Compounds > gossypol

gossypol and thalidomide

gossypol has been researched along with thalidomide in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Ekmekci, A; Erbas, D; Ergun, MA; Konac, E1
Johnson, PW1
Ailawadhi, S; Borrelo, I; Chanan-Khan, A; Chitta, K; Ersing, N; Khan, AN; Lee, KP; Manfredi, D; Masood, A; Miller, KC; Paulus, A; Sher, T1
Akhtar, S; Ansell, SM; Carr, J; Chanan-Khan, A; Chitta, K; Dispenzieri, A; Foran, J; Kumar, S; Mikhael, JR; Miller, KC; Paulus, A; Personett, D; Reeder, CB; Rivera, CE; Roy, V; Thompson, KJ1

Reviews

1 review(s) available for gossypol and thalidomide

ArticleYear
New targets for lymphoma treatment.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19 Suppl 4

    Topics: Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Clinical Trials, Phase II as Topic; Enzyme Inhibitors; Gossypol; Heat-Shock Proteins; Histone Deacetylase Inhibitors; Humans; Immunotherapy; Lymphoma; NF-kappa B; Proteasome Endopeptidase Complex; Protein Kinases; Receptors, Tumor Necrosis Factor; Thalidomide; TOR Serine-Threonine Kinases; Treatment Outcome; Tumor Necrosis Factors

2008

Trials

1 trial(s) available for gossypol and thalidomide

ArticleYear
Downregulation of BCL2 by AT-101 enhances the antileukaemic effect of lenalidomide both by an immune dependant and independent manner.
    British journal of haematology, 2012, Volume: 157, Issue:1

    Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Down-Regulation; Female; Gene Expression Regulation, Leukemic; Gossypol; Humans; Immunologic Factors; Lenalidomide; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Proto-Oncogene Proteins c-bcl-2; Rituximab; Thalidomide; Tumor Cells, Cultured

2012

Other Studies

3 other study(ies) available for gossypol and thalidomide

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Apoptosis and nitric oxide release induced by thalidomide, gossypol and dexamethasone in cultured human chronic myelogenous leukemic K-562 cells.
    Cell biology international, 2004, Volume: 28, Issue:3

    Topics: Apoptosis; Contraceptive Agents, Male; Dexamethasone; Dose-Response Relationship, Drug; Glucocorticoids; Gossypol; Humans; K562 Cells; Leprostatic Agents; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Nitric Oxide; Thalidomide

2004
AT-101 downregulates BCL2 and MCL1 and potentiates the cytotoxic effects of lenalidomide and dexamethasone in preclinical models of multiple myeloma and Waldenström macroglobulinaemia.
    British journal of haematology, 2014, Volume: 164, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Dexamethasone; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Profiling; Gossypol; Humans; Lenalidomide; Multiple Myeloma; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Thalidomide; Waldenstrom Macroglobulinemia

2014