Page last updated: 2024-09-05

gr 144053 and piperidines

gr 144053 has been researched along with piperidines in 19 studies

Compound Research Comparison

Studies
(gr 144053)
Trials
(gr 144053)
Recent Studies (post-2010)
(gr 144053)
Studies
(piperidines)
Trials
(piperidines)
Recent Studies (post-2010) (piperidines)
211240,2355,22114,545

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (42.11)18.2507
2000's9 (47.37)29.6817
2010's2 (10.53)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Eldred, CD; Evans, B; Hindley, S; Judkins, BD; Kelly, HA; Kitchin, J; Lumley, P; Porter, B; Ross, BC; Smith, KJ1
Heptinstall, S; Lösche, W; Sanderson, HM; Vickers, J1
Coller, BS; Lang, D; Scudder, LE1
Hayashi, H; Kaida, T; Kozawa, O; Matsuno, H; Niwa, M; Uematsu, T1
Hayashi, H; Ito, T; Kozawa, O; Matsuno, H; Nishida, M; Niwa, M; Tanabe, K; Uematsu, T1
Heptinstall, S; Storey, RF; Wilcox, RG1
Ito, T; Kozawa, O; Matsuno, H; Niwa, M; Sakai, N; Uematsu, T1
Kanamaru, M; Kozawa, O; Matsuno, H; Nagashima, S; Uematsu, T1
Collen, D; Kozawa, O; Matsuno, H; Matsuo, O; Uematsu, T; Ueshima, S1
Achison, M; Barnes, MJ; Elton, CM; Farndale, RW; Hargreaves, PG; Knight, CG1
Collen, D; Kozawa, O; Matsuno, H; Matsuo, O; Nishida, M; Uematsu, T; Ueshima, S1
Boncler, M; Golanski, J; Rozalski, M; Watala, C1
Kozawa, O; Matsuno, H; Matsuo, O; Okada, K; Uematsu, T; Ueshima, S1
Rozalski, M; Watala, C1
Essex, DW; Farndale, RW; Griffiths, D; Hamaia, SW; Hess, O; Knight, CG; Lahav, J; Makris, M; Wijnen, EM1
Ishisaki, A; Kitajima, Y; Kozawa, O; Matsuno, H; Tokuda, H; Zhou, Y1
Cooley, BC; Isogai, N; Kusada, A1
Diamond, SL; Herbig, BA1
Bai, J; Fernández, JÁ; Griffin, JH; Lamb, JA; Lei, IF; Leung, J; Lyden, PD; Pereira, BR; Rajput, PS1

Trials

1 trial(s) available for gr 144053 and piperidines

ArticleYear
Differential effects of glycoprotein IIb/IIIa antagonists on platelet microaggregate and macroaggregate formation and effect of anticoagulant on antagonist potency. Implications for assay methodology and comparison of different antagonists.
    Circulation, 1998, Oct-20, Volume: 98, Issue:16

    Topics: Adenosine Diphosphate; Anticoagulants; Citrates; Collagen; Eptifibatide; Hirudins; Humans; Nephelometry and Turbidimetry; Oligopeptides; Peptides; Peptides, Cyclic; Piperazines; Piperidines; Platelet Aggregation Inhibitors; Platelet Count; Platelet Glycoprotein GPIIb-IIIa Complex; Sodium Citrate; Thiazolidines

1998

Other Studies

18 other study(ies) available for gr 144053 and piperidines

ArticleYear
Orally active non-peptide fibrinogen receptor (GpIIb/IIIa) antagonists: identification of 4-[4-[4-(aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid as a long-acting, broad-spectrum antithrombotic agent.
    Journal of medicinal chemistry, 1994, Nov-11, Volume: 37, Issue:23

    Topics: Administration, Oral; Animals; Blood Platelets; Callithrix; Fibrinolytic Agents; Humans; Piperazines; Piperidines; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Structure-Activity Relationship

1994
Studies on the effects of agonists and antagonists on platelet shape change and platelet aggregation in whole blood.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 1996, Volume: 7, Issue:2

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Azepines; Blood Platelets; Humans; In Vitro Techniques; Piperazines; Piperidines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Serotonin; Succinates; Sulfonamides; Thromboxane A2; Triazoles; Vasoconstrictor Agents

1996
Rapid and simple platelet function assay to assess glycoprotein IIb/IIIa receptor blockade.
    Circulation, 1997, Feb-18, Volume: 95, Issue:4

    Topics: Abciximab; Analysis of Variance; Animals; Antibodies, Monoclonal; Hemagglutination; Humans; Immunoglobulin Fab Fragments; In Vitro Techniques; Mice; Observer Variation; Oligopeptides; Piperazines; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Fusion Proteins; Reference Values; Thrombasthenia

1997
GR144053, a fibrinogen receptor antagonist, enhances the suppression of neointima formation by losartan, an angiotensin II receptor antagonist, in the injured carotid artery of hamster.
    British journal of pharmacology, 1997, Volume: 122, Issue:6

    Topics: Angiotensin Receptor Antagonists; Animals; Carotid Arteries; Cell Division; Cricetinae; Drug Administration Schedule; Drug Synergism; Losartan; Male; Piperazines; Piperidines; Platelet Glycoprotein GPIIb-IIIa Complex

1997
Effect of GR144053, a fibrinogen-receptor antagonist, on thrombus formation and vascular patency after thrombolysis by tPA in the injured carotid artery of the hamster.
    Journal of cardiovascular pharmacology, 1998, Volume: 32, Issue:2

    Topics: Animals; Bleeding Time; Carotid Artery Thrombosis; Cell Division; Cricetinae; Disease Models, Animal; Drug Interactions; Fibrinogen; Fibrinolytic Agents; Male; Muscle, Smooth; Peptides; Piperazines; Piperidines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombolytic Therapy; Tissue Plasminogen Activator; Vascular Patency

1998
Comparison of the antithrombotic effects and bleeding risk of fractionated aurin tricarboxylic acid and the GPIIb/IIIa antagonist GR144053 in a hamster model of stenosis.
    Thrombosis research, 1999, Jul-01, Volume: 95, Issue:1

    Topics: Animals; Aurintricarboxylic Acid; Carotid Stenosis; Catheterization; Cricetinae; Endothelium, Vascular; Hemorrhage; Infusions, Intravenous; Male; Mesocricetus; Piperazines; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex

1999
Comparative antiplatelet effects of aspirin, vapiprost and GR144053, a GPIIb/IIIa antagonist, with a special reference to the role of platelet microaggregates.
    British journal of pharmacology, 1999, Volume: 127, Issue:5

    Topics: Animals; Aspirin; Biphenyl Compounds; Cricetinae; Fibrinolytic Agents; Heptanoic Acids; Male; Piperazines; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombosis

1999
Lack of tPA significantly affects antithrombotic therapy by a GPIIb/IIIa antagonist, but not by a thrombin inhibitor in mice.
    Thrombosis and haemostasis, 2000, Volume: 83, Issue:4

    Topics: Animals; Arginine; Bleeding Time; Carotid Artery Thrombosis; Dose-Response Relationship, Drug; Fibrinolytic Agents; Mice; Mice, Knockout; Pipecolic Acids; Piperazines; Piperidines; Platelet Glycoprotein GPIIb-IIIa Complex; Sulfonamides; Thrombin; Thrombolytic Therapy; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator

2000
Integrin-independent tyrosine phosphorylation of p125(fak) in human platelets stimulated by collagen.
    The Journal of biological chemistry, 2001, Feb-02, Volume: 276, Issue:5

    Topics: Adult; Animals; Blood Platelets; Calcium; Cattle; Collagen; Egtazic Acid; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Indoles; Integrins; Ionomycin; Ligands; Peptide Fragments; Phosphorylation; Piperazines; Piperidines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Precipitin Tests; Protein Kinase C; Protein-Tyrosine Kinases; Tyrosine

2001
tPA, but not uPA, significantly affects antithrombotic therapy by a glycoprotein IIb/IIIa antagonist, but not by a factor Xa inhibitor.
    Journal of cardiovascular pharmacology, 2000, Volume: 36, Issue:6

    Topics: Animals; Bleeding Time; Factor Xa Inhibitors; Fibrinolytic Agents; Indicators and Reagents; Mice; Naphthalenes; Partial Thromboplastin Time; Piperazines; Piperidines; Plasminogen Activators; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Propionates; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator

2000
Effects of fibrinogen receptor antagonist GR144053F and aurintricarboxylic acid on platelet activation and degranulation.
    Biochemical pharmacology, 2001, Nov-15, Volume: 62, Issue:10

    Topics: Adenosine Diphosphate; Adult; Aurintricarboxylic Acid; Cell Degranulation; Collagen Type I; Female; Flow Cytometry; Hemostasis; Humans; Male; Middle Aged; Piperazines; Piperidines; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex

2001
Inhibitors of fibrinolytic components play different roles in the formation and removal of arterial thrombus in mice.
    Journal of cardiovascular pharmacology, 2002, Volume: 39, Issue:2

    Topics: alpha-2-Antiplasmin; Animals; Arginine; Bleeding Time; Blood Coagulation; Carotid Artery Injuries; Endothelium, Vascular; Mice; Mice, Inbred C57BL; Mice, Knockout; Pipecolic Acids; Piperazines; Piperidines; Plasminogen Activator Inhibitor 1; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Serine Proteinase Inhibitors; Sulfonamides; Thrombin; Thrombin Time; Thrombosis; Vascular Patency

2002
Antagonists of platelet fibrinogen receptor are less effective in carriers of Pl(A2) polymorphism of beta(3) integrin.
    European journal of pharmacology, 2002, Nov-01, Volume: 454, Issue:1

    Topics: Adult; Eptifibatide; Female; Genotype; Humans; Integrin beta3; Intercellular Signaling Peptides and Proteins; Male; Nephelometry and Turbidimetry; Peptides; Piperazines; Piperidines; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Receptors, Fibrinogen

2002
Enzymatically catalyzed disulfide exchange is required for platelet adhesion to collagen via integrin alpha2beta1.
    Blood, 2003, Sep-15, Volume: 102, Issue:6

    Topics: 4-Chloromercuribenzenesulfonate; Anti-Bacterial Agents; Antibodies; Bacitracin; Carrier Proteins; Catalysis; Collagen; Cross-Linking Reagents; Disulfides; Dithionitrobenzoic Acid; Dose-Response Relationship, Drug; Humans; Integrin alpha2beta1; Ligands; Peptides; Piperazines; Piperidines; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Protein Binding; Protein Disulfide-Isomerases; Protein Structure, Tertiary; Recombinant Proteins; Sulfhydryl Compounds; Sulfhydryl Reagents

2003
P2Y12 receptors play a significant role in the development of platelet microaggregation in patients with diabetes.
    The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:2

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Aged; Diabetes Mellitus, Type 2; Female; Humans; Male; Membrane Proteins; Middle Aged; Piperazines; Piperidines; Platelet Aggregation; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Reference Values

2005
Electric injury model of murine arterial thrombosis.
    Thrombosis research, 2007, Volume: 121, Issue:1

    Topics: Animals; Carotid Arteries; Disease Models, Animal; Electric Injuries; Heparin; Kinetics; Mice; Piperazines; Piperidines; Platelet Aggregation; Thrombosis; Video Recording

2007
Pathological von Willebrand factor fibers resist tissue plasminogen activator and ADAMTS13 while promoting the contact pathway and shear-induced platelet activation.
    Journal of thrombosis and haemostasis : JTH, 2015, Volume: 13, Issue:9

    Topics: ADAM Proteins; ADAMTS13 Protein; Biopolymers; Blood Coagulation; Elastic Modulus; Fibrinolysin; Hemorheology; Humans; In Vitro Techniques; Lab-On-A-Chip Devices; P-Selectin; Piperazines; Piperidines; Platelet Activation; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Subunits; Solubility; Tissue Plasminogen Activator; von Willebrand Factor

2015
Neuroprotection and vasculoprotection using genetically targeted protease-ligands.
    Brain research, 2019, 07-15, Volume: 1715

    Topics: Animals; Anticoagulants; Brain; Brain Ischemia; Infarction, Middle Cerebral Artery; Ligands; Male; Neurons; Neuroprotection; Neuroprotective Agents; Piperazines; Piperidines; Protein C; Rats; Rats, Sprague-Dawley; Receptor, PAR-1; Receptors, Proteinase-Activated; Stroke; Thrombin

2019