gossypol has been researched along with gossypol acetic acid in 185 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 72 (38.92) | 18.7374 |
| 1990's | 21 (11.35) | 18.2507 |
| 2000's | 13 (7.03) | 29.6817 |
| 2010's | 67 (36.22) | 24.3611 |
| 2020's | 12 (6.49) | 2.80 |
| Authors | Studies |
|---|---|
| Abdeen, S; Chapman, E; Chitre, S; Hoang, QQ; Johnson, SM; Park, Y; Ray, AM; Salim, N; Sivinski, J; Stevens, M; Washburn, A | 1 |
| Deshpande, MK; Patil, DR; Udoh, P | 1 |
| Fang, L; Wu, ZH; Zheng, YH | 1 |
| Lorenzo, B; Reidenberg, MM; Sang, GW | 1 |
| Chadha, S; Kanwar, U; Sanyal, SN | 3 |
| Baker, MA; Daehler, CC; Daly, EP; Kleemeyer, KM; Majumdar, SK | 1 |
| Downing, TW; Ericsson, SA; Garner, DL; Kramer, RY; Redelman, D; Wesen, DA | 1 |
| Chin Lin, Y; Furuhashi, N; Gu, Y; Kono, H; Takayama, K; Yajima, A; Yamaguchi, M; Zuspan, FP | 1 |
| Lei, HQ; Xu, YX | 2 |
| Chen, ZX; Gu, ZP; Jiang, Y; Sang, GW; Shao, QX; Wang, WC; Wang, YX; Zhao, XJ | 1 |
| Huang, HF; Wang, M | 1 |
| Mohan, J; Moudgal, RP; Panda, JN; Singh, US | 1 |
| Wang, M; Xu, LF; Zhao, CL | 1 |
| Lin, YC; Rikihisa, Y | 1 |
| Chen, HC; Jin, Y; Wo, WH; Xue, SP; Yang, MZ | 1 |
| Fu, YF; Lu, ZM; Wang, W | 1 |
| Yuan, J; Zhang, JB; Zhang, SF | 1 |
| Ge, RS; Li, XX; Shi, QX; Zhang, YG | 1 |
| Yuan, J; Zhang, JB; Zhang, JF | 1 |
| Chang, CC; Gu, ZP; Zhuang, LZ | 1 |
| Han, ML; Tang, MY; Wang, YF; Zhu, YN | 1 |
| Díaz-Sánchez, V; Gamboa, S; Martínez, F | 1 |
| Dou, SJ; Fu, YF | 1 |
| Mohan, J; Panda, JN; Singh, US | 1 |
| Lei, HP; Song, MZ; Yao, KQ | 1 |
| Lei, HP; Qi, SQ; Zhou, LF | 1 |
| Guan, MZ; Lei, HP; Wang, NG | 1 |
| Best, RG; McKenzie, WH | 1 |
| Gupta, GS; Kapur, S; Kinsky, RG | 1 |
| Adam, H; Frick, J; Kainz, P; Kainz, V; Kalla, NR; Rovan, E | 1 |
| Fang, L; Wu, ZH; Xu, SF; Zhuang, WH | 1 |
| Bajpai, PK; Benghuzzi, HA | 1 |
| Hu, YQ; Liu, ZL; Wu, XR; Yu, MQ | 1 |
| Chester, AE; Meyers, FH | 1 |
| Heywood, R | 1 |
| Tan, YB; Wang, RL; Zhang, ZS | 1 |
| Reynolds, JM; Tone, JN | 1 |
| Bamji, MS; Giridharan, N; Madhyastha, MN; Sesikeran, B | 1 |
| Guan, MZ; Lei, HP; Li, HP; Wang, NG | 1 |
| MacNab, RK; Nollen, PM | 1 |
| Lei, HP; Wang, Y | 1 |
| Wu, XY; Yang, YQ | 1 |
| Ballas, LM; Hedeen, KM | 1 |
| Guo, RY; Qiu, SD | 1 |
| Higgins, C; Matlin, SA; Morris, ID | 1 |
| Chongthammakun, S; Ekavipat, C; Pavasuthipaisit, K; Sanitwongse, B | 1 |
| Foo, J; Frick, J; Hurkadli, KS; Kalla, NR; Rovan, E; Sheth, AR; Steiner, M; Weinbauer, G | 1 |
| Xue, SP; Yang, YZ; Yuan, J; Zhang, JB | 1 |
| Wu, YW; Yuan, D; Zhong, SD | 1 |
| Chen, LY; Huang, Y; Li, YF; Zhu, PD | 1 |
| Li, WJ; Sun, YB; Wang, Y; Zhu, JJ | 1 |
| Jensen, DR; Tone, JN | 1 |
| Lagerlöf, RK; Tone, JN | 1 |
| Breitbart, H; Nass-Arden, L; Rubinstein, S | 1 |
| Jiang, XR; Lu, Q; Pan, XX; Wang, MM; Wang, RL; Yao, YL; Zhang, ZS; Zheng, HZ | 2 |
| Huang, TH | 1 |
| Li, WJ; Ma, XN; Sun, YB | 1 |
| Hamasaki, Y; Miyazaki, S; Tai, HH | 1 |
| Qiu, JX; Shi, QX; Zhang, GY | 1 |
| Lei, HP; Li, HP; Song, MZ; Wang, NG | 1 |
| Cheng, J; Dang, MY; Han, ML; Sun, YT; Tian, L; Zu, PD | 1 |
| Homonnai, ZT; Paz, GF | 1 |
| Lei, HP; Zhou, LF | 1 |
| Frick, J; Rovan, E; Steiner, M | 1 |
| Lei, HP; Li, FY; Li, HP; Wang, NG | 1 |
| Friend, DS; Shi, QX | 1 |
| Haukkamaa, M; Luukkainen, T; Ratsula, K; Wichmann, K | 1 |
| Hunt, S; Mittwoch, U | 1 |
| Ahmed, MS; Cordell, GA; Fong, HH; Marcelle, GB; Pezzuto, JM; Soejarto, DD; Waller, DP | 1 |
| Hahnvajanawong, V; Sattayasai, J; Sattayasai, N | 1 |
| Fu, WO; Qiu, JP; Wong, PY | 1 |
| Eliasson, R; Virji, N | 1 |
| Aitken, RJ; Best, FS; Liu, J; Richardson, DW | 1 |
| Adam, H; Frick, J; Rovan, E; Weinbauer, GF | 1 |
| Lee, CS; Tso, WW | 1 |
| Gao, Y; Guo, Y; Lei, HP; Liu, Y; Wang, NY; Zhou, LF | 1 |
| Lee, CP; Tang, F; Tsang, AY; Wong, PY | 1 |
| Ingraham, HJ; Majumdar, SK; Prymowicz, DA | 1 |
| Hahn, DW; Homm, R; Johnson, AN; Probst, A; Rusticus, C | 1 |
| Fong, HH; Waller, DP; Zaneveld, LJ | 1 |
| Han, ML; Wang, YF; Zhang, YW | 1 |
| Ekmekçi, A; Menevşe, S; Orhan, G | 1 |
| Javed, MU; Waqar, MA | 1 |
| Cheng, J; Duan, J; Han, F; Sha, Y; Wu, T | 1 |
| Barhoumi, R; Burghardt, RC; Hutchinson, RW; Miles, JM | 1 |
| Burghardt, RC; Hutchinson, RW; Ing, NH | 1 |
| Javed, MH; Khan, MA | 1 |
| Lorenzo, BJ; Reidenberg, MM; Wang, MS | 1 |
| Cao, L; Chen, Y; Gu, ZP | 1 |
| Cao, L; Gu, ZP; Sun, ZX; Xu, Y; Yang, B | 1 |
| Cui, GH; Guo, Y; Xue, SP; Yang, ZJ; Ye, WS | 1 |
| Loberg, RD; McGregor, N; Pienta, KJ; Sargent, E; Ying, C | 1 |
| Gardner, JR; Gonen, M; Heaney, ML; Holmlund, J; Leopold, L; Manova, K; Marcucci, G; Mastrella, J; O'Connor, OA; Paoluzzi, L; Sorensen, M; Yang, D | 1 |
| Greipp, PR; Haug, JL; Kimlinger, TK; Kline, MP; Kumar, S; Lust, JA; Rajkumar, SV; Timm, MM | 1 |
| Johnson, PW | 1 |
| Balakrishnan, K; Burger, JA; Gandhi, V; Wierda, WG | 1 |
| Brill, K; Kelly, WK; Leopold, L; Liu, G; Somer, B; Wilding, G | 1 |
| Chen, NL; Fluchel, MN; Goldsmith, KC; Goyal, B; Hogarty, MD; Lestini, BJ; Liu, X; Pawel, BR | 1 |
| Bader El-Dein, MM; El-Shahawy, IN; El-Sharaky, AS; Fawzy, RA; Wahby, MM | 1 |
| Bartelink, H; Kuipers, G; Lafleur, V; Lippman, ME; Rooswinkel, R; Stoter, R; van Blitterswijk, WJ; Verheij, M; Yang, D; Zerp, SF | 1 |
| Bhumbla, A; Goldsmith, KC; Gross, M; Hogarty, MD; Ip, L; Lestini, BJ; Liu, X; Zhang, X; Zhao, H | 1 |
| Cheng, W; Li, YM; Yang, DJ; Zhao, YQ | 2 |
| Cirak, Y; Degirmenci, M; Karabulut, B; Karaca, B; Purcu, DU; Sanli, UA; Sezgin, C; Tunali, D; Uslu, R; Uzunoglu, S; Varol, U | 1 |
| Bai, QX; Chen, XQ; Huang, GS; Li, R; Wang, JH; Wang, WQ; Wang, Z; Zhang, WP | 1 |
| Chen, H; Kim, KW; Li, B; Lu, B; Moretti, L | 1 |
| Fulda, S | 1 |
| Craig, M; McGregor, N; Patel, L; Pienta, KJ; Wang, S; Weidner, S | 1 |
| Brainerd, V; Chinnasami, B; Fain, J; Fidias, P; Heist, RS; Khan, W; Leopold, L; Lynch, TJ; Molina, JR; Sequist, LV; Temel, JS | 1 |
| Atmaca, H; Karabulut, B; Karaca, B; Kisim, A; Sezgin, C; Uslu, R; Uzunoglu, S | 1 |
| Zwitter, M | 1 |
| Holmlund, JT; Karaseva, NA; Leopold, L; Luft, AV; Orlov, SV; Popovych, O; Ready, N; Wood, BA | 1 |
| Amm, HM; Buchsbaum, DJ; Kuo, H; Li, Y; Steg, AD; Zhou, T | 1 |
| Guo, Z; Huang, SS; Ma, JX; Wang, CJ; Xue, TM; Zhao, J | 1 |
| Armstrong, AJ; Berry, WR; Brookes, M; de Wit, R; Eisenberger, MA; Leopold, L; Pond, GR; Sonpavde, G; Tannock, IF; Wood, BA | 1 |
| Chang, Q; Hei, CC; Liu, Z; Ma, WZ; Qian, XJ; Shen, XS; Xu, ZL | 1 |
| Shen, Y; Ye, D | 1 |
| Hu, W; Liu, X; Nie, C; Tang, J; Wang, F; Wei, Y; Yuan, Z | 1 |
| Berry, WR; Brookes, M; Burke, JM; Caton, JR; Fleming, MT; Galsky, MD; Holmlund, JT; Hutson, TE; Karlov, P; Leopold, L; Matveev, V; Sonpavde, G; Wood, BA | 1 |
| Dong, Z; Imai, A; Krishnamurthy, S; Light, E; Nör, JE; Visioli, F; Wang, S; Worden, F; Zeitlin, BD; Zhang, Z | 1 |
| Ailawadhi, S; Borrelo, I; Chanan-Khan, A; Chitta, K; Ersing, N; Khan, AN; Lee, KP; Manfredi, D; Masood, A; Miller, KC; Paulus, A; Sher, T | 1 |
| Atmaca, H; Cakar, B; Karabulut, B; Karaca, B; Kisim, A; Sezgin, C; Uslu, R; Uzunoglu, S | 1 |
| Billard, C | 1 |
| Bertino, JR; DiPaola, RS; Gounder, MK; Kong, AN; Lin, H; Stein, MN | 1 |
| Armstrong, AJ; Galsky, MD; Leopold, L; Pond, GR; Sonpavde, G; Wood, BA | 1 |
| Berry, WR; Galsky, MD; Leopold, L; Pond, GR; Sonpavde, G; Wood, BA | 1 |
| Figg, WD; Hall, C; Kang, MH; Price, DK; Troutman, SM | 1 |
| Azmi, A; Banerjee, S; Lum, LG; Mohommad, R; Sarkar, FH; Schalk, D; Thakur, A | 1 |
| Liem, N; Wang, L; Wong, FY; Wong, WC; Xie, C; Yan, FL; Yong, WP | 1 |
| Atmaca, H; Bozkurt, E; Karabulut, B; Karaca, B; Kisim, A; Sanli, UA; Sezgin, C; Uslu, R; Uzunoglu, S | 1 |
| Khan, F; Prakash, O | 1 |
| Lin, J; Wu, Y; Yang, D; Zhao, Y | 1 |
| ElSayed, ME; Lin, YL; Nör, JE; Yuksel Durmaz, Y | 1 |
| Deng, S; Guo, C; He, Z; Lu, Y; Wei, Q; Wu, J; Yi, J; Yuan, H; Yuan, L | 1 |
| Alberti, DB; Eickhoff, J; Keppen, M; Kolesar, JM; Liu, G; Marnocha, RM; Mohammed, TA; Schelman, WR; Takebe, N; Traynor, AM; Wilding, G | 1 |
| Akhtar, S; Ansell, SM; Carr, J; Chanan-Khan, A; Chitta, K; Dispenzieri, A; Foran, J; Kumar, S; Mikhael, JR; Miller, KC; Paulus, A; Personett, D; Reeder, CB; Rivera, CE; Roy, V; Thompson, KJ | 1 |
| Armstrong, AJ; Chen, I; Chow-Maneval, E; Galsky, MD; Lechuga, M; Leopold, L; Michaelson, MD; Mooney, DJ; Paolini, J; Pond, GR; Smith, MR; Sonpavde, G; Wang, SL; Wood, BA | 1 |
| Lin, Z; Mei, H; Song, Y; Wang, Y; Wu, G | 1 |
| Budhraja, A; Cheng, Q; Cui, H; Gao, N; Li, G; Liu, L; Shan, C; Zhou, T | 1 |
| Advani, P; Akhtar, D; Chanan-Khan, A; Chitta, K; Colon-Otero, G; Foran, J; Khan, AN; Masood, A; Miller, KC; Paulus, A; Rivera, C; Roy, V | 1 |
| Chen, W; Fu, S; Peng, Q; Wu, Y | 1 |
| Garrido Castro, P; Pieters, R; Pinhanços, SM; Schneider, P; Spijkers-Hagelstein, JA; Stam, RW | 1 |
| Carroll, SL; Graham, CD; Kaza, N; Klocke, BJ; Kohli, L; Roth, KA | 1 |
| Anderson, MA; Huang, D; Roberts, A | 1 |
| Li, C; Li, M; Li, Q; Lu, G; Luo, H; Peng, Y; Qian, C; Qing, Y; Ren, T; Shan, J; Wang, D; Zhang, S; Zhang, W; Zhou, SF | 1 |
| Chen, DH; Hanus, J; Jin, P; Liu, Q; Wang, S; Zhang, H; Zhou, Q | 1 |
| Antonietti, P; Bartsch, G; Blaheta, R; Cinatl, J; Gessler, F; Haferkamp, A; Kögel, D; Mani, J; Michaelis, M; Rakel, S; Vallo, S | 1 |
| Cheng, Y; Li, C; Li, M; Li, Q; Lu, G; Luo, H; Peng, Y; Qian, C; Qing, Y; Ren, T; Shan, J; Wang, D; Wang, G; Yang, Y; Zhang, S; Zhou, SF | 1 |
| Huang, M; Liu, Y; Peng, Y; Tan, W; Wang, J; Yang, J | 1 |
| Dubbelman, R; Hoebers, FJ; Kuipers, GK; Lafleur, MV; Slotman, BJ; Stoter, TR; van den Brekel, MW; Verheij, M; Zerp, SF | 1 |
| DiPaola, RS; Goodin, S; Hussain, M; Jeyamohan, C; Kaufman, HL; Liu, G; Mehnert, J; Stadler, WM; Stein, MN; Tereshchenko, IV | 1 |
| Atmaca, H; Bulut, G; Degirmenci, M; Erdogan, AP; Karabulut, B; Karaca, B; Uslu, R; Uzunoglu, S | 1 |
| Chen, WF; Fu, S; Wei, YN; Wu, Y; Yue, WY | 1 |
| Antonietti, P; Düssmann, H; Gessler, F; Kögel, D; Mittelbronn, M; Prehn, JH; Reimertz, C | 1 |
| Duan, W; Gao, M; Huang, C; Li, Q; Li, Y; Luo, J; Sun, L; Wang, D; Wei, X; Xin, X; Zhang, S; Zheng, X | 1 |
| Duan, W; Gao, M; Li, Q; Li, Y; Sun, L; Wang, D; Wei, X; Xin, X; Zhang, S | 1 |
| Bellile, E; Bradford, C; Carey, TE; Chepeha, DB; Eisbruch, A; Jackson, TL; Malloy, K; McKean, E; McLean, S; Moyer, J; Nör, JE; Pearson, AT; Prince, M; Sacco, AG; Shuman, A; Spector, ME; Sukari, A; Swiecicki, PL; Taylor, JM; Wang, S; Wolf, GT; Worden, FP | 1 |
| Hai, P; Wang, YY; Xia, B; Zhang, CY; Zhao, R; Zhe, H; Zhou, S | 1 |
| Antonietti, P; Burger, MC; Fulda, S; Gessler, F; Hehlgans, S; Kögel, D; Linder, B; Mildenberger, IC; Mittelbronn, M; Rödel, F; Steinbach, JP | 1 |
| Carroll, SL; Gibson, LM; Graham, CD; Kaza, N; Klocke, BJ; Pruitt, HC; Roth, KA; Shevde, LA | 1 |
| Chen, K; Deng, M; Jiang, Z; Li, P; Li, Y; Shi, P; Wang, X; Xu, B; Zhang, L; Zhou, Y | 1 |
| Atmaca, H; Bozkurt, E; Cetinkalp, S; Karaca, B; Kisim, A; Ozgen, G; Saygili, F; Uslu, R; Uzunoglu, S; Yilmaz, C; Yurekli, BS | 1 |
| Adamski, V; Adelung, R; Ceynowa, F; Hattermann, K; Held-Feindt, J; Lucius, R; Schmitt, C; Synowitz, M | 1 |
| Behrends, C; Fulda, S; Kögel, D; Linder, B; Meyer, N; Michaelis, JB; Mittelbronn, M; Münch, C; Osiewacz, HD; Rakel, S; Warnsmann, V; Zielke, S | 1 |
| Feng, L; Jiang, J; Jiang, WD; Kuang, SY; Liu, Y; Tang, L; Wang, KZ; Wu, P; Zhang, YA; Zhou, XQ | 1 |
| Cao, S; Ge, F; Ge, RS; Li, X; Wang, G; Wang, Y; Zhu, Q | 1 |
| Adjei, AA; Bible, KC; Erlichman, C; Gandara, DR; Kane, MA; Menefee, ME; Quinn, DI; Reidy-Lagunes, D; Shah, MH; Xie, H; Yin, J | 1 |
| Bei, R; Benvenuto, M; Cerbelli, B; Ciuffa, S; Fazi, S; Izzi, V; Lucarelli, E; Masuelli, L; Mattera, R; Modesti, A; Potenza, V; Tresoldi, I; Zago, E | 1 |
| Bi, S; Chen, K; Chen, XL; Feng, L; Fu, G; Jiang, S; Lin, C; Xu, B; Yang, Q; Zhang, L; Zhao, H; Zhou, Y | 1 |
| Han, Z; He, J; Li, Y; Liang, J | 1 |
| Adamski, V; Adelung, R; Hattermann, K; Held-Feindt, J; Lucius, R; Rasch, F; Schmitt, C; Synowitz, M | 1 |
| Adamski, V; Held-Feindt, J; Kubelt, C; Mehner, M; Schmitt, C; Synowitz, M | 1 |
| Li, Z; Liu, Y; Ma, Y; Wang, G; Yang, Y; Yu, B; Zhang, Z | 1 |
| Adamski, V; Flak, DK; Held-Feindt, J; Jurga, S; Nowaczyk, G; Synowitz, M; Szutkowski, K | 1 |
| Ajani, JA; Bhutani, M; Chen, Q; Correa, A; Estrella, JS; Gan, B; Hofstetter, WL; Huo, L; Jin, J; Johnson, RL; Lee, JH; Lei, G; Li, CY; Li, Y; Liu, B; Ma, L; Pizzi, MP; Scott, A; Shanbhag, N; Song, S; Wang, Y; Wei, S; Weston, B; Xiao, L | 1 |
| Caylioglu, D; Held-Feindt, J; Hellmold, D; Kubelt, C; Meyer, RJ; Synowitz, M | 1 |
| Aktepe, N; Yukselten, Y | 1 |
| Chen, S; Fu, X; Liu, H; Luo, Y; Qu, K; Shi, H; Wang, S; Wu, A; Zeng, W; Zhang, C; Zhang, D; Zhang, H; Zhang, R; Zhang, Z | 1 |
| Chang, J; Xin, X; Yao, J; Yuan, J; Zhou, M | 1 |
| Akbari, M; Arnaldi, P; Held-Feindt, J; Hellmold, D; Synowitz, M | 1 |
| Adelung, R; Beckinger, S; Daunke, T; Haag, J; Hauck, M; Held-Feindt, J; Hellmold, D; Janssen, O; Kubelt, C; Lucius, R; Schütt, F; Sebens, S; Synowitz, M | 1 |
5 review(s) available for gossypol and gossypol acetic acid
| Article | Year |
|---|---|
New targets for lymphoma treatment.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Clinical Trials, Phase II as Topic; Enzyme Inhibitors; Gossypol; Heat-Shock Proteins; Histone Deacetylase Inhibitors; Humans; Immunotherapy; Lymphoma; NF-kappa B; Proteasome Endopeptidase Complex; Protein Kinases; Receptors, Tumor Necrosis Factor; Thalidomide; TOR Serine-Threonine Kinases; Treatment Outcome; Tumor Necrosis Factors | 2008 |
Modulation of apoptosis by natural products for cancer therapy.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Clinical Trials as Topic; Gossypol; Humans; Mitochondria; Neoplasms; Pentacyclic Triterpenes; Reactive Oxygen Species; Resveratrol; Signal Transduction; Stilbenes; Triterpenes; Vitamin E | 2010 |
Bcl-2 family of proteins as therapeutic targets in genitourinary neoplasms.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Clinical Trials as Topic; Gossypol; Humans; Molecular Targeted Therapy; Nitrophenols; Piperazines; Proto-Oncogene Proteins c-bcl-2; Sulfonamides; Thionucleotides; Urogenital Neoplasms | 2013 |
Targeting BCL2 for the treatment of lymphoid malignancies.
Topics: Aniline Compounds; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Gossypol; Hematologic Neoplasms; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Peptide Fragments; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides | 2014 |
Drugs and Clinical Approaches Targeting the Antiapoptotic Protein: A Review.
Topics: Aniline Compounds; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Gossypol; Humans; Lymphoma, B-Cell; Nitrophenols; Piperazines; Proto-Oncogene Proteins c-bcl-2; Sulfonamides; Thionucleotides | 2019 |
16 trial(s) available for gossypol and gossypol acetic acid
| Article | Year |
|---|---|
The effect of cottonseed components on testicular development in pubescent rams.
Topics: Animals; Cottonseed Oil; Epididymis; Flow Cytometry; Gossypol; Male; Organ Size; Organ Specificity; Sexual Maturation; Sheep; Sperm Motility; Spermatocidal Agents; Testis | 1991 |
An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer.
Topics: Adenocarcinoma; Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Cohort Studies; Drug Administration Schedule; Gossypol; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Staging; Neoplasms, Hormone-Dependent; Orchiectomy; Prognosis; Prostate-Specific Antigen; Prostatic Neoplasms; Treatment Outcome | 2009 |
Phase I/II study of AT-101 with topotecan in relapsed and refractory small cell lung cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Drug Resistance, Neoplasm; Female; Gossypol; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Salvage Therapy; Small Cell Lung Carcinoma; Survival Rate; Topotecan; Treatment Outcome | 2010 |
Double-blind, placebo-controlled, randomized phase 2 study of the proapoptotic agent AT-101 plus docetaxel, in second-line non-small cell lung cancer.
Topics: Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Docetaxel; Double-Blind Method; Female; Follow-Up Studies; Gossypol; Humans; Lung Neoplasms; Male; Middle Aged; Prognosis; Prospective Studies; Survival Rate; Taxoids | 2011 |
Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Docetaxel; Gossypol; Humans; Kaplan-Meier Estimate; Lymphatic Metastasis; Male; Middle Aged; Neoplastic Cells, Circulating; Orchiectomy; Placebos; Prednisone; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Taxoids; Treatment Outcome | 2012 |
Downregulation of BCL2 by AT-101 enhances the antileukaemic effect of lenalidomide both by an immune dependant and independent manner.
Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Down-Regulation; Female; Gene Expression Regulation, Leukemic; Gossypol; Humans; Immunologic Factors; Lenalidomide; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Proto-Oncogene Proteins c-bcl-2; Rituximab; Thalidomide; Tumor Cells, Cultured | 2012 |
A validated HPLC assay for the determination of R-(-)-gossypol in human plasma and its application in clinical pharmacokinetic studies.
Topics: Antineoplastic Agents, Phytogenic; Chromatography, High Pressure Liquid; Gossypol; Humans; Limit of Detection; Neoplasms; Reproducibility of Results; Sensitivity and Specificity; Time Factors | 2012 |
Efficacy of docetaxel-based chemotherapy following ketoconazole in metastatic castration-resistant prostate cancer: implications for prior therapy in clinical trials.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Docetaxel; Gossypol; Humans; Ketoconazole; Male; Middle Aged; Neoplasm Metastasis; Outcome Assessment, Health Care; Prednisone; Proportional Hazards Models; Prospective Studies; Prostate-Specific Antigen; Prostatic Neoplasms, Castration-Resistant; Retrospective Studies; Taxoids | 2013 |
Neutropenia as a potential pharmacodynamic marker for docetaxel-based chemotherapy in men with metastatic castration-resistant prostate cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Docetaxel; Gossypol; Humans; Kaplan-Meier Estimate; Male; Neoplasm Metastasis; Neutropenia; Prednisone; Prognosis; Prostate-Specific Antigen; Prostatic Neoplasms; Retrospective Studies; Survival Analysis; Taxoids | 2012 |
A phase I study of AT-101 with cisplatin and etoposide in patients with advanced solid tumors with an expanded cohort in extensive-stage small cell lung cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Etoposide; Female; Gossypol; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms | 2014 |
Radiographic progression by Prostate Cancer Working Group (PCWG)-2 criteria as an intermediate endpoint for drug development in metastatic castration-resistant prostate cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Disease Progression; Disease-Free Survival; Docetaxel; Drug Discovery; Gossypol; Humans; Indoles; Male; Prednisone; Prostatic Neoplasms, Castration-Resistant; Pyrroles; Radiography; Retrospective Studies; Sunitinib; Survival Rate; Taxoids; Time Factors | 2014 |
Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancer.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Chemoradiotherapy; Chromatography, High Pressure Liquid; Gossypol; Head and Neck Neoplasms; Humans; Proto-Oncogene Proteins c-bcl-2; Radiation-Sensitizing Agents; Squamous Cell Carcinoma of Head and Neck | 2015 |
A Phase II Study of AT-101 to Overcome Bcl-2--Mediated Resistance to Androgen Deprivation Therapy in Patients With Newly Diagnosed Castration-Sensitive Metastatic Prostate Cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Androgen Antagonists; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Gossypol; Humans; Lymphatic Metastasis; Male; Middle Aged; Prostatic Neoplasms; Treatment Outcome | 2016 |
A phase II trial of the BCL-2 homolog domain 3 mimetic AT-101 in combination with docetaxel for recurrent, locally advanced, or metastatic head and neck cancer.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Disease-Free Survival; Docetaxel; Drug Administration Schedule; Female; Gossypol; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Taxoids; Treatment Outcome | 2016 |
A phase II study of the orally administered negative enantiomer of gossypol (AT-101), a BH3 mimetic, in patients with advanced adrenal cortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Antineoplastic Agents, Phytogenic; Female; Gossypol; Humans; Male; Middle Aged; Proto-Oncogene Proteins c-bcl-2; Response Evaluation Criteria in Solid Tumors | 2019 |
Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Docetaxel; Esophageal Neoplasms; Female; Gossypol; Humans; Male; Mice; Middle Aged; Neoplastic Stem Cells; Pilot Projects; Proto-Oncogene Proteins c-bcl-2; Stomach Neoplasms | 2021 |
164 other study(ies) available for gossypol and gossypol acetic acid
| Article | Year |
|---|---|
HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules.
Topics: Biological Products; Chaperonin 10; Chaperonin 60; Escherichia coli; Humans; Inhibitory Concentration 50; Protein Folding; Rafoxanide; Salicylanilides; Suramin | 2019 |
Histopathological and biochemical effects of gossypol acetate on pituitary-gonadal axis of male albino rats.
Topics: Acid Phosphatase; Animals; Citrates; Citric Acid; Epididymis; Follicle Stimulating Hormone; Fructose; Glycerylphosphorylcholine; Gossypol; Leydig Cells; Luteinizing Hormone; Male; Oligospermia; Pituitary Gland; Prolactin; Prostate; Rats; Sertoli Cells; Spermatocidal Agents; Spermatozoa; Testis; Time Factors | 1992 |
[Effect of gossypol acetic acid on hCG-stimulated progesterone production of dissociated rat luteal cells].
Topics: Animals; Cells, Cultured; Chorionic Gonadotropin; Cyclic AMP; Female; Gossypol; Luteal Cells; Progesterone; Pseudopregnancy; Rats; Spermatocidal Agents | 1991 |
Inhibitory effects of gossypol on corticosteroid 11-beta-hydroxysteroid dehydrogenase from guinea pig kidney: a possible mechanism for causing hypokalemia.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Animals; Gossypol; Guinea Pigs; Hydroxysteroid Dehydrogenases; Hypokalemia; Kidney; Kinetics; Male; Microsomes | 1991 |
Alterations and reversibility of the effects of gossypol acetic acid on the intestinal uptake of end product nutrients in normal and protein calorie-malnourished male rats.
Topics: Amino Acids; Animals; Calcium; Contraceptive Agents, Male; Glucose; Gossypol; Intestinal Absorption; Male; Nutritional Physiological Phenomena; Protein-Energy Malnutrition; Rats | 1991 |
Genotoxic effects of gossypol acetic acid on cultured murine erythroleukemia cells.
Topics: Animals; Cell Division; Cell Membrane; Chromosome Aberrations; DNA Damage; DNA Replication; Gossypol; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Microscopy, Electron, Scanning; Mitotic Index; Mutagens; Thymidine; Tritium; Tumor Cells, Cultured | 1991 |
Gossypol effects on monoamine oxidase (MAO) activity in several organs of term rats.
Topics: Animals; Female; Fetus; Gossypol; Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Placenta; Pregnancy; Rats; Rats, Inbred Strains; Uterus | 1991 |
[Effects of gossypol acetic acid on transport and development of fertilized eggs in rats].
Topics: Animals; Embryo Implantation, Delayed; Embryo, Mammalian; Embryonic and Fetal Development; Female; Gossypol; Ovum Transport; Rats; Rats, Inbred Strains; Zygote | 1990 |
Relationship between hormone profiles and the restoration of spermatogenesis in men treated with gossypol.
Topics: Administration, Oral; Adult; Double-Blind Method; Estradiol; Follicle Stimulating Hormone; Follow-Up Studies; Gossypol; Humans; Luteinizing Hormone; Male; Oligospermia; Prolactin; Prospective Studies; Random Allocation; Sperm Count; Spermatocidal Agents; Spermatogenesis; Testosterone; Time Factors | 1990 |
[Effects of gossypol acetate, progesterone, danazol and GnRH-A (gonadotropin release hormone-A) on the DNA-synthesis of human endometrial cell in vitro].
Topics: Adult; Cells, Cultured; Danazol; DNA; Endometrium; Female; Gossypol; Humans; Pituitary Hormone-Releasing Hormones; Progesterone | 1990 |
Studies on antifertility effects of gossypol acetic acid in domestic cocks.
Topics: Acrosin; Animals; Chickens; Fertility; Gossypol; Hyaluronoglucosaminidase; Male; Peptidyl-Dipeptidase A; Semen; Sperm Count; Spermatocidal Agents; Spermatozoa | 1989 |
[Clinical effects and experimental study on gossypol in endometriosis].
Topics: Adult; Antineoplastic Agents, Phytogenic; Drugs, Chinese Herbal; Endometriosis; Female; Gossypol; Humans; Middle Aged; Ovarian Neoplasms; Uterine Neoplasms | 1989 |
Reversibility of the effects of gossypol acetic acid, an antispermatogenic/antifertility agent on the intestinal structure and functions of male albino rats.
Topics: Amino Acids; Animals; Biological Transport; Body Weight; Glucose; Gossypol; Intestinal Absorption; Intestinal Mucosa; Intestines; Kinetics; Male; Rats; Spermatocidal Agents | 1989 |
Effect of gossypol on the thyroid in young rats.
Topics: Animals; Gossypol; Male; Microscopy, Electron; Random Allocation; Rats; Rats, Inbred Strains; Spermatocidal Agents; Thyroid Gland; Thyroid Hormones; Thyroxine; Time Factors; Triiodothyronine; Triiodothyronine, Reverse | 1989 |
Effects of gossypol on Na+, K+ transmembrane fluxes in human red cells.
Topics: Erythrocyte Membrane; Gossypol; Humans; Potassium; Sodium | 1989 |
Gossypol inhibition of kidney (Na+ + K+)-ATPase.
Topics: Animals; Gossypol; Kidney; Rabbits; Sodium-Potassium-Exchanging ATPase | 1987 |
[Synergic effects of gossypol acetate and sulphadiazine on the LDH-x activity and viability of human sperm].
Topics: Drug Synergism; Gossypol; Humans; Isoenzymes; L-Lactate Dehydrogenase; Male; Spermatocidal Agents; Spermatozoa; Sulfadiazine | 1985 |
[Spermicidal effects in vitro of gossypol acetic acid-povidone coprecipitate].
Topics: Animals; Cricetinae; Dogs; Gossypol; Guinea Pigs; Humans; Male; Mesocricetus; Mice; Povidone; Rats; Species Specificity; Spermatocidal Agents; Spermatozoa | 1986 |
[Experimental studies on the cytotoxic effect of gossypol in mice, rats and human tumor cell lines and its possible mechanism].
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line; DNA; Gossypol; HeLa Cells; Humans; Isoenzymes; L-Lactate Dehydrogenase; Liver Neoplasms; Mice; Multiple Myeloma; Rats | 1986 |
Comparison of sensitivities of rat spermatozoa, Sertoli and Leydig cells to gossypol acetic acid in vitro by the LD50.
Topics: Animals; Cells, Cultured; Gossypol; Lethal Dose 50; Leydig Cells; Male; Rats; Rats, Inbred Strains; Sertoli Cells; Spermatocidal Agents; Spermatozoa | 1986 |
[Ultrastructural changes in smooth muscle cells in leiomyoma and the myometrium of the human uterus after gossypol treatment].
Topics: Adult; Female; Gossypol; Humans; Leiomyoma; Middle Aged; Mitochondria, Muscle; Muscle, Smooth; Myometrium; Uterine Neoplasms | 1987 |
Biochemical effects of gossypol in isolated mitochondria: monovalent cations and ATPase activity.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Cations, Monovalent; Energy Metabolism; Gossypol; Hydrogen-Ion Concentration; Lithium; Male; Mitochondria, Liver; Oxygen Consumption; Potassium; Rats; Rats, Inbred Strains; Rubidium; Sodium; Uncoupling Agents | 1988 |
[Effects of gossypol acetic acid on heart mitochondrial membranes ATPase].
Topics: Adenosine Triphosphatases; Animals; Cell Membrane; Gossypol; Mitochondria, Heart; Spermatocidal Agents; Swine | 1988 |
Effect of gossypol acetic acid on spermatozoal ATPases activity and fertility in chicken.
Topics: Adenosine Triphosphatases; Animals; Chickens; Fertility; Gossypol; Male; Spermatocidal Agents; Spermatozoa | 1988 |
[Influence of gossypol on the potassium metabolism of human erythrocytes].
Topics: Ca(2+) Mg(2+)-ATPase; Calcium-Transporting ATPases; Erythrocyte Membrane; Gossypol; Hemolysis; Humans; Potassium; Sodium-Potassium-Exchanging ATPase | 1985 |
Effect of gossypol acetic acid on the epididymis: histochemical and scanning electron microscope studies.
Topics: Animals; Epididymis; Esterases; Glycogen; Gossypol; Male; Microscopy, Electron; Phosphoric Monoester Hydrolases; Rats; Rats, Inbred Strains; Succinate Dehydrogenase | 1987 |
Effects of gossypol acetic acid on rat luteal cells in vitro.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclase Inhibitors; Animals; Chorionic Gonadotropin; Corpus Luteum; Cyclic AMP; Female; Gossypol; In Vitro Techniques; Infertility, Female; Progesterone; Rats; Rats, Inbred Strains | 1987 |
Variable sister-chromatid exchange response in human lymphocytes exposed in vitro to gossypol acetic acid.
Topics: Cells, Cultured; Gossypol; Humans; Lymphocytes; Male; Mutagenicity Tests; Mutagens; Sister Chromatid Exchange; Spermatocidal Agents | 1988 |
Inhibition kinetics of lactate dehydrogenase isoenzymes by gossypol acetic acid.
Topics: Animals; Goats; Gossypol; In Vitro Techniques; Isoenzymes; Kinetics; L-Lactate Dehydrogenase; Lactates; Liver; Male; Myocardium; NAD; Pyruvates; Spermatocidal Agents; Testis | 1988 |
The effect of gossypol acetic acid on the different stages of the spermatogenic cycle in the rat.
Topics: Animals; Fertility; Gonadotropins; Gossypol; Male; Rats; Rats, Inbred Strains; Seminiferous Epithelium; Sertoli Cells; Spermatogenesis; Testosterone | 1988 |
[Effect of gossypol acetate on the testicular HCG reactivity and its receptor in the rats].
Topics: Animals; Gossypol; Leydig Cells; Male; Rats; Receptors, LH; Spermatocidal Agents; Testosterone | 1988 |
Ceramic systems for long-term delivery of chemicals and biologicals.
Topics: Adrenalectomy; Aluminum; Animals; Blood Proteins; Brain Chemistry; Calcium; Calcium Compounds; Ceramics; Corticosterone; Drug Implants; Gossypol; Hormones; Humans; Male; Oxides; Phosphorus; Phosphorus Compounds; Rats; Reference Values; Spermatocidal Agents; Steroids; Testosterone | 1988 |
Effects of gossypol acetic acid on the absorptive and digestive functions of rat intestine.
Topics: Administration, Oral; Animals; Body Weight; Digestion; Gossypol; Intestinal Mucosa; Intestines; Kinetics; Male; Microvilli; Rats; Rats, Inbred Strains; Spermatocidal Agents; Thermodynamics | 1988 |
Ultrastructural observation on influence of gossypol on the hormone-secreting cells of pituitary-testis axis of rats.
Topics: Animals; Gossypol; Male; Pituitary Gland; Rats; Rats, Inbred Strains; Sertoli Cells; Spermatocidal Agents; Testis | 1988 |
Central sympathoplegic and norepinephrine-depleting effects of antioxidants.
Topics: Animals; Antioxidants; Brain; Carbon Disulfide; Dithiothreitol; Dopamine; Gossypol; Male; Norepinephrine; Organotin Compounds; Rats; Rats, Inbred Strains; Serotonin; Sympathetic Nervous System; Sympatholytics; Tetraethyl Lead | 1988 |
The toxicology of gossypol acetic acid and (-)-gossypol.
Topics: Animals; Body Weight; Contraceptive Agents, Male; Gossypol; Macaca fascicularis; Male; Rats; Rats, Inbred Strains; Spermatocidal Agents | 1988 |
Gossypol acetate-induced SCEs in spermatogonia and bone marrow cells of mice: dose-response relationships.
Topics: Animals; Bone Marrow; Contraceptive Agents, Male; Dose-Response Relationship, Drug; Gossypol; Male; Mice; Sister Chromatid Exchange; Spermatocidal Agents; Spermatogonia; Spermatozoa | 1988 |
Subchronic oral administration of gossypol-acetic acid (GAA) alters the distribution and utilization of radioiron in male rats.
Topics: Administration, Oral; Animals; Body Weight; Bone Marrow; Erythrocytes; Gossypol; Iron; Iron Radioisotopes; Liver; Male; Rats; Spermatocidal Agents; Spleen | 1988 |
Dose and time related changes in LDH-X activity, epididymal carnitine levels and fertility, in gossypol-treated male rats.
Topics: Animals; Carnitine; Epididymis; Fertility; Gossypol; Infertility, Male; L-Lactate Dehydrogenase; Malate Dehydrogenase; Male; Rats; Rats, Inbred Strains; Spermatozoa; Testis | 1987 |
[Effect of gossypol acetic acid (GAA) and 15-methyl PGF2 alpha-methyl ester (PG05) on estrogen receptors of rat uteri].
Topics: Animals; Carboprost; Female; Gossypol; Pseudopregnancy; Rats; Rats, Inbred Strains; Receptors, Estrogen; Spermatocidal Agents; Uterus | 1987 |
The effects of gossypol on spermatogenesis and development of the eyefluke, Philophthalmus gralli, and its chicken host.
Topics: Animal Feed; Animals; Body Weight; Chickens; Ferric Compounds; Gossypol; Male; Organ Size; Poultry Diseases; Spermatogenesis; Testis; Trematoda; Trematode Infections | 1987 |
Hepatotoxicity of gossypol in rats.
Topics: Animals; Calcium; Cell Membrane Permeability; Chemical and Drug Induced Liver Injury; Gossypol; Lipid Peroxides; Liver; Male; Microscopy, Electron; Rats; Rats, Inbred Strains | 1987 |
Antifertility mechanisms of gossypol acetic acid in female rats.
Topics: Animals; Embryo Implantation; Female; Fertility; Gossypol; Progesterone; Rats; Rats, Inbred Strains | 1987 |
Inhibition of glycerolipid synthesis by gossypol acetate.
Topics: Acyltransferases; Glycerol-3-Phosphate O-Acyltransferase; Gossypol; Microbodies | 1987 |
[Effects of gossypol acetic acid on the secretory activity of Leydig cells and LH/hCG receptor development in the immature rat testis].
Topics: Animals; Gossypol; Leydig Cells; Male; Rats; Receptors, LH; Spermatocidal Agents; Testosterone | 1987 |
Inhibition of testicular LDH-X from laboratory animals and man by gossypol and its isomers.
Topics: Animals; Cricetinae; Cytosol; Gossypol; Humans; In Vitro Techniques; Isoenzymes; L-Lactate Dehydrogenase; Male; Mesocricetus; Mice; Mice, Inbred Strains; Middle Aged; Rabbits; Rats; Rats, Inbred Strains; Testis | 1986 |
Effects of gossypol on human and monkey sperm motility in vitro.
Topics: Animals; Dose-Response Relationship, Drug; Gossypol; Humans; Kinetics; Macaca fascicularis; Male; Photomicrography; Sperm Motility | 1986 |
Ultrastructure of monkey (Macaca radiata) spermatozoa: effect of gossypol in vivo.
Topics: Administration, Oral; Animals; Gossypol; Macaca radiata; Male; Microscopy, Electron; Spermatozoa | 1986 |
[Observations of in vitro fertilization capacity and the transformation of human sperm nuclei before and after administration of gossypol acetic acid].
Topics: Adult; Animals; Cricetinae; Female; Fertilization in Vitro; Gossypol; Humans; Male; Mesocricetus; Sperm Head; Sperm-Ovum Interactions; Spermatocidal Agents; Spermatozoa | 1985 |
[The effects of gossypol on the secretive function of Sertoli cells in the rat by a method of collection of rete testis fluid of the rat].
Topics: Androgen-Binding Protein; Animals; Body Fluids; Gossypol; Male; Rats; Rats, Inbred Strains; Rete Testis; Secretory Rate; Sertoli Cells; Testis | 1985 |
[Study on the preparation and stability of solid dispersion of gossypol acetic acid-PVP and its spermicidal activity in vitro].
Topics: Gossypol; Humans; Male; Povidone; Solvents; Spermatocidal Agents; Spermatozoa | 1985 |
An antifertility dose of gossypol does not affect the hypothalamo-pituitary testis axis of male rats.
Topics: Animals; Gonadotropin-Releasing Hormone; Gossypol; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Male; Rats; Rats, Inbred Strains; Spermatocidal Agents; Spermatozoa; Testis | 1985 |
Radioiron utilization and gossypol acetic acid in male rats.
Topics: Animals; Body Weight; Erythrocytes; Erythropoiesis; Gossypol; Iron; Iron Radioisotopes; Male; Rats; Spermatocidal Agents; Splenectomy | 1985 |
The effect of gossypol acetic acid on female reproduction.
Topics: Animals; Body Weight; Estrus; Female; Gossypol; Rats; Reproduction | 1985 |
Effect of gossypol-acetic acid on calcium transport and ATPase activity in plasma membranes from ram and bull spermatozoa.
Topics: Adenosine Triphosphatases; Animals; Biological Transport, Active; Ca(2+) Mg(2+)-ATPase; Calcimycin; Calcium; Calcium-Transporting ATPases; Cattle; Cell Membrane; Gossypol; Male; Sheep; Spermatocidal Agents; Spermatozoa | 1984 |
[Effect of gossypol acetic acid on the induction of sister chromatid exchange of spermatogonial cell in mice].
Topics: Animals; DNA; Gossypol; Male; Mice; Mice, Inbred ICR; Sister Chromatid Exchange; Spermatocidal Agents; Spermatogonia; Spermatozoa | 1984 |
[Effect of gossypol acetic acid on induction of sister chromatid exchange of spermatogonial cell in mice].
Topics: Animals; DNA; Gossypol; Male; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Sister Chromatid Exchange; Spermatocidal Agents; Spermatogonia; Spermatozoa | 1984 |
[The effect of gossypol acetate on the function of rRNA gene and acrocentric chromosome association in human cells].
Topics: Adult; Chromosomes, Human; Genes; Gossypol; Humans; Male; RNA, Ribosomal | 1983 |
[Effect of gossypol acetic acid on testosterone, LH and FSH levels of male rats].
Topics: Animals; Follicle Stimulating Hormone; Gossypol; Luteinizing Hormone; Male; Organ Size; Rats; Rats, Inbred Strains; Spermatocidal Agents; Testis; Testosterone | 1983 |
[Rat basophilic leukemia-1 cell possesses 12-lipoxygenase and 5-lipoxygenase activities which are specifically inhibited by gossypol acetic acid].
Topics: Animals; Arachidonate Lipoxygenases; Basophils; Cells, Cultured; Gossypol; Hydroxyeicosatetraenoic Acids; Hypersensitivity, Immediate; Leukemia; Lipoxygenase Inhibitors; Rats | 1984 |
[Analysis on exfoliated cells in human semen after oral administrations of gossypol acetic acid (author's transl)].
Topics: Adult; Gossypol; Humans; Male; Semen; Sperm Count; Sperm Motility; Spermatocidal Agents | 1981 |
[Antisteroidal and antigonadotrophic effects of gossypol acetic acid in rats].
Topics: Animals; Chorionic Gonadotropin; Female; Gonadal Steroid Hormones; Gonadotropins; Gossypol; Male; Rats; Spermatocidal Agents; Testosterone | 1984 |
Electron microscopic observations of the effects of gossypol on the human endometrium.
Topics: Endocrine Glands; Endometriosis; Endometrium; Female; Gossypol; Humans; Leiomyoma; Menstruation; Time Factors; Uterine Neoplasms | 1984 |
Effect of the antifertility agent, gossypol acetic acid, on the metabolism and testosterone secretion of isolated rat interstitial cells in vitro.
Topics: Animals; Cells, Cultured; Glucose; Gossypol; In Vitro Techniques; Leydig Cells; Male; Oxygen Consumption; Rats; Rats, Inbred Strains; Testosterone; Time Factors | 1984 |
[Effect of gossypol acetic acid on the uterus and ovary].
Topics: Animals; Female; Gossypol; Ovary; Rats; Rats, Inbred Strains; Spermatocidal Agents; Uterus | 1984 |
In vivo study of LDH isoenzyme activities in heart, liver and testis cytosols of gossypol-treated rats.
Topics: Animals; Butyrates; Cytosol; Dose-Response Relationship, Drug; Gossypol; Isoenzymes; L-Lactate Dehydrogenase; Liver; Male; Myocardium; Rats; Rats, Inbred Strains; Sperm Motility; Substrate Specificity; Testis | 1984 |
[Effect of gossypol acetic acid on early pregnancy in rats].
Topics: Animals; Castration; Chorionic Gonadotropin; Contraceptive Agents, Female; Female; Gossypol; Male; Ovary; Pregnancy; Pregnancy, Animal; Progesterone; Rats | 1984 |
Gossypol-induced inhibition of guinea pig sperm capacitation in vitro.
Topics: Acrosome; Animals; Calcium; Depression, Chemical; Gossypol; Guinea Pigs; In Vitro Techniques; Male; Sperm Capacitation; Sperm Motility; Spermatocidal Agents; Spermatozoa | 1983 |
Vaginal contraception with gossypol: a clinical study.
Topics: Adult; Female; Gels; Gossypol; Humans; Male; Sperm Count; Sperm Motility; Spermatocidal Agents; Spermatozoa; Sterilization, Tubal; Vagina; Vaginal Creams, Foams, and Jellies | 1983 |
Effects of gossypol on sperm counts in two inbred strains of mice.
Topics: Animals; Epididymis; Gossypol; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Organ Size; Seminal Vesicles; Sperm Count; Spermatogenesis; Testis | 1984 |
Analysis of gossypol and gossypol-acetic acid by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Gossypol; Spectrophotometry, Ultraviolet | 1984 |
High-performance liquid chromatographic determination of gossypol in plasma.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Drug Stability; Gossypol; Male; Rats; Spermatocidal Agents | 1984 |
Gossypol does not affect testicular fluid secretion in rats.
Topics: Animals; Extracellular Space; Fertility; Gossypol; Male; Rats; Rats, Inbred Strains; Sertoli Cells; Sperm Motility; Spermatocidal Agents | 1984 |
Effects of gossypol acetic acid on the activity of LDH-C4 from human and rabbit spermatozoa.
Topics: Animals; Gossypol; Humans; In Vitro Techniques; Isoenzymes; L-Lactate Dehydrogenase; Male; Rabbits; Species Specificity; Spermatozoa | 1983 |
An analysis of the direct effects of gossypol on human spermatozoa.
Topics: Animals; Cervix Mucus; Cricetinae; Female; Gossypol; Humans; In Vitro Techniques; Male; Ovum; Sperm Motility; Sperm-Ovum Interactions; Spermatozoa | 1983 |
Ultrastructural analysis of rat testes after gossypol acetic acid (GAA) treatment.
Topics: Animals; Contraceptive Agents, Male; Gossypol; Male; Rats; Rats, Inbred Strains; Sertoli Cells; Spermatozoa; Testis | 1983 |
Cottonseed oil as a vaginal contraceptive.
Topics: Buffers; Cottonseed Oil; Emulsions; Female; Gossypol; Humans; Male; Species Specificity; Sperm Motility; Spermatocidal Agents; Vagina | 1982 |
[Further observations on the effect of prolonged administration of gossypol acetic acid to rats].
Topics: Adrenal Glands; Animals; Gossypol; Histocytochemistry; Kidney; Liver; Male; Rats; Rats, Inbred Strains | 1982 |
Inhibition of catechol-O-methyltransferase by gossypol: the effect of plasma proteins.
Topics: Animals; Blood Proteins; Catechol O-Methyltransferase Inhibitors; Catecholamines; Gossypol; In Vitro Techniques; Liver; Rats; Spermatocidal Agents | 1982 |
Gossypol--an effective male contraceptive was not mutagenic in sperm head abnormality assay in mice.
Topics: Animals; Dose-Response Relationship, Drug; Gossypol; Male; Mice; Mice, Inbred Strains; Mutagenicity Tests; Mutation; Sperm Head; Spermatozoa | 1982 |
Antifertility and endocrine activities of gossypol in rodents.
Topics: Animals; Cricetinae; Dose-Response Relationship, Drug; Drug Synergism; Female; Fertility; Gossypol; Male; Methyltestosterone; Mice; Pregnancy; Pregnancy, Animal; Rats; Species Specificity; Spermatocidal Agents; Testis | 1981 |
In vitjro spermicidal activity of gossypol.
Topics: Drug Combinations; Gossypol; In Vitro Techniques; Male; Povidone; Sperm Motility; Spermatocidal Agents | 1980 |
[Estrogen and progesterone cytosol receptor concentrations in patients with endometriosis and their changes after gossypol therapy].
Topics: Adult; Antineoplastic Agents, Phytogenic; Endometriosis; Endometrium; Estradiol; Female; Gossypol; Humans; Middle Aged; Ovarian Diseases; Receptors, Estrogen; Receptors, Progesterone; Uterine Diseases | 1994 |
[Effects of gossypol acetic acid on the motility of rat oviduct smooth muscle].
Topics: Alprostadil; Animals; Contraceptive Agents, Female; Dinoprostone; Estrus; Fallopian Tubes; Female; Gossypol; Muscle Contraction; Muscle, Smooth; Rats; Rats, Sprague-Dawley | 1993 |
The effect of the male contraceptive agent gossypol acetic acid on mouse bone marrow cells in vivo: micronuclei and mitotic index.
Topics: Animals; Bone Marrow; DNA Damage; Dose-Response Relationship, Drug; Gossypol; Humans; Injections, Intraperitoneal; Male; Mice; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mitosis; Mitotic Index; Spermatocidal Agents | 1993 |
Inhibition studies on LDH isoenzyme purified from Uromastix testes.
Topics: Animals; Antineoplastic Agents; Caproates; Cisplatin; Enzyme Inhibitors; Gossypol; Isoenzymes; L-Lactate Dehydrogenase; Lizards; Male; NAD; Oxalates; Oxalic Acid; Pyruvic Acid; Testis | 1996 |
[Effects of gossypol acetic acid on human ejaculated sperm Ca2+ influx and rat vas deferens contraction action].
Topics: Adult; Animals; Biological Transport, Active; Calcium; Dose-Response Relationship, Drug; Gossypol; Humans; Male; Muscle Contraction; Rats; Rats, Sprague-Dawley; Spermatocidal Agents; Spermatozoa; Vas Deferens | 1996 |
Attenuation of gossypol cytotoxicity by cyclic AMP in a rat liver cell line.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Monophosphate; Animals; Calcium; Cell Communication; Cell Line; Connexin 43; Cytoplasm; Gap Junctions; Glutathione; Gossypol; Hydrogen-Ion Concentration; Intracellular Membranes; Liver; Membrane Potentials; Mitochondria; Rats; Reactive Oxygen Species | 1998 |
Induction of c-fos, and cytochrome c oxidase subunits I and II by gossypol acetic acid in rat liver cells.
Topics: Animals; Cell Line, Transformed; Clone Cells; Electron Transport Complex IV; Gene Expression Regulation; Genes, fos; Gossypol; Liver; Nucleic Acid Hybridization; Rats | 1998 |
Effect of amino acids on inhibition of lactate dehydrogenase-X by gossypol.
Topics: Amino Acids; Animals; Enzyme Inhibitors; Goats; Gossypol; Isoenzymes; L-Lactate Dehydrogenase; Male; Spermatocidal Agents; Testis | 1999 |
NAD- and NADP-dependent 11 beta-hydroxysteroid dehydrogenase isoforms in guinea pig kidney with gossypol inhibition.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Animals; Contraceptive Agents, Female; Gossypol; Guinea Pigs; Hydroxysteroid Dehydrogenases; Isoenzymes; Kidney Cortex; Male; Microsomes; NAD; NADP | 1997 |
[Effect of gossypol in combination with misoprostol on termination of early pregnancy in rats and mice].
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Animals; Contraceptive Agents, Female; Decidua; Drug Synergism; Female; Gossypol; Male; Mice; Misoprostol; Pregnancy; Rats; Uterine Contraction | 1997 |
[The effects of gossypol on rat luteal cells, human decidual cells and cytotrophoblasts].
Topics: Animals; Cell Survival; Cells, Cultured; Contraceptive Agents, Female; Decidua; Female; Gossypol; Humans; Luteal Cells; Progesterone; Rats; Rats, Sprague-Dawley; Trophoblasts | 1997 |
Combined administration of low-dose gossypol acetic acid with desogestrel/mini-dose ethinylestradiol/testosterone undecanoate as an oral contraceptive for men.
Topics: Animals; Body Weight; Contraceptive Agents, Male; Contraceptives, Oral, Synthetic; Desogestrel; Ethinyl Estradiol; Fertility; Gossypol; Male; Organ Size; Random Allocation; Rats; Rats, Wistar; Sexual Behavior, Animal; Sperm Motility; Spermatogenesis; Testis; Testosterone | 2004 |
In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Caspases; Combined Modality Therapy; Down-Regulation; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Gossypol; Humans; Male; Mice; Mice, SCID; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Orchiectomy; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; RNA, Neoplasm; Xenograft Model Antitumor Assays | 2007 |
Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Biomimetics; Blotting, Western; Cell Line, Tumor; Cyclophosphamide; Disease Models, Animal; Flow Cytometry; Gossypol; Humans; In Vitro Techniques; Lymphoma, B-Cell; Membrane Potential, Mitochondrial; Mice; Microscopy, Confocal; Proto-Oncogene Proteins c-bcl-2; Rituximab; Xenograft Model Antitumor Assays | 2008 |
R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells.
Topics: Analgesics; Apoptosis; Caspases; Cell Proliferation; Cell Survival; Dexamethasone; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Flow Cytometry; Gossypol; Humans; Immunoblotting; Mitochondria; Mitochondrial Membranes; Multiple Myeloma; Proto-Oncogene Proteins c-bcl-2; Time Factors; Tumor Cells, Cultured | 2008 |
AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; B-Lymphocytes; Cell Communication; Dose-Response Relationship, Drug; Down-Regulation; Drug Resistance, Neoplasm; Gossypol; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Stromal Cells; Tumor Cells, Cultured; Vidarabine | 2009 |
Mcl1 downregulation sensitizes neuroblastoma to cytotoxic chemotherapy and small molecule Bcl2-family antagonists.
Topics: Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Down-Regulation; Gene Silencing; Gossypol; Humans; Microscopy, Phase-Contrast; Myeloid Cell Leukemia Sequence 1 Protein; Neuroblastoma; Nitrophenols; Piperazines; Proto-Oncogene Proteins c-bcl-2; RNA Interference; Sulfonamides; Transfection | 2009 |
Mutual anti-oxidative effect of gossypol acetic acid and gossypol-iron complex on hepatic lipid peroxidation in male rats.
Topics: Animals; Antineoplastic Agents; Antioxidants; Chemical and Drug Induced Liver Injury; Gossypol; Iron; Lipid Peroxidation; Liver; Male; Rats | 2009 |
AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Line, Tumor; Combined Modality Therapy; Dose-Response Relationship, Radiation; Gossypol; Humans; JNK Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Radiation-Sensitizing Agents; Radiotherapy; Signal Transduction | 2009 |
BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists.
Topics: Apoptosis; Biphenyl Compounds; Cell Line; Cell Line, Tumor; Cytochromes c; Gossypol; Humans; Immunoblotting; Immunoprecipitation; Mitochondria; Neuroblastoma; Nitrophenols; Peptide Fragments; Piperazines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Sulfonamides | 2010 |
[Effect of gossypol acetate on proliferation and apoptosis in Raji lymphoblastoid cell line].
Topics: Apoptosis; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Gossypol; Humans; Proto-Oncogene Proteins c-bcl-2 | 2009 |
The effect of racemic gossypol and at-101 on angiogenic profile of ovcar-3 cells: a preliminary molecular framework for gossypol enantiomers.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Gossypol; Humans; Isomerism; Neovascularization, Pathologic; Polymerase Chain Reaction; RNA, Messenger | 2009 |
[Apoptosis of multiple myeloma cells induced by gossypol acetic acid in vitro and its mechanism].
Topics: Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 8; Cell Line, Tumor; Cell Proliferation; Gossypol; Humans; Membrane Potential, Mitochondrial; Multiple Myeloma | 2009 |
AT-101, a pan-Bcl-2 inhibitor, leads to radiosensitization of non-small cell lung cancer.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Gamma Rays; Gossypol; Humans; Immunoblotting; Lung Neoplasms; Proto-Oncogene Proteins c-bcl-2; Radiation Tolerance; Radiation-Sensitizing Agents; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2010 |
AT-101 (R-(-)-gossypol acetic acid) enhances the effectiveness of androgen deprivation therapy in the VCaP prostate cancer model.
Topics: Androgen Antagonists; Androgens; Anilides; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-X Protein; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dihydrotestosterone; Drug Synergism; Gossypol; Humans; Immunoblotting; Male; Nitriles; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Receptors, Androgen; Tosyl Compounds | 2010 |
Comparison of XTT and Alamar blue assays in the assessment of the viability of various human cancer cell lines by AT-101 (-/- gossypol).
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Cell Survival; Female; Gossypol; Humans; Indicators and Reagents; Male; Neoplasms; Oxazines; Reproducibility of Results; Tetrazolium Salts; Tumor Stem Cell Assay; Xanthenes | 2010 |
Combining cytotoxic and targeted therapies for lung cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Gossypol; Humans; Lung Neoplasms; Topotecan | 2010 |
Mechanisms of drug sensitization to TRA-8, an agonistic death receptor 5 antibody, involve modulation of the intrinsic apoptotic pathway in human breast cancer cells.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azocines; Benzhydryl Compounds; Boronic Acids; Bortezomib; Breast Neoplasms; Caspases; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Female; Genes, bcl-2; Gossypol; Humans; Mice; Pyrazines; Receptors, TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured | 2011 |
[Gossypol acetic acid induces DNA double-strand breaks in human mucoepidermoid carcinoma cell MEC-1].
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Mucoepidermoid; Cell Line, Tumor; Cell Proliferation; DNA Breaks, Double-Stranded; Gossypol; Humans; Parotid Neoplasms | 2011 |
Evaluating the value of number of cycles of docetaxel and prednisone in men with metastatic castration-resistant prostate cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Clinical Trials as Topic; Disease-Free Survival; Docetaxel; Gossypol; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Prednisone; Prostate-Specific Antigen; Prostatic Neoplasms; Retrospective Studies; Taxoids; Treatment Outcome | 2012 |
Drug synergistic antifertility effect of combined administration of low-dose gossypol with steroid hormones in rats.
Topics: Animals; Desogestrel; Epididymis; Ethinyl Estradiol; Flow Cytometry; Gossypol; Male; Random Allocation; Rats; Sperm Motility; Spermatogenesis; Spermatozoa; Testis; Testosterone | 2011 |
Re: Gregory R. Pond, Andrew J. Armstrong, Brian A. Wood, et al. Evaluating the value of number of cycles of docetaxel and prednisone in men with metastatic castration-resistant prostate cancer. Eur Urol 2012;61:363-9.
Topics: Antineoplastic Combined Chemotherapy Protocols; Docetaxel; Gossypol; Humans; Male; Prednisone; Prostatic Neoplasms; Taxoids | 2012 |
Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cisplatin; Down-Regulation; Drug Resistance, Neoplasm; Female; Gossypol; Humans; Intracellular Signaling Peptides and Proteins; Mitochondria; Mitochondrial Proteins; Ovarian Neoplasms; Proto-Oncogene Proteins c-akt; Tumor Suppressor Protein p53; X-Linked Inhibitor of Apoptosis Protein | 2012 |
Metronomic dosing of BH3 mimetic small molecule yields robust antiangiogenic and antitumor effects.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Cells, Cultured; Docetaxel; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Endothelial Cells; Gossypol; Head and Neck Neoplasms; Humans; Inhibitory Concentration 50; Kaplan-Meier Estimate; Male; Mice; Mice, SCID; Neovascularization, Pathologic; Neovascularization, Physiologic; Taxoids; Treatment Outcome; Xenograft Model Antitumor Assays | 2012 |
Pretreatment with AT-101 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of breast cancer cells by inducing death receptors 4 and 5 protein levels.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Female; Gossypol; Humans; Mitochondria; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand | 2012 |
Development of Noxa-like BH3 mimetics for apoptosis-based therapeutic strategy in chronic lymphocytic leukemia.
Topics: Aniline Compounds; Apoptosis; Biomimetic Materials; Gossypol; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Myeloid Cell Leukemia Sequence 1 Protein; Peptide Fragments; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides | 2012 |
[Effects of gossypol acetate on apoptosis in primary cultured cells from patients with lymphoid leukemia and its synergy with dexamethasone].
Topics: Apoptosis; Cell Line; Dexamethasone; Gossypol; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured | 2012 |
Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells.
Topics: Antibodies, Bispecific; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Combined Modality Therapy; Cross-Priming; Drug Screening Assays, Antitumor; ErbB Receptors; Flow Cytometry; Gossypol; Granzymes; Humans; Immunotherapy; Interferon-gamma; Kinetics; Models, Biological; Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; STAT1 Transcription Factor; STAT3 Transcription Factor; T-Lymphocytes | 2012 |
Combination therapy with gossypol reveals synergism against gemcitabine resistance in cancer cells with high BCL-2 expression.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-X Protein; Cell Line, Tumor; Deoxycytidine; Down-Regulation; Drug Interactions; Drug Resistance, Neoplasm; Drug Synergism; Gemcitabine; Gene Expression Regulation, Neoplastic; Gossypol; Humans; Inhibitory Concentration 50; Multigene Family; Neoplasms; Proto-Oncogene Proteins c-bcl-2; Reproducibility of Results; Signal Transduction; Up-Regulation | 2012 |
Combination of AT-101/cisplatin overcomes chemoresistance by inducing apoptosis and modulating epigenetics in human ovarian cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Survival; Cisplatin; DNA (Cytosine-5-)-Methyltransferases; DNA Fragmentation; DNA Methylation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Epigenesis, Genetic; Female; Fluorescent Antibody Technique; Gossypol; Histone Deacetylases; Humans; Ovarian Neoplasms | 2013 |
Development of method for three-point data estimation and SVR-QSAR model to screen anti cancer leads.
Topics: Antineoplastic Agents; Colorectal Neoplasms; Gossypol; High-Throughput Screening Assays; Humans; Models, Molecular; Proto-Oncogene Proteins c-bcl-2; Quantitative Structure-Activity Relationship; Regression Analysis; Support Vector Machine | 2013 |
Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-X Protein; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Gossypol; Humans; Mice; Mice, Inbred BALB C; Multiple Myeloma; Proto-Oncogene Proteins c-bcl-2; Small Molecule Libraries | 2013 |
Synergistic combination of small molecule inhibitor and RNA interference against antiapoptotic Bcl-2 protein in head and neck cancer cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Gossypol; Head and Neck Neoplasms; Humans; Proto-Oncogene Proteins c-bcl-2; RNA Interference; RNA, Small Interfering | 2013 |
Gossypol acetic acid induces apoptosis in RAW264.7 cells via a caspase-dependent mitochondrial signaling pathway.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Gossypol; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Reactive Oxygen Species; Signal Transduction | 2013 |
AT-101 downregulates BCL2 and MCL1 and potentiates the cytotoxic effects of lenalidomide and dexamethasone in preclinical models of multiple myeloma and Waldenström macroglobulinaemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Dexamethasone; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Profiling; Gossypol; Humans; Lenalidomide; Multiple Myeloma; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Thalidomide; Waldenstrom Macroglobulinemia | 2014 |
Autophagy inhibition enhances pan-Bcl-2 inhibitor AT-101-induced apoptosis in non-small cell lung cancer.
Topics: Apoptosis; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Gossypol; Humans; Lung Neoplasms; Proto-Oncogene Proteins c-bcl-2 | 2014 |
RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Gossypol; Humans; Leukemia; Mice; Mice, Inbred NOD; Mice, SCID; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; PTEN Phosphohydrolase; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 2014 |
The investigational agent MLN2238 induces apoptosis and is cytotoxic to CLL cells in vitro, as a single agent and in combination with other drugs.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boron Compounds; Caspase 3; Caspase 9; Cell Death; Cell Survival; Dexamethasone; Drug Synergism; Enzyme Activation; Glycine; Gossypol; Humans; Intracellular Membranes; Leukemia, Lymphocytic, Chronic, B-Cell; Middle Aged; Mitochondria; Neoplasm Staging; Permeability; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured; Vidarabine | 2014 |
[Effects of gossypol acetic acid on the proliferation and methylation level of the human MutL homologue 1 gene in human tongue carcinoma cell line Tca8113].
Topics: Cell Line; Cell Line, Tumor; Cell Proliferation; Gossypol; Humans; Methylation; Tongue Neoplasms | 2014 |
Glucocorticoid sensitisation in Mixed Lineage Leukaemia-rearranged acute lymphoblastic leukaemia by the pan-BCL-2 family inhibitors gossypol and AT-101.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gene Order; Glucocorticoids; Gossypol; Humans; Infant; Leukemia, Biphenotypic, Acute; Myeloid Cell Leukemia Sequence 1 Protein; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Proto-Oncogene Proteins c-bcl-2; Sirolimus; Tumor Cells, Cultured | 2014 |
BNIP3 regulates AT101 [(-)-gossypol] induced death in malignant peripheral nerve sheath tumor cells.
Topics: Antineoplastic Agents, Phytogenic; Autophagy; Cell Death; Cell Line, Tumor; Dose-Response Relationship, Drug; Gossypol; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Iron; Membrane Proteins; Neurilemmoma; Proto-Oncogene Proteins; Schwann Cells | 2014 |
Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Cisplatin; DNA-(Apurinic or Apyrimidinic Site) Lyase; Dose-Response Relationship, Drug; Gossypol; Humans; Interleukin-6; Lung Neoplasms; Molecular Structure; Signal Transduction; STAT3 Transcription Factor; Structure-Activity Relationship; Tumor Cells, Cultured | 2014 |
Gossypol Acetic Acid Prevents Oxidative Stress-Induced Retinal Pigment Epithelial Necrosis by Regulating the FoxO3/Sestrin2 Pathway.
Topics: Antioxidants; Cell Death; Cell Line; Cell Survival; Forkhead Box Protein O3; Forkhead Transcription Factors; Gossypol; Humans; Macular Degeneration; Necrosis; Nuclear Proteins; Oxidative Stress; Reactive Oxygen Species; Retinal Pigment Epithelium; Retinal Pigments; Signal Transduction; United States; United States Food and Drug Administration | 2015 |
Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101).
Topics: Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line, Tumor; Cisplatin; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Gossypol; Humans; Membrane Proteins; Peptide Fragments; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Urinary Bladder Neoplasms | 2015 |
Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cisplatin; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Gossypol; Human Umbilical Vein Endothelial Cells; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Oxidation-Reduction; Xenograft Model Antitumor Assays | 2015 |
AT-101 inhibits hedgehog pathway activity and cancer growth.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Cerebellar Neoplasms; Colonic Neoplasms; Gossypol; Hedgehog Proteins; HEK293 Cells; Humans; Medulloblastoma; Mice; Mice, Inbred C3H; Mice, Transgenic; NIH 3T3 Cells; Signal Transduction | 2015 |
Octreotide in combination with AT-101 induces cytotoxicity and apoptosis through up-regulation of somatostatin receptors 2 and 5 in DU-145 prostate cancer cells.
Topics: Androgens; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Gossypol; Humans; Male; Octreotide; Prostatic Neoplasms; Receptors, Somatostatin | 2016 |
Influence of gossypol acetic acid on the growth of human adenoid cystic carcinoma ACC-M cells and the expression of DNA methyltransferase 1.
Topics: Apoptosis; Carcinoma, Adenoid Cystic; Cell Line, Tumor; Cell Proliferation; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Flow Cytometry; Gossypol; Humans | 2015 |
AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localization of Bcl-xL and Bcl-2 in MCF7 cells.
Topics: Apoptosis; Autophagy; bcl-X Protein; Breast Neoplasms; Cytoprotection; Female; Gene Expression Regulation, Neoplastic; Gossypol; Humans; MCF-7 Cells; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured | 2016 |
Prediction of survival prognosis of non-small cell lung cancer by APE1 through regulation of Epithelial-Mesenchymal Transition.
Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; DNA-(Apurinic or Apyrimidinic Site) Lyase; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Gossypol; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Prognosis; Xenograft Model Antitumor Assays | 2016 |
AT101 exerts a synergetic efficacy in gastric cancer patients with 5-FU based treatment through promoting apoptosis and autophagy.
Topics: AC133 Antigen; Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Movement; DNA-(Apurinic or Apyrimidinic Site) Lyase; Drug Synergism; Female; Fluorouracil; Gossypol; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Microtubule-Associated Proteins; Middle Aged; Nanog Homeobox Protein; Receptor, ErbB-2; Stomach Neoplasms; Xenograft Model Antitumor Assays | 2016 |
AT-101 enhances gefitinib sensitivity in non-small cell lung cancer with EGFR T790M mutations.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-X Protein; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Synergism; ErbB Receptors; Female; Gefitinib; Gossypol; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Quinazolines | 2016 |
Interference with the HSF1/HSP70/BAG3 Pathway Primes Glioma Cells to Matrix Detachment and BH3 Mimetic-Induced Apoptosis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-X Protein; Biomarkers, Tumor; Biphenyl Compounds; Cell Adhesion; Cell Line, Tumor; DNA-Binding Proteins; Drug Resistance, Neoplasm; Gene Expression; Gene Knockdown Techniques; Glioma; Gossypol; Heat Shock Transcription Factors; HSP70 Heat-Shock Proteins; Humans; Inhibitor of Apoptosis Proteins; Mice; Molecular Mimicry; NF-kappa B; Nitrophenols; Piperazines; Protein Binding; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Signal Transduction; Sulfonamides; Survivin; Transcription Factors | 2017 |
BH3 mimetics suppress CXCL12 expression in human malignant peripheral nerve sheath tumor cells.
Topics: Antineoplastic Agents; Biphenyl Compounds; Cell Line, Tumor; Chemokine CXCL12; Down-Regulation; Gene Expression Regulation, Neoplastic; Gossypol; Humans; Indoles; Molecular Mimicry; Neurilemmoma; Nitrophenols; Piperazines; Poly (ADP-Ribose) Polymerase-1; Protein Binding; Protein Interaction Domains and Motifs; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides | 2017 |
The pan-Bcl2 Inhibitor AT101 Activates the Intrinsic Apoptotic Pathway and Causes DNA Damage in Acute Myeloid Leukemia Stem-Like Cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Proliferation; DNA Damage; Gossypol; Humans; Leukemia, Myeloid, Acute; Neoplastic Stem Cells; Proto-Oncogene Proteins c-bcl-2 | 2017 |
AT-101 acts as anti-proliferative and hormone suppressive agent in mouse pituitary corticotroph tumor cells.
Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Adrenocorticotropic Hormone; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Cell Proliferation; Gossypol; Mice; Pituitary Neoplasms; Tumor Cells, Cultured | 2018 |
Effects of sequentially applied single and combined temozolomide, hydroxychloroquine and AT101 treatment in a long-term stimulation glioblastoma in vitro model.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Growth Processes; Cell Line, Tumor; Dacarbazine; Drug Administration Schedule; Drug Synergism; Glioblastoma; Gossypol; Humans; Hydroxychloroquine; Temozolomide | 2018 |
AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells.
Topics: Autophagy; Autophagy-Related Protein 5; Cell Line, Tumor; Glioma; Gossypol; Heme Oxygenase-1; Humans; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Proteins; Mitophagy; Neoplasm Proteins; Proteomics | 2018 |
Dietary gossypol reduced intestinal immunity and aggravated inflammation in on-growing grass carp (Ctenopharyngodon idella).
Topics: Aeromonas hydrophila; Animal Feed; Animals; Carps; Diet; Dietary Supplements; Dose-Response Relationship, Drug; Fish Diseases; Gossypol; Gram-Negative Bacterial Infections; Immunity, Innate; Inflammation; Intestines; Random Allocation | 2019 |
Gossypol inhibits 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase: Its possible use for the treatment of prostate cancer.
Topics: 5-alpha Reductase Inhibitors; Alcohol Oxidoreductases; Animals; Gossypol; Hydroxysteroid Dehydrogenases; Leydig Cells; Male; Molecular Docking Simulation; Molecular Structure; Prostatic Neoplasms; Rats, Sprague-Dawley | 2019 |
In vivo and in vitro inhibition of osteosarcoma growth by the pan Bcl-2 inhibitor AT-101.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Gossypol; Humans; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; Polyphenols; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction | 2020 |
Synthetic lethality of combined AT-101 with idarubicin in acute myeloid leukemia via blockade of DNA repair and activation of intrinsic apoptotic pathway.
Topics: Adolescent; Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers, Tumor; Case-Control Studies; Cell Proliferation; DNA Repair; Drug Synergism; Female; fms-Like Tyrosine Kinase 3; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Gossypol; Humans; Idarubicin; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred NOD; Mice, SCID; Middle Aged; Prognosis; RUNX1 Translocation Partner 1 Protein; Survival Rate; Synthetic Lethal Mutations; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; Young Adult | 2019 |
Establishment of a glioblastoma in vitro (in)complete resection dual co-culture model suitable for drug testing.
Topics: Analysis of Variance; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Astrocytes; Brain; Coculture Techniques; Glioblastoma; Gossypol; Humans; Microglia; Temozolomide | 2020 |
Combined treatment of AT101 and demethoxycurcumin yields an enhanced anti-proliferative effect in human primary glioblastoma cells.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Proliferation; Diarylheptanoids; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression; Glioblastoma; Gossypol; Humans; Membrane Potential, Mitochondrial; Signal Transduction; Tumor Cells, Cultured | 2020 |
Investigation of Inhibition Effect of Gossypol-Acetic Acid on Gastric Cancer Cells Based on a Network Pharmacology Approach and Experimental Validation.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Drug Screening Assays, Antitumor; Gossypol; Humans; Software; Stomach Neoplasms; Tumor Cells, Cultured | 2020 |
AT101-Loaded Cubosomes as an Alternative for Improved Glioblastoma Therapy.
Topics: Antineoplastic Agents, Phytogenic; Biological Availability; Brain Neoplasms; Cell Line, Tumor; Colloids; Cytoskeleton; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Glioblastoma; Glycerides; Gossypol; Humans; Lipids; Magnetic Resonance Spectroscopy; Nanoparticles; Poloxamer; Solubility | 2020 |
Effects of the Anti-Tumorigenic Agent AT101 on Human Glioblastoma Cells in the Microenvironmental Glioma Stem Cell Niche.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Glioblastoma; Glioma; Gossypol; Humans; Neoplastic Stem Cells; Signal Transduction; Stem Cell Niche; Temozolomide; Tumor Microenvironment | 2021 |
Induction of apoptosis in human hormone-refractory prostate cancer cell lines by using resveratrol in combination with AT-101.
Topics: Apoptosis; Cell Line; Cell Line, Tumor; Gossypol; Hormones; Humans; Male; Prostatic Neoplasms; Resveratrol | 2022 |
Cyclic RGD-Decorated Liposomal Gossypol AT-101 Targeting for Enhanced Antitumor Effect.
Topics: Animals; Cell Line, Tumor; Gossypol; Liposomes; Male; Mice; Mice, Nude; Peptides, Cyclic; Tissue Distribution | 2022 |
Comparison of the efficacy of gossypol acetate enantiomers in rats with uterine leiomyoma.
Topics: Animals; China; Gossypol; Leiomyoma; Rats; Stereoisomerism | 2023 |
A biopolymeric mesh enriched with PLGA microparticles loaded with AT101 for localized glioblastoma treatment.
Topics: Antineoplastic Agents; Drug Delivery Systems; Glioblastoma; Gossypol; Humans; Microspheres; Surgical Mesh | 2023 |
Sequential Treatment with Temozolomide Plus Naturally Derived AT101 as an Alternative Therapeutic Strategy: Insights into Chemoresistance Mechanisms of Surviving Glioblastoma Cells.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Glioblastoma; Gossypol; Humans; Neoplasm Recurrence, Local; Temozolomide; TOR Serine-Threonine Kinases | 2023 |