gr 89696 has been researched along with u-50488 in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Birch, PJ; Hayes, AG; Judd, DB; Lloyd, JE; Naylor, A; Scopes, DI | 1 |
| Englberger, W; Geiger, C; Lehmkuhl, K; Schepmann, D; Wünsch, B; Zelenka, C | 1 |
| Rack, E; Schepmann, D; Sunnam, SK; Wünsch, B | 1 |
| Aiello, D; Diana, P; Jonas, H; Schepmann, D; Wünsch, B | 1 |
| Headley, PM; Herrero, JF | 1 |
| Ehret, A; Jackisch, R; Maier, CA; Predoiu, U; Soukara, S; Wünsch, B | 1 |
| Dolber, PC; Fraser, MO; Gu, B; Thor, KB | 1 |
| Lasukova, TV; Lishmanov, AIu; Maslov, LN; Platonov, AA | 1 |
| Autar, R; Bouzanne des Mazery, R; Fröhlich, R; Molenveld, P; Schepmann, D; Soeberdt, M; Sterk, GJ; Storcken, RP; van der Haas, RN; van Oss, B; Wünsch, B | 1 |
| Khaliuli, I; Maslov, LN; Mukhomedzyanov, AV; Oeltgen, PR; Popov, SV; Prasad, NR; Tsibulnikov, SY | 1 |
10 other study(ies) available for gr 89696 and u-50488
| Article | Year |
|---|---|
A potent new class of kappa-receptor agonist: 4-substituted 1-(arylacetyl)-2-[(dialkylamino)methyl]piperazines.
Topics: Analgesics; Animals; Cricetinae; Male; Mice; Molecular Conformation; Piperazines; Pyrrolidines; Rabbits; Rats; Receptors, Opioid, kappa; Stereoisomerism; Structure-Activity Relationship; Vas Deferens | 1993 |
Conformationally constrained kappa receptor agonists: stereoselective synthesis and pharmacological evaluation of 6,8-diazabicyclo[3.2.2]nonane derivatives.
Topics: Animals; Azabicyclo Compounds; Cell Line; Guinea Pigs; Humans; In Vitro Techniques; Molecular Conformation; Radioligand Assay; Receptors, Opioid, kappa; Stereoisomerism; Structure-Activity Relationship | 2010 |
Synthesis of 7,9-diazabicyclo[4.2.2]decanes as conformationally restricted κ receptor agonists: fine tuning of the dihedral angle of the ethylenediamine pharmacophore.
Topics: Animals; Azabicyclo Compounds; Ethylenediamines; Guinea Pigs; Ligands; Models, Molecular; Molecular Structure; Receptors, Opioid, kappa; Stereoisomerism; Structure-Activity Relationship | 2011 |
Synthesis of 8-aminomorphans with high KOR affinity.
Topics: Molecular Conformation; Pyrrolidines; Receptors, Opioid, kappa; Stereoisomerism; Structure-Activity Relationship | 2022 |
Functional evidence for multiple receptor activation by kappa-ligands in the inhibition of spinal nociceptive reflexes in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Anticonvulsants; Benzeneacetamides; Benzofurans; Blood Pressure; Decerebrate State; Male; Naloxone; Nociceptors; Piperazines; Pyrroles; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reflex; Spinal Cord; Thiophenes | 1993 |
Methylated analogues of methyl (R)-4-(3,4-dichlorophenylacetyl)- 3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate (GR-89,696) as highly potent kappa-receptor agonists: stereoselective synthesis, opioid-receptor affinity, receptor selectivity, and functio
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Animals; Binding Sites; Brain; Electric Stimulation; Guinea Pigs; Hippocampus; In Vitro Techniques; Piperazines; Pyrrolidines; Rabbits; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship | 2001 |
Induction of bladder sphincter dyssynergia by kappa-2 opioid receptor agonists in the female rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Ataxia; Dose-Response Relationship, Drug; Female; Piperazines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Urinary Bladder | 2004 |
[Role of kappa-opioid receptors in the regulation of cardiac resistance to arrhythmogenic effects of ischemia and reperfusion].
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Myocardial Reperfusion Injury; Myocardium; Naloxone; Naltrexone; Piperazines; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, Opioid, kappa | 2006 |
Conformationally restricted κ-opioid receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Crystallography, X-Ray; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Molecular Structure; Piperazines; Protein Binding; Pyrrolidines; Quinoxalines; Receptors, Opioid, kappa; Stereoisomerism | 2015 |
Activation of Peripheral Opioid Kappa1 Receptor Prevents Cardiac Reperfusion Injury.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Administration, Intravenous; Analgesics, Opioid; Animals; Arrhythmias, Cardiac; Disease Models, Animal; Heart Rate; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Narcotic Antagonists; Piperazines; Pyrrolidines; Rats, Wistar; Receptors, Opioid, kappa; Signal Transduction | 2021 |