gossypolone has been researched along with gossypol in 22 studies
*Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer. [MeSH]
*Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer. [MeSH]
| Studies (gossypolone) | Trials (gossypolone) | Recent Studies (post-2010) (gossypolone) | Studies (gossypol) | Trials (gossypol) | Recent Studies (post-2010) (gossypol) |
|---|---|---|---|---|---|
| 22 | 0 | 8 | 1,810 | 47 | 471 |
| Protein | Taxonomy | gossypolone (IC50) | gossypol (IC50) |
|---|---|---|---|
| Mcl-1 | Homo sapiens (human) | 1.1916 | |
| Estrogen receptor 1 | Homo sapiens (human) | 2.5513 | |
| Prolyl endopeptidase | Rattus norvegicus (Norway rat) | 0.28 | |
| Malate dehydrogenase, mitochondrial | Sus scrofa (pig) | 4.2683 | |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | 0.86 | |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | 0.86 | |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | 0.86 | |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | 0.86 | |
| Apoptosis regulator Bcl-2 | Homo sapiens (human) | 0.8268 | |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | 0.86 | |
| Malate dehydrogenase, cytoplasmic | Sus scrofa (pig) | 4.7683 | |
| DNA-3-methyladenine glycosylase | Homo sapiens (human) | 3 | |
| Caspase-1 | Homo sapiens (human) | 1.23 | |
| DNA repair protein RAD52 homolog | Homo sapiens (human) | 5 | |
| 5-hydroxytryptamine receptor 7 | Cavia porcellus (domestic guinea pig) | 2.274 | |
| BH3-interacting domain death agonist | Homo sapiens (human) | 2.39 | |
| Bcl-2-like protein 1 | Homo sapiens (human) | 2.784 | |
| Induced myeloid leukemia cell differentiation protein Mcl-1 | Homo sapiens (human) | 1.8192 | |
| L-lactate dehydrogenase | Plasmodium falciparum (malaria parasite P. falciparum) | 2.64 | |
| Aspartyl/asparaginyl beta-hydroxylase | Homo sapiens (human) | 0.2725 | |
| L-lactate dehydrogenase | Plasmodium falciparum CDC/Honduras | 4.562 | |
| L-lactate dehydrogenase B chain | Bos taurus (cattle) | 4.562 | |
| L-lactate dehydrogenase | Plasmodium falciparum (malaria parasite P. falciparum) | 2.03 | |
| Inosine-5'-monophosphate dehydrogenase | Pseudomonas aeruginosa PAO1 | 0.9 | |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | 4.5709 | |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | 3.2359 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 7 (31.82) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 7 (31.82) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, X; Cui, Y; Jiang, B; Jiang, H; Wang, F; Zhang, L; Zhao, H | 1 |
| Gu, Y; Lin, YC | 1 |
| Brueggemeier, RW; Gu, Y; Li, PK; Lin, YC; Rikihisa, Y | 1 |
| Cordell, GA; Fong, HH; Kim, IC; Marcelle, GB; Matlin, SA; Pilla, L; Pirkle, WH; Waller, DP | 1 |
| Brueggemeier, RW; Chang, CJ; Gilbert, NE; Lin, YC; O'Reilly, JE | 1 |
| Ohmura, H | 1 |
| Benz, CC; Liang, XS; Matlin, SA; Ormsby, TJ; Rogers, AJ; Tiritan, ME; Webber, CL | 1 |
| Blackstaffe, L; Fish, RG; Shelley, MD | 1 |
| Evans, A; Fish, RG; Groundwater, P; Hartley, L; Mason, M; Morgan, JJ; Mort, D; Shelley, MD | 1 |
| Dao, VT; Gaspard, C; Mayer, M; Michelot, RJ; Nguyen, SN; Werner, GH | 1 |
| Dabrowski, K; Lee, KJ | 2 |
| Dao, VT; Dowd, MK; Gaspard, C; Hémez, J; Laprévote, O; Martin, MT; Mayer, M; Michelot, RJ | 1 |
| Dao, VT; Dowd, MK; Gaspard, C; Martin, MT; Mayer, M; Michelot, RJ | 1 |
| Dowd, MK; Mellon, JE; Zelaya, CA | 1 |
| Beltz, SB; Dowd, MK; Klich, MA; Mellon, JE; Zelaya, CA | 1 |
| Beltz, SB; Dowd, MK; Mellon, JE | 1 |
| Beltz, SB; Dowd, MK; Mellon, JE; Moore, GG | 1 |
| Guo, F; Lan, B; Li, X; Peng, B; Shi, Z; Wang, X; Zhang, G | 1 |
| Appelman, C; Aubé, J; De Guzman, RN; Gao, P; Gowthaman, R; Karanicolas, J; Lan, L; Larsen, S; Liu, FY; Liu, H; Marquez, RT; Neufeld, KL; Rogers, S; Smith, AR; Wu, X; Xu, L; Yu, J | 1 |
| Li, K; Liu, Y; Ma, J; Tang, P; Wu, D; Wu, Y | 1 |
| Bieber, K; Ludwig, RJ; Petersen, F; Riemekasten, G; Yang, K; Yin, J; Yu, X; Yue, X | 1 |
22 other study(ies) available for gossypolone and gossypol
| Article | Year |
|---|---|
Chiral gossypol derivatives: evaluation of their anticancer activity and molecular modeling.
Topics: Cell Line, Tumor; Drug Screening Assays, Antitumor; Gossypol; HeLa Cells; Humans; Models, Molecular; Molecular Conformation; Protein Binding; Proto-Oncogene Proteins c-bcl-2; Schiff Bases; Structure-Activity Relationship | 2009 |
Suppression of adrenocorticotropic hormone (ACTH)-induced corticosterone secretion in cultured rat adrenocortical cells by gossypol and gossypolone.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Cells, Cultured; Corticosterone; Cyclic AMP; Female; Gossypol; Male; Rats; Rats, Inbred Strains; Spermatocidal Agents | 1991 |
Gossypolone suppresses progesterone synthesis in bovine luteal cells.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Cattle; Cells, Cultured; Cholesterol Side-Chain Cleavage Enzyme; Chorionic Gonadotropin; Female; Gossypol; Hydroxycholesterols; Luteal Cells; Microscopy, Electron; Pregnenolone; Progesterone | 1991 |
Comparative in vitro spermicidal effects of (+/-)-gossypol, (+)-gossypol, (-)-gossypol and gossypolone.
Topics: Animals; Cricetinae; Gossypol; Humans; In Vitro Techniques; Male; Mesocricetus; Mice; Rabbits; Rats; Rats, Inbred Strains; Sperm Motility; Spermatocidal Agents; Spermatozoa; Stereoisomerism | 1984 |
Antiproliferative activity of gossypol and gossypolone on human breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Gossypol; Humans; Neoplasms, Hormone-Dependent; Thymidine; Tritium; Tumor Cells, Cultured | 1995 |
[Suppressive effect of Gossypol, Gossypolone and serum from Gossypol treated rats on steroidogenesis in cultured porcine granulosa cells].
Topics: Animals; Cells, Cultured; Depression, Chemical; Dose-Response Relationship, Drug; Estradiol; Female; Gossypol; Granulosa Cells; Progesterone; Rats; Swine | 1996 |
Developing gossypol derivatives with enhanced antitumor activity.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Epithelium; Female; Gossypol; Humans; Molecular Conformation; Schiff Bases; Tumor Cells, Cultured | 1995 |
Cytotoxicity of gossypol enantiomers and its quinone metabolite gossypolone in melanoma cell lines.
Topics: Cell Adhesion; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Gossypol; Humans; Melanoma; Microscopy, Electron, Scanning; Stereoisomerism; Tumor Cells, Cultured | 1997 |
Stereo-specific cytotoxic effects of gossypol enantiomers and gossypolone in tumour cell lines.
Topics: Antineoplastic Agents; Cell Cycle; Cell Survival; DNA Damage; Drug Screening Assays, Antitumor; Gossypol; Humans; Mutagenicity Tests; Tumor Cells, Cultured | 1999 |
Synthesis and cytotoxicity of gossypol related compounds.
Topics: Antineoplastic Agents; Catalase; Cell Division; Culture Media, Serum-Free; Drug Screening Assays, Antitumor; Free Radical Scavengers; Gossypol; Humans; Mannitol; Structure-Activity Relationship; Tumor Cells, Cultured | 2000 |
Gossypol and gossypolone enantiomers in tissues of rainbow trout fed low and high levels of dietary cottonseed meal.
Topics: Animals; Cottonseed Oil; Diet; Gossypol; Intestines; Kidney; Liver; Male; Muscle, Skeletal; Oncorhynchus mykiss; Stereoisomerism; Stomach; Testis; Tissue Distribution | 2002 |
High-performance liquid chromatographic determination of gossypol and gossypolone enantiomers in fish tissues using simultaneous electrochemical and ultraviolet detectors.
Topics: Animals; Chromatography, High Pressure Liquid; Electrochemistry; Fishes; Gossypol; Reference Standards; Spectrophotometry, Ultraviolet; Stereoisomerism | 2002 |
New thioderivatives of gossypol and gossypolone, as prodrugs of cytotoxic agents.
Topics: Cell Line, Tumor; Gossypol; Humans; Prodrugs; Sulfhydryl Compounds | 2003 |
Cytotoxicity of enantiomers of gossypol Schiff's bases and optical stability of gossypolone.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Survival; Chromatography, High Pressure Liquid; Doxorubicin; Ethylamines; Gossypol; Humans; KB Cells; Mass Spectrometry; Schiff Bases; Stereoisomerism; Structure-Activity Relationship; Temperature; Tumor Cells, Cultured | 2004 |
Inhibitory effects of gossypol-related compounds on growth of Aspergillus flavus.
Topics: Antifungal Agents; Aspergillus flavus; Gossypol | 2011 |
Inhibitory effects of gossypol, gossypolone, and apogossypolone on a collection of economically important filamentous fungi.
Topics: Aflatoxins; Antifungal Agents; Aspergillus; Fusarium; Gossypium; Gossypol; Penicillium; Plant Extracts | 2012 |
Effects of temperature and medium composition on inhibitory activities of gossypol-related compounds against aflatoxigenic fungi.
Topics: Aflatoxins; Agar; Antifungal Agents; Aspergillus; Aspergillus flavus; Culture Media; Gossypol; Temperature | 2013 |
Growth inhibitory effects of gossypol and related compounds on fungal cotton root pathogens.
Topics: Antifungal Agents; Fusarium; Gossypium; Gossypol; Inhibitory Concentration 50; Microbial Sensitivity Tests; Naphthalenes; Phenols; Plant Diseases; Plant Roots; Pythium; Rhizoctonia | 2014 |
Combination therapy with BH3 mimetic and hyperthermia tends to be more effective on anti-melanoma treatment.
Topics: Animals; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Biomimetics; Cell Line, Tumor; Cell Movement; Combined Modality Therapy; Gossypol; Humans; Hyperthermia, Induced; Inhibitor of Apoptosis Proteins; Lung Neoplasms; Male; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Microwaves; Signal Transduction; Skin Neoplasms | 2018 |
Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins.
Topics: Animals; Apoptosis; Biological Products; Cell Line, Tumor; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Gossypol; Humans; Liposomes; Mice; Nerve Tissue Proteins; RNA-Binding Proteins; Signal Transduction; Xenograft Model Antitumor Assays | 2018 |
PVA reinforced gossypolone and doxorubicin π-π stacking nanoparticles towards tumor targeting and ultralow dose synergistic chemotherapy.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Screening Assays, Antitumor; Gossypol; Humans; Hyaluronic Acid; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Nanoparticles; Polyvinyl Alcohol; Structure-Activity Relationship | 2019 |
Luteolin peracetate and gossypolone inhibit immune complex-mediated neutrophil activation
Topics: Antigen-Antibody Complex; Biological Products; Epidermolysis Bullosa Acquisita; Gossypol; Humans; Immunoglobulin G; Luteolin; Neutrophil Activation | 2023 |