gossypol has been researched along with apogossypolone in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (16.13) | 29.6817 |
| 2010's | 25 (80.65) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Cellitti, J; Dahl, R; Kitada, S; Pellecchia, M; Placzek, W; Reed, JC; Rega, MF; Stebbins, JL; Wei, J; Wu, B; Yang, L; Zhai, D; Zhang, Z | 1 |
| An, J; Huang, Z; Mao, Y; Xu, Y; Yang, S; Zhang, H | 1 |
| Murphy, PV; Negi, A | 1 |
| Hu, ZY; Jiang, WQ; Li, ZM; Lin, XB; Sun, J; Xian, LJ; Yang, DJ; Zhou, NN | 1 |
| Mi, JX; Ni, XY; Sun, XQ; Tang, JM; Wang, GF; Wang, HB; Yang, DJ; Zhang, XW | 1 |
| Lin, J; Wu, YJ; Yang, DJ; Zhao, YQ | 1 |
| Hu, ZY; Jiang, WQ; Li, ZM; Sun, J; Yang, DJ; Zeng, ZL | 1 |
| Hu, ZY; Sun, J; Yang, D; Zeng, YX; Zhu, XF | 1 |
| Aboukameel, A; Banerjee, S; Chen, J; Choi, M; Mohammad, M; Mohammad, RM; Sarkar, FH; Wang, Z; Yang, D | 1 |
| An, QX; Chen, R; Hu, XB; Huang, XF; Mu, SJ; Wu, DC; Xia, AJ; Yang, SM; Yi, J; Zhan, YH; Zhang, XQ | 1 |
| Cheng, G; Hu, ZY; Huang, P; Wang, J; Yang, D; Zeng, YX; Zhu, XF | 1 |
| Dowd, MK; Mellon, JE; Zelaya, CA | 1 |
| Beltz, SB; Dowd, MK; Klich, MA; Mellon, JE; Zelaya, CA | 1 |
| Ahmad, A; Hadi, SM; Khan, HY; Ullah, MF; Wu, D; Zubair, H | 1 |
| Huang, J; Li, S; Niu, X; Wang, S; Wei, F; Wu, G; Xu, D; Xu, L | 1 |
| Aggarwal, S; Balakrishnan, K; Gandhi, V; Wierda, W | 1 |
| Liang, JM; Nie, YZ; Tian, J; Xia, LM; Xin, J; Zhan, YH; Zhu, HW | 1 |
| Anderson, MA; Huang, DC; Roberts, AW | 1 |
| Cheng, P; Dai, X; Ding, W; He, F; Lian, J; Ni, Z; Rae Smith, A; Wang, B; Wu, D; Xu, L | 1 |
| Beltz, SB; Dowd, MK; Mellon, JE | 1 |
| An, QX; Hu, XB; Huang, XF; Liu, ZX; Zhan, YH; Zhang, XQ | 1 |
| Billard, C | 1 |
| Beltz, SB; Dowd, MK; Mellon, JE; Moore, GG | 1 |
| Chen, WD; Deng, R; Han, ZP; He, JH; Jiang, JW; Li, DD; Liao, XL; Wang, W; Yang, D; Zhu, XF | 1 |
| An, Q; Hu, X; Huang, X; Liu, Z; Mu, S; Zhan, Y; Zhang, X | 1 |
| Deng, F; Deng, Y; Haydon, RC; He, TC; Huang, E; Li, R; Luu, HH; Qiao, M; Wang, J; Wang, Z; Wei, Q; Yan, Z; Ye, J; Zhang, H; Zhang, Q; Zhang, Z; Zhou, G | 1 |
| Chen, M; Gao, W; Li, K; Liu, H; Liu, J; Wu, D; Xu, L; Zeng, Y | 1 |
| Chen, YF; Fan, YH; Hu, ZY; Sun, J; Sun, R; Xu, F; Zhang, DS | 1 |
| Das, SK; Dash, R; Emdad, L; Fisher, PB; Klibanov, AL; Pellecchia, M; Quinn, BA; Sarkar, D; Sarkar, S; Shen, XN; Wang, XY | 1 |
| Fan, Y; Li, S; Li, T; Sun, J; Ye, L; Yuan, G; Zhang, L | 1 |
| Ahmad, A; Azim, S; Hadi, SM; Khan, HY; Singh, AP; Ullah, MF; Wu, D; Zubair, H | 1 |
3 review(s) available for gossypol and apogossypolone
| Article | Year |
|---|---|
The chemical biology of apoptosis: Revisited after 17 years.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Design; Humans; Neoplasms; Proto-Oncogene Proteins c-bcl-2 | 2019 |
Development of Mcl-1 inhibitors for cancer therapy.
Topics: Antineoplastic Agents; Cell Proliferation; Drug Development; Heterocyclic Compounds; Humans; Molecular Structure; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasms | 2021 |
BH3 mimetics: status of the field and new developments.
Topics: Amino Acid Motifs; Aniline Compounds; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Clinical Trials as Topic; Drug Design; Drug Screening Assays, Antitumor; Gossypol; Humans; Indoles; Molecular Mimicry; Neoplasms; Peptide Fragments; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides | 2013 |
28 other study(ies) available for gossypol and apogossypolone
| Article | Year |
|---|---|
Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Membrane Permeability; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Drug Stability; Female; Gossypol; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Mice, Nude; Mice, Transgenic; Microsomes; Models, Molecular; Naphthoquinones; Neoplasm Transplantation; Peptide Fragments; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Structure-Activity Relationship; Transplantation, Heterologous | 2010 |
ApoG2 inhibits antiapoptotic Bcl-2 family proteins and induces mitochondria-dependent apoptosis in human lymphoma U937 cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Caspase 3; Caspase 9; Cytochromes c; DNA Fragmentation; Gossypol; Humans; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; U937 Cells | 2008 |
Synergistic antitumoral activity and induction of apoptosis by novel pan Bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Dose-Response Relationship, Drug; Doxorubicin; Drug Therapy, Combination; Gossypol; Humans; In Situ Nick-End Labeling; Liver Neoplasms; Mice; Mice, Nude; Molecular Structure; Neoplasm Transplantation; Proto-Oncogene Proteins c-bcl-2; Transplantation, Heterologous | 2008 |
[Effect of apogossypolone on induction apoptosis in multiple myeloma cells and its mechanisms].
Topics: Apoptosis; bcl-X Protein; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Proliferation; Gossypol; Humans; Proto-Oncogene Proteins c-bcl-2 | 2009 |
Apogossypolone inhibits cell growth by inducing cell cycle arrest in U937 cells.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Cycle; Cell Proliferation; Cell Survival; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cytochromes c; Dose-Response Relationship, Drug; Gossypol; Humans; Lymphoma; Mitochondria; Proto-Oncogene Proteins c-myc; Time Factors; U937 Cells | 2009 |
ApoG2 induces cell cycle arrest of nasopharyngeal carcinoma cells by suppressing the c-Myc signaling pathway.
Topics: Cell Cycle; Cell Line; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Gossypol; Humans; Molecular Structure; Nasopharyngeal Neoplasms; Neoplasm Transplantation; Proto-Oncogene Proteins c-myc; RNA Interference; Signal Transduction; Transplantation, Heterologous | 2009 |
Preclinical studies of apogossypolone, a novel pan inhibitor of bcl-2 and mcl-1, synergistically potentiates cytotoxic effect of gemcitabine in pancreatic cancer cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; Cell Line, Tumor; Deoxycytidine; Drug Resistance, Neoplasm; Drug Synergism; Female; Gemcitabine; Gossypol; Humans; Membrane Proteins; Mice; Mice, SCID; Myeloid Cell Leukemia Sequence 1 Protein; Pancreatic Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Xenograft Model Antitumor Assays | 2010 |
Apogossypolone, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Drug Screening Assays, Antitumor; Gossypol; Growth Inhibitors; Humans; Male; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2 | 2010 |
Apogossypolone targets mitochondria and light enhances its anticancer activity by stimulating generation of singlet oxygen and reactive oxygen species.
Topics: Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Proliferation; Gossypol; Humans; Light; Membrane Potential, Mitochondrial; Mice; Mice, Nude; Nasopharyngeal Neoplasms; Neoplasm Transplantation; Photochemotherapy; Reactive Oxygen Species; Singlet Oxygen; Tumor Burden | 2011 |
Inhibitory effects of gossypol-related compounds on growth of Aspergillus flavus.
Topics: Antifungal Agents; Aspergillus flavus; Gossypol | 2011 |
Inhibitory effects of gossypol, gossypolone, and apogossypolone on a collection of economically important filamentous fungi.
Topics: Aflatoxins; Antifungal Agents; Aspergillus; Fusarium; Gossypium; Gossypol; Penicillium; Plant Extracts | 2012 |
Apogossypolone, derivative of gossypol, mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage.
Topics: Antineoplastic Agents; Cell Nucleus; Chelating Agents; Chromatin; Copper; DNA Breaks; DNA Damage; Gossypol; Humans; Hydrogen Peroxide; Iron; Lymphocytes; Oxidative Stress; Permeability; Reactive Oxygen Species; Zinc | 2012 |
Apogossypolone induces autophagy and apoptosis in breast cancer MCF-7 cells in vitro and in vivo.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; bcl-2-Associated X Protein; Beclin-1; Breast Neoplasms; Cell Cycle Checkpoints; Cell Proliferation; Dose-Response Relationship, Drug; Female; Gossypol; Humans; MCF-7 Cells; Membrane Proteins; Mice, Nude; Proto-Oncogene Proteins c-bcl-2; Xenograft Model Antitumor Assays | 2014 |
Bax and Bak are required for apogossypolone, a BH3-mimetic, induced apoptosis in chronic lymphocytic leukemia cells.
Topics: Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Gene Expression; Gene Knockout Techniques; Gossypol; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Mice | 2013 |
ApoG2 as the most potent gossypol derivatives inhibits cell growth and induces apoptosis on gastric cancer cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Down-Regulation; Flow Cytometry; Gene Expression Regulation, Neoplastic; Gossypol; Humans; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Stomach Neoplasms; Time Factors; Up-Regulation | 2013 |
BH3 mimetic therapy: an emerging and promising approach to treating chronic lymphocytic leukemia.
Topics: Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Gossypol; Humans; Leukemia, Lymphocytic, Chronic, B-Cell | 2013 |
The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis Regulatory Proteins; Autophagy; bcl-X Protein; Beclin-1; Carcinoma, Hepatocellular; Cell Line, Tumor; Cyclin D1; Extracellular Signal-Regulated MAP Kinases; Gossypol; Hep G2 Cells; HMGB1 Protein; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Membrane Proteins; Microtubule-Associated Proteins; Phosphorylation; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; TOR Serine-Threonine Kinases | 2013 |
Effects of temperature and medium composition on inhibitory activities of gossypol-related compounds against aflatoxigenic fungi.
Topics: Aflatoxins; Agar; Antifungal Agents; Aspergillus; Aspergillus flavus; Culture Media; Gossypol; Temperature | 2013 |
Growth inhibition and apoptosis induction of human umbilical vein endothelial cells by apogossypolone.
Topics: Apoptosis; Cell Movement; Cell Proliferation; Cells, Cultured; Collagen; Drug Combinations; Flow Cytometry; Gossypol; Human Umbilical Vein Endothelial Cells; Humans; Laminin; Neovascularization, Physiologic; Proteoglycans | 2013 |
Growth inhibitory effects of gossypol and related compounds on fungal cotton root pathogens.
Topics: Antifungal Agents; Fusarium; Gossypium; Gossypol; Inhibitory Concentration 50; Microbial Sensitivity Tests; Naphthalenes; Phenols; Plant Diseases; Plant Roots; Pythium; Rhizoctonia | 2014 |
Apogossypolone, a small-molecule inhibitor of Bcl-2, induces radiosensitization of nasopharyngeal carcinoma cells by stimulating autophagy.
Topics: Animals; Autophagy; Carcinoma; Cell Line, Tumor; Cell Proliferation; Chemoradiotherapy; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Gossypol; Humans; Mice; Mice, Nude; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasms, Experimental; Proto-Oncogene Proteins c-bcl-2; Radiation-Sensitizing Agents; Xenograft Model Antitumor Assays | 2014 |
Apogossypolone inhibits the proliferation of LNCaP cells in vitro and in vivo.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; bcl-2 Homologous Antagonist-Killer Protein; Beclin-1; Caspase 3; Caspase 8; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Gossypol; Humans; In Situ Nick-End Labeling; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron, Transmission; Proto-Oncogene Proteins c-bcl-2; Xenograft Model Antitumor Assays | 2014 |
Canonical Wnt signaling acts synergistically on BMP9-induced osteo/odontoblastic differentiation of stem cells of dental apical papilla (SCAPs).
Topics: Animals; Cell Differentiation; Cell Line; Dental Papilla; Drug Synergism; Female; Gossypol; Growth Differentiation Factors; HeLa Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Odontogenesis; Rats; Signal Transduction; Stem Cells; Wnt Proteins | 2015 |
Mulberry-like dual-drug complicated nanocarriers assembled with apogossypolone amphiphilic starch micelles and doxorubicin hyaluronic acid nanoparticles for tumor combination and targeted therapy.
Topics: Animals; Doxorubicin; Drug Delivery Systems; Gossypol; HeLa Cells; Humans; Hyaluronic Acid; Male; Mice; Mice, Inbred BALB C; Micelles; Morus; Nanoparticles; Starch | 2015 |
Apogossypolone induces reactive oxygen species accumulation and controls cell cycle progression in Raji Burkkit's lymphoma cells.
Topics: Antineoplastic Agents; Apoptosis; Burkitt Lymphoma; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; DNA Helicases; DNA-Binding Proteins; Down-Regulation; G1 Phase Cell Cycle Checkpoints; Gossypol; Humans; NADPH Oxidases; Onium Compounds; Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Reactive Oxygen Species | 2015 |
Therapy of prostate cancer using a novel cancer terminator virus and a small molecule BH-3 mimetic.
Topics: Adenoviridae; Animals; Antineoplastic Agents; Apoptosis; Biological Mimicry; Cell Line, Tumor; Cysteine-Rich Protein 61; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Gossypol; Humans; Interleukins; Male; Mice, Nude; Mice, Transgenic; Myeloid Cell Leukemia Sequence 1 Protein; Oncolytic Virotherapy; Oncolytic Viruses; Peptide Fragments; Promoter Regions, Genetic; Prostatic Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Rats; Time Factors; Transfection; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
ApoG2 inhibits the antiapoptotic protein, Mcl‑1, and induces mitochondria‑dependent apoptosis in human colorectal cancer cells.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Colon; Colorectal Neoplasms; Gossypium; Gossypol; Humans; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Rectum | 2015 |
Mobilization of Intracellular Copper by Gossypol and Apogossypolone Leads to Reactive Oxygen Species-Mediated Cell Death: Putative Anticancer Mechanism.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Copper; DNA Damage; Epithelial Cells; Gossypol; Humans; Oxidative Stress; Reactive Oxygen Species | 2016 |