Compounds > gr 127935
Page last updated: 2024-09-02

gr 127935 and sb-224289

gr 127935 has been researched along with sb-224289 in 4 studies

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (50.00)18.2507
2000's2 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Blaney, FE; Davies, S; Duckworth, DM; Gaster, LM; Hagan, JJ; Ham, P; Hatcher, J; Jenkins, S; Jennings, AJ; Joiner, GF; Jones, BJ; King, FD; Middlemiss, DN; Mulholland, KR; Price, GW; Riley, G; Roberts, C; Routledge, C; Selkirk, J; Slade, PD; Wyman, PA1
Burton, MJ; Collin, L; Gaster, LM; Ho, M; Jones, BJ; Middlemiss, DN; Price, GW; Scott, C; Selkirk, JV; Watson, J1
Böttcher, H; Cremers, T; Greiner, H; Harting, J; Liao, Y; März, J; Rautenberg, W; Sundell, S; van Amsterdam, C; Wikström, H1
Bae, SA; Huang, Y; Laruelle, M; Roth, BL1

Other Studies

4 other study(ies) available for gr 127935 and sb-224289

ArticleYear
The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function b
    Journal of medicinal chemistry, 1998, Apr-09, Volume: 41, Issue:8

    Topics: Animals; Aspartic Acid; Autoreceptors; CHO Cells; Cricetinae; Frontal Lobe; Guinea Pigs; Humans; Hypothermia; In Vitro Techniques; Indoles; Male; Models, Molecular; Oxadiazoles; Piperazines; Piperidones; Radioligand Assay; Rats; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Structure-Activity Relationship; Swine

1998
SB-224289--a novel selective (human) 5-HT1B receptor antagonist with negative intrinsic activity.
    British journal of pharmacology, 1998, Volume: 125, Issue:1

    Topics: Animals; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); HeLa Cells; Humans; Piperidones; Radioligand Assay; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Recombinant Proteins; Serotonin; Serotonin Antagonists; Spiro Compounds; Sulfur Radioisotopes

1998
New selective and potent 5-HT(1B/1D) antagonists: chemistry and pharmacological evaluation of N-piperazinylphenyl biphenylcarboxamides and biphenylsulfonamides.
    Journal of medicinal chemistry, 2000, Feb-10, Volume: 43, Issue:3

    Topics: Acetylcholine; Animals; Biphenyl Compounds; Cattle; Crystallography, X-Ray; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Microdialysis; Molecular Structure; Muscle Contraction; Muscle, Smooth, Vascular; Piperazines; Rabbits; Radioligand Assay; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Saphenous Vein; Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Sulfonamides

2000
Synthesis of potent and selective serotonin 5-HT1B receptor ligands.
    Bioorganic & medicinal chemistry letters, 2005, Nov-01, Volume: 15, Issue:21

    Topics: Amides; Humans; Ligands; Piperazines; Protein Binding; Radioligand Assay; Receptor, Serotonin, 5-HT1B; Serotonin Agents; Structure-Activity Relationship

2005