gossypol has been researched along with navitoclax in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 11 (78.57) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Barelier, S; Krimm, I; Lancelin, JM; Marcillat, O; Pons, J | 1 |
| Bonovolias, ID; Chatzopoulou, M; Demopoulos, VJ; Nicolaou, I; Tsiftsoglou, AS; Vizirianakis, IS | 1 |
| Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ | 1 |
| An, J; Huang, Z; Mao, Y; Xu, Y; Yang, S; Zhang, H | 1 |
| Brewitz, L; Schofield, CJ; Tumber, A; Zhang, X | 1 |
| Azmi, AS; Mohammad, RM | 1 |
| Kang, MH; Reynolds, CP | 1 |
| Billard, C | 2 |
| Butterworth, M; Cohen, GM; Dinsdale, D; Pellecchia, M; Varadarajan, S; Wei, J | 1 |
| Anderson, MA; Huang, D; Roberts, A | 1 |
| Bello, M; Correa-Basurto, J; Zacarías-Lara, OJ | 1 |
| Davids, MS; Lampson, BL | 1 |
| Han, Z; He, J; Li, Y; Liang, J | 1 |
8 review(s) available for gossypol and navitoclax
| Article | Year |
|---|---|
Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Differentiation; Clinical Trials as Topic; Drug Evaluation, Preclinical; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Leukemia; Multipotent Stem Cells; Neoplastic Stem Cells; Pharmacogenetics | 2010 |
The chemical biology of apoptosis: Revisited after 17 years.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Design; Humans; Neoplasms; Proto-Oncogene Proteins c-bcl-2 | 2019 |
Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy.
Topics: Aniline Compounds; Animals; Apoptosis; Benzamides; Binding Sites; Biphenyl Compounds; Gossypol; Humans; Indoles; Lymphoma; Models, Molecular; Neoplasms; Nitrophenols; Piperazines; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides; Sulfones | 2009 |
Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Gossypol; Humans; Indoles; Mitochondria; Neoplasms; Nitrophenols; Piperazines; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides; Thionucleotides | 2009 |
BH3 mimetics: status of the field and new developments.
Topics: Amino Acid Motifs; Aniline Compounds; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Clinical Trials as Topic; Drug Design; Drug Screening Assays, Antitumor; Gossypol; Humans; Indoles; Molecular Mimicry; Neoplasms; Peptide Fragments; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides | 2013 |
Targeting BCL2 for the treatment of lymphoid malignancies.
Topics: Aniline Compounds; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Gossypol; Hematologic Neoplasms; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Peptide Fragments; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides | 2014 |
The Development and Current Use of BCL-2 Inhibitors for the Treatment of Chronic Lymphocytic Leukemia.
Topics: Aniline Compounds; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Gossypol; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Neutropenia; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides; Thionucleotides | 2017 |
Drugs and Clinical Approaches Targeting the Antiapoptotic Protein: A Review.
Topics: Aniline Compounds; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Gossypol; Humans; Lymphoma, B-Cell; Nitrophenols; Piperazines; Proto-Oncogene Proteins c-bcl-2; Sulfonamides; Thionucleotides | 2019 |
6 other study(ies) available for gossypol and navitoclax
| Article | Year |
|---|---|
Fragment-based deconstruction of Bcl-xL inhibitors.
Topics: bcl-X Protein; Binding Sites; Binding, Competitive; Drug Design; Humans; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Molecular Weight; Organic Chemicals; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Structure-Activity Relationship | 2010 |
Identification of potent Yes1 kinase inhibitors using a library screening approach.
Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-β-hydroxylase.
Topics: Antibiotics, Antineoplastic; Bleomycin; Dose-Response Relationship, Drug; Drug Compounding; Enzyme Inhibitors; Gossypol; Humans; Mixed Function Oxygenases; Molecular Docking Simulation; Molecular Structure; Small Molecule Libraries; Structure-Activity Relationship | 2020 |
Development of Noxa-like BH3 mimetics for apoptosis-based therapeutic strategy in chronic lymphocytic leukemia.
Topics: Aniline Compounds; Apoptosis; Biomimetic Materials; Gossypol; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Myeloid Cell Leukemia Sequence 1 Protein; Peptide Fragments; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides | 2012 |
Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis.
Topics: Adenosine Triphosphate; Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Cell Line; Dynamins; Gossypol; GTP Phosphohydrolases; Humans; Membrane Potential, Mitochondrial; Mice; Microtubule-Associated Proteins; Mitochondria; Mitochondrial Dynamics; Mitochondrial Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Reactive Oxygen Species; Sulfonamides | 2013 |
Exploring the conformational and binding properties of unphosphorylated/phosphorylated monomeric and trimeric Bcl-2 through docking and molecular dynamics simulations.
Topics: Aniline Compounds; Binding Sites; Biphenyl Compounds; Gossypol; Humans; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Nitrophenols; Paclitaxel; Phosphorylation; Piperazines; Principal Component Analysis; Protein Binding; Protein Domains; Protein Multimerization; Protein Structure, Secondary; Proto-Oncogene Proteins c-bcl-2; Sulfonamides; Thermodynamics | 2016 |