gr 127935 has been researched along with oxadiazoles in 193 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 92 (47.67) | 18.2507 |
| 2000's | 80 (41.45) | 29.6817 |
| 2010's | 20 (10.36) | 24.3611 |
| 2020's | 1 (0.52) | 2.80 |
| Authors | Studies |
|---|---|
| Hill, RG; Longmore, J; Razzaque, Z | 1 |
| Feniuk, W; Skingle, M; Sleight, AJ | 1 |
| Bristow, LJ; Cunningham, JR; Hogg, JE; Hutson, PH; Longmore, J; Murray, F; Pearce, D; Razzaque, Z; Saywell, K; Tricklebank, MD | 1 |
| Colpaert, FC; Pauwels, PJ | 2 |
| Craven, R; Grahame-Smith, D; Newberry, N | 1 |
| Davidson, C; Stamford, JA | 3 |
| Maura, G; Raiteri, M | 1 |
| Kalkman, HO; Neumann, V | 1 |
| Palmier, C; Pauwels, PJ | 1 |
| Bobirnac, I; Schoeffter, P | 1 |
| Crick, H; Manuel, NA; Wallis, DI | 1 |
| Beattie, DT; Connor, HE; Walsh, DM | 1 |
| De Vries, P; Heiligers, JP; Saxena, PR; Villalón, CM | 3 |
| Terrón, JA | 5 |
| Burton, M; Jones, BJ; Middlemiss, DN; Mulholland, K; Price, GW; Roberts, C; Watson, J | 1 |
| Beattie, DT; Connor, HE; Feniuk, W; Scopes, DI; Skingle, M; Starkey, SJ; Tyers, MB | 1 |
| Colpaert, FC; Palmier, C; Pauwels, PJ; Wurch, T | 1 |
| Clarke, T; Rollema, H; Schulz, DW; Sprouse, JS | 1 |
| Fernández, AG; O'Neill, MF; Palacios, JM | 1 |
| Bonnafous, R; John, GW; Valentin, JP | 1 |
| Centurión, D; Sánchez-López, A; Villalón, CM | 1 |
| Burton, MJ; Jones, BJ; Middlemiss, DN; Price, GW; Watson, JM | 1 |
| Macor, JE; Mansbach, RS; Rovetti, CC | 1 |
| Bertolino, F; Fauré, P; John, GW; Valentin, JP; Vieu, S | 1 |
| Cistarelli, L; Gobert, A; Millan, MJ; Rivet, JM | 1 |
| Millan, MJ; Perrin-Monneyron, S | 1 |
| Centurión, D; Luján-Estrada, M; Sánchez-López, A; Terrón, JA; Villalón, CM | 1 |
| Apaydin, S; De Vries, P; Heiligers, JP; Saxena, PR; Villalón, CM | 1 |
| Curtis, MJ; Ellwood, AJ | 2 |
| Hållbus, M; Magnusson, O; Magnusson, T | 1 |
| Cutrer, FM; Moskowitz, MA; Waeber, C; Yu, XJ | 1 |
| Hen, R; Lucas, JJ; Segu, L | 1 |
| Centurión, D; Terrón, JA; Villalón, CM | 1 |
| Gartside, SE; Sharp, T; Umbers, V | 1 |
| Bulcäo, C; Cunha, M; De Castro-e-Silva, E; De Oliveira, IR; Fregoneze, JB; Luz, CP; Marinho, A; Nascimento, TA; Sarmento, C; Soares, T | 1 |
| Gaster, L; Hagan, JJ; Hatcher, JP; Jeffrey, P; Middlemiss, DN; Slade, PD | 1 |
| Goadsby, PJ; Knight, Y | 1 |
| Beleta, J; Bernabeu, E; Bou, J; Cortijo, J; Domènech, T; Fernández, AG; Martí-Cabrera, M; Morcillo, EJ; Palacios, JM | 1 |
| Hong, E; Meneses, A; Terrón, JA | 1 |
| Audinot, V; Cistarelli, L; Gobert, A; Millan, MJ; Newman-Tancredi, A; Rivet, JM | 1 |
| Gleason, SD; Shannon, HE | 1 |
| Blaney, FE; Davies, S; Duckworth, DM; Gaster, LM; Hagan, JJ; Ham, P; Hatcher, J; Jenkins, S; Jennings, AJ; Joiner, GF; Jones, BJ; King, FD; Middlemiss, DN; Mulholland, KR; Price, GW; Riley, G; Roberts, C; Routledge, C; Selkirk, J; Slade, PD; Wyman, PA | 1 |
| Goadsby, PJ; Hoskin, KL | 1 |
| Belden, M; Carvey, PM; Goetz, CG; Pappert, EJ; Stebbins, GT | 1 |
| Belenguer, A; Middlemiss, DN; Roberts, C; Routledge, C | 1 |
| De Vries, P; Heiligers, JP; Saxena, PR; Villalón, CM; Willems, EW | 1 |
| John, GW; Le Grand, B; Vié, B | 1 |
| Artigas, F; Bel, N; Fernández, AG; Hervás, I; Palacios, JM | 1 |
| Dando, SB; Jordan, D; Ramage, AG; Skinner, MR | 1 |
| Koob, GF; Parsons, LH; Weiss, F | 1 |
| Pauwels, PJ | 1 |
| Aguerre, S; Chaouloff, F; Mormede, P | 1 |
| Branchek, TA; Zgombick, JM | 1 |
| Beer, MS; Heald, MA; McAllister, G; Stanton, JA | 1 |
| Nielsen, CK | 1 |
| John, GW; Le Grand, B; Panissié, A; Pauwels, PJ | 1 |
| Carvey, PM; Goetz, CG; Leurgans, S; Ling, ZD; Pappert, EJ; Raman, R; Vu, TQ | 1 |
| Grailhe, R; Hen, R; Moskowitz, MA; Waeber, C; Yu, XJ | 1 |
| Gaster, LM; Hagan, JJ; Ham, P; Joiner, GF; King, FD; Middlemiss, DN; Mulholland, KR; Price, GW; Roberts, C; Routledge, C; Selkirk, J; Slade, PD; Wyman, PA | 1 |
| Centurión, D; Rabelo, G; Sánchez-López, A; Villalón, CM | 1 |
| Barton, CL; Hutson, PH | 1 |
| Harrison, AA; Koob, GF; Markou, A; Parsons, LH | 1 |
| Chaouloff, F; Courvoisier, H; Moisan, MP; Mormède, P | 1 |
| Hållbus, M; Larsson, LG; Magnusson, O; Magnusson, T; Ross, SB; Stenfors, C; Yu, H | 1 |
| Beer, MS; Heald, MA; Hill, RG; Longmore, J; Maskell, L; Pickard, JD; Razzaque, Z | 1 |
| Centurión, D; De Vries, P; Rabelo, G; Sánchez-López, A; Saxena, P; Villalón, CM | 1 |
| Marcoli, M; Maura, G; Munari, C; Raiteri, M; Ruelle, A | 1 |
| De Visser, PA; De Vries, P; Heiligers, JP; Saxena, PR; Villalón, CM | 1 |
| Ayata, G; Cutrer, FM; Moskowitz, MA; Waeber, C; Yu, XJ | 1 |
| Bankson, MG; Cunningham, KA; McCreary, AC | 1 |
| Cohen, ML; Hemrick-Luecke, SH; Schenck, KW | 1 |
| Fanelli, E; Grignaschi, G; Samanin, R; Scagnol, I | 1 |
| Li, XF; Lovren, F; Lytton, J; Triggle, C | 1 |
| De Vries, P; Heiligers, JP; Saxena, PR; Trion, M; Villalón, CM; Willems, EW | 1 |
| Dawson, LA; Geiger, A; Nguyen, HQ | 1 |
| Belknap, JK; Hain, HS; Mogil, JS | 1 |
| Bischoff, A; Diener, H; Fetscher, C; Limmroth, V; Michel, MC; Wermelskirchen, D | 1 |
| Faccidomo, S; Fish, EW; Miczek, KA | 1 |
| Matsumoto, M; Miyamoto, A; Mori, K; Togashi, H; Ueno, K; Yoshioka, M | 1 |
| Adrien, J; Chastanet, M; Evrard, A; Hamon, M; Hen, R; Laporte, AM | 1 |
| Ferrari, MD; Maassen Van Den Brink, A; Roon, KI; Saxena, PR | 1 |
| Dunn, AJ; Swiergiel, AH | 1 |
| Knobelman, DA; Kung, HF; Lucki, I | 1 |
| Fillion, G; Hong, E; Meneses, A; Orozco, G | 1 |
| Dawson, LA; Nguyen, HQ | 1 |
| Heisler, LK; Tecott, LH | 1 |
| Lutz, EA; Shannon, HE | 1 |
| Dulawa, SC; Geyer, MA; Hen, R; Scearce-Levie, KA | 1 |
| Chen, J; Purdy, RE; Yildiz, O | 1 |
| O'Neill, MF; Tomkins, DM | 1 |
| Bosker, FJ; Cremers, TI; de Boer, P; den Boer, JA; Liao, Y; Westerink, BH; Wikström, HV | 1 |
| John, GW; Le Grand, B; Panissié, A; Pauwels, PJ; Perez, M | 1 |
| Boers, PM; Donaldson, C; Lambert, GA; Zagami, AS | 1 |
| Beaufour, C; Evrard, A; Fabre, V; Hamon, M; Hanoun, N; Lanfumey, L; Lesch, KP; Martres, MP; Murphy, DL; Rioux, A | 1 |
| Centurión, D; De Vries, P; Ortiz, MI; Sánchez-López, A; Saxena, PR; Villalón, CM | 1 |
| Dremencov, E; Garcia, F; Gur, E; Lerer, B; Newman, ME; Van de Kar, LD | 2 |
| Davidson, C; Hopwood, SE; McLaughlin, DP; Stamford, JA | 1 |
| Dremencov, E; Gur, E; Lerer, B; Newman, ME | 2 |
| Clarke, RW; Jenkins, S; Richardson, B | 1 |
| Cordi, AA; Ragonnet, C; Vayssettes-Courchay, C; Verbeuren, TJ | 1 |
| Bourin, M; Gardier, AM; Hen, R; Jacquot, C; Malagié, I; Trillat, AC | 1 |
| Castanon, N; Hen, R; Lucas, JJ; Rocha, B; Scearce-Levie, K | 1 |
| Conway, MW; O'Neill, MF | 1 |
| Centurión, D; Sánchez-López, A; Saxena, PR; Villalón, CM | 1 |
| Centurión, D; De Vries, P; Sánchez-López, A; Saxena, PR; Villalón, CM | 1 |
| Akita, H; Inoue, N; Ishida, T; Kawashima, S; Miwa, Y; Sakoda, T; Shimokawa, Y; Shiomi, M; Ueyama, T; Yokoyama, M | 1 |
| Filip, M; Papla, I; Przegalinski, E; Siwanowicz, J | 1 |
| Bourin, M; Colombel, MC; David, D; Gardier, AM; Hascoët, M; Hen, R; Jacquot, C; Jolliet, P; Malagié, I; Trillat, AC | 1 |
| Flieger, M; Pertz, HH; Schöning, C | 1 |
| Honda, M; Ono, H | 1 |
| Cooper, J; Greenslade, RG; Mitchell, SN | 1 |
| Hicks, MN; Keegan, A; MacLean, MR; Morecroft, I; Smillie, D | 1 |
| Bankson, MG; Cunningham, KA | 1 |
| Dremencov, E; Gur, E; Lerer, B; Newman, ME; Van De Kar, LD | 1 |
| Lin, D; Parsons, LH | 1 |
| Clifton, PG; Dourish, CT; Hewitt, KN; Lee, MD | 1 |
| Azampanah, A; Fletcher, PJ; Korth, KM | 1 |
| De Vries, P; Heiligers, JP; John, GW; Kapoor, K; Saxena, PR; Tom, B; Willems, EW | 1 |
| Baker, GB; Fletcher, PJ; Korth, KM; Robinson, SR | 1 |
| de Groote, L; Klompmakers, AA; Olivier, B; Westenberg, HG | 1 |
| Colpaert, FC; John, GW; Le Grand, B; Letienne, R; Perez, M; Verscheure, Y | 1 |
| Crema, A; Crema, F; De Ponti, F; Frigo, G; Moro, E; Nardelli, G | 1 |
| Adnot, S; Eddahibi, S; Hamon, M; Marcos, E; Nosjean, A; Pham, MH; Raffestin, B | 1 |
| Avraham, Y; Berry, EM; Dremencov, E; Gur, E; Newman, ME | 1 |
| Beauverie, P; Bourin, M; David, DJ; Douvier, E; Durier, S; Gardier, AM; Gruwez, B; Hen, R; Jacquot, C; Jego, G; Poisson, N; Przybylski, C | 1 |
| Arulmani, U; Centurión, D; Sánchez-Lopez, A; Saxena, PR; Vázquez, E; Villalón, CM | 2 |
| Donaldson, C; Hoskin, KL; Lambert, GA; Zagami, AS | 1 |
| Folz, RJ; Liu, JQ | 1 |
| Buhot, MC; Cazala, P; David, V; Ichaye, M; Segu, L | 1 |
| Chojnacka-Wójcik, E; Kłodzińska, A; Stachowicz, K; Tatarczyńska, E | 2 |
| Clarke, RW; Harris, J; Jackson, E; Lo, WC; Merriman, A | 1 |
| Clifton, PG; Dourish, CT; Kennett, GA; Lee, MD; Somerville, EM | 1 |
| Jähnichen, S; Pertz, HH; Radtke, OA | 1 |
| Day, RM; Fanburg, BL; Liu, Y; Suzuki, YJ | 1 |
| Honda, M; Imaida, K; Ono, H; Tanabe, M | 1 |
| Castro, ME; Mostany, R; Pazos, A | 1 |
| Bockaert, J; Compan, V; Conductier, G; Crosson, C; Hen, R | 1 |
| Chojnacka-Wójcik, E; Kłodzińska, A; Tatarczyńska, E | 1 |
| Greenshaw, A; Hayes, D; Mosher, T | 1 |
| Bosker, FJ; Cremers, TI; den Boer, JA; Jongsma, ME; Westerink, BH | 1 |
| Blanchet, JC; John, GW; Le Grand, B; Létienne, R; Sole, E | 1 |
| Clarke, KL; Dawson, LA; Hagan, JJ; Langmead, CJ; Price, GW; Scott, C; Smith, PW; Starr, KR; Watson, J; Wyman, P | 1 |
| Benini, Q; De Almeida, RM; Miczek, KA; Rosa, MM; Saft, DM; Santos, DM | 1 |
| Aubel, B; Bourgoin, S; Farré, A; Hamon, M; Kayser, V | 1 |
| Bloemarts, E; Groenink, L; Olivier, B; Oosting, RS; van den Bergh, FS | 1 |
| Komada, T; Yano, S | 1 |
| Centurión, D; Gupta, S; Mehrotra, S; Saxena, PR; VandenBrink, AM; Villalón, CM | 1 |
| Bannai, M; Faccidomo, S; Fish, EW; Miczek, KA | 1 |
| Martínez-García, E; Sánchez-Maldonado, C; Terrón, JA | 2 |
| Fink, H; Rex, A; Voigt, JP; Wicke, KM | 1 |
| Chen, ZQ; Cheng, HW; Dennis, RL | 1 |
| Inoue, T; Koyama, T; Muraki, I | 1 |
| Guptarak, J; Hiegel, C; Maswood, N; Uphouse, L | 1 |
| Bourin, M; Chenu, F; David, DJ; Gardier, AM; Le Maître, E; Leroux-Nicollet, I | 1 |
| Ansorge, M; Dulawa, SC; Geyer, MA; Gingrich, JA; Hen, R; Holick Pierz, KA; Masten, VL; Shanahan, NA; Waeber, C | 1 |
| Graham, DA; Greenshaw, AJ; Hayes, DJ | 1 |
| García-Iglesias, B; Martínez-García, E; Terrón, JA | 1 |
| Centurión, D; Cobos-Puc, LE; González-Hernández, A; Lozano-Cuenca, J; Muñoz-Islas, E; Pertz, HH; Sánchez-López, A; Villalón, CM | 1 |
| Carson, RE; Ding, YS; Frost, JJ; Huang, Y; McCarthy, T; Nabulsi, N; Ropchan, J; Weinzimmer, D | 1 |
| Jiang, Z; Shang, J; Wang, W; Zhang, H; Zhang, L | 1 |
| Abman, SH; Delaney, C; Gien, J; Grover, TR; Roe, G | 1 |
| Cheng, HW; Dennis, RL | 1 |
| Altamirano-Espinoza, AH; González-Hernández, A; MaassenVanDenBrink, A; Manrique-Maldonado, G; Marichal-Cancino, BA; Ruiz-Salinas, II; Villalón, CM | 1 |
| Khatri, N; Lin, RC; Paul, IA; Simpson, KL | 1 |
| Beaudet, G; Bouet, V; Boulouard, M; Dauphin, F; Freret, T; Gusmao-Montaigne, A; Nee, G; Paizanis, E | 1 |
| Jamshidi-Mehr, M; Khakpai, F; Nasehi, M; Zarrindast, MR | 1 |
| Anguiano-Robledo, L; Lacivita, E; Leopoldo, M; López-Sánchez, P; Sánchez-Maldonado, C; Terrón, JA | 1 |
| Avila-Rojas, SH; Barragán-Iglesias, P; Granados-Soto, V; Pineda-Farias, JB; Salinas-Abarca, AB; Velázquez-Lagunas, I | 1 |
| Cai, J; Chen, Z; Ji, G; Ji, Q; Li, Q; Liu, X; Song, H; Sui, H; Xu, H; Xu, Y; Zhou, L; Zhou, X | 1 |
| Haeri-Rohani, SA; Najar, F; Nasehi, M; Zarrindast, MR | 1 |
| Kawatani, M; Koyama, Y; Matsumoto-Miyai, K; Shimada, S; Shinzawa, E; Yamada, E; Yoshizumi, M | 1 |
| Aronsen, D; Bukholt, N; Foote, J; Highgate, Q; Schenk, S; Van de Wetering, R; Webster, J | 1 |
| Bojanowska, E; Drobnik, J; Juszczak, M; Wierucka-Rybak, M; Wolak, M | 1 |
| Babapour, V; Keramati-Nojedehsadat, M; Oryan, S; Zarrindast, MR | 1 |
| Afshari, K; Daneshpazhooh, M; Dehpour, AR; Foroutan, A; Haddadi, NS; Ostadhadi, S; Shakiba, S | 1 |
| González-Hernández, A; Lozano-Cuenca, J; MaassenVanDenBrink, A; Marichal-Cancino, BA; Villalón, CM | 1 |
| Abbaszadeh-Kasbi, A; Afshari, K; Amirlak, B; Dehdashtian, A; Dehpour, AR; Haddadi, NS; Jazaeri, F; Sheikhi, M; Tavangar, SM; Zarifeh Jazaeri, S | 1 |
| Abdollahi, A; Dehpour, AR; Gharishvandi, F; Mohammad Jafari, R; Pasalar, P; Shafaroodi, H | 1 |
2 review(s) available for gr 127935 and oxadiazoles
| Article | Year |
|---|---|
GR127935: a potent and selective 5-HT1D receptor antagonist.
Topics: Animals; Behavior, Animal; Dogs; Guinea Pigs; Humans; Oxadiazoles; Piperazines; Rats; Receptors, Serotonin; Serotonin Antagonists | 1996 |
Control of dorsal raphé 5-HT function by multiple 5-HT(1) autoreceptors: parallel purposes or pointless plurality?
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Second-Generation; Autoreceptors; Dimerization; Guinea Pigs; Humans; Ion Channels; Ion Transport; Mice; Nerve Tissue Proteins; Neurons; Oxadiazoles; Piperazines; Protein Isoforms; Pyridines; Pyrimidines; Raphe Nuclei; Rats; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Second Messenger Systems; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Receptor Agonists; Spiperone; Sumatriptan | 2000 |
191 other study(ies) available for gr 127935 and oxadiazoles
| Article | Year |
|---|---|
Differences in the effects of ketanserin and GR127935 on 5-HT-receptor mediated responses in rabbit saphenous vein and guinea-pig jugular vein.
Topics: Animals; Dose-Response Relationship, Drug; Guinea Pigs; Jugular Veins; Ketanserin; Male; Myenteric Plexus; Nifedipine; Oxadiazoles; Piperazines; Rabbits; Saphenous Vein; Serotonin; Serotonin Antagonists; Sumatriptan | 1995 |
Effects of the 5-HT1D receptor antagonist GR127935 on extracellular levels of 5-HT in the guinea-pig frontal cortex as measured by microdialysis.
Topics: Animals; Frontal Lobe; Guinea Pigs; Male; Microdialysis; Neurons; Oxadiazoles; Piperazines; Serotonin; Serotonin Antagonists; Tetrodotoxin | 1995 |
The effects of GR127935, a putative 5-HT1D receptor antagonist, on brain 5-HT metabolism, extracellular 5-HT concentration and behaviour in the guinea pig.
Topics: Animals; Biogenic Monoamines; Brain; Dyskinesia, Drug-Induced; Electric Stimulation; Fluoxetine; Guinea Pigs; Humans; In Vitro Techniques; Male; Methiothepin; Oxadiazoles; Paroxetine; Piperazines; Raphe Nuclei; Serotonin Antagonists; Synaptic Transmission; Tryptophan | 1995 |
The 5-HT1D receptor antagonist GR 127,935 is an agonist at cloned human 5-HT1D alpha receptor sites.
Topics: Animals; Cells, Cultured; Cloning, Molecular; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Oxadiazoles; Piperazines; Rats; Receptors, Serotonin; Serotonin Antagonists | 1995 |
WAY-100635 and GR127935: effects on 5-hydroxytryptamine-containing neurones.
Topics: Action Potentials; Animals; Guinea Pigs; In Vitro Techniques; Male; Mesencephalon; Neurons; Oxadiazoles; Piperazines; Pyridines; Raphe Nuclei; Receptors, Serotonin; Serotonin; Serotonin Antagonists | 1994 |
The effect of paroxetine on 5-HT efflux in the rat dorsal raphe nucleus is potentiated by both 5-HT1A and 5-HT1B/D receptor antagonists.
Topics: Animals; Electric Stimulation; Male; Methiothepin; Oxadiazoles; Paroxetine; Piperazines; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Time Factors | 1995 |
Serotonin 5-HT1D and 5-HT1A receptors respectively mediate inhibition of glutamate release and inhibition of cyclic GMP production in rat cerebellum in vitro.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Afferent Pathways; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebellum; Cyclic GMP; Glutamic Acid; Male; N-Methylaspartate; Oxadiazoles; Piperazines; Potassium; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1D; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Agents; Signal Transduction; Sumatriptan; Synapses; Synaptic Transmission | 1996 |
Evidence for a 5-HT1D receptor-mediated hypothermic effect of the alpha 1-adrenoceptor agonist, SDZ NVI-085, in guinea-pigs.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Body Temperature; Bridged-Ring Compounds; Clonidine; Guinea Pigs; In Vitro Techniques; Male; Oxadiazoles; Oxazines; Piperazines; Prazosin; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1995 |
Functional effects of the 5-HT1D receptor antagonist GR 127,935 at human 5-HT1D alpha, 5-HT1D beta, 5-HT1A and opossum 5-HT1B receptors.
Topics: Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; HeLa Cells; Humans; Methiothepin; Opossums; Oxadiazoles; Piperazines; Receptors, Serotonin; Serotonin Antagonists; Spiperone; Transfection | 1995 |
5-Hydroxytryptamine 5-HT1D receptors mediating inhibition of cyclic AMP accumulation in Madin-Darby canine kidney (MDCK) cells.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alprostadil; Animals; Cells, Cultured; Cyclic AMP; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Epithelial Cells; Epithelium; Ketanserin; Kidney Cortex; Methiothepin; Oxadiazoles; Pertussis Toxin; Piperazines; Propranolol; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Structure-Activity Relationship; Sumatriptan; Virulence Factors, Bordetella; Yohimbine | 1995 |
Ketanserin-sensitive depressant actions of 5-HT receptor agonists in the neonatal rat spinal cord.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Depression, Chemical; Dioxanes; Dopamine Antagonists; Drug Interactions; Female; Ketanserin; Male; Motor Neurons; Oxadiazoles; Pindolol; Piperazines; Propranolol; Rats; Rats, Wistar; Receptors, Serotonin; Reflex, Monosynaptic; Serotonin; Serotonin Antagonists; Spinal Cord; Spiro Compounds; Sumatriptan | 1995 |
The activity of 5-HT1D receptor ligands at cloned human 5-HT1D alpha and 5-HT1D beta receptors.
Topics: Cyclic AMP; HeLa Cells; Humans; Metergoline; Methiothepin; Oxadiazoles; Piperazines; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan | 1995 |
Blockade of porcine carotid vascular response to sumatriptan by GR 127935, a selective 5-HT1D receptor antagonist.
Topics: Animals; Arteriovenous Anastomosis; Blood Flow Velocity; Blood Pressure; Carotid Artery, Common; Heart Rate; Oxadiazoles; Piperazines; Receptors, Serotonin; Serotonin Antagonists; Sumatriptan; Swine | 1996 |
GR127935 is a potent antagonist of the 5-HT1-like receptor mediating contraction in the canine coronary artery.
Topics: Animals; Coronary Vessels; Dogs; Drug Interactions; Ketanserin; Muscle, Smooth, Vascular; Oxadiazoles; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Sumatriptan; Vasoconstriction | 1996 |
Selective antagonism of human 5-HT1D and 5-HT1B receptor-mediated responses in stably transfected C6-glial cells by ketanserin and GR 127,935.
Topics: Animals; Cell Line; Colforsin; Cyclic AMP; Drug Interactions; Humans; Ketanserin; Neuroglia; Oxadiazoles; Piperazines; Rats; Serotonin Antagonists; Transfection | 1996 |
Species differences in 5-HT autoreceptors.
Topics: Animals; Central Nervous System; Guinea Pigs; Humans; Mice; Oxadiazoles; Piperazines; Rabbits; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Species Specificity; Swine | 1996 |
The relaxant 5-HT receptor in the dog coronary artery smooth muscle: pharmacological resemblance to the cloned 5-ht7 receptor subtype.
Topics: Animals; Antipsychotic Agents; Cloning, Molecular; Coronary Vessels; Dinoprost; Dogs; Endothelium, Vascular; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Oxadiazoles; Piperazines; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1996 |
Promotion of cell growth by stimulation of cloned human 5-HT1D receptor sites in transfected C6-glial cells is highly sensitive to intrinsic activity at 5-HT1D receptors.
Topics: Animals; Cell Division; Cyclic AMP; Humans; Metergoline; Neuroglia; Oxadiazoles; Piperazines; Rats; Receptors, Serotonin; Serotonin; Thymidine; Transfection | 1996 |
Combined administration of a 5-hydroxytryptamine (5-HT)1D antagonist and a 5-HT reuptake inhibitor synergistically increases 5-HT release in guinea pig hypothalamus in vivo.
Topics: 1-Naphthylamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Drug Synergism; Guinea Pigs; Hydroxyindoleacetic Acid; Hypothalamus; Indoles; Kinetics; Neurons; Oxadiazoles; Piperazines; Pyridines; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Sertraline | 1996 |
GR 127935 blocks the locomotor and antidepressant-like effects of RU 24969 and the action of antidepressants in the mouse tail suspension test.
Topics: Animals; Dose-Response Relationship, Drug; Indoles; Locomotion; Male; Mice; Mice, Inbred Strains; Oxadiazoles; Piperazines; Serotonin Antagonists; Serotonin Receptor Agonists; Tail | 1996 |
Influence of the endothelium and nitric oxide on the contractile responses evoked by 5-HT1D receptor agonists in the rabbit isolated saphenous vein.
Topics: Animals; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Piperazines; Rabbits; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Saphenous Vein; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan | 1996 |
Typical and atypical antipsychotic drugs are potent antagonists of the relaxant 5-hydroxytryptamine receptor in the smooth muscle of canine coronary artery.
Topics: Animals; Antipsychotic Agents; Clozapine; Coronary Vessels; Dogs; In Vitro Techniques; Muscle, Smooth, Vascular; Oxadiazoles; Piperazines; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Vasoconstriction; Vasodilation | 1996 |
Operational characteristics of the 5-HT1-like receptors mediating external carotid vasoconstriction in vagosympathectomized dogs. Close resemblance to the 5-HT1D receptor subtype.
Topics: Analysis of Variance; Animals; Blood Pressure; Carotid Artery, Common; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Male; Methysergide; Oxadiazoles; Piperazines; Receptors, Serotonin; Regional Blood Flow; Ritanserin; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan; Vasoconstriction | 1996 |
GR127935 acts as a partial agonist at recombinant human 5-HT1D alpha and 5-HT1D beta receptors.
Topics: Adenylyl Cyclases; Alkylating Agents; Animals; CHO Cells; Cricetinae; Cyclic AMP; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Logistic Models; Oxadiazoles; Piperazines; Quinolines; Receptors, Serotonin; Recombinant Proteins; Serotonin Antagonists; Serotonin Receptor Agonists | 1996 |
CP-135,807, a selective 5-HT1D agonist: effects in drug discrimination and punishment procedures in the pigeon.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Columbidae; Conditioning, Operant; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Indoles; Male; Oxadiazoles; Piperazines; Punishment; Pyridines; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1996 |
Differential involvement of serotonin 2A/C and thromboxane A2/prostanoid receptors in high- vs. low-shear rate arterial thrombosis in rabbits.
Topics: Animals; Arteriovenous Shunt, Surgical; Aspirin; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Carotid Arteries; Carotid Stenosis; Endothelium, Vascular; Fatty Acids, Unsaturated; Heart Rate; Hemodynamics; Hydrazines; Jugular Veins; Ketanserin; Male; Oxadiazoles; Piperazines; Platelet Aggregation; Prazosin; Rabbits; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Prostaglandin; Receptors, Serotonin; Receptors, Thromboxane; Ritanserin; Serotonin Antagonists; Stress, Mechanical | 1997 |
Potentiation of the fluoxetine-induced increase in dialysate levels of serotonin (5-HT) in the frontal cortex of freely moving rats by combined blockade of 5-HT1A and 5-HT1B receptors with WAY 100,635 and GR 127,935.
Topics: Animals; Drug Synergism; Fluoxetine; Frontal Lobe; Male; Microdialysis; Oxadiazoles; Piperazines; Pyridines; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists | 1997 |
5-HT1B/D antagonists potentiate paroxetine's effect on 5-HT efflux in the lateral geniculate nucleus: in vitro voltammetric data.
Topics: Animals; Electrochemistry; Geniculate Bodies; Male; Methiothepin; Oxadiazoles; Paroxetine; Piperazines; Propanolamines; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin; Serotonin Antagonists | 1997 |
Potentiation of fluoxetine-induced penile erections by combined blockade of 5-HT1A and 5-HT1B receptors.
Topics: Animals; Antidepressive Agents, Second-Generation; Drug Synergism; Fluoxetine; Male; Oxadiazoles; Penile Erection; Piperazines; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists | 1997 |
Mediation of 5-HT-induced external carotid vasodilatation in GR 127935-pretreated vagosympathectomized dogs by the putative 5-HT7 receptor.
Topics: 5-Methoxytryptamine; Acetylcholine; Animals; Carotid Arteries; Dogs; Hemodynamics; Oxadiazoles; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Vasodilation | 1997 |
Interactions of GR127935, a 5-HT(1B/D) receptor ligand, with functional 5-HT receptors.
Topics: Animals; Cats; Dose-Response Relationship, Drug; Male; Oxadiazoles; Piperazines; Rabbits; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Sumatriptan | 1997 |
Mechanism of actions of sumatriptan on coronary flow before and after endothelial dysfunction in guinea-pig isolated heart.
Topics: Animals; Coronary Circulation; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Ergolines; Guinea Pigs; Heart; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Piperazines; Saponins; Serotonin Receptor Agonists; Sumatriptan; Vasoconstrictor Agents | 1997 |
Influence of 5-HT1B/1D receptors on dopamine release in the guinea pig nucleus accumbens: a microdialysis study.
Topics: Analysis of Variance; Animals; Dopamine; Guinea Pigs; Male; Microdialysis; Nucleus Accumbens; Oxadiazoles; Piperazines; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan | 1997 |
The 5-HT1D receptor antagonist GR-127,935 prevents inhibitory effects of sumatriptan but not CP-122,288 and 5-CT on neurogenic plasma extravasation within guinea pig dura mater.
Topics: Animals; Dose-Response Relationship, Drug; Dura Mater; Electric Stimulation; Female; Guinea Pigs; Male; Oxadiazoles; Pertussis Toxin; Piperazines; Prosencephalon; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Sumatriptan; Trigeminal Nerve; Virulence Factors, Bordetella | 1997 |
5-Hydroxytryptamine1B receptors modulate the effect of cocaine on c-fos expression: converging evidence using 5-hydroxytryptamine1B knockout mice and the 5-hydroxytryptamine1B/1D antagonist GR127935.
Topics: Animals; Cocaine; Corpus Striatum; Gene Expression Regulation; Genes, fos; Indoles; Mice; Mice, Knockout; Oxadiazoles; Piperazines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1997 |
GR127935 antagonizes the 5-HT1-like receptor-mediated external carotid vasoconstriction in vagosympathectomized dogs.
Topics: Animals; Dogs; Oxadiazoles; Piperazines; Receptors, Serotonin; Serotonin Antagonists; Sympathectomy; Vagotomy; Vasoconstriction | 1997 |
Effect of a selective 5-HT reuptake inhibitor in combination with 5-HT1A and 5-HT1B receptor antagonists on extracellular 5-HT in rat frontal cortex in vivo.
Topics: Animals; Electrophysiology; Extracellular Space; Male; Microdialysis; Neurons; Oxadiazoles; Paroxetine; Piperazines; Prefrontal Cortex; Pyridines; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Stereotaxic Techniques | 1997 |
Nature of 5-HT1-like receptors mediating depressor responses in vagosympathectomized rats; close resemblance to the cloned 5-ht7 receptor.
Topics: 5-Methoxytryptamine; Adrenergic beta-Agonists; Animals; Blood Pressure; Clozapine; Ergolines; Heart Rate; Isoproterenol; Lisuride; Male; Metergoline; Methiothepin; Oxadiazoles; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan; Sympathectomy | 1997 |
Synergism of 5-HT 1B/D antagonists with paroxetine on serotonin efflux in rat ventral lateral geniculate nucleus slices.
Topics: Animals; Anti-Anxiety Agents; Drug Synergism; Geniculate Bodies; Male; Oxadiazoles; Paroxetine; Piperazines; Propanolamines; Rats; Rats, Wistar; Serotonin | 1997 |
Effect of third ventricle administration of L-694,247, a selective 5-HT1D receptor agonist, on water intake in rats.
Topics: Adrenergic beta-Agonists; Angiotensin II; Animals; Carbachol; Drinking; Injections, Intraventricular; Isoproterenol; Male; Microinjections; Muscarinic Agonists; Oxadiazoles; Piperazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tryptamines; Water Deprivation | 1997 |
Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig.
Topics: Animals; Benzamides; Biphenyl Compounds; Body Temperature; Dose-Response Relationship, Drug; Guinea Pigs; Hypothermia; Indoles; Male; Oxadiazoles; Piperazines; Piperidones; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds | 1997 |
Involvement of 5-HT(1B/1D) and 5-HT2A receptors in 5-HT-induced contraction of endothelium-denuded rabbit epicardial coronary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Coronary Vessels; Endothelium, Vascular; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Oxadiazoles; Pericardium; Piperazines; Rabbits; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan; Vasoconstrictor Agents | 1997 |
Inhibition of trigeminal neurones after intravenous administration of naratriptan through an action at 5-hydroxy-tryptamine (5-HT(1B/1D)) receptors.
Topics: Animals; Cats; Craniotomy; Electric Stimulation; Evoked Potentials, Somatosensory; Indoles; Injections, Intravenous; Neurons; Oxadiazoles; Piperazines; Piperidines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Trigeminal Nucleus, Spinal; Tryptamines | 1997 |
Characterization of 5-HT receptors on human pulmonary artery and vein: functional and binding studies.
Topics: Abortifacient Agents, Nonsteroidal; Adult; Aged; Benzamides; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Dinoprost; Dioxanes; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Oxadiazoles; Piperazines; Piperidines; Pulmonary Artery; Pulmonary Veins; Pyridines; Receptors, Serotonin; Ritanserin; Serotonin; Serotonin Antagonists; Sumatriptan; Vasoconstrictor Agents | 1997 |
Effects of the 5-HT receptor antagonists GR127935 (5-HT1B/1D) and MDL100907 (5-HT2A) in the consolidation of learning.
Topics: Animals; Conditioning, Operant; Drug Interactions; Fluorobenzenes; Learning; Male; Oxadiazoles; Piperazines; Piperidines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1997 |
Simultaneous quantification of serotonin, dopamine and noradrenaline levels in single frontal cortex dialysates of freely-moving rats reveals a complex pattern of reciprocal auto- and heteroreceptor-mediated control of release.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzopyrans; Dopamine; Dopamine Agonists; Frontal Lobe; Guanabenz; Guinea Pigs; Homeostasis; Idazoxan; Imidazoles; Indoles; Isoindoles; Male; Medetomidine; Models, Neurological; Motor Activity; Norepinephrine; Oxadiazoles; Piperazines; Prazosin; Raclopride; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Serotonin; Salicylamides; Serotonin | 1998 |
Meta-chlorophenylpiperazine induced changes in locomotor activity are mediated by 5-HT1 as well as 5-HT2C receptors in mice.
Topics: Animals; Dose-Response Relationship, Drug; Ergolines; Male; Mice; Motor Activity; Oxadiazoles; Piperazines; Pyridines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists | 1998 |
The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function b
Topics: Animals; Aspartic Acid; Autoreceptors; CHO Cells; Cricetinae; Frontal Lobe; Guinea Pigs; Humans; Hypothermia; In Vitro Techniques; Indoles; Male; Models, Molecular; Oxadiazoles; Piperazines; Piperidones; Radioligand Assay; Rats; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Structure-Activity Relationship; Swine | 1998 |
Characterization of 5-HT receptors mediating constriction of porcine carotid arteriovenous anastomoses; involvement of 5-HT1B/1D and novel receptors.
Topics: Animals; Arteriovenous Anastomosis; Carotid Arteries; Ergot Alkaloids; Hemodynamics; Ketanserin; Oxadiazoles; Oxygen; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Swine; Vasoconstriction | 1998 |
Serotonin inhibits trigeminal nucleus activity evoked by craniovascular stimulation through a 5HT1B/1D receptor: a central action in migraine?
Topics: Animals; Cats; Electric Stimulation; Electrophysiology; Membrane Potentials; Migraine Disorders; Neural Inhibition; Oxadiazoles; Piperazines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Trigeminal Nucleus, Spinal | 1998 |
5-Hydroxytryptophan-induced myoclonus in guinea pigs: mediation through 5-HT1/2 receptor subtypes.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Ergolines; Guinea Pigs; Male; Methiothepin; Myoclonus; Oxadiazoles; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Substrate Specificity | 1998 |
Differential effects of 5-HT1B/1D receptor antagonists in dorsal and median raphe innervated brain regions.
Topics: Animals; Antidepressive Agents, Second-Generation; Brain; Cerebral Cortex; Chromatography, High Pressure Liquid; Dentate Gyrus; Electrochemistry; Extracellular Space; Guinea Pigs; Male; Microdialysis; Neostriatum; Oxadiazoles; Paroxetine; Piperazines; Piperidones; Raphe Nuclei; Serotonin Antagonists; Spiro Compounds | 1998 |
The antimigraine agent alniditan selectively constricts porcine carotid arteriovenous anastomoses via 5-HT1B/1D receptors.
Topics: Analgesics; Animals; Arteriovenous Anastomosis; Benzopyrans; Carotid Arteries; Hemodynamics; Humans; Jugular Veins; Male; Migraine Disorders; Oxadiazoles; Oxygen; Piperazines; Propylamines; Pyrimidines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Swine; Vasoconstrictor Agents | 1998 |
Effects of sumatriptan on coronary flow and left ventricular function in the isolated perfused guinea pig heart.
Topics: Animals; Coronary Circulation; Diastole; Dihydroergotamine; Endothelium, Vascular; Guinea Pigs; In Vitro Techniques; NG-Nitroarginine Methyl Ester; Oxadiazoles; Oxazoles; Oxazolidinones; Perfusion; Piperazines; Rabbits; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Receptor Agonists; Sumatriptan; Tryptamines; Ventricular Function, Left | 1998 |
In vivo control of 5-hydroxytryptamine release by terminal autoreceptors in rat brain areas differentially innervated by the dorsal and median raphe nuclei.
Topics: Animals; Autoreceptors; Brain; Chromatography, High Pressure Liquid; Hydroxyindoleacetic Acid; Male; Methiothepin; Microdialysis; Oxadiazoles; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists | 1998 |
Modulation of the vagal bradycardia evoked by stimulation of upper airway receptors by central 5-HT1 receptors in anaesthetized rabbits.
Topics: Anesthesia; Animals; Aortic Bodies; Bradycardia; Buspirone; Ligands; Male; Oxadiazoles; Piperazines; Pyridines; Rabbits; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reflex; Serotonin Antagonists; Serotonin Receptor Agonists; Smoke | 1998 |
Serotonin1B receptor stimulation enhances cocaine reinforcement.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Indoles; Injections, Intraventricular; Male; Oxadiazoles; Piperazines; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Self Administration; Serotonin Antagonists; Serotonin Receptor Agonists | 1998 |
Na(+)-dependent metabolic coupling upon 5-HT1B receptor activation by sumatriptan and related agonists.
Topics: Animals; CHO Cells; Cricetinae; Oxadiazoles; Piperazines; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Signal Transduction; Sodium; Sumatriptan; Vasoconstrictor Agents | 1998 |
GR 127935 and (+)-WAY 100135 do not affect TFMPP-induced inhibition of 5-HT synthesis in the midbrain and hippocampus of Wistar-Kyoto rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Hippocampus; Idazoxan; Ketanserin; Male; Mesencephalon; Mianserin; Nerve Endings; Oxadiazoles; Piperazines; Rats; Rats, Inbred WKY; Rats, Wistar; Reserpine; Serotonin; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists; Species Specificity; Tryptophan Hydroxylase | 1998 |
Antagonism of the relaxant 5-HT receptor in the dog basilar artery by the high-affinity 5-HT7 receptor ligand, LY215840.
Topics: Animals; Basilar Artery; Dinoprost; Dogs; Dose-Response Relationship, Drug; In Vitro Techniques; Ketanserin; Lysergic Acid; Muscle Relaxation; Muscle, Smooth, Vascular; Oxadiazoles; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1998 |
Native 5-HT1B receptors expressed in OK cells display dual coupling to elevation of intracellular calcium concentrations and inhibition of adenylate cyclase.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Calcium; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Kidney; Methiothepin; Opossums; Oxadiazoles; Pertussis Toxin; Pindolol; Piperazines; Pyridines; Pyrroles; Radioligand Assay; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Virulence Factors, Bordetella | 1998 |
Pharmacological characterisation of a cloned dog 5-HT1B receptor cell line.
Topics: Animals; Binding, Competitive; CHO Cells; Clone Cells; Cricetinae; Dogs; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Methiothepin; Oxadiazoles; Piperazines; Radioligand Assay; Rats; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Recombinant Fusion Proteins; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfur Radioisotopes; Tritium | 1998 |
Head and whole-body jerking in guinea pigs are differentially modulated by 5-HT1A, 5-HT1B/1D and 5-HT2A receptor antagonists.
Topics: 5-Hydroxytryptophan; Animals; Benzazepines; Guinea Pigs; Head Movements; Male; Methoxydimethyltryptamines; Myoclonus; Oxadiazoles; Piperazines; Pyridines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists | 1998 |
Activation of recombinant h 5-HT1B and h 5-HT1D receptors stably expressed in C6 glioma cells produces increases in Ca2+-dependent K+ current.
Topics: Animals; Calcium; Cyclic AMP; Dose-Response Relationship, Drug; Glioma; Oxadiazoles; Piperazines; Potassium; Potassium Channels; Rats; Receptors, Serotonin; Recombinant Proteins; Serotonin Antagonists; Sumatriptan; Tumor Cells, Cultured | 1998 |
Animal model of posthypoxic myoclonus: effects of serotonergic antagonists.
Topics: Acoustic Stimulation; Animals; Brain Chemistry; Disease Models, Animal; Dose-Response Relationship, Drug; Ergolines; Heart Arrest; Hypoxia; Hypoxia, Brain; Male; Methiothepin; Myoclonus; Oxadiazoles; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists | 1999 |
Putative 5-ht5 receptors: localization in the mouse CNS and lack of effect in the inhibition of dural protein extravasation.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Binding Sites; Blood Proteins; Brain; Crosses, Genetic; Female; Lysergic Acid Diethylamide; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Specificity; Oxadiazoles; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Trigeminal Ganglion; Tritium | 1998 |
The selective 5-HT1B receptor inverse agonist SB-224289, potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo.
Topics: Animals; Body Temperature Regulation; Cerebral Cortex; CHO Cells; Cricetinae; Dentate Gyrus; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Humans; Oxadiazoles; Piperazines; Piperidones; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Recombinant Proteins; Serotonin; Serotonin Antagonists; Spiro Compounds; Sumatriptan; Transfection | 1998 |
Pharmacological profile of the prejunctional 5-HT1 receptors mediating inhibition of sympathetic vasopressor outflow in the pithed rat.
Topics: 5-Methoxytryptamine; Animals; Blood Pressure; Central Nervous System; Oxadiazoles; Pindolol; Piperazines; Pyridines; Pyrroles; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan; Sympathetic Nervous System | 1998 |
Evidence for the putative 5-HT7 receptor mediating direct relaxation to 5-hydroxytryptamine in canine cerebral blood vessels.
Topics: 5-Hydroxytryptophan; Animals; Basilar Artery; Cerebral Arteries; Cerebrovascular Circulation; Dinoprost; Dogs; In Vitro Techniques; Muscle, Smooth, Vascular; Oxadiazoles; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Vasoconstriction; Vasodilation | 1998 |
Inhibition of hippocampal 5-HT synthesis by fluoxetine and paroxetine: evidence for the involvement of both 5-HT1A and 5-HT1B/D autoreceptors.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Enzyme Inhibitors; Fluoxetine; Hippocampus; Hydrazines; Male; Oxadiazoles; Paroxetine; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1999 |
RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist.
Topics: Animals; Brain; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electric Stimulation; Indoles; Male; Oxadiazoles; Piperazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reward; Self Stimulation; Serotonin Antagonists; Serotonin Receptor Agonists | 1999 |
GR 127935 reduces basal locomotor activity and prevents RU 24969-, but not D-amphetamine-induced hyperlocomotion, in the Wistar-Kyoto hyperactive (WKHA) rat.
Topics: Animals; Central Nervous System Stimulants; Dextroamphetamine; Dose-Response Relationship, Drug; Indoles; Male; Motor Activity; Oxadiazoles; Piperazines; Rats; Rats, Inbred WKY; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists | 1999 |
Synergism between 5-HT1B/1D and 5-HT1A receptor antagonists on turnover and release of 5-HT in guinea-pig brain in vivo.
Topics: Animals; Brain; Drug Synergism; Guinea Pigs; Hydroxyindoleacetic Acid; Male; Microdialysis; Oxadiazoles; Piperazines; Pyridines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Synaptic Transmission | 1999 |
Vasoconstriction in human isolated middle meningeal arteries: determining the contribution of 5-HT1B- and 5-HT1F-receptor activation.
Topics: Animals; Benzamides; Binding, Competitive; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Humans; In Vitro Techniques; Meningeal Arteries; Oxadiazoles; Piperazines; Pyridines; Receptors, Serotonin; RNA, Messenger; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan; Vasoconstriction | 1999 |
Canine external carotid vasoconstriction to methysergide, ergotamine and dihydroergotamine: role of 5-HT1B/1D receptors and alpha2-adrenoceptors.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Flow Velocity; Carotid Arteries; Clonidine; Dihydroergotamine; Dogs; Ergotamine; Female; Hemodynamics; Male; Methysergide; Oxadiazoles; Phenylephrine; Piperazines; Prazosin; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Adrenergic, alpha-2; Receptors, Serotonin; Serotonin Antagonists; Sumatriptan; Vasoconstriction; Vasoconstrictor Agents; Yohimbine | 1999 |
Pharmacological diversity between native human 5-HT1B and 5-HT1D receptors sited on different neurons and involved in different functions.
Topics: Adult; Aged; Binding Sites; Biphenyl Compounds; Cerebral Cortex; Female; Glutamic Acid; Humans; Male; Middle Aged; Neurons; Oxadiazoles; Piperazines; Piperidones; Potassium Chloride; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiro Compounds; Synaptosomes; Tritium | 1999 |
Changes in systemic and regional haemodynamics during 5-HT7 receptor-mediated depressor responses in rats.
Topics: Adrenal Glands; Animals; Blood Pressure; Cardiac Output; Heart Rate; Hemodynamics; Kidney; Lisuride; Lung; Male; Muscle, Skeletal; Oxadiazoles; Pancreas; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; Reference Values; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Stereoisomerism; Stroke Volume; Vascular Capacitance | 1999 |
Effects of PNU-109,291, a selective 5-HT1D receptor agonist, on electrically induced dural plasma extravasation and capsaicin-evoked c-fos immunoreactivity within trigeminal nucleus caudalis.
Topics: Animals; Benzopyrans; Binding, Competitive; Blood Pressure; Blood Proteins; Capsaicin; Dura Mater; Electric Stimulation; Guinea Pigs; Male; Oxadiazoles; Piperazines; Proto-Oncogene Proteins c-fos; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Trigeminal Nuclei | 1999 |
Pharmacological studies of the acute and chronic effects of (+)-3, 4-methylenedioxymethamphetamine on locomotor activity: role of 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B/1D) receptors.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Behavior, Animal; Drug Administration Schedule; Frontal Lobe; Indoles; Male; Motor Activity; Oxadiazoles; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists; Sodium Chloride | 1999 |
5-Hydroxytryptamine(1A) receptor activation enhances norepinephrine release from nerves in the rabbit saphenous vein.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Adrenergic Fibers; Animals; Electric Stimulation; Ergolines; Male; Muscle Contraction; Norepinephrine; Oxadiazoles; Piperazines; Pyridines; Rabbits; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Saphenous Vein; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan; Synaptic Transmission | 1999 |
Studies on the role of serotonin receptor subtypes in the effect of sibutramine in various feeding paradigms in rats.
Topics: Animals; Appetite Depressants; Cyclobutanes; Dose-Response Relationship, Drug; Eating; Male; Neuropeptide Y; Oxadiazoles; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin | 1999 |
Functional characterization and m-RNA expression of 5-HT receptors mediating contraction in human umbilical artery.
Topics: Humans; Ketanserin; Oxadiazoles; Piperazines; Receptors, Serotonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serotonin; Sumatriptan; Umbilical Arteries; Vasoconstriction | 1999 |
Pharmacological evidence that alpha1-and alpha2-adrenoceptors mediate vasoconstriction of carotid arteriovenous anastomoses in anaesthetized pigs.
Topics: Anesthesia; Animals; Arteriovenous Anastomosis; Azepines; Carotid Arteries; Hemodynamics; Migraine Disorders; Oxadiazoles; Phenylephrine; Piperazines; Prazosin; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Serotonin; Sumatriptan; Swine; Vasoconstriction | 1999 |
Effects of venlafaxine on extracellular concentrations of 5-HT and noradrenaline in the rat frontal cortex: augmentation via 5-HT1A receptor antagonism.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebral Cortex; Cyclohexanols; Dose-Response Relationship, Drug; Idazoxan; Male; Norepinephrine; Oxadiazoles; Piperazines; Prazosin; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Venlafaxine Hydrochloride | 1999 |
Pharmacogenetic evidence for the involvement of 5-hydroxytryptamine (Serotonin)-1B receptors in the mediation of morphine antinociceptive sensitivity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Oxadiazoles; Piperazines; Receptors, Serotonin; Sensitivity and Specificity; Serotonin Antagonists; Species Specificity; Time Factors | 1999 |
Effects of alniditan on neurogenic oedema in the rat dura mater and on contraction of rat basilar artery.
Topics: Animals; Basilar Artery; Benzopyrans; Brain Edema; Capillary Permeability; Dose-Response Relationship, Drug; Dura Mater; Extravasation of Diagnostic and Therapeutic Materials; In Vitro Techniques; Ketanserin; Male; Oxadiazoles; Piperazines; Propylamines; Pyrimidines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents; Serotonin Antagonists; Substance P; Sumatriptan; Vasoconstriction; Vasoconstrictor Agents | 1999 |
Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT(1B) receptor agonist CP-94,253.
Topics: Aggression; Animals; Behavior, Animal; Central Nervous System Depressants; Ethanol; Male; Mice; Oxadiazoles; Piperazines; Pyridines; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1999 |
Characterization of endogenous serotonin-mediated regulation of dopamine release in the rat prefrontal cortex.
Topics: Animals; Dopamine; Dose-Response Relationship, Drug; Electric Stimulation; Fluoxetine; Male; Microdialysis; Oligonucleotides, Antisense; Oxadiazoles; Piperazines; Prefrontal Cortex; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Time Factors | 1999 |
5-HT1A and 5-HT1B receptors control the firing of serotoninergic neurons in the dorsal raphe nucleus of the mouse: studies in 5-HT1B knock-out mice.
Topics: Animals; Autoradiography; Brain; Citalopram; Electric Stimulation; Evoked Potentials; Membrane Potentials; Mice; Mice, Knockout; Neurons; Oxadiazoles; Piperazines; Pyridines; Radioligand Assay; Raphe Nuclei; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tritium | 1999 |
Bovine isolated middle cerebral artery contractions to antimigraine drugs.
Topics: Animals; Cattle; In Vitro Techniques; Ketanserin; Middle Cerebral Artery; Muscle Contraction; Muscle, Smooth, Vascular; Oxadiazoles; Piperazines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan; Vasoconstrictor Agents | 1999 |
Lack of evidence for a role of serotonin in interleukin-1-induced hypophagia.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Eating; Interleukin-1; Ketanserin; Lipopolysaccharides; Male; Mice; Oxadiazoles; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiro Compounds; Sulfonamides | 2000 |
Regulation of extracellular concentrations of 5-hydroxytryptamine (5-HT) in mouse striatum by 5-HT(1A) and 5-HT(1B) receptors.
Topics: Animals; Autoreceptors; Corpus Striatum; Fenfluramine; Fluoxetine; Male; Mice; Microdialysis; Oxadiazoles; Piperazines; Pyridines; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Tetrahydronaphthalenes | 2000 |
Effect of 5-HT-moduline, an endogenous peptide, in associative learning.
Topics: Animals; Association Learning; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Neuropeptides; Oligopeptides; Oxadiazoles; Piperazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1999 |
The role of 5-HT(1A) and 5-HT(1B/1D) receptors on the modulation of acute fluoxetine-induced changes in extracellular 5-HT: the mechanism of action of (+/-)pindolol.
Topics: Animals; Autoreceptors; Drug Synergism; Extracellular Space; Fluoxetine; Male; Microdialysis; Oxadiazoles; Pindolol; Piperazines; Propanolamines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists | 2000 |
A paradoxical locomotor response in serotonin 5-HT(2C) receptor mutant mice.
Topics: Animals; Drug Interactions; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Motor Activity; Mutation; Oxadiazoles; Piperazines; Pyridines; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 2000 |
Yohimbine produces antinociception in the formalin test in rats: involvement of serotonin(1A) receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Ergolines; Formaldehyde; Male; Nociceptors; Oxadiazoles; Pain; Pain Measurement; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Time Factors; Yohimbine | 2000 |
Serotonin releasers increase prepulse inhibition in serotonin 1B knockout mice.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Mice; Mice, Knockout; N-Methyl-3,4-methylenedioxyamphetamine; Oxadiazoles; Piperazines; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Reflex, Startle; Serotonin; Serotonin Agents; Serotonin Antagonists | 2000 |
Phenylephrine precontraction increases the sensitivity of rabbit femoral artery to serotonin by enabling 5-HT1-like receptors.
Topics: Animals; Dose-Response Relationship, Drug; Femoral Artery; In Vitro Techniques; Oxadiazoles; Phenylephrine; Piperazines; Prazosin; Rabbits; Receptors, Serotonin; Ritanserin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Specific Pathogen-Free Organisms; Sumatriptan; Vasoconstriction | 2000 |
Effect of 5-HT(1B) receptor ligands on self-administration of ethanol in an operant procedure in rats.
Topics: Alcohol Drinking; Animals; Conditioning, Operant; Ethanol; Indoles; Male; Oxadiazoles; Piperazines; Pyridines; Quinoxalines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Self Administration | 2000 |
Augmentation with a 5-HT(1A), but not a 5-HT(1B) receptor antagonist critically depends on the dose of citalopram.
Topics: Animals; Autoreceptors; Citalopram; Dose-Response Relationship, Drug; Drug Synergism; Hippocampus; Injections, Subcutaneous; Male; Oxadiazoles; Piperazines; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Agents; Time Factors | 2000 |
Zolmitriptan stimulates a Ca(2+)-dependent K(+) current in C6 glioma cells stably expressing recombinant human 5-HT(1B) receptors.
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Humans; Membrane Potentials; Oxadiazoles; Oxazoles; Oxazolidinones; Peptides; Piperazines; Potassium Channels; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Recombinant Fusion Proteins; Serotonin Antagonists; Serotonin Receptor Agonists; Tetraethylammonium; Tryptamines; Tumor Cells, Cultured | 2000 |
5-HT(1A) and 5-HT(1B/1D) receptors are involved in the modulation of the trigeminovascular system of the cat: a microiontophoretic study.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Benzopyrans; Cats; Electric Stimulation; Iontophoresis; Oxadiazoles; Piperazines; Propylamines; Pyridines; Pyrimidines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Trigeminal Caudal Nucleus | 2000 |
Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter.
Topics: Animals; Autoreceptors; Binding, Competitive; Brain Chemistry; Carrier Proteins; Citalopram; Dipeptides; Down-Regulation; Gene Expression; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hydroxyindoleacetic Acid; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Oxadiazoles; Piperazines; Pyridines; Pyrimidines; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Serotonin Receptor Agonists; Spiro Compounds; Substantia Nigra; Sulfur Radioisotopes; Synaptic Transmission; Tritium | 2000 |
Mediation of 5-HT-induced internal carotid vasodilatation in GR127935- and ritanserin-pretreated dogs by 5-HT7 receptors.
Topics: Animals; Carotid Arteries; Dogs; Female; Hemodynamics; In Vitro Techniques; Male; Oxadiazoles; Piperazines; Receptors, Serotonin; Ritanserin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sympathectomy; Vagotomy; Vasodilation | 2000 |
Chronic clomipramine alters presynaptic 5-HT(1B) and postsynaptic 5-HT(1A) receptor sensitivity in rat hypothalamus and hippocampus, respectively.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Tricyclic; Clomipramine; Corticosterone; Cyclic AMP; Hippocampus; Hypothalamus; Male; Microdialysis; Oxadiazoles; Piperazines; Rats; Receptor, Serotonin, 5-HT1B; Receptors, Presynaptic; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists | 2000 |
Chronic repetitive transcranial magnetic stimulation induces subsensitivity of presynaptic serotonergic autoreceptor activity in rat brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoreceptors; Depression; Male; Microdialysis; Oxadiazoles; Piperazines; Prefrontal Cortex; Presynaptic Terminals; Rats; Rats, Inbred Strains; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Transcranial Magnetic Stimulation | 2000 |
Effects of a selective 5-HT(1B/1D) receptor agonist on spinal and trigeminal reflexes in the anaesthetized rabbit.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Female; Heart Rate; Male; Oxadiazoles; Pain; Piperazines; Rabbits; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Reflex; Serotonin Receptor Agonists; Spinal Cord; Trigeminal Caudal Nucleus | 2000 |
In vivo analysis of adrenergic and serotoninergic constrictions of the rabbit saphenous vein.
Topics: Adrenergic Agents; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Animals; Benzazepines; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Ergolines; Imidazoles; Indoles; Injections, Intravenous; Isoindoles; Oxadiazoles; Peripheral Nervous System; Phenylephrine; Piperazines; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Receptors, Serotonin; Saphenous Vein; Serotonin; Serotonin Agents; Serotonin Receptor Agonists; Sumatriptan; Tetrahydronaphthalenes; Time Factors; Ultrasonography, Doppler; Vasoconstrictor Agents | 2000 |
Functional effects of corticosterone on 5-HT(1A) and 5-HT(1B) receptor activity in rat brain: in vivo microdialysis studies.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Inflammatory Agents; Brain; Colforsin; Corticosterone; Cyclic AMP; Hippocampus; Hypothalamus; Male; Microdialysis; Oxadiazoles; Piperazines; Rats; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 2001 |
5-HT1B Autoreceptors limit the effects of selective serotonin re-uptake inhibitors in mouse hippocampus and frontal cortex.
Topics: Animals; Antidepressive Agents, Second-Generation; Autoreceptors; Drug Combinations; Frontal Lobe; Hippocampus; Male; Mice; Mice, Knockout; Microdialysis; Oxadiazoles; Paroxetine; Piperazines; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Reference Values; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists | 2001 |
Modulation of the effects of cocaine by 5-HT1B receptors: a comparison of knockouts and antagonists.
Topics: Animals; Cocaine; Corpus Striatum; Dopamine Uptake Inhibitors; Male; Mice; Mice, Knockout; Motor Activity; Oxadiazoles; Piperazines; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Self Administration; Serotonin Antagonists | 2000 |
Role of 5-HT(1A) and 5-HT(1B) receptors in the mediation of behavior in the forced swim test in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Dose-Response Relationship, Drug; Female; Imipramine; Indoles; Mice; Mice, Inbred Strains; Motor Activity; Oxadiazoles; Piperazines; Piperidines; Pyridines; Reaction Time; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming | 2001 |
Unravelling the pharmacological profile of the canine external carotid vasodilator '5-HT1-like' receptors: coexistence of sympatho-inhibitory 5-HT1B and postjunctional 5-HT7 receptors.
Topics: 5-Methoxytryptamine; Acetylcholine; Animals; Biphenyl Compounds; Blood Flow Velocity; Blood Pressure; Carotid Artery, External; Chromans; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Hemodynamics; Male; Neuromuscular Junction; Oxadiazoles; Piperazines; Piperidones; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Sumatriptan; Sympathetic Nervous System; Vasodilation | 2001 |
The GR127935-sensitive 5-HT(1) receptors mediating canine internal carotid vasoconstriction: resemblance to the 5-HT(1B), but not to the 5-HT(1D) or 5-ht(1F), receptor subtype.
Topics: Animals; Blood Pressure; Carotid Artery, Internal; Dogs; Female; Heart Rate; Male; Oxadiazoles; Piperazines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptor, Serotonin, 5-HT1F; Receptors, Serotonin; Regional Blood Flow; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Vasoconstriction | 2001 |
Serotonin-induced hypercontraction through 5-hydroxytryptamine 1B receptors in atherosclerotic rabbit coronary arteries.
Topics: Animals; Arteriosclerosis; Calcium; Coronary Vessels; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Ketanserin; Male; Oxadiazoles; Phenylephrine; Piperazines; Rabbits; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; RNA, Messenger; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan; Vasoconstriction | 2001 |
Effect of serotonin (5-HT)1B receptor ligands on cocaine sensitization in rats.
Topics: Animals; Cocaine-Related Disorders; Discrimination Learning; Drug Interactions; Drug Tolerance; Male; Motivation; Motor Activity; Oxadiazoles; Piperazines; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 2001 |
[5-HT1B serotonin receptors and antidepressant effects of selective serotonin reuptake inhibitors ].
Topics: Animals; Antidepressive Agents; Drug Synergism; Frontal Lobe; Hippocampus; Male; Mice; Mice, Knockout; Microdialysis; Oxadiazoles; Paroxetine; Piperazines; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists | 2001 |
Complex interaction of ergovaline with 5-HT2A, 5-HT1B/1D, and alpha1 receptors in isolated arteries of rat and guinea pig.
Topics: Animals; Arteries; Ergotamines; Guinea Pigs; Iliac Artery; Ketanserin; Norepinephrine; Oxadiazoles; Piperazines; Rats; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptor, Serotonin, 5-HT2A; Receptors, Adrenergic, alpha-1; Receptors, Serotonin; Vasoconstriction | 2001 |
No involvement of 5-HT(7) or 5-HT(1D) receptors in the (R)-8-OH-DPAT-induced depression of the monosynaptic reflex in spinalized rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Clozapine; Decerebrate State; Dose-Response Relationship, Drug; Ergolines; Indoles; Male; Methiothepin; Oxadiazoles; Phenols; Piperazines; Pyridines; Rats; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Reflex, Monosynaptic; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfonamides; Time Factors | 2001 |
LY393558, a 5-hydroxytryptamine reuptake inhibitor and 5-HT(1B/1D) receptor antagonist: effects on extracellular levels of 5-hydroxytryptamine in the guinea pig and rat.
Topics: Administration, Oral; Animals; Cyclic S-Oxides; Dose-Response Relationship, Drug; Extracellular Space; Female; Fenfluramine; Fluoxetine; Frontal Lobe; Guinea Pigs; Hypothalamus; Injections, Intraperitoneal; Male; Oxadiazoles; Paroxetine; Piperazines; Rats; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Tetrodotoxin; Thiadiazines; Time Factors | 2001 |
Contribution of the 5-HT(1B) receptor to hypoxia-induced pulmonary hypertension: converging evidence using 5-HT(1B)-receptor knockout mice and the 5-HT(1B/1D)-receptor antagonist GR127935.
Topics: Animals; Atmosphere Exposure Chambers; Blood Pressure; Chronic Disease; Heart Rate; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Lung; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Organ Size; Oxadiazoles; Piperazines; Pulmonary Artery; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Vasoconstrictor Agents; Vasodilator Agents; Ventricular Dysfunction, Right | 2001 |
Pharmacological studies of the acute effects of (+)-3,4-methylenedioxymethamphetamine on locomotor activity: role of 5-HT(1B/1D) and 5-HT(2) receptors.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Fluorobenzenes; Hallucinogens; Indoles; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Oxadiazoles; Piperazines; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Serotonin Antagonists | 2002 |
Effects of chronically administered venlafaxine on 5-HT receptor activity in rat hippocampus and hypothalamus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Corticosterone; Cyclohexanols; Hippocampus; Hypothalamus; Male; Oxadiazoles; Oxytocin; Piperazines; Rats; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists; Venlafaxine Hydrochloride | 2002 |
Anxiogenic-like effect of serotonin(1B) receptor stimulation in the rat elevated plus-maze.
Topics: Animals; Anxiety; Behavior, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Oxadiazoles; Piperazines; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 2002 |
Serotonin 2C receptor agonists and the behavioural satiety sequence in mice.
Topics: Aminopyridines; Animals; Diet; Dose-Response Relationship, Drug; Ethylamines; Feeding Behavior; Indoles; Mice; Oxadiazoles; Piperazines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Satiety Response; Serotonin Antagonists; Serotonin Receptor Agonists | 2002 |
Activation of 5-HT(1B) receptors in the nucleus accumbens reduces self-administration of amphetamine on a progressive ratio schedule.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamine; Amphetamines; Animals; Central Nervous System Stimulants; Conditioning, Operant; Dose-Response Relationship, Drug; Food; Male; Nucleus Accumbens; Oxadiazoles; Piperazines; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Reinforcement Schedule; Self Administration; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 2002 |
Effects of donitriptan on carotid haemodynamics and cardiac output distribution in anaesthetized pigs.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Brain; Cardiac Output; Carotid Arteries; Dose-Response Relationship, Drug; Heart Rate; Nitriles; Oxadiazoles; Piperazines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Regional Blood Flow; Serotonin Antagonists; Serotonin Receptor Agonists; Swine; Tryptamines; Vascular Resistance | 2002 |
Multiple 5-HT receptors are involved in the effects of acute MDMA treatment: studies on locomotor activity and responding for conditioned reinforcement.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Ethylamines; Indoles; Ketanserin; Male; Motor Activity; Oxadiazoles; Piperazines; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Reinforcement, Psychology; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists; Time Factors | 2002 |
Functional effects of chronic electroconvulsive shock on serotonergic 5-HT(1A) and 5-HT(1B) receptor activity in rat hippocampus and hypothalamus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cyclic AMP; Electroshock; Extracellular Space; Hippocampus; Hypothalamus; Male; Oxadiazoles; Piperazines; Rats; Rats, Inbred Strains; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Synaptic Transmission | 2002 |
An evaluation of the effect of NAS-181, a new selective 5-HT(1B) receptor antagonist, on extracellular 5-HT levels in rat frontal cortex.
Topics: Animals; Benzopyrans; Dose-Response Relationship, Drug; Extracellular Fluid; Extracellular Space; Fluvoxamine; Frontal Lobe; Male; Microdialysis; Morpholines; Oxadiazoles; Piperazines; Piperidones; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Spiro Compounds; Time Factors | 2003 |
Donitriptan selectively decreases jugular venous oxygen saturation in the anesthetized pig: further insights into its mechanism of action relevant to headache relief.
Topics: Anesthesia; Animals; Blood Gas Analysis; Carbon Dioxide; Carotid Arteries; Electrocardiography; Headache; Hemodynamics; Hemoglobins; Jugular Veins; Male; Nitriles; Oxadiazoles; Oxygen; Piperazines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Swine; Tryptamines; Vascular Resistance; Vasoconstriction | 2003 |
Role of 5-HT1B/D receptors in canine gastric accommodation: effect of sumatriptan and 5-HT1B/D receptor antagonists.
Topics: Animals; Atropine; Benzamides; Bethanechol; Biphenyl Compounds; Dogs; Enzyme Inhibitors; Female; Gastric Emptying; NG-Nitroarginine Methyl Ester; Oxadiazoles; Parasympatholytics; Parasympathomimetics; Piperazines; Pressure; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Stomach; Sumatriptan; Vagus Nerve | 2003 |
Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension.
Topics: Analysis of Variance; Animals; Carrier Proteins; Chronic Disease; Citalopram; Disease Models, Animal; Fluoxetine; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Ketanserin; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Muscle, Smooth, Vascular; Nerve Tissue Proteins; Oxadiazoles; Piperazines; Pulmonary Artery; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Statistics, Nonparametric | 2003 |
The differential effects of food restriction on 5-HT1A and 5-HT1B receptor mediated control of serotonergic transmission in the hippocampus and hypothalamus of rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Weight; Female; Hippocampus; Hypothalamus; Oxadiazoles; Piperazines; Rats; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 2003 |
Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice.
Topics: Animals; Brain Chemistry; Carrier Proteins; Chromatography, High Pressure Liquid; Dialysis Solutions; Drug Administration Routes; Extracellular Space; Hippocampus; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Knockout; Microdialysis; Nerve Tissue Proteins; Oxadiazoles; Paroxetine; Piperazines; Prefrontal Cortex; Pyridines; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Time | 2003 |
Pharmacological profile of the 5-HT-induced inhibition of cardioaccelerator sympathetic outflow in pithed rats: correlation with 5-HT1 and putative 5-ht5A/5B receptors.
Topics: Animals; Autonomic Fibers, Preganglionic; Blood Pressure; Decerebrate State; Desipramine; Disease Models, Animal; Drug Therapy, Combination; Electric Stimulation; Ergotamine; Infusions, Intravenous; Injections, Intravenous; Male; Oxadiazoles; Piperazines; Pyridines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sympathetic Nervous System; Tachycardia | 2003 |
Further characterization of the 5-HT1 receptors mediating cardiac sympatho-inhibition in pithed rats: pharmacological correlation with the 5-HT1B and 5-HT1D subtypes.
Topics: Animals; Biphenyl Compounds; Decerebrate State; Male; Norepinephrine; Oxadiazoles; Piperazines; Piperidones; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Spiro Compounds; Sumatriptan; Sympathomimetics; Tachycardia | 2004 |
The 5-hydroxytryptamine1B/1D/1F receptor agonists eletriptan and naratriptan inhibit trigeminovascular input to the nucleus tractus solitarius in the cat.
Topics: Action Potentials; Animals; Cats; Drug Interactions; Electric Stimulation; Indoles; Maximum Tolerated Dose; Neural Inhibition; Oxadiazoles; Piperazines; Piperidines; Pyrrolidines; Reaction Time; Receptor, Serotonin, 5-HT1F; Receptors, Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Serotonin Receptor Agonists; Solitary Nucleus; Trigeminal Nuclei; Tryptamines | 2004 |
Extracellular superoxide enhances 5-HT-induced murine pulmonary artery vasoconstriction.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Antioxidants; Endothelium, Vascular; Extracellular Fluid; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Nitric Oxide; Oxadiazoles; Oxidants; Piperazines; Pulmonary Artery; Serotonin; Serotonin Antagonists; Superoxides; Vasoconstriction; Vasoconstrictor Agents | 2004 |
Rewarding effects elicited by cocaine microinjections into the ventral tegmental area of C57BL/6 mice: involvement of dopamine D1 and serotonin1B receptors.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Benzazepines; Cocaine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Mice, Inbred C57BL; Microinjections; Oxadiazoles; Piperazines; Reaction Time; Receptor, Serotonin, 5-HT1B; Receptors, Dopamine D1; Reward; Self Administration; Serotonin Antagonists; Spatial Behavior; Ventral Tegmental Area | 2004 |
Effect of combined administration of 5-HT1A or 5-HT1B/1D receptor antagonists and antidepressants in the forced swimming test.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Citalopram; Depression; Desipramine; Imipramine; Male; Moclobemide; Monoamine Oxidase Inhibitors; Oxadiazoles; Piperazines; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Swimming | 2004 |
5-HT receptors involved in opioid-activated descending inhibition of spinal withdrawal reflexes in the decerebrated rabbit.
Topics: Afferent Pathways; Analgesics, Opioid; Analysis of Variance; Animals; Blood Pressure; Decerebrate State; Dose-Response Relationship, Drug; Electric Stimulation; Female; Fentanyl; Indoles; Injections, Intraventricular; Male; Muscle, Skeletal; Neural Inhibition; Oxadiazoles; Piperazines; Quinolines; Rabbits; Reaction Time; Receptors, Serotonin; Reflex; Serotonin Antagonists; Spinal Cord; Tropisetron | 2004 |
Tonic regulation of satiety by 5-HT receptors in the mouse: converging evidence from behavioural and c-fos immunoreactivity studies?
Topics: Animals; Behavior, Animal; Body Weight; Brain; Dose-Response Relationship, Drug; Drug Interactions; Eating; Feeding Behavior; Gene Expression Regulation; Immunohistochemistry; Mice; Mice, Knockout; Oxadiazoles; Piperazines; Piperidones; Proto-Oncogene Proteins c-fos; Pyridines; Receptor, Serotonin, 5-HT1B; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Time Factors | 2004 |
Involvement of 5-HT1B receptors in triptan-induced contractile responses in guinea-pig isolated iliac artery.
Topics: Animals; Benzamides; Brain; Carbazoles; Dinoprost; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endothelium, Vascular; Female; Forecasting; Guinea Pigs; Iliac Artery; Indoles; Ketanserin; Male; Muscle Contraction; Muscle, Smooth; Oxadiazoles; Oxazolidinones; Piperazines; Piperidines; Pyrrolidines; Receptor, Serotonin, 5-HT1B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Sumatriptan; Triazoles; Tryptamines | 2004 |
Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin.
Topics: Active Transport, Cell Nucleus; Amides; Animals; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cell Division; Cells, Cultured; Cytochalasin D; Enzyme Activation; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin-Light-Chain Phosphatase; Oxadiazoles; Phosphoproteins; Phosphorylation; Piperazines; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Subunits; Protein Transport; Pulmonary Artery; Pyridines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Recombinant Fusion Proteins; rho-Associated Kinases; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Signal Transduction; Thiazoles; Thiazolidines; Transcription Factors | 2004 |
Endogenously released 5-hydroxytryptamine depresses the spinal monosynaptic reflex via 5-HT1D receptors.
Topics: Animals; Biphenyl Compounds; Clorgyline; Decerebrate State; Male; Monoamine Oxidase Inhibitors; Oxadiazoles; p-Chloroamphetamine; Piperazines; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1D; Reflex, Monosynaptic; Serotonin; Serotonin Agents; Serotonin Antagonists; Spinal Cord | 2004 |
Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; Benzamides; Conflict, Psychological; Depressive Disorder; Diazepam; Electroshock; Exploratory Behavior; Imipramine; Male; Mice; Motor Activity; Oxadiazoles; Piperazines; Pyridines; Rats; Rats, Wistar; Reaction Time; Receptor, Serotonin, 5-HT1B; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming | 2004 |
Autoradiographic characterisation of [35S]GTPgammaS binding stimulation mediated by 5-HT1B receptor in postmortem human brain.
Topics: Aged; Autoradiography; Binding, Competitive; Biphenyl Compounds; Brain; Dipeptides; Drug Interactions; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Middle Aged; Oxadiazoles; Piperazines; Piperidones; Postmortem Changes; Protein Binding; Pyridines; Pyrroles; Receptor, Serotonin, 5-HT1B; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Sulfur Isotopes | 2005 |
3,4-N-methlenedioxymethamphetamine-induced hypophagia is maintained in 5-HT1B receptor knockout mice, but suppressed by the 5-HT2C receptor antagonist RS102221.
Topics: Animals; Body Weight; Eating; Hallucinogens; Kinetics; Male; Mice; Mice, Knockout; N-Methyl-3,4-methylenedioxyamphetamine; Oxadiazoles; Piperazines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists; Spiro Compounds; Starvation; Sulfonamides | 2005 |
The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzamides; Conflict, Psychological; Diazepam; Disease Models, Animal; Drinking Behavior; Drug Administration Schedule; Electroshock; Flumazenil; Men; Neurons; Oxadiazoles; p-Chloroamphetamine; Piperazines; Poland; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Water | 2005 |
Differential effects of 5-HT2C receptor ligands on place conditioning and locomotor activity in rats.
Topics: Aminopyridines; Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Indoles; Ligands; Male; Motor Activity; Oxadiazoles; Piperazines; Pyrazines; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Time Factors | 2005 |
The effect of chronic selective serotonin reuptake inhibitor treatment on serotonin 1B receptor sensitivity and HPA axis activity.
Topics: Adrenocorticotropic Hormone; Animals; Brain; Catecholamines; Citalopram; Corticosterone; Extracellular Space; Hippocampus; Hypothalamo-Hypophyseal System; Male; Microdialysis; Oxadiazoles; Piperazines; Piperidones; Prefrontal Cortex; Rats; Receptor, Serotonin, 5-HT1B; Receptors, Presynaptic; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Spiro Compounds | 2005 |
Donitriptan decreases jugular venous oxygen saturation in rats in the absence of cranial vasoconstriction: an overlooked mechanism of antimigraine action?
Topics: Animals; Blood Gas Analysis; Cerebrovascular Circulation; Hemodynamics; Jugular Veins; Male; Migraine Disorders; Nitriles; Oxadiazoles; Oxygen; Piperazines; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan; Tryptamines; Vasoconstriction | 2005 |
SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2'methyl-4'-(5-methyl-1,2,3-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): a novel, potent and selective 5-HT1B receptor antagonist.
Topics: Analysis of Variance; Animals; Binding, Competitive; Cerebral Cortex; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Humans; In Vitro Techniques; Indoles; Membrane Potentials; Neurons; Oxadiazoles; Patch-Clamp Techniques; Piperazines; Protein Binding; Rats; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Sulfur Isotopes; Tritium | 2006 |
5-HT(1B) receptors, ventral orbitofrontal cortex, and aggressive behavior in mice.
Topics: Aggression; Animals; Behavior, Animal; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Limbic System; Male; Mice; Microinjections; Oxadiazoles; Piperazines; Prefrontal Cortex; Pyridines; Receptor, Serotonin, 5-HT1B; Serotonin Antagonists; Serotonin Receptor Agonists | 2006 |
Evidence for adenosine- and serotonin-mediated antihyperalgesic effects of cizolirtine in rats suffering from diabetic neuropathy.
Topics: Adenosine; Analgesics; Animals; Area Under Curve; Caffeine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hyperalgesia; Male; Oxadiazoles; Pain Measurement; Pain Threshold; Piperazines; Psychomotor Performance; Pyrazoles; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Vocalization, Animal | 2007 |
Delay aversion: effects of 7-OH-DPAT, 5-HT1A/1B-receptor stimulation and D-cycloserine.
Topics: Animals; Central Nervous System Stimulants; Cycloserine; Dextroamphetamine; Impulsive Behavior; Male; Oxadiazoles; Piperazines; Rats; Rats, Wistar; Receptors, Dopamine D3; Receptors, N-Methyl-D-Aspartate; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Tetrahydronaphthalenes | 2006 |
Pharmacological characterization of 5-Hydroxytryptamine-receptor subtypes in circular muscle from the rat stomach.
Topics: Animals; Atropine; Dose-Response Relationship, Drug; Drug Synergism; Gastric Emptying; Gastric Fundus; In Vitro Techniques; Indoles; Ketanserin; Methysergide; Muscle Contraction; Muscle, Smooth; Ondansetron; Oxadiazoles; Phenols; Piperazines; Piperidines; Protein Isoforms; Pyloric Antrum; Pyridines; Pyrimidines; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Stomach; Sulfonamides; Tetrodotoxin | 2007 |
A61603-induced contractions of the porcine meningeal artery are mediated by alpha1- and alpha2-adrenoceptors.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Alkaloids; Animals; Benzophenanthridines; Colforsin; Dose-Response Relationship, Drug; Female; Forecasting; Imidazoles; In Vitro Techniques; Meningeal Arteries; Methiothepin; Norepinephrine; Oxadiazoles; Phenylephrine; Piperazines; Potassium Chloride; Prazosin; Protein Kinase C; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Ritanserin; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Swine; Tetrahydronaphthalenes; Vasoconstriction; Yohimbine | 2007 |
Anti-aggressive effects of agonists at 5-HT1B receptors in the dorsal raphe nucleus of mice.
Topics: Aggression; Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Mice; Oxadiazoles; Piperazines; Pyridines; Pyrroles; Raphe Nuclei; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Serotonin Receptor Agonists | 2007 |
Pharmacological evidence that 5-HT(1B/1D) receptors mediate hypotension in anesthetized rats.
Topics: Anesthesia; Animals; Blood Pressure; Hypotension; Male; Oxadiazoles; Phenols; Piperazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfonamides | 2007 |
In vivo/ex vivo and behavioural study on central effects of 5-HT1B/1D and 5-HT1A antagonists in guinea pigs.
Topics: Animals; Behavior, Animal; Brain Chemistry; Depression; Female; Guinea Pigs; Hydroxyindoleacetic Acid; Microdialysis; Oxadiazoles; Piperazines; Pyridines; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Serotonin; Serotonin Antagonists; Swimming | 2008 |
Serotonergic mediation of aggression in high and low aggressive chicken strains.
Topics: Agonistic Behavior; Animals; Body Weight; Chickens; Dopamine; Epinephrine; Female; Norepinephrine; Oxadiazoles; Piperazines; Random Allocation; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Selection, Genetic; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists | 2008 |
Effect of co-administration of the selective 5-HT1A receptor antagonist WAY 100,635 and selective 5-HT1B/1D receptor antagonist GR 127,935 on anxiolytic effect of citalopram in conditioned fear stress in the rat.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Citalopram; Conditioning, Psychological; Data Interpretation, Statistical; Fear; Male; Motor Activity; Oxadiazoles; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Stress, Psychological; Synaptic Transmission | 2008 |
Progesterone reduces the effect of the serotonin 1B/1D receptor antagonist, GR 127935, on lordosis behavior.
Topics: Analysis of Variance; Animals; Catheterization; Estradiol; Estrogens; Female; Ovariectomy; Oxadiazoles; Piperazines; Posture; Progesterone; Rats; Rats, Inbred F344; Restraint, Physical; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Sexual Behavior, Animal; Ventromedial Hypothalamic Nucleus | 2009 |
Serotonin1B heteroreceptor activation induces an antidepressant-like effect in mice with an alteration of the serotonergic system.
Topics: 5,7-Dihydroxytryptamine; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Citalopram; Dopamine; Male; Mice; Oxadiazoles; Piperazines; Piperidines; Pyridines; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Serotonin Receptor Agonists | 2008 |
Chronic reductions in serotonin transporter function prevent 5-HT1B-induced behavioral effects in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Female; Fluoxetine; Globus Pallidus; Indoles; Mice; Mice, Inbred BALB C; Mice, Knockout; Motor Activity; Oxadiazoles; Piperazines; Pyridines; Receptor, Serotonin, 5-HT1B; Reflex, Startle; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin Plasma Membrane Transport Proteins; Substantia Nigra | 2009 |
Effects of systemic 5-HT(1B) receptor compounds on ventral tegmental area intracranial self-stimulation thresholds in rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Oxadiazoles; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Reward; Self Stimulation; Sensory Thresholds; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Ventral Tegmental Area | 2009 |
Effect of central serotonin depletion on 5-HT receptor-mediated vasomotor responses in the middle meningeal artery of anaesthetized rats.
Topics: 5,7-Dihydroxytryptamine; Anesthesia; Animals; Blood Pressure; Cerebrovascular Circulation; Dopamine; Heart Rate; Male; Meningeal Arteries; Meninges; Norepinephrine; Oxadiazoles; Paraventricular Hypothalamic Nucleus; Phenols; Piperazines; Raphe Nuclei; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfonamides; Vasodilation | 2009 |
Pharmacological profile of the inhibition by dihydroergotamine and methysergide on the cardioaccelerator sympathetic outflow in pithed rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Blood Pressure; Decerebrate State; Dihydroergotamine; Dose-Response Relationship, Drug; Drug Combinations; Electric Stimulation; Heart Rate; Hemodynamics; Male; Methysergide; Norepinephrine; Oxadiazoles; Piperazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Adrenergic, alpha-2; Serotonin Antagonists; Sympathetic Nervous System; Tachycardia; Yohimbine | 2009 |
High-resolution imaging of brain 5-HT 1B receptors in the rhesus monkey using [11C]P943.
Topics: Animals; Brain; Carbon Radioisotopes; Macaca mulatta; Magnetic Resonance Imaging; Oxadiazoles; Piperazines; Positron-Emission Tomography; Pyrrolidinones; Receptor, Serotonin, 5-HT1B; Serotonin 5-HT1 Receptor Antagonists; Substrate Specificity | 2010 |
Differential involvement of 5-HT(1A) and 5-HT(1B/1D) receptors in human interferon-alpha-induced immobility in the mouse forced swimming test.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Depression; Fluoxetine; Interferon-alpha; Male; Mice; Mice, Inbred ICR; Motor Activity; Oxadiazoles; Piperazines; Pyridines; Quinoxalines; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming | 2010 |
Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Dose-Response Relationship, Drug; Female; Fetus; Fluoxetine; Hemodynamics; Hypertension, Pulmonary; Hysterotomy; Indoles; Ketanserin; Lung; Oxadiazoles; Piperazines; Pregnancy; Pulmonary Artery; Pyridines; Receptors, Serotonin; rho-Associated Kinases; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Sertraline; Sheep; Vascular Resistance | 2011 |
Effects of selective serotonin antagonism on central neurotransmission.
Topics: Aggression; Animals; Chickens; Chromatography, High Pressure Liquid; Female; Hypothalamus; Oxadiazoles; Piperazines; Random Allocation; Raphe Nuclei; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Selection, Genetic; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Antagonists; Species Specificity; Synaptic Transmission | 2012 |
5-HT7 receptor-mediated meningeal dilatation induced by 5-carboxamidotryptamine in rats is not altered by 5-HT depletion and chronic corticosterone treatment.
Topics: Animals; Brain; Corticosterone; Male; Meningeal Arteries; Oxadiazoles; Phenols; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Sulfonamides; Vasodilation | 2011 |
Intrathecal dihydroergotamine inhibits capsaicin-induced vasodilatation in the canine external carotid circulation via GR127935- and rauwolscine-sensitive receptors.
Topics: Acetylcholine; Animals; Blood Circulation; Calcitonin Gene-Related Peptide; Capsaicin; Carotid Arteries; Dihydroergotamine; Dogs; Dose-Response Relationship, Drug; Hemodynamics; Injections, Spinal; Male; Oxadiazoles; Piperazines; Propylene Glycol; Receptor, Serotonin, 5-HT1B; Serotonin 5-HT1 Receptor Antagonists; Vasodilation; Vasodilator Agents; Yohimbine | 2012 |
Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Brain; Citalopram; Exploratory Behavior; Female; Freezing Reaction, Cataleptic; Locomotion; Male; Oxadiazoles; Piperazines; Pyridines; Quinoxalines; Rats; Rats, Long-Evans; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists; Social Behavior | 2014 |
Modulation of 5-HT7 receptor: effect on object recognition performances in mice.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Male; Memory, Episodic; Mice; Oxadiazoles; Phenols; Piperazines; Receptors, Serotonin; Recognition, Psychology; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfonamides | 2014 |
Possible involvement of CA1 5-HT1B/1D and 5-HT2A/2B/2C receptors in harmaline-induced amnesia.
Topics: Amnesia; Animals; CA1 Region, Hippocampal; Central Nervous System Stimulants; Cinanserin; Harmaline; Male; Memory; Mice, Inbred Strains; Oxadiazoles; Piperazines; Pyridines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists | 2014 |
GR-127935-sensitive mechanism mediating hypotension in anesthetized rats: are 5-HT5B receptors involved?
Topics: Animals; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ergotamine; Hypotension; Oxadiazoles; Piperazines; Piperidones; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds | 2015 |
Role of spinal 5-HT5A, and 5-HT1A/1B/1D, receptors in neuropathic pain induced by spinal nerve ligation in rats.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Female; Ganglia, Spinal; Hyperalgesia; Lumbar Vertebrae; Methiothepin; Neuralgia; Oxadiazoles; Piperazines; Pyridines; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord; Spinal Nerves; Touch | 2015 |
5-hydroxytryptamine receptor (5-HT1DR) promotes colorectal cancer metastasis by regulating Axin1/β-catenin/MMP-7 signaling pathway.
Topics: Animals; Axin Protein; beta Catenin; Blotting, Western; Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; Female; Gene Expression Regulation, Neoplastic; HCT116 Cells; HT29 Cells; Humans; Immunohistochemistry; Male; Matrix Metalloproteinase 7; Mice, Nude; Middle Aged; Neoplasm Metastasis; Oxadiazoles; Piperazines; Receptor, Serotonin, 5-HT1D; Reverse Transcriptase Polymerase Chain Reaction; Serotonin Antagonists; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
The involvement of medial septum 5-HT1 and 5-HT2 receptors on ACPA-induced memory consolidation deficit: possible role of TRPC3, TRPC6 and TRPV2.
Topics: Animals; Arachidonic Acids; Avoidance Learning; Cinanserin; Imidazoles; Male; Memory Consolidation; Memory Disorders; Oxadiazoles; Piperazines; Pyridines; Rats; Septal Nuclei; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; TRPC Cation Channels | 2015 |
Serotonergic regulation of distention-induced ATP release from the urothelium.
Topics: Adenosine Triphosphate; Animals; Citalopram; Dioxanes; Male; Mice; Oxadiazoles; Piperazines; Piperidines; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin, 5-HT4; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Urinary Bladder; Urothelium | 2016 |
Serotonin antagonists fail to alter MDMA self-administration in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Drug-Seeking Behavior; Extinction, Psychological; Ketanserin; Male; N-Methyl-3,4-methylenedioxyamphetamine; Oxadiazoles; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Self Administration; Serotonin Antagonists | 2016 |
The inhibitory effect of combination treatment with leptin and cannabinoid CB1 receptor agonist on food intake and body weight gain is mediated by serotonin 1B and 2C receptors.
Topics: Aminopyridines; Animals; Cannabinoid Receptor Agonists; Drug Synergism; Eating; Indoles; Leptin; Male; Oxadiazoles; Piperazines; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Antagonists; Weight Gain | 2016 |
Activation and Deactivation of 5-HT1 Receptor of Accumbens Shell Area does not Alter ACPA-induced Aversive Memory Deficit in Male Rat.
Topics: Animals; Arachidonic Acids; Avoidance Learning; Behavior, Animal; Exploratory Behavior; Male; Maze Learning; Memory; Memory Disorders; Microinjections; Nucleus Accumbens; Oxadiazoles; Piperazines; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists | 2017 |
Attenuation of serotonin-induced itch by sumatriptan: possible involvement of endogenous opioids.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Humans; Injections, Intradermal; Male; Mice; Naltrexone; Narcotic Antagonists; Opioid Peptides; Oxadiazoles; Piperazines; Pruritus; Quaternary Ammonium Compounds; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Sumatriptan | 2018 |
Functional Characterization of the Prejunctional Receptors Mediating the Inhibition by Ergotamine of the Rat Perivascular Sensory Peptidergic Drive.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Autonomic Nervous System; Blood Pressure; Calcitonin Gene-Related Peptide; Dopamine Antagonists; Electric Stimulation; Ergotamine; Haloperidol; Heart Rate; Male; Oxadiazoles; Piperazines; Rats; Rats, Wistar; Serotonin Antagonists; Yohimbine | 2019 |
Sumatriptan Increases Skin Flap Survival through Activation of 5-Hydroxytryptamine 1b/1d Receptors in Rats: The Mediating Role of the Nitric Oxide Pathway.
Topics: Animals; Graft Survival; Male; Nitric Oxide; Oxadiazoles; Piperazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Skin Transplantation; Sumatriptan; Surgical Flaps; Vasodilator Agents | 2019 |
Involvement of 5-HT1B/1D receptors in the inflammatory response and oxidative stress in intestinal ischemia/reperfusion in rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Ileum; Inflammation; Intestinal Mucosa; Male; Mesenteric Ischemia; Oxadiazoles; Oxidative Stress; Piperazines; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Reperfusion Injury; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Sumatriptan | 2020 |