gr 127935 has been researched along with methiothepin in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (83.33) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Burton, MJ; Jones, BJ; Middlemiss, DN; Price, GW; Watson, JM | 1 |
| Gommeren, W; Haegeman, G; Heylen, L; Lesage, AS; Leysen, JE; Luyten, WH; Schotte, A; Van de Weyer, I; Van Gompel, P; Vanhoenacker, P; Wouters, R | 1 |
| Grånäs, C; Larhammar, D | 1 |
| Bristow, LJ; Cunningham, JR; Hogg, JE; Hutson, PH; Longmore, J; Murray, F; Pearce, D; Razzaque, Z; Saywell, K; Tricklebank, MD | 1 |
| Davidson, C; Stamford, JA | 2 |
| Palmier, C; Pauwels, PJ | 1 |
| Bobirnac, I; Schoeffter, P | 1 |
| Beattie, DT; Connor, HE; Walsh, DM | 1 |
| De Vries, P; Heiligers, JP; Saxena, PR; Villalón, CM | 1 |
| Belden, M; Carvey, PM; Goetz, CG; Pappert, EJ; Stebbins, GT | 1 |
| Artigas, F; Bel, N; Fernández, AG; Hervás, I; Palacios, JM | 1 |
| Branchek, TA; Zgombick, JM | 1 |
| Beer, MS; Heald, MA; McAllister, G; Stanton, JA | 1 |
| Carvey, PM; Goetz, CG; Leurgans, S; Ling, ZD; Pappert, EJ; Raman, R; Vu, TQ | 1 |
| Honda, M; Ono, H | 1 |
| Centurión, D; Gupta, S; Mehrotra, S; Saxena, PR; VandenBrink, AM; Villalón, CM | 1 |
| Avila-Rojas, SH; Barragán-Iglesias, P; Granados-Soto, V; Pineda-Farias, JB; Salinas-Abarca, AB; Velázquez-Lagunas, I | 1 |
18 other study(ies) available for gr 127935 and methiothepin
| Article | Year |
|---|---|
GR127935 acts as a partial agonist at recombinant human 5-HT1D alpha and 5-HT1D beta receptors.
Topics: Adenylyl Cyclases; Alkylating Agents; Animals; CHO Cells; Cricetinae; Cyclic AMP; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Logistic Models; Oxadiazoles; Piperazines; Quinolines; Receptors, Serotonin; Recombinant Proteins; Serotonin Antagonists; Serotonin Receptor Agonists | 1996 |
Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamin
Topics: Animals; Benzopyrans; Cattle; Cloning, Molecular; Glioma; HeLa Cells; Humans; Mice; Migraine Disorders; Propylamines; Protein Binding; Pyrimidines; Radioligand Assay; Receptors, Serotonin; Serotonin Receptor Agonists; Signal Transduction; Tritium; Tumor Cells, Cultured; Vasoconstrictor Agents | 1996 |
Identification of an amino acid residue important for binding of methiothepin and sumatriptan to the human 5-HT(1B) receptor.
Topics: Amino Acid Sequence; Amino Acids; Animals; Benzamides; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Methiothepin; Molecular Sequence Data; Mutation; Protein Binding; Pyridines; Radioligand Assay; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Sequence Homology, Amino Acid; Serotonin Antagonists; Serotonin Receptor Agonists; Sodium; Sumatriptan; Tritium | 1999 |
The effects of GR127935, a putative 5-HT1D receptor antagonist, on brain 5-HT metabolism, extracellular 5-HT concentration and behaviour in the guinea pig.
Topics: Animals; Biogenic Monoamines; Brain; Dyskinesia, Drug-Induced; Electric Stimulation; Fluoxetine; Guinea Pigs; Humans; In Vitro Techniques; Male; Methiothepin; Oxadiazoles; Paroxetine; Piperazines; Raphe Nuclei; Serotonin Antagonists; Synaptic Transmission; Tryptophan | 1995 |
The effect of paroxetine on 5-HT efflux in the rat dorsal raphe nucleus is potentiated by both 5-HT1A and 5-HT1B/D receptor antagonists.
Topics: Animals; Electric Stimulation; Male; Methiothepin; Oxadiazoles; Paroxetine; Piperazines; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Time Factors | 1995 |
Functional effects of the 5-HT1D receptor antagonist GR 127,935 at human 5-HT1D alpha, 5-HT1D beta, 5-HT1A and opossum 5-HT1B receptors.
Topics: Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; HeLa Cells; Humans; Methiothepin; Opossums; Oxadiazoles; Piperazines; Receptors, Serotonin; Serotonin Antagonists; Spiperone; Transfection | 1995 |
5-Hydroxytryptamine 5-HT1D receptors mediating inhibition of cyclic AMP accumulation in Madin-Darby canine kidney (MDCK) cells.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alprostadil; Animals; Cells, Cultured; Cyclic AMP; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Epithelial Cells; Epithelium; Ketanserin; Kidney Cortex; Methiothepin; Oxadiazoles; Pertussis Toxin; Piperazines; Propranolol; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Structure-Activity Relationship; Sumatriptan; Virulence Factors, Bordetella; Yohimbine | 1995 |
The activity of 5-HT1D receptor ligands at cloned human 5-HT1D alpha and 5-HT1D beta receptors.
Topics: Cyclic AMP; HeLa Cells; Humans; Metergoline; Methiothepin; Oxadiazoles; Piperazines; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan | 1995 |
5-HT1B/D antagonists potentiate paroxetine's effect on 5-HT efflux in the lateral geniculate nucleus: in vitro voltammetric data.
Topics: Animals; Electrochemistry; Geniculate Bodies; Male; Methiothepin; Oxadiazoles; Paroxetine; Piperazines; Propanolamines; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin; Serotonin Antagonists | 1997 |
Nature of 5-HT1-like receptors mediating depressor responses in vagosympathectomized rats; close resemblance to the cloned 5-ht7 receptor.
Topics: 5-Methoxytryptamine; Adrenergic beta-Agonists; Animals; Blood Pressure; Clozapine; Ergolines; Heart Rate; Isoproterenol; Lisuride; Male; Metergoline; Methiothepin; Oxadiazoles; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan; Sympathectomy | 1997 |
5-Hydroxytryptophan-induced myoclonus in guinea pigs: mediation through 5-HT1/2 receptor subtypes.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Ergolines; Guinea Pigs; Male; Methiothepin; Myoclonus; Oxadiazoles; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Substrate Specificity | 1998 |
In vivo control of 5-hydroxytryptamine release by terminal autoreceptors in rat brain areas differentially innervated by the dorsal and median raphe nuclei.
Topics: Animals; Autoreceptors; Brain; Chromatography, High Pressure Liquid; Hydroxyindoleacetic Acid; Male; Methiothepin; Microdialysis; Oxadiazoles; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists | 1998 |
Native 5-HT1B receptors expressed in OK cells display dual coupling to elevation of intracellular calcium concentrations and inhibition of adenylate cyclase.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Calcium; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Kidney; Methiothepin; Opossums; Oxadiazoles; Pertussis Toxin; Pindolol; Piperazines; Pyridines; Pyrroles; Radioligand Assay; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Virulence Factors, Bordetella | 1998 |
Pharmacological characterisation of a cloned dog 5-HT1B receptor cell line.
Topics: Animals; Binding, Competitive; CHO Cells; Clone Cells; Cricetinae; Dogs; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Methiothepin; Oxadiazoles; Piperazines; Radioligand Assay; Rats; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Recombinant Fusion Proteins; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfur Radioisotopes; Tritium | 1998 |
Animal model of posthypoxic myoclonus: effects of serotonergic antagonists.
Topics: Acoustic Stimulation; Animals; Brain Chemistry; Disease Models, Animal; Dose-Response Relationship, Drug; Ergolines; Heart Arrest; Hypoxia; Hypoxia, Brain; Male; Methiothepin; Myoclonus; Oxadiazoles; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists | 1999 |
No involvement of 5-HT(7) or 5-HT(1D) receptors in the (R)-8-OH-DPAT-induced depression of the monosynaptic reflex in spinalized rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Clozapine; Decerebrate State; Dose-Response Relationship, Drug; Ergolines; Indoles; Male; Methiothepin; Oxadiazoles; Phenols; Piperazines; Pyridines; Rats; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Reflex, Monosynaptic; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfonamides; Time Factors | 2001 |
A61603-induced contractions of the porcine meningeal artery are mediated by alpha1- and alpha2-adrenoceptors.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Alkaloids; Animals; Benzophenanthridines; Colforsin; Dose-Response Relationship, Drug; Female; Forecasting; Imidazoles; In Vitro Techniques; Meningeal Arteries; Methiothepin; Norepinephrine; Oxadiazoles; Phenylephrine; Piperazines; Potassium Chloride; Prazosin; Protein Kinase C; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Ritanserin; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Swine; Tetrahydronaphthalenes; Vasoconstriction; Yohimbine | 2007 |
Role of spinal 5-HT5A, and 5-HT1A/1B/1D, receptors in neuropathic pain induced by spinal nerve ligation in rats.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Female; Ganglia, Spinal; Hyperalgesia; Lumbar Vertebrae; Methiothepin; Neuralgia; Oxadiazoles; Piperazines; Pyridines; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord; Spinal Nerves; Touch | 2015 |