dichroism; Drug Evaluation, Preclinical; Escherichia coli; Gramicidin; Hydrocarbons; Magnetic Resonance Spectroscopy; Methane; Microbial Sensitivity Tests; Ornithine; Protein Conformation; Staphylococcus aureus; Structure-Activity Relationship	1999

Article

Year

Preparation and properties of novel gramicidin S analogs possessing a tri-, tetra- or pentamethylene bridge between ornithine side chains.

The journal of peptide research : official journal of the American Peptide Society, 1999, Volume: 53, Issue:6

Gramicidin S (GS) analogs in which the Ndelta atoms of the two Orn side chains are linked by an oligomethylene bridge [-(CH2)n-; n=3-5] were prepared via the bis(p-nitrobenzenesulfonyl) derivative [Orn(NBS)2,2']GS. For comparison the nonbridged secondary amino group-containing analog [Orn(Me)2,2']GS was also prepared. 1H NMR and CD spectral analysis indicated that these analogs adopt the same beta-sheet conformation as GS. The antimicrobial activities of these analogs were very similar, but were slightly dependent on the bridge chain length, the trimethylene-bridged analog being the most potent.

Topics: Anti-Bacterial Agents; Bacillus subtilis; Circular Dichroism; Drug Evaluation, Preclinical; Escherichia coli; Gramicidin; Hydrocarbons; Magnetic Resonance Spectroscopy; Methane; Microbial Sensitivity Tests; Ornithine; Protein Conformation; Staphylococcus aureus; Structure-Activity Relationship

1999