gr 127935 has been researched along with 2-piperidone in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (41.67) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gaster, L; Hagan, JJ; Hatcher, JP; Jeffrey, P; Middlemiss, DN; Slade, PD | 1 |
| Blaney, FE; Davies, S; Duckworth, DM; Gaster, LM; Hagan, JJ; Ham, P; Hatcher, J; Jenkins, S; Jennings, AJ; Joiner, GF; Jones, BJ; King, FD; Middlemiss, DN; Mulholland, KR; Price, GW; Riley, G; Roberts, C; Routledge, C; Selkirk, J; Slade, PD; Wyman, PA | 1 |
| Belenguer, A; Middlemiss, DN; Roberts, C; Routledge, C | 1 |
| Gaster, LM; Hagan, JJ; Ham, P; Joiner, GF; King, FD; Middlemiss, DN; Mulholland, KR; Price, GW; Roberts, C; Routledge, C; Selkirk, J; Slade, PD; Wyman, PA | 1 |
| Marcoli, M; Maura, G; Munari, C; Raiteri, M; Ruelle, A | 1 |
| Centurión, D; Sánchez-López, A; Saxena, PR; Villalón, CM | 1 |
| de Groote, L; Klompmakers, AA; Olivier, B; Westenberg, HG | 1 |
| Arulmani, U; Centurión, D; Sánchez-López, A; Saxena, PR; Vázquez, E; Villalón, CM | 1 |
| Clifton, PG; Dourish, CT; Kennett, GA; Lee, MD; Somerville, EM | 1 |
| Castro, ME; Mostany, R; Pazos, A | 1 |
| Bosker, FJ; Cremers, TI; den Boer, JA; Jongsma, ME; Westerink, BH | 1 |
| Anguiano-Robledo, L; Lacivita, E; Leopoldo, M; López-Sánchez, P; Sánchez-Maldonado, C; Terrón, JA | 1 |
12 other study(ies) available for gr 127935 and 2-piperidone
| Article | Year |
|---|---|
Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig.
Topics: Animals; Benzamides; Biphenyl Compounds; Body Temperature; Dose-Response Relationship, Drug; Guinea Pigs; Hypothermia; Indoles; Male; Oxadiazoles; Piperazines; Piperidones; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds | 1997 |
The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function b
Topics: Animals; Aspartic Acid; Autoreceptors; CHO Cells; Cricetinae; Frontal Lobe; Guinea Pigs; Humans; Hypothermia; In Vitro Techniques; Indoles; Male; Models, Molecular; Oxadiazoles; Piperazines; Piperidones; Radioligand Assay; Rats; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Structure-Activity Relationship; Swine | 1998 |
Differential effects of 5-HT1B/1D receptor antagonists in dorsal and median raphe innervated brain regions.
Topics: Animals; Antidepressive Agents, Second-Generation; Brain; Cerebral Cortex; Chromatography, High Pressure Liquid; Dentate Gyrus; Electrochemistry; Extracellular Space; Guinea Pigs; Male; Microdialysis; Neostriatum; Oxadiazoles; Paroxetine; Piperazines; Piperidones; Raphe Nuclei; Serotonin Antagonists; Spiro Compounds | 1998 |
The selective 5-HT1B receptor inverse agonist SB-224289, potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo.
Topics: Animals; Body Temperature Regulation; Cerebral Cortex; CHO Cells; Cricetinae; Dentate Gyrus; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Humans; Oxadiazoles; Piperazines; Piperidones; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Recombinant Proteins; Serotonin; Serotonin Antagonists; Spiro Compounds; Sumatriptan; Transfection | 1998 |
Pharmacological diversity between native human 5-HT1B and 5-HT1D receptors sited on different neurons and involved in different functions.
Topics: Adult; Aged; Binding Sites; Biphenyl Compounds; Cerebral Cortex; Female; Glutamic Acid; Humans; Male; Middle Aged; Neurons; Oxadiazoles; Piperazines; Piperidones; Potassium Chloride; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiro Compounds; Synaptosomes; Tritium | 1999 |
Unravelling the pharmacological profile of the canine external carotid vasodilator '5-HT1-like' receptors: coexistence of sympatho-inhibitory 5-HT1B and postjunctional 5-HT7 receptors.
Topics: 5-Methoxytryptamine; Acetylcholine; Animals; Biphenyl Compounds; Blood Flow Velocity; Blood Pressure; Carotid Artery, External; Chromans; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Hemodynamics; Male; Neuromuscular Junction; Oxadiazoles; Piperazines; Piperidones; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Sumatriptan; Sympathetic Nervous System; Vasodilation | 2001 |
An evaluation of the effect of NAS-181, a new selective 5-HT(1B) receptor antagonist, on extracellular 5-HT levels in rat frontal cortex.
Topics: Animals; Benzopyrans; Dose-Response Relationship, Drug; Extracellular Fluid; Extracellular Space; Fluvoxamine; Frontal Lobe; Male; Microdialysis; Morpholines; Oxadiazoles; Piperazines; Piperidones; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Spiro Compounds; Time Factors | 2003 |
Further characterization of the 5-HT1 receptors mediating cardiac sympatho-inhibition in pithed rats: pharmacological correlation with the 5-HT1B and 5-HT1D subtypes.
Topics: Animals; Biphenyl Compounds; Decerebrate State; Male; Norepinephrine; Oxadiazoles; Piperazines; Piperidones; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Spiro Compounds; Sumatriptan; Sympathomimetics; Tachycardia | 2004 |
Tonic regulation of satiety by 5-HT receptors in the mouse: converging evidence from behavioural and c-fos immunoreactivity studies?
Topics: Animals; Behavior, Animal; Body Weight; Brain; Dose-Response Relationship, Drug; Drug Interactions; Eating; Feeding Behavior; Gene Expression Regulation; Immunohistochemistry; Mice; Mice, Knockout; Oxadiazoles; Piperazines; Piperidones; Proto-Oncogene Proteins c-fos; Pyridines; Receptor, Serotonin, 5-HT1B; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Time Factors | 2004 |
Autoradiographic characterisation of [35S]GTPgammaS binding stimulation mediated by 5-HT1B receptor in postmortem human brain.
Topics: Aged; Autoradiography; Binding, Competitive; Biphenyl Compounds; Brain; Dipeptides; Drug Interactions; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Middle Aged; Oxadiazoles; Piperazines; Piperidones; Postmortem Changes; Protein Binding; Pyridines; Pyrroles; Receptor, Serotonin, 5-HT1B; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Sulfur Isotopes | 2005 |
The effect of chronic selective serotonin reuptake inhibitor treatment on serotonin 1B receptor sensitivity and HPA axis activity.
Topics: Adrenocorticotropic Hormone; Animals; Brain; Catecholamines; Citalopram; Corticosterone; Extracellular Space; Hippocampus; Hypothalamo-Hypophyseal System; Male; Microdialysis; Oxadiazoles; Piperazines; Piperidones; Prefrontal Cortex; Rats; Receptor, Serotonin, 5-HT1B; Receptors, Presynaptic; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Spiro Compounds | 2005 |
GR-127935-sensitive mechanism mediating hypotension in anesthetized rats: are 5-HT5B receptors involved?
Topics: Animals; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ergotamine; Hypotension; Oxadiazoles; Piperazines; Piperidones; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds | 2015 |